Navigation Links
Discovery of widespread tumor growth gene holds promise for effective anti-cancer treatment
Date:9/24/2007

Barcelona, Spain: Italian scientists will announce today (Monday September 24) that they have found a new and promising target for anti-tumour therapy in cancer. Professor Saverio Alberti, from the CESI, University of Chieti Foundation, Chieti, will tell the European Cancer Conference (ECCO 14) that he and his team have found a widespread mechanism for the stimulation of tumour growth in man, and that this is leading to the development of novel diagnostic and therapeutic procedures.

Professor Alberti and his team have discovered the function of the Trop-2 gene, a product of the TACTD2 gene, which is expressed in placenta, an invasive normal tissue. The function of Trop-2 was a mystery until now, says Professor Alberti, but knowing its expression in the trophoblast (cells forming the outer layer of the blastocyst the stage between the fertilised egg and the embryo) during pregnancy, we thought that it might well be involved in another invasive function tumour growth.

The scientists analysed the genes in human tumours and found that Trop-2 was expressed in the vast majority of human cancers, for example, breast, colon, stomach, lung, prostate, ovary, endometrium, uterine cervix and pancreas. Over-expression of the Trop-2 gene was also found when immunohistochemical (IHC) analysis of 1,755 tumours was undertaken. IHC analysis looks at the interaction of antibodies and antigens in tissues, and has the advantage of showing exactly where in a tissue a given protein is located. This has allowed us to develop anti-Trop-2 monoclonal antibodies for immunotherapy (modulation of the immune system to reject and destroy tumours) of Trop-2 expressing tumours, explains Professor Alberti.

Trop-2 over-expression was found in between 65% and 90% of the tumour types analysed, with an average of 74% across the board. These figures are high, explains Professor Alberti. In comparison, telomerase over-expression, possibly the most fundamental mechanism
'/>"/>

Contact: Mary Rice
mary@mrcommunication.org
44-078-030-48897
ECCO-the European CanCer Conference
Source:Eurekalert

0

GOOD

Page: 1 2 3

Related medicine news :

1. OHSU Researchers Announce New Discovery
2. Discovery of bone gene
3. Latest discovery on Autism
4. Bacterial discovery may help CF patients
5. A new discovery about Acetaminophen
6. A new discovery about Acetaminophen
7. Resistant tumors could be treated with the discovery of a new molecule within cancer cells
8. Treatment for cholesterol-related illnesses likely with the discovery of receptor in mice
9. Ways to counter radiation effects with new molecule discovery
10. Canada stunned as mad cow discovery leads to beef ban
11. Mouth Infection better handled with new discovery
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/23/2013)... 23, 2013 Jim Fitzpatrick just did ... Advertising developed yet another outside-of-the-box approach to reaching the ... he brings daily newscasts to the retail automotive industry, ... of a broadcast news format. , CBTNews.com is ... news. Co-anchors Bridget Everett and Russell Brown host the ...
(Date:5/23/2013)... 23, 2013 To better serve ... company, is pleased to announce the release of ... its pacesetting space division products. Provided by Koroseal, ... the new patterns and colors represent a sophisticated ... meetings with a team of Koroseal experts, Modernfold ...
(Date:5/23/2013)... now, little was scientifically known about the human potential ... for people who are suffering in a way that ... researchers at the Center for Investigating Healthy Minds at ... that adults can be trained to be more compassionate. ... Psychological Science , is the first to investigate whether ...
(Date:5/23/2013)... New techniques in imaging of brain activity developed ... Neurological Institute, and his colleagues lead to improved ... combination of electroencephalogram (EEG) and functional magnetic resonance ... the areas generating epileptic seizures, giving neurosurgeons a ... if appropriate. These results were presented at ...
(Date:5/23/2013)... HealthDay Reporter , , WEDNESDAY, May 22 (HealthDay News) -- Physicians ... lung cancer now have more information to help with the ... that low-dose CT scans pick up significantly more lung tumors ... of smoking are at high risk for lung cancer, the ... have to consider the potential harm of radiation exposure when ...
Breaking Medicine News(10 mins):Health News:Fitzpatrick Advertising Founder Brings Auto Industry into Focus with CBT News 2Health News:Modernfold Debuts New Colors and Patterns for Space Division Products 2Health News:Study shows people can be trained to be more compassionate 2Health News:Study shows people can be trained to be more compassionate 3Health News:Study shows people can be trained to be more compassionate 4Health News:New imaging techniques used to help patients suffering from epilepsy 2Health News:CT Scans Reduce Lung Cancer Deaths, Study Confirms 2Health News:CT Scans Reduce Lung Cancer Deaths, Study Confirms 3
... ... ... ... ...
... ... ... ... ...
... ... ... ... ...
... ... ... ... ...
... Two stroke-prevention procedures are safe and equally beneficial for ... effectiveness does vary by age, say researchers at the ... other North American stroke investigators. In findings reported ... Antonio, Texas, the researchers say physicians now have better ...
... on routes they knew well , FRIDAY, Feb. 26 ... drivers can make fatal mistakes on familiar routes, German ... brain activity in 16 experienced and 16 less experienced ... the routes on the simulator, the participants, brains were ...
Cached Medicine News:Health News:Stroke Conference Daily News Summary -- Friday 2Health News:Stroke Conference Daily News Summary -- Friday 3Health News:Stroke Conference Daily News Summary -- Friday 4Health News:Stroke Conference Daily News Summary -- Friday 5Health News:Stroke Conference Daily News Summary -- Friday 6Health News:Aurora BayCare Hosts Statewide Medical Device Business Development Meeting 2Health News:Aurora BayCare Hosts Statewide Medical Device Business Development Meeting 3Health News:Aurora BayCare Hosts Statewide Medical Device Business Development Meeting 4Health News:Aurora BayCare Hosts Statewide Medical Device Business Development Meeting 5Health News:Aurora BayCare Hosts Statewide Medical Device Business Development Meeting 6Health News:Aurora BayCare Hosts Statewide Medical Device Business Development Meeting 7Health News:National Alliance for Hispanic Health Urges Action on Insurance Access as First Step to Achieving Best Health Outcomes for All 2Health News:National Alliance for Hispanic Health Urges Action on Insurance Access as First Step to Achieving Best Health Outcomes for All 3Health News:National Alliance for Hispanic Health Urges Action on Insurance Access as First Step to Achieving Best Health Outcomes for All 4Health News:American National Announces Corrected Dividend Dates 2Health News:Study: Choice between stroke-prevention procedures influenced by patient age 2Health News:Study: Choice between stroke-prevention procedures influenced by patient age 3
(Date:5/23/2013)... , May 23, 2013   BioLife Solutions ... of proprietary clinical grade hypothermic storage and ... and contract aseptic media manufacturer , today announced ... & Regenerative Medicine Congress 2013 this week in ... http://photos.prnewswire.com/prnh/20090814/BIOLIFELOGO ) Dr. Aby J. Mathew, BioLife,s ...
(Date:5/23/2013)... SAN DIEGO and PARIS ... VOLC ), a leading developer and manufacturer of ... and treatment of coronary and peripheral vascular disease, today ... V asodilator I ndependent S tenosis ... late breaking clinical trial session at EuroPCR 2013. These ...
(Date:5/23/2013)... LAUSANNE , Switzerland ... 23, 2013 Cenix BioScience, ... developer specialized in RNAi-, miRNA- and high content-driven ... biopharmaceutical group of companies with a focus on ... medical needs, including oncology and companion diagnostics, today ...
Breaking Medicine Technology:BioLife Solutions Announces Presentation at 8th World Stem Cells & Regenerative Medicine Congress 2BioLife Solutions Announces Presentation at 8th World Stem Cells & Regenerative Medicine Congress 3Volcano Announces Preliminary Results from the ADVISE II Study and Inclusion in the SYNTAX2 Trial During Hot Line Late Breaking Clinical Trial Sessions at EuroPCR 2013 2Volcano Announces Preliminary Results from the ADVISE II Study and Inclusion in the SYNTAX2 Trial During Hot Line Late Breaking Clinical Trial Sessions at EuroPCR 2013 3Volcano Announces Preliminary Results from the ADVISE II Study and Inclusion in the SYNTAX2 Trial During Hot Line Late Breaking Clinical Trial Sessions at EuroPCR 2013 4Volcano Announces Preliminary Results from the ADVISE II Study and Inclusion in the SYNTAX2 Trial During Hot Line Late Breaking Clinical Trial Sessions at EuroPCR 2013 5Cenix BioScience and Debiopharm Group Collaborate to Identify Predictive Biomarkers 2Cenix BioScience and Debiopharm Group Collaborate to Identify Predictive Biomarkers 3Cenix BioScience and Debiopharm Group Collaborate to Identify Predictive Biomarkers 4
... IOMI ) today announced that Stanley C. Erck, the ... Acumen BioFin,Rodman & Renshaw 9th Annual Healthcare Conference in ... will begin at 9:10 a.m. Eastern,Time in the Kennedy ... Mr. Erck,s presentation will focus on Iomai,s portfolio of ...
... Exelixis, Inc. (Nasdaq:,EXEL) today presented data from ... with albuminuria due to diabetic nephropathy. XL784 is ... enzymes that may,play a role in the pathogenesis ... presented during a poster session (Abstract/Poster PO1030) at,the ...
Cached Medicine Technology:Iomai CEO to Speak at Acumen BioFin Rodman & Renshaw Annual Healthcare Conference on Monday, Nov. 5 2Phase 2 Trial Results for Exelixis' XL784 Presented at the 2007 American Society of Nephrology Conference 2Phase 2 Trial Results for Exelixis' XL784 Presented at the 2007 American Society of Nephrology Conference 3Phase 2 Trial Results for Exelixis' XL784 Presented at the 2007 American Society of Nephrology Conference 4
...
...
The Lineage acetabular system with metal liners uses sophisticated manufacturing methods and materials to minimize wear debris generation....
The Pivot Bipolar was designed with a simple one-step assembly interface between the femoral head and the compression molded liner which requires no instruments and reduces OR time....
Medicine Products: