Navigation Links
Discovery sheds new light on marijuana's anxiety relief effects
Date:3/6/2014

An international group led by Vanderbilt University researchers has found cannabinoid receptors, through which marijuana exerts its effects, in a key emotional hub in the brain involved in regulating anxiety and the flight-or-fight response.

This is the first time cannabinoid receptors have been identified in the central nucleus of the amygdala in a mouse model, they report in the current issue of the journal Neuron.

The discovery may help explain why marijuana users say they take the drug mainly to reduce anxiety, said Sachin Patel, M.D., Ph.D., the paper's senior author and professor of Psychiatry and of Molecular Physiology and Biophysics.

Led by first author Teniel Ramikie, a graduate student in Patel's lab, the researchers also showed for the first time how nerve cells in this part of the brain make and release their own natural "endocannabinoids."

The study "could be highly important for understanding how cannabis exerts its behavioral effects," Patel said. As the legalization of marijuana spreads across the country, more people and especially young people whose brains are still developing are being exposed to the drug.

Previous studies at Vanderbilt and elsewhere, Patel said, have suggested the following:

  • The natural endocannabinoid system regulates anxiety and the response to stress by dampening excitatory signals that involve the neurotransmitter glutamate.

  • Chronic stress or acute, severe emotional trauma can cause a reduction in both the production of endocannabinoids and the responsiveness of the receptors. Without their "buffering" effect, anxiety goes up.

  • While marijuana's "exogenous" cannabinoids also can reduce anxiety, chronic use of the drug down-regulates the receptors, paradoxically increasing anxiety. This can trigger "a vicious cycle" of increasing marijuana use that in some cases leads to addiction.

In the current study
'/>"/>

Contact: Craig Boerner
craig.boerner@vanderbilt.edu
615-322-4747
Vanderbilt University Medical Center
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Zebrafish discovery may shed light on human kidney function
2. NUS researchers make new discovery of protein as a promising target for treatment of ATC
3. Drug discovery potential of natural microbial genomes
4. Prion discovery could help keep deadly brain diseases in check
5. Autism Learning Games: Camp Discovery App Utilizes Technology to Revolutionize Learning for Children with Autism
6. Discovery to Facilitate Eradication of Polio Worldwide
7. Cell division discovery could offer fresh insight into cancer
8. Expert Project Manager Joins TERIS, a National Leader in eDiscovery, Information Governance, Computer Forensics and Relativity
9. Transvaginal Mesh Lawsuit News: Bernstein Liebhard LLP Notes Issuance of New Order Pertaining to Discovery in Federal Boston Scientific Litigation
10. Judge Overseeing Federal Biomet Hip Lawsuits Won't Name Special Discovery Master, Bernstein Liebhard LLP Reports
11. Ovarian cancer discovery deepens knowledge of survival outcomes
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/27/2015)... ... ... Florida Hospital North Pinellas, located at 1395 South Pinellas Avenue in Tarpon Springs, will open ... will be located at US Highway 19 North and Highlands Boulevard, less than eight miles ... on the project is slated to begin in September 2015. , The new ...
(Date:8/27/2015)... ... August 27, 2015 , ... King Kullen, America’s First Supermarket, is celebrating 85 ... Cullen in 1930 and recognized by the Smithsonian Institute as America’s First Supermarket, King ... operated, the Cullen & Kennedy families have created a culture of caring while building ...
(Date:8/27/2015)... ... 2015 , ... Since its launch on August 16, 2007, ... in three counties, LA, Orange and San Bernardino. Their twenty physicians have ... Dr. Richy Agajanian, the Oncology Institute of Hope and Innovation is dedicated to ...
(Date:8/27/2015)... ... August 27, 2015 , ... ... solutions for drugs, biologics and consumer health products, today announced that Ms. Esther ... Conference, to be held at the Radisson Blu Edwardian Hotel, London Heathrow, on ...
(Date:8/27/2015)... ... 27, 2015 , ... "I need a little help supporting and stabilizing myself ... Camp Hill, Pa. "I developed this support handle to give me the extra little ... GRIP to provide a helping hand when stepping into or out of the tub ...
Breaking Medicine News(10 mins):Health News:Florida Hospital North Pinellas is Opening a New Free-Standing Emergency Room in Palm Harbor 2Health News:Florida Hospital North Pinellas is Opening a New Free-Standing Emergency Room in Palm Harbor 3Health News:King Kullen Honors Their 85 Years of Success this August 2Health News:California’s Largest Private Oncology Practice Serves 50,000 Patients in 8 years 2Health News:Clinical Trial Supply Chain Logistics to be Discussed By Catalent Expert at Upcoming Flypharma Conference 2Health News:Inventor and InventHelp Client Develops Bathroom Stabilization Aid (LCC-432) 2
... infections (UTI) are often caused by bacteria and ... Fluoroquinolones have been recommended empirical therapy for treatment ... high activity against E. coli that causes the ... formulation of ciprofloxacin may provide a convenient// once-daily ...
... helps in natural tumor control process. They said radiotherapy ... conducted on mice researchers identified an cell suicide enzyme, ... tumor nourishing blood vessels to die. Tumors cannot survive ... that damage to the DNA in the nuclei of ...
... from Australia says that older people taking anti-depressants are ... its not so much that anti-depressants do, but its ... peoples psychological stress, help treat them. There has been ... of depression and responding to them. With data collected ...
... cancer could save thousands of lives. Doctors found that nodular ... cancers but caused up to 70 per cent of the ... melanoma is the most dangerous. However these are often missed ... melanoma. It appears anywhere on the body, often the head ...
... an electronic nose which is capable of sniffing out distinctive ... 60 patients and proved to be accurate. The electronic nose ... olfactory system. The patient is asked to exhale into a ... is then pumped inside the cube and hence into the ...
... In a recent study Scientists have discovered that the substance ... natural moisturizer, wound-healer and antiseptic. The greasy, white secretion, called ... early at 32 to 33 weeks are covered with vernix. ... at the Cincinnati Children's Hospital Medical Center says that vernix ...
Cached Medicine News:
(Date:8/27/2015)... PUNE, India , August 27, 2015 ... "Radiology Information Systems Market by Type (Integrated, Standalone), by ... (Hospitals, Office based Physicians, Emergency Healthcare Service Providers), by ... global Radiology Information Systems Market is estimated at $501.1 ... by 2019, at a CAGR of 7.6% from 2014 ...
(Date:8/27/2015)... , Aug. 27, 2015  BioElectronics Corporation (OTC Pink: ... today that three abstracts featuring the use of ActiPatch®, ... the 9 th Congress of the European Pain ... th September 2015. The Company will also be ... Dr Gianluca Bagnato , department clinical and experimental ...
(Date:8/27/2015)...   Americord Registry , a private cord ... tissue banking company, announced today the launch of ... new website makes the expecting parent,s cord blood banking ... and checkout process. Logo - http://photos.prnewswire.com/prnh/20150827/261520LOGO ... make this service difficult to purchase online. We want ...
Breaking Medicine Technology:Radiology Information Systems Market Worth $722.7 Million by 2019 2Radiology Information Systems Market Worth $722.7 Million by 2019 3Radiology Information Systems Market Worth $722.7 Million by 2019 4BioElectronics Selected to Present its Pain Research and Devices at the European Pain Federation Conference 2Cord Blood Bank Revolutionizes Process of Online Cord Blood Banking 2
The Aortic Root Cannulae With Vent Line are flanged, with radiopaque tips; two side holes in tip....
The KAVD Venous Cannula is the first of its kind. It is a combination of cannulae/venous line designed to "bridge the gap between the patient and the Medtronic Resting Heart System circuit....
... Medtronic Select CAP® cannulae provides a ... pressure readings. An innovative combination of ... monitoring line, the Select CAP® can ... central arterial pressure readings on which ...
Intermittent catheter...
Medicine Products: