Navigation Links
Discovery of key malaria proteins could mean sticky end for parasite
Date:7/9/2008

Scientists funded by the Wellcome Trust have identified a key mechanism that enables malaria-infected red blood cells to stick to the walls of blood vessels and avoid being destroyed by the body's immune system. The research, published today in the journal Cell, highlights an important potential new target for anti-malarial drugs.

Malaria is one of the world's biggest killers, killing over a million people every year, mainly children and pregnant women in Africa and south east Asia. It is caused by the malaria parasite, which is injected into the bloodstream from the salivary glands of infected mosquitoes. There are a number of different species of parasite, but the deadliest is the Plasmodium falciparum parasite, which accounts for 90% of deaths from malaria.

The malaria parasite infects healthy red blood cells, where it reproduces, producing up to thirty-two new daughter parasites. The parasite secretes a "glue", known as PfEMP1, which travels to the surface of the infected red blood cells, leading to the formation of the knobs on the surface of the cells. The cells become sticky and adhere to the walls of the blood vessels. This prevents the cells being flushed through the spleen, where the parasites would be destroyed by the body's immune system, but also restricts blood supply to vital organs.

Now, an international collaboration of scientists has identified eight new proteins that transport the P. falciparum parasite's "glue" to the surface of the infected red blood cells. The researchers, led by Professor Alan Cowman from the Walter and Eliza Hall Institute of Medical Research in Melbourne, Australia, have shown that removing just one of these proteins prevents the infected red blood cells from sticking to the walls of the blood vessels.

"These findings greatly enhance our understanding of how the malaria parasite commandeers the red blood cell for its own survival and avoids our immune defences," says Pr
'/>"/>

Contact: Craig Brierley
c.brierley@wellcome.ac.uk
44-207-611-7329
Wellcome Trust
Source:Eurekalert

Page: 1 2

Related medicine news :

1. 9/11 Workers Refute Citys Allegation of Discovery Abuse and Malingering
2. Discovery of gene mechanism could bring about new ways to treat metastatic cancer
3. MYSTERY ER Season 2 Takes Viewers Behind the Curtain for Real-Life Medical Mysteries on Discovery Health
4. NIAID creates HIV vaccine discovery branch
5. Could new discovery about a shape-shifting protein lead to a mighty morpheein bacteria fighter?
6. Core Informatics Deploys Core LIMS to Support Antibody Discovery at Fabrus
7. Dynamin drug discovery team win prestigious international epilepsy grant
8. Singapore Is One of the Fastest Growing Bioclusters in Asia; Wave of Investments in Drug Discovery and Translational Research
9. New Molecule Discovery Shows Promise Against Tamoxifen-Resistant Breast Cancers
10. Stem cell discovery sheds light on placenta development
11. Discovery of new signal pathway important to diabetes research
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/30/2014)... valuable procedure by which to screen for the ... healthy Americans who do undergo this sometimes uncomfortable ... actually should. Gina Kruse of Massachusetts General ... endoscopists stick to the national guidelines more closely. ... General Internal Medicine , published by Springer. ...
(Date:9/30/2014)... (PRWEB) September 30, 2014 MyServer2Go.com ... Arvixe as the Best VPS Hosting this year for ... well as affordable price. , MyServer2Go.com is a ... of VPS hosting services. And this announcement will help ... , According to MyServer2Go.com, Arvixe ( http://www.arvixe.com ) is ...
(Date:9/30/2014)... September 30, 2014 MyMobileUni seeks to ... NGO’s who have similar shared vision to transform individuals ... Honorary Advisor (MMU):, , ... 24/7 for all ages , to have ... empowerment , to promote equal access to ...
(Date:9/30/2014)... University of Eastern Finland shows that dietary polyunsaturated fatty ... The sources of polyunsaturated fatty acids include fish, vegetable ... Arteriosclerosis, Thrombosis & Vascular Biology , an esteemed journal ... not found an association between the consumption of saturated ... that the mere reduction of saturated fats from the ...
(Date:9/30/2014)... Doheny HealthDay Reporter , ... are given broad-spectrum antibiotics before the age of 2 ... during childhood, new research suggests. Broad-spectrum antibiotics target ... to the study. "It is a reason to ... you are picking," said lead researcher Dr. Charles Bailey, ...
Breaking Medicine News(10 mins):Health News:Americans undergo colonoscopies too often, study finds 2Health News:Arvixe Is Named Best VPS Hosting by MyServer2Go.com 2Health News:MyMobileUniversity Call to Public and Private Organisations, NGOs’ and Individuals: Catalyze Positive Social Change, Let’s Transform Individuals and Empower Communities 2Health News:MyMobileUniversity Call to Public and Private Organisations, NGOs’ and Individuals: Catalyze Positive Social Change, Let’s Transform Individuals and Empower Communities 3Health News:Dietary polyunsaturated fatty acids linked to smaller risk of coronary heart disease 2Health News:Antibiotic Use Before Age 2 Might Raise Obesity Risk, Study Says 2Health News:Antibiotic Use Before Age 2 Might Raise Obesity Risk, Study Says 3
... Dec. 7 Transcept Pharmaceuticals,Inc. today announced that Glenn ... an expert panel on "Drug Development in a,Changed Environment" ... Westin New York Hotel at Times Square on Thursday, ... multi-company panel will be moderated by Ken Trbovich, Vice,President, ...
... Ventures, a health and life,sciences focused venture capital firm ... of the firm., "We are pleased to name ... Partner of Radius. "David has demonstrated an outstanding,ability to ... have his,energy and continued contribution as we develop Radius ...
... one of the commonest surgical procedures performed on ... both physical and psychological harm, while recent evidence ... debate the issue in this weeks BMJ. , ... infant circumcision, yet ritual (non-therapeutic) male circumcision continues ...
... inadequate and should be replaced with charters of health ... But even these raise ethical tensions, says Harald Schmidt, ... Medical Association (BMA) recently called for a charter setting ... Service and what patients can expect from the NHS. ...
... 7 Bond,Laboratories, Inc. (OTC Bulletin Board: BNDB), a ... file with the NASD to implement,a 2-for-1 forward split ... as of the record date will receive,two (2) shares ... For,example, shareholders owning 5,000 shares prior to the stock ...
... REHOVOT, Israel and NORTH BRUNSWICK, New Jersey, December 7, ... in,the development of microRNA-based diagnostics and therapeutics, announced,today that ... Rosetta Genomics,will present at RBC Capital Markets 2007 Healthcare ... the Westin Hotel in New York., A live ...
Cached Medicine News:Health News:Transcept Pharmaceuticals to Present at RBC Capital Markets 2007 Healthcare Conference 2Health News:Is infant male circumcision an abuse of the rights of the child? 2Health News:Concept of patients' charters 'inadequate' 2Health News:Rosetta Genomics to Webcast Panel Presentation at RBC Capital Markets 2007 Healthcare Conference 2
(Date:9/30/2014)... 2014 Heart Imaging Technologies LLC (HeartIT) ... provider of complete digital software and hardware imaging ... The licensed patents cover the use of zero ... images in a standard Internet web browser. ... its Subsidiaries will not challenge the validity or ...
(Date:9/30/2014)... Sept. 30, 2014 It is evident from the ... is not performing upto expectations due to the lack of ... with the intake of omega-3 fatty acids. Among omega-3 ingredient ... fish oil, attributed to the large vegetarian population in ... polyunsaturated fatty acid (PUFAs) ingredients is in growth stage of ...
(Date:9/30/2014)... BETHESDA, Md. , Sept. 30, 2014 ... "Company") (Nasdaq: CHDX ) today announced the ... ("Healthy Harmony") for $24.00 per share in cash.  Healthy ... (Group) Co., Ltd. ("Fosun") and Ms. Roberta Lipson ... previously announced merger agreement was adopted by Chindex,s stockholders ...
Breaking Medicine Technology:Omega-3 Polyunsaturated Fatty Acids (PUFAs) - An Indian Market Overview 2Chindex Completes Go-Private Transaction With Healthy Harmony Holdings, L.P. 2Chindex Completes Go-Private Transaction With Healthy Harmony Holdings, L.P. 3Chindex Completes Go-Private Transaction With Healthy Harmony Holdings, L.P. 4Chindex Completes Go-Private Transaction With Healthy Harmony Holdings, L.P. 5
... Development Plan Completed Successfully, DUBLIN, Ireland, July ... today announced that the Company recently met with,officials ... to discuss the,Company,s plans to develop AMR101 for ... is,proceeding to Phase 3 with AMR101 in hypertriglyceridemia., ...
... Stress the Importance to Patients of Passing a ... Follow- On Biologics Approval Pathway, ... developer of follow-on biologics and biopharmaceuticals, today,announced that Geoffrey Allan, ... Friday, July 25th, 2008 to discuss the,significant need for establishing ...
Cached Medicine Technology:Amarin Proceeding to Phase 3 With AMR101 for Hypertriglyceridemia 2Amarin Proceeding to Phase 3 With AMR101 for Hypertriglyceridemia 3Insmed CEO to Present at Congressional Briefing on Follow-On Biologics 2Insmed CEO to Present at Congressional Briefing on Follow-On Biologics 3
... For use as a ... detecting IgG antibody to Toxoplasma ... to rubella virus (rubella IgG), ... IgG) and IgG antibody to ...
... The VITROS HBsAg assay is ... by the U.S. Food and ... in a random,access format on ... Intellicheck. Now you can run ...
... The Total PSA method for ... immunoassay module is an in vitro ... total prostate specific antigen (TPSA) in ... used as an aid in the ...
... based on sequential binding of HCG from ... for the *-chain of HCG) immobilized on ... the *-chain of HCG) conjugated to the ... chromogenic substrate is added and colors developed. ...
Medicine Products: