Navigation Links
Discovery opens door to new drug options for serious diseases
Date:3/4/2013

CORVALLIS, Ore. Researchers have discovered how oxidative stress can turn to the dark side a cellular protein that's usually benign, and make it become a powerful, unwanted accomplice in neuronal death.

This finding, reported today in Proceedings of the National Academy of Sciences, could ultimately lead to new therapeutic approaches to many of the world's debilitating or fatal diseases.

The research explains how one form of oxidative stress called tyrosine nitration can lead to cell death. Through the common link of inflammation, this may relate to health problems ranging from heart disease to chronic pain, spinal injury, cancer, aging, and amyotrophic lateral sclerosis, or Lou Gehrig's disease.

As part of the work, the scientists also identified a specific "chaperone" protein damaged by oxidants, which is getting activated in this spiral of cellular decline and death. This insight will provide a new approach to design therapeutic drugs.

The findings were published by scientists from the Linus Pauling Institute at Oregon State University; Maria Clara Franco and Alvaro Estevez, now at the University of Central Florida; and researchers from several other institutions. They culminate a decade of work.

"These are very exciting results and could begin a major shift in medicine," said Joseph Beckman.

Beckman is an LPI principal investigator, distinguished professor of biochemistry, and director of the OSU Environmental Health Sciences Center. He also last year received the Discovery Award from the Medical Research Foundation of Oregon, given to the leading medical scientist in the state.

"Preventing this process of tyrosine nitration may protect against a wide range of degenerative diseases," Beckman said. "The study shows that drugs could effectively target oxidatively-damaged proteins."

Scientists have known for decades about the general concept of oxidative damage to cells, resulting
'/>"/>

Contact: Joseph Beckman
joe.beckman@oregonstate.edu
541-737-8867
Oregon State University
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Scientist awarded $1 million grant to develop tools for hepatitis C treatment discovery
2. Washingtons Life Sciences Discovery Fund awards commercialization grants
3. Discovery could help to develop drugs for organ transplant and cancer patients
4. Feelings of immaturity accompany alcohol misuse into adulthood; discovery could improve treatments
5. H1N1 discovery paves way for universal flu vaccine: UBC research
6. Scientists make breakthrough in bile duct cancer with discovery of new gene mutations
7. Researchers make promising discovery in pursuit of effective lymphoma treatments
8. Discovery suggests new combination therapy strategy for basal-like breast cancers
9. Discovery of Gene May Lead to New Male Contraceptive
10. 5 more pharmaceutical companies join NIH initiative to speed therapeutic discovery
11. Illnesses in Colorado childrens hospital prompts discovery of contaminated alcohol pads
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/31/2015)... As the demand for optimized mobile content continues ... mobile-friendly website online sometime during the month of May ... commitment to bring the best and most accurate information ... same great fitness information at http://www.chunkfitness.com will ... read while browsing on a mobile device. , About ...
(Date:3/31/2015)... 2015 Dr. Parsa Mohebi, founder of Parsa Mohebi ... on the forefront of using beard hair to fill ... as a novelty has now become an absolute option for giving ... “I really do believe that beard to scalp hair transplant can ... donor area isn’t as dense as we would like it,” says ...
(Date:3/31/2015)... FL (PRWEB) March 31, 2015 ... Systems (ADS) is offering advice for buying from ... Equipment Dealers Association (NMEDA) is a nonprofit organization ... professionalism in the manufacturing and installation of mobility ... companies in the industry that consistently adhere to ...
(Date:3/31/2015)... Simeon Boyd, UC Davis professor of genetics and ... from the National Institute of Dental and Craniofacial Research ... more than 10 centers in the United States and ... Italy and the United Kingdom, to study craniosynostosis, the ... in infants. , The researchers are members of the ...
(Date:3/31/2015)... March 31, 2015 Indosoft, developer of the ... 1.4 support in development of their 5.x line. The industry ... has been deployed around the world for more than a ... as a telephony platform, Q-Suite can fully embrace newer Asterisk ... call center software on Asterisk for more than a decade. ...
Breaking Medicine News(10 mins):Health News:Is Beard to Scalp Hair Transplant the Future? 2Health News:Advanced Driving Systems Celebrates National Disability Month 2Health News:International team of researchers led by UC Davis receives $4 million NIH grant to study skull disorder in infants 2Health News:International team of researchers led by UC Davis receives $4 million NIH grant to study skull disorder in infants 3Health News:Indosoft Announces End of Life for Asterisk 1.4 Support in Q-Suite 5 Call Center Software 2
... On-call radiology residents generally provide accurate preliminary interpretation of ... unavailable, according to results of a large study performed ... December issue of the Journal of the American ... The accuracy of image interpretation is the most essential ...
... from Boston University School of Medicine (BUSM) and ... a number of proteins whose activation allows them ... almost 97 percent accuracy. In addition, the BU ... analyze this data and specifically identify key biological ...
... , SAN FRANCISCO, Nov. 24 Quantros, a ... provider, announced today that it has licensed intellectual property ... for integration into Quantros, suite of safety and risk ... the SRM product family will enable automated safety data ...
... ... staffing, is pleased to announce its agreement with VHA Inc., a national healthcare network, ... ... recruiting firm LocumTenens.com , a leading provider of temporary physician staffing, is ...
... NIP, Inc. today announced the acquisition of Retirement Capital ... benefit plan providers headquartered in San Diego, California with additional ... RCG was founded in 2002 by William MacDonald, a renowned ... are excited to announce the acquisition of RCG which already ...
... , SAN CLEMENTE, Calif., Nov. ... of natural remedies, announced today the availability of new ... children,s health. A tip sheet on "Staying Naturally ... "Natural Moms" series, is now available on the company,s ...
Cached Medicine News:Health News:Researchers identify proteins in lung cancer cells that may provide potential drug targets 2Health News:Quantros Licenses Adverse Event Identification Technology from University of Michigan 2Health News:Quantros Licenses Adverse Event Identification Technology from University of Michigan 3Health News:VHA Names LocumTenens.com as Preferred Physician Staffing Vendor 2Health News:NIP Acquires San Diego Executive Benefits Firm 2Health News:Bionorica Offers Expert Resources, Health Tips for 'Natural Moms' 2
(Date:3/31/2015)... --  Halyard Health (NYSE: HYH ), formerly ... new purchasing agreement with HealthTrust for its ... Halyard,s standard and ASTM-rated face masks , including ... to HealthTrust members made up of 1,350 acute care ... practices and alternate care facilities. "We ...
(Date:3/31/2015)... 2015 Immune Pharmaceuticals Inc. ("Immune", the "Company") ... to expand its planned bullous pemphigoid (BP) clinical development ... Bullous Pemphigoid is an orphan auto-immune blistering disease of ... and Europe . As ... a Phase II clinical trial in Israel ...
(Date:3/31/2015)... March 31, 2015  Oxis International, Inc. (OXIS) (OXI.PA) ... and commercialization, announced today Oxis CEO Tony Cataldo ... Oxis common shares on the Euronext exchange. Oxis shares ... symbol OXIS.   Oxis Chairman and CEO ... move forward with its strategies launched in 2014 and ...
Breaking Medicine Technology:Halyard Health Signs First GPO Contracts As Independent Company 2Halyard Health Signs First GPO Contracts As Independent Company 3Immune Pharmaceuticals To Expand Bullous Pemphigoid Clinical Development Plan For Bertilimumab 2Immune Pharmaceuticals To Expand Bullous Pemphigoid Clinical Development Plan For Bertilimumab 3Immune Pharmaceuticals To Expand Bullous Pemphigoid Clinical Development Plan For Bertilimumab 4Oxis International Inc. Announces Request for Euronext Trading Suspension 2
... KNDL ) announced today it will release its third ... Nov. 8, 2010. The Company will host a telephone conference ... a.m. Eastern Time. A question and answer session will follow. ... To participate in the telephone conference call, interested parties in ...
... Ore., Oct. 18 Bend Research Inc. ( ... and manufacturing organization, announced today it has extended ... with Bristol-Myers Squibb Company ( www.bms.com ) (NYSE: ... Under the terms of the ...
Cached Medicine Technology:Kendle Announces Details Regarding Third Quarter 2010 Earnings Conference Call and Webcast 2Bend Research Announces Extension of Drug-Discovery Enablement and Development Services Agreement With Bristol-Myers Squibb 2
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
Medicine Products: