Discovery opens door to 'personalized' asth... (of air passages and sacs in the lungs (w...)

Discovery opens door to 'personalized' asthma therapy

Date:1/17/2008

of air passages and sacs in the lungs (which swell closed when they are inflamed during an asthma attack).

In each sample, we measured 25 different cytokines, inflammatory signaling proteins that play a very important role in asthma, Brasier said. We found that our samples fell into one group associated with severe asthma, another group that looks like it represents less severe disease, and two additional groups whose significance we dont yet understand.

The unknown protein profiles, Brasier said, could be produced by types of asthma that respond differently to treatment, or that are generated by different genetic or environmental sources. These and other as-yet-undiscovered protein patterns may eventually be used to diagnose types of asthma aggravated by cigarette smoke, for example, or that cause a steady decline in lung function over a number of years.

Until now, all we knew was that asthma was a disease that manifested itself in many different ways, Brasier said. By using these patterns of multiple different proteins, we can start defining those different subtypes much more accurately which is very useful for trying to identify which ones will respond to which treatments.

According to Brasier, clinical applications of asthma protein profiling will have to await the discovery of additional protein patterns to match with other subtypes of asthma, as well as more sensitive tests that would allow for less invasive sampling techniquesa blood test, for example, or an analysis of exhaled breath.

Were still a little bit away from treating people, but thats coming, Brasier said. This is the proof of principle that you can apply proteomic patterns to personalized medicine in asthma.

'/>"/>

Contact: Tom Curtis
tcurtis@utmb.edu
409-772-2455
University of Texas Medical Branch at Galveston
Source:Eurekalert

0

GOOD

Page: 1 2
Related medicine news :

1. Linguamatics and 81qd Sign Multi-Year Collaboration in Knowledge Discovery for Product Life Cycle Management
2. Fight against hay fever and other allergies helped by new immune system discovery
3. Discovery Healths Fifth Annual National Body Challenge Takes a Stand Against Obesity by Offering the Keys to Adopting a Healthy, Active Lifestyle
4. Overweight Twins Battle the Bulge and Gain A New Lease on Life in National Body Challenge: Twins Edition on Discovery Health
5. Kaiser Permanente and Discovery Health Team Up to Fight Childhood Obesity Epidemic
6. Panomics Inc.: Recipient of the Frost & Sullivan 2007 United States Drug Discovery Technologies Entrepreneurial Company of the Year Award
7. OHSU Cancer Institute research discovery opens new window to understanding chronic myeloid leukemia
8. Orion Pharma Selects ChemDiv as A Partner in Drug Discovery Services
9. BioDiscovery Joins Illumina Connect Bioinformatics Program
10. Discovery Health Travels the World to Present the Groundbreaking Documentary - Diabetes: A Global Epidemic
11. Beactica Announces Drug Discovery Collaboration With Arrow Therapeutics

Post Your Comments:

(Date:5/24/2013)... May 24, 2013 In a coup that ... Greg DeLange of the Estetica Institute of the Palm ... KOOL 105.5 FM’s popular morning show, “The Mo & Sally ... experiences and their satisfaction with the results, giving Dr. DeLange ... located in Palm Beach Gardens, very valuable free publicity. , ...

(Date:5/24/2013)... CBT News.com recently announced the addition of Tom ... automotive industry news organization with 12 years experience in online ... a group that’s so forward-thinking in their approach,” says Gonter. ... content is on the rise.” , Atlanta born and raised, ... into advertising at Cycle News and Boating World. He made ...

(Date:5/24/2013)... 24, 2013 The Institute for Integrative ... announce that it has donated $10,000 to the Cleveland ... captive in Cleveland, Ohio. , “When the news came out ... and Amanda Berry and her daughter had escaped from a ... were shocked and horrified,” said Integrative Nutrition Founder, Director, and ...

(Date:5/24/2013)... 24, 2013 The point-of-care (POC) ... used outside the central laboratory, by other healthcare ... practitioner or by consumers. This includes products that ... pregnancy, infectious and cardiovascular disease and cancer, as ... critical care, surgical and emergency departments. , Critical ...

(Date:5/24/2013)... first conference of its kind, Impacts World 2013 ... decision makers from politics, business and civil society ... climate impact research across sectors and scales. , ... 2013 on May 27th, 1pm to 1:55pm and ... Speakers include: , Connie Hedegaard, EU ...

Breaking Medicine News(10 mins):Health News:Dr. Greg DeLange of the Estetica Institute Recently Performed Eye Surgery on Both Members of Popular Morning Radio Team 2 Health News:Integrative Nutrition Donates $10,000 to the Cleveland Courage Fund 2 Health News:Point of Care Diagnostics Market (POC) Analysis and 5 Year Forecast in New Research Report at ReportsnReports.com 2 Health News:Point of Care Diagnostics Market (POC) Analysis and 5 Year Forecast in New Research Report at ReportsnReports.com 3

[0] Dr. Greg DeLange of the Estetica Institute Recently Performed Eye Surgery on Both Members of Popular Morning Radio Team [0] Tom Gonter to Drive Sales at Retail Automotive News Organization CBT News [0] Integrative Nutrition Donates $10,000 to the Cleveland Courage Fund [0] Point of Care Diagnostics Market (POC) Analysis and 5 Year Forecast in New Research Report at ReportsnReports.com [0] Impacts conference on climate change effects

... , , FRANKLIN ... (NYSE: MHS ), the world,s most advanced pharmacy(R) ... into a joint venture with United Drug plc, a Pan-European healthcare ... for patients covered by the country,s National Health Service (NHS). ...

... , MARINA DEL RAY, Calif., Aug. 12 Dr. ... to welcome Italian students from the University of L,Aquila by assisting ... school is being rebuilt after the devastating April 5th earthquake in ... who were displaced by the earthquake in L,Aquila, Italy, including the ...

... ISELIN, N.J., Aug. 12 Pharmos Corporation (Pink Sheets: PARS) today reported financial ... , Second Quarter Ended June 30, 2009 , ... or $0.05 per share, for the second quarter 2009 compared to a net ... Cash and cash equivalents totaled $2.9 million at June 30, 2009. , ...

... have given for years , WEDNESDAY, Aug. 12 (HealthDay News) ... painful swelling of the arm that often occurs after breast ... to what women have been told for years -- that ... other exercise because muscle strain can cause lymphedema to worsen. ...

... Goal is to help patients who might benefit from ... By clarifying rules governing patient access to so-called investigational ... to expand the number of people who might benefit ... can get the drugs hasn,t changed, but there is ...

... , WASHINGTON, Aug. 12 During a town ... stated his opposition to legislation that would cover illegal aliens. Specter ... was the author of the 2006 amnesty bill (S. 2611) that ... illegal aliens under the proposed reforms is a clear indication of ...

Medco Health Solutions, United Drug Announce U.K. Homecare Pharmacy Joint Venture Serving Patients with Chronic and Complex Health Conditions; Innovations to Improve Clinical Quality, Reduce Costs Heritage Provider Network and Dr. Richard Merkin Come to the Aid of Italian Earthquake Victims Pharmos Corporation Reports 2009 Second Quarter Results Weight Lifting Can Ease Arm Swelling in Breast Cancer Survivors FDA Details Access to 'Investigational' Drugs Specter Promises to Oppose Health Care Reform That Covers Illegal Aliens

(Date:5/23/2013)... Md. , May 23, 2013 BioElectronics Corporation ... consumer medical devices, comments on the FDA panel meeting ... Advisory Panel Reclassification – Pulsed Shortwave Therapy Meeting was ... MD , USA. The focus of the meeting ... the panel to focus solely on the application of ...

(Date:5/23/2013)... Medical Systems, Inc. (NASDAQ: CASM ) (CASMED), a ... that Thomas M. Patton , President and ... Annual Marcum MicroCap Conference on Thursday, May 30, 2013, at ... . The presentation is scheduled to begin ... will be available via a live webcast at http://wsw.com/webcast/marcum/casm/ ...

(Date:5/23/2013)... , May 23, 2013 Halozyme ... announced the appointment of David A. ... Ramsay was most recently Vice President, Corporate Development ... ) "With his established financial management ... gained by working in our commercial group for ...

Breaking Medicine Technology:BioElectronics and Pulsed Shortwave Therapy Make Progress 2 CASMED to Present at the 2nd Annual Marcum MicroCap Conference 2 Halozyme Therapeutics Names David A. Ramsay Chief Financial Officer 2

[0] BioElectronics and Pulsed Shortwave Therapy Make Progress [0] CASMED to Present at the 2nd Annual Marcum MicroCap Conference [0] Halozyme Therapeutics Names David A. Ramsay Chief Financial Officer

... ... ... ... ...

Cached Medicine Technology:Diabetics Twice as Likely to Have Hearing Loss; California HearUSA Centers to Offer Free Hearing Screening and Diabetes Video in March 2 Diabetics Twice as Likely to Have Hearing Loss; California HearUSA Centers to Offer Free Hearing Screening and Diabetes Video in March 3 Diabetics Twice as Likely to Have Hearing Loss; California HearUSA Centers to Offer Free Hearing Screening and Diabetes Video in March 4 Diabetics Twice as Likely to Have Hearing Loss; California HearUSA Centers to Offer Free Hearing Screening and Diabetes Video in March 5 Diabetics Twice as Likely to Have Hearing Loss; California HearUSA Centers to Offer Free Hearing Screening and Diabetes Video in March 6 Diabetics Twice as Likely to Have Hearing Loss; California HearUSA Centers to Offer Free Hearing Screening and Diabetes Video in March 7 Biomedical Advanced Research and Development Authority (BARDA) Project for Radiation Exposure Research Awarded to SRI International 2 Biomedical Advanced Research and Development Authority (BARDA) Project for Radiation Exposure Research Awarded to SRI International 3 Biomedical Advanced Research and Development Authority (BARDA) Project for Radiation Exposure Research Awarded to SRI International 4 Biomedical Advanced Research and Development Authority (BARDA) Project for Radiation Exposure Research Awarded to SRI International 5 Biomedical Advanced Research and Development Authority (BARDA) Project for Radiation Exposure Research Awarded to SRI International 6 Biomedical Advanced Research and Development Authority (BARDA) Project for Radiation Exposure Research Awarded to SRI International 7

Diabetics Twice as Likely to Have Hearing Loss; California HearUSA Centers to Offer Free Hearing Screening and Diabetes Video in March Biomedical Advanced Research and Development Authority (BARDA) Project for Radiation Exposure Research Awarded to SRI International

For the qualitative detection of single and multiple drugs and drug metabolites in human urine...

Medicine Products:

AMPII BZO300 COC MAMPII MOP THC SureStep Morphine (MOP)THC COC MOP AMPII MAMPII BZO200 SureStep MOP AMPII THC COC BZO200