Navigation Links
Discovery of 'sugar sensor' in intestine could benefit diabetes

Diabetes patients could benefit from new research at the University of Liverpool that has identified a molecule in the intestine that can taste the sugar content of the diet.

Researchers found that the sweet taste receptor that senses sugar and artificial sweeteners is not only present in the tongue, but also in the intestine. The discovery will open new avenues for the treatment of diabetes and obesity, as well as suggest reasons for why artificially sweetened foods and beverages sometimes fail to result in weight loss.

Scientists have previously shown that the absorption of dietary sugars in the intestine is mediated by a protein a sugar transporter that varies in response to the sugar content of foods. The intestine uses a glucose sensing system to monitor these variations, but until now the nature of this system was unknown.

Professor Soraya Shirazi-Beechey, from the Faculty of Veterinary Science, said: We found that the sweet taste receptor and the taste protein, gustducin, are present in the taste cells of the gut. These sweet sensing proteins allow humans and animals to detect glucose within the intestine. We discovered that mice missing the gene for either of these proteins were unable to process the production of the intestinal sugar and were therefore unable to regulate the intestinal capacity to absorb dietary sugars.

Surprisingly we also found that the receptor was able to detect artificial sweeteners in foods and drinks resulting in increased capacity of the intestine to absorb dietary sugars, which would explain why these sweeteners are unsuccessful at helping people lose weight.

We are now researching mechanisms in which these receptors can be adjusted to benefit those with diet-related disorders. Diabetes for example, is where the bodys blood sugar level is higher than normal; if we could use the taste receptor like a dimmer switch we could set it so that the appropriate amount of sugar is absorbed in the body.

From a veterinary perspective, the discovery could also have implications for race horses. Horses need high levels of glucose to sustain them in long races; activating the receptor through dietary supplements, before and during the race, will increase intestinal absorption of glucose.


Contact: Samantha Martin
University of Liverpool

Related medicine news :

1. Discovery of bone gene
2. Latest discovery on Autism
3. Bacterial discovery may help CF patients
4. A new discovery about Acetaminophen
5. A new discovery about Acetaminophen
6. Resistant tumors could be treated with the discovery of a new molecule within cancer cells
7. Treatment for cholesterol-related illnesses likely with the discovery of receptor in mice
8. Ways to counter radiation effects with new molecule discovery
9. Canada stunned as mad cow discovery leads to beef ban
10. Mouth Infection better handled with new discovery
11. New discovery made about the Nipah Virus
Post Your Comments:
(Date:10/13/2015)... Angeles, CA (PRWEB) , ... October 13, 2015 , ... ... To incentivize would-be customers, eMarketing Concepts began a $1 promotion – effectively offering all ... a resounding success, and within weeks the company was flooded with phone calls from ...
(Date:10/13/2015)... ... 13, 2015 , ... The Bill Howe Family of Companies is an award ... and flood remediation services. Family-owned and operated for 35 years, they have maintained value, ... Diego plumber two years in a row from the Union Tribune Reader’s Poll, a ...
(Date:10/12/2015)... , ... October 13, 2015 , ... ... its biannual Heroes in Recovery Awards at Foundations Recovery Network’s Moments of Change ... presented the one-of-a-kind awards to Noah Levine and Dean Dauphinais who exemplify the ...
(Date:10/12/2015)... North Carolina (PRWEB) , ... October 12, 2015 , ... Kevin Costello, winner of the ... North Carolina , embarks today for his dream vacation to Hawaii. , “I didn’t believe ... worked out,” he says. “This contest encouraged me to get to the gym and invest ...
(Date:10/12/2015)... ... 2015 , ... The American Society of Clinical Hypnosis (ASCH) ... and clinical training in a health care discipline. , Many practitioners claim ... losing weight, managing pain, or stopping smoking, etc. Frequently, extravagant statements and guarantees ...
Breaking Medicine News(10 mins):
(Date:10/12/2015)... LONDON , Oct. 12, 2015 ... eye, it is quite challenging to deliver an ophthalmic drug ... be overcome for a successful ocular drug delivery. These include ... by the lymphatic system of conjunctiva and drug permeation issues ... of the drug, in topical eye drops, is lost due ...
(Date:10/12/2015)... Oct. 12, 2015  The Pharmacy Compounding Accreditation ... Compounding Pharmacy in Costa Mesa ... of the pharmacy,s commitment to meeting and/or exceeding ... --> --> ... --> --> Harbor ...
(Date:10/12/2015)... 2015  MiMedx Group, Inc. (NASDAQ: MDXG ), ... and patent-protected processes to develop and market advanced products ... Sports Medicine, Ophthalmic, and the Dental sectors of healthcare, ... quarter of 2015, its guidance for the fourth quarter ... $50 million Senior Secured Credit Facility. ...
Breaking Medicine Technology: