Navigation Links
Discovery shows promise against severe side effects
Date:11/4/2010

November 4, 2010 (BRONX, NY) -- A team of scientists has found a way to eliminate a debilitating side effect associated with one of the main chemotherapy drugs used for treating colon cancer. The strategy used in their preclinical researchinhibiting an enzyme in bacteria of the digestive tractcould allow patients to receive higher and more effective doses of the drug, known as CPT-11 or Irinotecan.

The study, spearheaded by scientists at the University of North Carolina at Chapel Hill and involving collaborators at Albert Einstein College of Medicine of Yeshiva University and North Carolina Central University in Durham, is described in the November 5 issue of Science.

While the chemotherapy agent CPT-11 has proven useful in attacking colorectal tumors, it can also cause severe diarrhea - limiting the dosage that patients can tolerate and curbing the drug's potential effectiveness. The primary cause of the diarrhea is believed to be beta glucuronidase, an enzyme found in bacteria that live in the gastrointestinal tract. After the liver has rendered CPT-11 inert, the drug enters the intestine where it's reactivated by the beta glucuronidase of the gut bacteria. The revived CPT-11 irritates the intestine and causes severe diarrhea in up to 30 percent of patients who receive it.

To overcome this crippling side effect, the UNC researchers decided to look for compounds that would block the action of beta glucuronidase without eliminating the gut bacteria, which are important for human health.

"We need to retain our intestinal bacteria they help us digest food, make critical vitamins and protect us from infection," said Matthew R. Redinbo, Ph.D., who led the UNC research team, and is professor and chair of the chemistry department in the UNC College of Arts and Sciences and a member of the UNC Lineberger Comprehensive Cancer Center. "This targeted approach stops the one bacterial protein thought to cause the drug's devastating side effect, but without damaging the beneficial microbes or the intestines."


'/>"/>

Contact: Patric Lane
patric_lane@unc.edu
919-962-8596
Albert Einstein College of Medicine
Source:Eurekalert

Related medicine news :

1. Life Sciences Discovery Fund to support drug discovery, foster new R&D initiative
2. Cell survival protein discovery rewrites immune system story
3. Gene discovery could yield treatments for nearsightedness
4. A discovery by Dr. Andre Veillettes team could impact the treatment of autoimmune diseases
5. Discovery may aid search for anti-aging drugs
6. Discovery Moves Use of Stone Tools Back 800,000 Years
7. New discovery brings hope to treatment of incurable blood cancer
8. Discovery Opens Door for New Options in Prevention and Treatment of Mesothelioma
9. Discovery of Napoleon Hill Book Bound to Change Fate for Millions
10. B2Discovery: Entrepreneurs and researchers join forces to conquer cancer
11. Sun-induced skin cancer: new discovery permits doctors to assess genetic risk
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/25/2017)... ... February 25, 2017 , ... FCPX users now have the ability ... Film Studios. With ProSharpen Color users have total control over sharpening amount, sharpening radius, ... range. With color spectrum tools users can visually see the color range effected with ...
(Date:2/24/2017)... ... February 24, 2017 , ... WHAT: , The New Jersey ... as well as advocacy for the state and region‘s technology businesses, hosted their ... The Council's Innovation Forecast event highlights innovation throughout the region from small to ...
(Date:2/24/2017)... ... February 24, 2017 , ... In the Health Care ... a top priority because it’s not if you will be attacked, but when.” However, ... it comes to digital health care. , Improvements in auditing and monitoring have taken ...
(Date:2/24/2017)... (PRWEB) , ... February 24, 2017 , ... With ProGlass ... Cut Pro X . Users have total control over position, rotation, distortion, edge softness, ... all within Final Cut Pro X. , With ProGlass Prism users are given the ...
(Date:2/24/2017)... ... February 24, 2017 , ... Indiana Fiber Network (IFN) President and ... this year. Dyer started as the Chairman of the Management Committee when IFN ... the corporation including the recruitment of investor/owners and development of the business plan. ...
Breaking Medicine News(10 mins):
(Date:2/24/2017)... Feb. 24, 2017 Research and Markets has announced ... - Industry Forecast to 2025" report to their offering. ... The Global Empty Capsules Market is ... decade to reach approximately $2.9 billion by 2025. This ... segments on global as well as regional levels presented in the research ...
(Date:2/24/2017)... Feb. 24, 2017 Physician General Dr. ... Alcohol Programs Jennifer Smith commended South Central ... for and using naloxone, a life-saving overdose reversal drug. ... a recovery specialist and overdose survivor who was saved ... "A significant part of fighting the opioid ...
(Date:2/24/2017)... YORK , Feb. 24, 2017 ... Monteverde & Associates PC , a boutique securities firm ... New York City , announces that a class ... Massachusetts  against Inotek Pharmaceuticals Corporation ... of the Company,s securities between July 23, 2015 and December ...
Breaking Medicine Technology: