Navigation Links
Discovery of 'overdrive' protein could broaden drug design options
Date:2/12/2008

CHAPEL HILL New research by scientists at the University of North Carolina at Chapel Hill shows for the first time that an important family of proteins known to function at the cell surface also functions at a site within the cell.

The findings have potential implications for drug development as they involve G protein-coupled receptors (GPCRs). These molecules are the target of forty to fifty percent of modern medicinal drugs, such as antihistamines and drugs for high blood pressure.

The study identified the first protein to activate the G-protein signaling pathway from within a cell. In humans, reactions to everything from taste and smell to stimulants like adrenaline or caffeine requires G-protein signaling.

Until now, the only known way to turn on a G-protein was via a receptor sitting on a cells surface membrane. This receptor acts like a telegraph operator, accepting outside signals and relaying them inside the cell. It converts an external signal, like caffeine, into action in this case, a nerve signal to the brain.

More than half of all drugs, from asthma and heart medicine to antidepressants, target G-protein receptors. Discovering a protein that activates G-proteins from inside a cell could open up an entirely new pathway for drug development, said Henrik Dohlman, Ph.D., senior study author and a professor of biochemistry and biophysics in UNCs School of Medicine.

No drug is 100 percent effective, 100 percent free of side effects and 100 percent safe. The more options we have biochemically, the more selective we can be in designing new drugs. If we can find another way of modulating G-proteins, we could expand the drug targets that are available to pharmacology, Dohlman said.

The study appeared online Feb.7, 2008, in the journal Current Biology and will be published in the Feb. 14, 2008, print edition. Funding was provided by the National Institutes of Health and a UNC Cell and Molecular Biolo
'/>"/>

Contact: Leslie Lang
llang@med.unc.edu
919-843-9687
University of North Carolina at Chapel Hill
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Discovery of sugar sensor in intestine could benefit diabetes
2. Discovery suggests location of genes for breast density, a strong risk factor for breast cancer
3. Stem cell research produces a key discovery for Fragile X Syndrome
4. Welch Foundation gives $1.6 million for drug discovery research
5. New discovery leaves blood-doping athletes scratching their heads
6. Chemical Diversity Initiates International Prostrate Cancer Discovery Partnership
7. New discovery leaves blood-doping athletes scratching their heads
8. Discovery of widespread tumor growth gene holds promise for effective anti-cancer treatment
9. Discovery supports theory of Alzheimers disease as form of diabetes
10. Discovery Health CME Explores the Benefits and Risks of Aspirin in Aspirin Therapy: Maximizing the Benefits
11. New discovery may improve treatment of one of the worlds leading causes of blindness
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/31/2014)... July 31, 2014 The Alaska ... hiring of new dentist Dr. Jonathan Oudin, DDS, who ... previously practiced in Barrow, Alaska, for three years. According ... Dentistry hired Dr. Oudin to help take on new ... Dentistry to continue growing and serving the greater Anchorage ...
(Date:7/31/2014)... THURSDAY, July 31, 2014 (HealthDay News) -- With the ... the West African Ebola outbreak has risen to 729, ... on Thursday issued a travel warning for,the region. ... travel to the affected countries -- Guinea, Liberia and ... is that Ebola is worsening in West Africa," CDC ...
(Date:7/31/2014)... Scientists have learned that recent fears of invasive lionfish ... efforts to control lionfish by fishing derbies and targeted ... invasion. And there,s a simple way to know for ... after it,s been cooked. , Pacific lionfish were first ... and have been gaining swiftly in number ever since. ...
(Date:7/31/2014)... 31, 2014 Insight Accelerator Labs member ... A round of investment for $4.6 million to fund ... collecting vital signs. The company joined Insight Accelerator ... fruition with the help of Insight development teams. ... for launching the Accelerator,” says Steve McPhilliamy, Executive Director ...
(Date:7/31/2014)... FL (PRWEB) July 31, 2014 Women ... to take charge of their financial future. The ... women, has opened registration for 6 upcoming Los Angeles ... women, for women, and with input from Kim Kiyosaki, ... and It’s Rising Time) who is passionate about women’s ...
Breaking Medicine News(10 mins):Health News:Dr. Jonathan Oudin to Join Alaska Center for Dentistry at Wasilla Location 2Health News:CDC Issues Travel Warning as West Africa Ebola Outbreak Worsens 2Health News:Invasive lionfish likely safe to eat after all 2Health News:Invasive lionfish likely safe to eat after all 3Health News:Insight Accelerator Labs Advances Member Toward Commercialization 2Health News:Insight Accelerator Labs Advances Member Toward Commercialization 3Health News:The Independent Woman to Offer Financial Workshops in the Los Angeles Area - Developed by Women for Women 2
... 31 /PRNewswire-FirstCall/ - MDS Inc. (TSX: MDS; NYSE:,MDZ), ... the global life,sciences markets, announced today that Stephen ... presenting at the Thomas Weisel Partners,Healthcare Conference in ... Standard Time. Interested parties may access the ...
... 31 Mylan Laboratories Inc.,(NYSE: MYL ) ("Mylan") ... for cash any and all of its outstanding 5.750% ... Notes due 2015 (CUSIP Nos.,628530AF4, 628530AC1) (collectively, the "Notes"). ... of a broader strategy to,establish its new global capital ...
... - QLT USA, Inc., a subsidiary,of QLT Inc. ... that the European,approval procedure for the Eligard(R) 45 ... formulation in 23 European countries,is expected to follow ... the individual countries. The 6-month formulation was launched ...
... UHW-West and 121RN, their, first ever wage scales ... Calif., Aug. 30 Caregivers at Providence St.,Joseph Medical ... -,West (UHW) and SEIU 121RN, reached a tentative agreement ... contract, which expires,Sept. 30, 2011, grants workers their first ...
... are likely culprits behind the increase, , , THURSDAY, Aug. ... in one sport early -- playing year-round, joining competitive ... programs -- believing they,ll put themselves on the fast ... sports career. , But for too many of these ...
... Over Health & Safety of,Seniors in Nursing Homes, ... death linked to an untreated oral infection, the,statewide organization ... oral health of seniors residing in nursing and,convalescent homes., ... it can be a matter of life and,death, especially ...
Cached Medicine News:Health News:Mylan Commences Tender Offers and Consent Solicitations for Its 5.750% Senior Notes Due 2010 and 6.375% Senior Notes Due 2015 in Connection With Its Proposed Acquisition of Merck's Generic Pharmaceutical Business 2Health News:Mylan Commences Tender Offers and Consent Solicitations for Its 5.750% Senior Notes Due 2010 and 6.375% Senior Notes Due 2015 in Connection With Its Proposed Acquisition of Merck's Generic Pharmaceutical Business 3Health News:Mylan Commences Tender Offers and Consent Solicitations for Its 5.750% Senior Notes Due 2010 and 6.375% Senior Notes Due 2015 in Connection With Its Proposed Acquisition of Merck's Generic Pharmaceutical Business 4Health News:Eligard(R) six-month formulation successfully completes European approval procedure 2Health News:Eligard(R) six-month formulation successfully completes European approval procedure 3Health News:Providence St. Joseph Medical Center, Caregivers Reach Agreement on a Union Contract 2Health News:More Kids Are Suffering Sports Injuries 2Health News:More Kids Are Suffering Sports Injuries 3Health News:Oral Health a Matter of Life and Death for Seniors 2
(Date:7/31/2014)... July 31, 2014   Auxilium Pharmaceuticals , Inc. ... biopharmaceutical company, today announced that the Company will release ... August 7, 2014 before the opening of the U.S. ... call that day at 8:30 a.m. ET to discuss ... The presentation slides to be used during the call ...
(Date:7/31/2014)... , July 31, 2014  A substantial share ... decisions about which therapies are included in formularies—say ... according to a new Manhattan Research study, ... The study finds that P&T committee members in ... managers (PBMs) have set a high bar for ...
(Date:7/31/2014)... Catylix, Inc. ( Burbank, California ... California ) announced today the formation of ... fluorination products and related chemistry. Developing ... use of substituents that are chemically stable, resistant ... improve binding and bioavailability. Fluorinated functional groups are ...
Breaking Medicine Technology:Auxilium Pharmaceuticals, Inc. To Announce Second Quarter 2014 Results On August 7, 2014 2Auxilium Pharmaceuticals, Inc. To Announce Second Quarter 2014 Results On August 7, 2014 3Formulary Decision Makers Say Pharma-Provided Patient Support Solutions Influence Formulary Placement 2Formulary Decision Makers Say Pharma-Provided Patient Support Solutions Influence Formulary Placement 3Catylix, Inc. and Aspira Scientific Announce Joint Venture to Commercialize New Fluorination Technologies 2
... FDA Clearance for a Phase II Trial of Its Long-Acting... -- NES-ZIONA, Israel, Aug. 24 ... ... ... ,; var first_result; // Results are keyed by longUrl, so we need to grab the first one. ...
... CHICAGO, Aug. 24 Advanced Life Sciences Holdings, ... a biopharmaceutical company engaged in the discovery, development and ... infection, oncology and respiratory diseases, today announced plans to ... once-daily antibiotic, Restanza™ (cethromycin) based on a new, high-profile ...
Cached Medicine Technology:PROLOR Biotech Receives FDA Clearance for a Phase II Trial of Its Long-Acting Human Growth Hormone in the U.S. 2PROLOR Biotech Receives FDA Clearance for a Phase II Trial of Its Long-Acting Human Growth Hormone in the U.S. 3PROLOR Biotech Receives FDA Clearance for a Phase II Trial of Its Long-Acting Human Growth Hormone in the U.S. 4PROLOR Biotech Receives FDA Clearance for a Phase II Trial of Its Long-Acting Human Growth Hormone in the U.S. 5PROLOR Biotech Receives FDA Clearance for a Phase II Trial of Its Long-Acting Human Growth Hormone in the U.S. 6PROLOR Biotech Receives FDA Clearance for a Phase II Trial of Its Long-Acting Human Growth Hormone in the U.S. 7PROLOR Biotech Receives FDA Clearance for a Phase II Trial of Its Long-Acting Human Growth Hormone in the U.S. 8Advanced Life Sciences Sees Funding Opportunity for Restanza in New HHS Medical Countermeasure Report 2Advanced Life Sciences Sees Funding Opportunity for Restanza in New HHS Medical Countermeasure Report 3Advanced Life Sciences Sees Funding Opportunity for Restanza in New HHS Medical Countermeasure Report 4Advanced Life Sciences Sees Funding Opportunity for Restanza in New HHS Medical Countermeasure Report 5
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
Medicine Products: