Navigation Links
Discovery opens door to 'personalized' asthma therapy
Date:1/17/2008

GALVESTON, Texas In the last few years, personalized medicine using genetic or other molecular biology-based diagnostic tests to customize treatment for a particular patient has emerged as a powerful new tool for health care.

Therapy guided by genetic testing has proven highly successful in treating some types of leukemia and breast and lung cancer. Similar personalized therapies are on the horizon for other types of cancer, as well as diabetes, heart disease and other deadly disorders.

Now, University of Texas Medical Branch at Galveston (UTMB) researchers and their colleagues elsewhere have taken the first steps toward bringing the methods of personalized medicine to asthma.

Applying state-of-the-art protein screening techniques to samples taken from 84 asthmatic volunteers, theyve made the first identification of different subtypes of asthma based on distinct protein profiles, unique combinations of 10 or more proteins with which they are associated.

One of these profiles corresponds to a variety of severe, treatment-resistant asthma that, while rare, is responsible for 40 to 50 percent of the total health care costs associated with the disease.

We know that in asthma some people respond to very specific types of therapies and others dont, said Dr. Allan Brasier, director of UTMBs Sealy Center for Molecular Medicine and a senior author of a paper on the study appearing in the just-published January issue of the Journal of Allergy and Clinical Immunology (online at http://journals.elsevierhealth.com/periodicals/ymai). Being able to discover different asthma subtypes should allow us to tailor our treatments to increase the odds of a positive response, Brasier added.

To obtain their samples, researchers squirted a small amount of saline solution through tiny tubes into the anesthetized volunteers lungs. They then sucked the saline back out, bringing with it proteins washed free from walls of the network of air passages and sacs in the lungs (which swell closed when they are inflamed during an asthma attack).

In each sample, we measured 25 different cytokines, inflammatory signaling proteins that play a very important role in asthma, Brasier said. We found that our samples fell into one group associated with severe asthma, another group that looks like it represents less severe disease, and two additional groups whose significance we dont yet understand.

The unknown protein profiles, Brasier said, could be produced by types of asthma that respond differently to treatment, or that are generated by different genetic or environmental sources. These and other as-yet-undiscovered protein patterns may eventually be used to diagnose types of asthma aggravated by cigarette smoke, for example, or that cause a steady decline in lung function over a number of years.

Until now, all we knew was that asthma was a disease that manifested itself in many different ways, Brasier said. By using these patterns of multiple different proteins, we can start defining those different subtypes much more accurately which is very useful for trying to identify which ones will respond to which treatments.

According to Brasier, clinical applications of asthma protein profiling will have to await the discovery of additional protein patterns to match with other subtypes of asthma, as well as more sensitive tests that would allow for less invasive sampling techniquesa blood test, for example, or an analysis of exhaled breath.

Were still a little bit away from treating people, but thats coming, Brasier said. This is the proof of principle that you can apply proteomic patterns to personalized medicine in asthma.


'/>"/>

Contact: Tom Curtis
tcurtis@utmb.edu
409-772-2455
University of Texas Medical Branch at Galveston
Source:Eurekalert

Related medicine news :

1. Linguamatics and 81qd Sign Multi-Year Collaboration in Knowledge Discovery for Product Life Cycle Management
2. Fight against hay fever and other allergies helped by new immune system discovery
3. Discovery Healths Fifth Annual National Body Challenge Takes a Stand Against Obesity by Offering the Keys to Adopting a Healthy, Active Lifestyle
4. Overweight Twins Battle the Bulge and Gain A New Lease on Life in National Body Challenge: Twins Edition on Discovery Health
5. Kaiser Permanente and Discovery Health Team Up to Fight Childhood Obesity Epidemic
6. Panomics Inc.: Recipient of the Frost & Sullivan 2007 United States Drug Discovery Technologies Entrepreneurial Company of the Year Award
7. OHSU Cancer Institute research discovery opens new window to understanding chronic myeloid leukemia
8. Orion Pharma Selects ChemDiv as A Partner in Drug Discovery Services
9. BioDiscovery Joins Illumina Connect Bioinformatics Program
10. Discovery Health Travels the World to Present the Groundbreaking Documentary - Diabetes: A Global Epidemic
11. Beactica Announces Drug Discovery Collaboration With Arrow Therapeutics
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/22/2017)... CA (PRWEB) , ... March 22, 2017 , ... ... the California Bay Area providing insurance assistance, financial planning, and related services to ... Endangered Species International to promote awareness of threatened species and wild lands. , ...
(Date:3/22/2017)... ... March 22, 2017 , ... ... Milpitas with a robust, ongoing community enrichment program, has announced their latest charity ... which has provided for the critical needs of homeless families with children for ...
(Date:3/22/2017)... ... March 22, 2017 , ... The American ... prior authorization (PA) form for prescribers to improve patients’ access to the revolutionary ... tools published as part of the article entitled “PCSK9 Inhibitor Access Barriers: ...
(Date:3/22/2017)... (PRWEB) , ... March 22, 2017 , ... Old School ... boxing champ Ashley Theophane as a new Brand Ambassador. Theophane, who trained with Floyd ... welterweight title in 2011. He has racked up an impressive number of wins in ...
(Date:3/22/2017)... ... 2017 , ... Soriant recognizes that identifying savings opportunities can ... facilities across the country are always forced to focus on costs and budgets. ... country, an efficient and quick way to estimate savings potential within specific support ...
Breaking Medicine News(10 mins):
(Date:3/22/2017)... , 22 de marzo de 2017 /PRNewswire/ ... global líder de soluciones de productos y servicios ... hoy que ha adquirido EPL Archives, Inc., una ... los clientes en todo el ciclo de vida ... ofreciendo una muestra de archivo, almacenamiento de documentos ...
(Date:3/22/2017)... DUBLIN , Mar. 22, 2017 Research ... Care Devices Market Analysis & Trends - Industry Forecast to 2025" ... ... to grow at a CAGR of around 10.9% over the next ... This industry report analyzes the market estimates and forecasts for all ...
(Date:3/22/2017)... March 22, 2017  DarioHealth Corp. (NASDAQ: DRIO), ... health and big data solutions, today reported financial ... month period ended December 31, 2016. ... $2.8 million, increased 241% compared to the full ... growth throughout the entire year  ...
Breaking Medicine Technology: