Navigation Links
Discovery suggests location of genes for breast density, a strong risk factor for breast cancer
Date:8/31/2007

stmenopausal women, the researchers note.

Vachons team took what they term an agnostic approach to uncovering genes, or gene regulators like microRNA, that are involved in the development of dense breasts. We assume we dont know anything about the biology of the trait and we let the genomes of our participants and their breast densities guide us, Vachon said.

Their method contrasts the traditional candidate gene approach, where scientists look at variations in specific genes thought to be involved with the disease or trait of interest. Such linkage studies have been used to uncover many high-impact risk genes, such as the breast cancer susceptibility genes BRCA1 and BRCA2.

The Mayo researchers performed a genome-wide linkage scan to identify possible chromosome regions in 89 families, part of a multi-generational Minnesota family study that began in 1944 at the University of Minnesota. Blood samples and mammograms were collected and analyzed for 756 female participants; 133 men were also included to help clarify genetic information in their offspring, mothers and sisters. We used the relationship between family members and breast density to inform where a gene might be, Vachon says.

Researchers first studied 403 DNA markers spaced across the genome to determine the amount of genetic information shared at and between each of these genomic signposts and its correlation to breast density as measured on mammography. They found three regions of interest, and narrowed the most promising region further by studying 21 additional, more densely spaced DNA markers. This secondary analysis highlighted one region consisting of approximately 45 known genes on chromosome 5p that was significantly associated with increased breast density.

The researchers then adjusted their analysis to eliminate the contribution of body mass index (BMI), which is a known breast cancer risk factor and also inversely associated with breast density, and found
'/>"/>

Contact: Greg Lester
lester@aacr.org
267-646-0554
American Association for Cancer Research
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Discovery of bone gene
2. Latest discovery on Autism
3. Bacterial discovery may help CF patients
4. A new discovery about Acetaminophen
5. A new discovery about Acetaminophen
6. Resistant tumors could be treated with the discovery of a new molecule within cancer cells
7. Treatment for cholesterol-related illnesses likely with the discovery of receptor in mice
8. Ways to counter radiation effects with new molecule discovery
9. Canada stunned as mad cow discovery leads to beef ban
10. Mouth Infection better handled with new discovery
11. New discovery made about the Nipah Virus
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/30/2014)... Chinese researchers say a protein that makes ... be used as a prognostic indicator in people on chemotherapy ... full article on the study , just posted on the ... Respiratory Medicine at Shandong University Hospital in China analyzed the ... between 1995 and 2013. They found that, the lower the ...
(Date:7/30/2014)... 2014 The Independent Woman , ... holding 5 free financial workshops in the San Francisco ... goal of these workshops is our collective success, linking ... financial empowerment. , These workshops were designed by women, ... successful investor, entrepreneur, and bestselling author (Rich Woman and ...
(Date:7/30/2014)... 2014 It is often said the reason that ... be in life is because they only use about ten per ... this belief is only an erroneous myth propagated as ... they been only “smarter”. , So, success in life is defined ... to work hard for that success. Thankfully, some people have finally ...
(Date:7/30/2014)... July 30, 2014 With the ... of personal health expenditure as well as the ... system, China diagnostic reagent industry has been developing ... 90%. In 2013, Chinese in vitro diagnostics market ... came from in vitro diagnostic reagents. , ...
(Date:7/30/2014)... 30, 2014 Computer Resources of America, ... in New York City, has been awarded the contract ... headquarters of a large global bank. The bank is ... Chico Ramnarayan, CEO of CRA said, “Being awarded this ... to further develop what has already been a successful ...
Breaking Medicine News(10 mins):Health News:Study Finds Common Blood Protein May Predict Mesothelioma Survival, Reports Surviving Mesothelioma 2Health News:The Independent Woman is Coming to the San Francisco Area in August - Women Helping Women Reach Their Financial Goals 2Health News:The Independent Woman is Coming to the San Francisco Area in August - Women Helping Women Reach Their Financial Goals 3Health News:Brain Evolution System - #1 Brainwave Entrainment Meditation Program Review | Unleashing One’s Ultimate Potential Improving Mind Power – Vinamy 2Health News:Brain Evolution System - #1 Brainwave Entrainment Meditation Program Review | Unleashing One’s Ultimate Potential Improving Mind Power – Vinamy 3Health News:China Diagnostic Reagent Industry (biochemical, molecular & immunodiagnostic) 2016 Forecasts in New Research Report at ChinaMarketResearchReports.com 2Health News:China Diagnostic Reagent Industry (biochemical, molecular & immunodiagnostic) 2016 Forecasts in New Research Report at ChinaMarketResearchReports.com 3Health News:China Diagnostic Reagent Industry (biochemical, molecular & immunodiagnostic) 2016 Forecasts in New Research Report at ChinaMarketResearchReports.com 4
... January 14, 2009 Obesity continues to increase for ... Mexican-American women. Between the ages of 35-44, there are ... and 575,000 Mexican-American women who are obese. A new ... reveals that there is an increased risk for ...
... LIVONIA, Mich., Jan. 14 On the heels of ... 11 states, American Community,Mutual Insurance Company today announced that ... Indiana. Designed to help consumer,s hold,down their medical expenses, ... through independent agents for a coverage effective date beginning,March ...
... much about it. FlameEz.com is launched to provide the latest information ... of the most feared illnesses in middle and old age. ... ... Millions of Americans are affected by chronic inflammation without knowing much ...
... SHANGHAI, China, Jan. 14 /PRNewswire-Asia-FirstCall/ -- China-Biotics, ... Company"), a leading Chinese firm,specializing in the ... products, today announced it has signed contracts,with ... Co., Ltd. ("Yuejia Food"),Shandong Huwa Dairy Industry ...
... N.Y., Jan. 14 /PRNewswire/ -- Scarguard Labs, ... of scars and other dermatological problems through the use ... system, announced it has appointed Richard E. Pino as ... Company,s finance, accounting, and treasury functions and will report ...
... in outbreak rises to 425 in 43 states, CDC says ... of people sickened by salmonella-contaminated peanut butter rose to 425 ... death in Minnesota and two in Virginia were probably tied ... the three people, whose names and hometowns haven,t been released, ...
Cached Medicine News:Health News:Economic status affects obesity rates in Mexican-American and white women 2Health News:American Community Introduces Community Flex(TM), an Affordable Health Plan in Arizona and Indiana 2Health News:Control of Inflammation May Benefit Many of the Most Feared Illnesses in Middle and Old Age 2Health News:Control of Inflammation May Benefit Many of the Most Feared Illnesses in Middle and Old Age 3Health News:China-Biotics, Inc. Signs Agreements With Four Additional Food Manufacturers 2Health News:China-Biotics, Inc. Signs Agreements With Four Additional Food Manufacturers 3Health News:China-Biotics, Inc. Signs Agreements With Four Additional Food Manufacturers 4Health News:Scarguard Labs, LLC Appoints Richard E. Pino as CFO 2Health News:Salmonella Linked to Deaths in Virginia, Minnesota 2Health News:Salmonella Linked to Deaths in Virginia, Minnesota 3
(Date:7/30/2014)... 30, 2014 Silicon Valley Bank, the bank ... today that examines the merger, acquisition and IPO ... According to the annual report based on 2013 data, ... since SVB started tracking the data in 2005. ... on solid healthcare M&A activity over the last few ...
(Date:7/30/2014)... and SAN DIEGO , July 30, ... ARNA ) announced today that an article based on ... lorcaserin entitled, "Early Weight Loss While on Lorcaserin, Diet, and ... recently published in the online issue of Obesity , ... objective of these analyses was to identify whether there is ...
(Date:7/30/2014)... and NEW YORK , ... ACCP), a developer of new products for oncology supportive ... MuGard ® , has been featured in an article ... Mucositis Symptoms in Head and Neck Cancers."  Dr. ... provides insight on the growing demand seen in the ...
Breaking Medicine Technology:Report: Biopharma and Medical Device Companies Beat Historic Investment Returns 2Report: Biopharma and Medical Device Companies Beat Historic Investment Returns 3Eisai and Arena Pharmaceuticals Announce Publication of Post-Hoc Analyses of Lorcaserin Phase 3 Clinical Trial Results in Obesity 2Eisai and Arena Pharmaceuticals Announce Publication of Post-Hoc Analyses of Lorcaserin Phase 3 Clinical Trial Results in Obesity 3Eisai and Arena Pharmaceuticals Announce Publication of Post-Hoc Analyses of Lorcaserin Phase 3 Clinical Trial Results in Obesity 4Eisai and Arena Pharmaceuticals Announce Publication of Post-Hoc Analyses of Lorcaserin Phase 3 Clinical Trial Results in Obesity 5Eisai and Arena Pharmaceuticals Announce Publication of Post-Hoc Analyses of Lorcaserin Phase 3 Clinical Trial Results in Obesity 6Eisai and Arena Pharmaceuticals Announce Publication of Post-Hoc Analyses of Lorcaserin Phase 3 Clinical Trial Results in Obesity 7Access Pharmaceuticals Featured On OncLive.com 2Access Pharmaceuticals Featured On OncLive.com 3
... smartest choice , ... event is to ... environment. But will the device be durable enough? Can ... on its signal quality? Will the battery last? Is it comfortable, ...
... ideal as a primary chemistry-immuno analyzer ... laboratories or as a dedicated specialty ... consolidate chemistry-immuno testing with Olympus 122 ... specific proteins, esoteric chemistries and tests ...
The Calcitonin ELISA is intended for the quantitative determination of Calcitonin in human serum....
... nm and 940 nm) laser system is ... solid-state laser quickly and effectively treats vascular ... offers the clinical versatility to precisely target ... vessels in a convenient, affordable package. , ...
Medicine Products: