Navigation Links
Discovery of 'executioner' protein opens door to new options for stroke ALS, spinal cord injury
Date:3/4/2013

Oxidative stress turns a protein that normally protects healthy cells into their executioner, according to a study released today in the Proceedings of the National Academy of Sciences journal.

Alvaro Estevez, an associate professor at the University of Central Florida's College of Medicine, led the multi-university team that made the discovery, which could eventually help scientists develop new therapies to combat a host of conditions from stroke to Lou Gehrig's disease

Researchers have long known that oxidative stress damages cells and results in neurodegeneration, inflammation and aging. It was commonly believed that oxidation made a "crude," demolition-like attack on cells, causing them to crumble like a building in an earthquake, Estevez said. However, the latest findings show that oxidation results in a much more targeted attack to specific parts of the cell. Oxidative stress damages a specific "chaperone" cell protein called Hsp90. It plays a role in up to 200 different cell functions. But when a form of oxidative stress called tyrosine nitration modifies that protein, it turns into the cell "executioner" shutting it down.

"The concept that a protein that is normally protective and indispensable for cell survival and growth can turn into a killing machine, and just because of one specific oxidative modification, is amazing," said Maria C. Franco, a postdoctoral associate at UCF's Burnett School of Biomedical Sciences. She co-wrote the study. "Considering that this modified protein is present in a vast number of pathologies, it gives us hopes on finding new therapeutics approaches for several different diseases."

For example, researchers could devise a drug that stroke patients could take at the onset of their symptoms to prevent more healthy cells from dying, thus limiting the damage of the stroke. Because oxidation is linked to inflammation, researchers believe tyrosine nitration could also be related to other
'/>"/>

Contact: Wendy Sarubbi
wendy.sarubbi@ucf.edu
407-266-1418
University of Central Florida
Source:Eurekalert  

Page: 1 2

Related medicine news :

1. PrimerLife Celebrates Anniversary of DNA Discovery with Launch of New Social Network
2. A new way of looking at drug discovery
3. Discovery in HIV may solve efficiency problems for gene therapy
4. Chili peppers spark discovery
5. Nottingham expertise in major European drug discovery partnership
6. DMG Productions to Feature Knee Creations Subchondroplasty® Procedure in its Health Heroes Series Airing via Discovery Channel
7. 176 Pradaxa Lawsuits Now Pending in Federal Litigation, Discovery Well Underway, Bernstein Liebhard LLP Reports
8. UGA discovery promises to improve drugs used to fight cancer, other diseases
9. Life Sciences Discovery Fund makes grants to commercialize health-related technologies
10. Discovery in Ghent could improve screening for sudden cardiac death
11. UAlberta medical researchers make key discovery in fight against Alzheimers disease
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Discovery of 'executioner' protein opens door to new options for stroke ALS, spinal cord injury
(Date:4/17/2014)... It,s estimated that as many as 10 million older ... of loneliness and isolation. , However, new research ... retired older Americans for six years found that ... of depression by more than 30 percent. , "That,s ... State University professor of telecommunication, information studies and media ...
(Date:4/17/2014)... April 17, 2014-- Colic affects about one in five ... numerous pediatric visits during the first several months after ... symptoms was showing promise; however, the April 1, 2014 ... Sung, Valerie) reported on a study, "Probiotics and Infant ... L reuteri for infant colic did not ...
(Date:4/17/2014)... University School of Medicine (BUSM) have discovered that ... an experimental model. The findings, reported in the ... , may lead to more effective treatments for ... of the leading causes of illness and death ... impact by limiting the productivity of workers and ...
(Date:4/17/2014)... researchers at UC Davis has shown that the cyclin ... cell division, also boosts the mitochondrial activity to power ... has been shown to perform both jobs. This newfound ... control cellular energy production, potentially advancing cancer care and ... the journal Developmental Cell . , "These proteins ...
(Date:4/17/2014)... by Cesar A. Arias, M.D., Ph.D., at The University ... identified a new superbug that caused a bloodstream infection ... April 17 issue of The New England Journal ... of a class of highly-resistant bacteria known as methicillin-resistant ... major cause of hospital and community-associated infections. The superbug ...
Breaking Medicine News(10 mins):Health News:Internet use can help ward off depression among elderly 2Health News:New study says probiotic use for infant colic is not effective in reducing symptoms 2Health News:BUSM researchers find anti-seizure drug may reduce alcohol consumption 2Health News:Dual role: Key cell division proteins also power up mitochondria 2Health News:New MRSA superbug emerges in Brazil 2
... Nov. 19 Have you ever asked yourself, "What in the ... it,s safe to give your puppy a leftover turkey drumstick - ... , , To address these ... Association (AVMA) today launched a new podcast series, "Chew on This," ...
... “OneMedForum 2009” finance conference for emerging medtech companies ... Francisco at the Sir Francis Drake Hotel. The ... to be a vital resource for emerging medtech ... two-day OneMedForum event will include industry-focused panel sessions, ...
... PC Brands, a,California-based manufacturer of nutrition bars, today ... shelf stable all-natural bars. The,"on the go" bars ... does not require refrigeration. , ... in a 90-calorie Yogurt,Fruit and Nut with Cranberries, Almonds ...
... study by researchers at the Bradley Hasbro Children,s Research Center ... among teens and young adults particularly those who have ... that show anal sex rates among adults doubled between the ... the American Journal of Public Health , is among ...
... of thousands of Americans are injured or die on our nation,s ... scores in a new roadway safety scorecard released today by the ... and South Dakota received the lowest scores. The report, ... for Injury Prevention , examines roadway safety laws in all 50 ...
... developer of voice solutions for healthcare, has been ... to help researchers assess the impact of automated ... on commonly prescribed medications. Using interactive voice response ... healthcare providers to evaluate real time patient data. ...
Cached Medicine News:Health News:AVMA Launches 'Chew on This' Podcast Series on Food Safety 2Health News: OneMedPlace announces "OneMedForum 2009" finance conference for emerging medtech companies : Second annual event to be held January 13-14, 2009, in San Francisco 2Health News:PC Brands Introduces Great Tasting Shelf-Stable Nutrition Bar With Probiotics 2Health News:More at-risk teens and young adults engaging in anal intercourse 2Health News:Oregon, Washington State Doing the Most to Promote Roadway Safety, According to New Emergency Nurses Association National Scorecard 2Health News:Oregon, Washington State Doing the Most to Promote Roadway Safety, According to New Emergency Nurses Association National Scorecard 3Health News:Brigham and Women's Researchers Partner with Vocantas to use CallAssure in Clinical Research Study 2
(Date:1/15/2014)... , Jan. 15, 2014  A novel wearable injector slightly larger ... painless for patients to self-inject prescription drugs in the large ... cancer, blood diseases, autoimmune deficiencies, and genetic disorders.  ... to $220B by 2018, according to analysts.   Many of these ...
(Date:1/14/2014)... , Jan. 14, 2014 The Brandeis Medical Center, led ... a premier and affordable laser tattoo removal experience with ... Brandeis, focus is in providing high quality cosmetic services with cutting ... " Southern California has seen a ...
(Date:1/14/2014)... 2014   NuAire , a manufacturer of ergonomically designed laboratory ... Koki of Japan to sell and ... . NuAire will utilize its network of sales professionals throughout ... to offer assistance in application use, product benefits and ...
Breaking Medicine Technology:Enable Injections Presents A New Class of Injectors for Drug Delivery at PEPTalk, Drug Delivery Partnership Meetings 2Beverly Hills Physician Features Tattoo Removal with the Astanza Duality Laser, Offers $99 Special 2NuAire announces sales and service of Hitachi Koki centrifuges in North America 2
... VIVUS, Inc. (NASDAQ: VVUS ) today announced that ... Congress on Obesity (ECO) in Istanbul, Turkey.  ECO is the ... of Obesity (EASO). ECO is regularly attended by more than ... be the most important annual scientific event on obesity in ...
... 2011 MicroVention-Terumo, Inc., a leader in developing, ... the final 18-month follow-up data in a landmark ... Packing Study (HELPS) published in The Lancet ... treating cerebral aneurysms reduced recurrence and retreatment rates ...
Cached Medicine Technology:Additional Data From QNEXA Clinical Trials Presented at the European Congress on Obesity 2Additional Data From QNEXA Clinical Trials Presented at the European Congress on Obesity 3Additional Data From QNEXA Clinical Trials Presented at the European Congress on Obesity 4Additional Data From QNEXA Clinical Trials Presented at the European Congress on Obesity 5Final Published Trial Data in The Lancet Supports Safety and Effectiveness of MicroVention-Terumo's HydroCoil® Embolic System for Treatment of Cerebral Aneurysms 2Final Published Trial Data in The Lancet Supports Safety and Effectiveness of MicroVention-Terumo's HydroCoil® Embolic System for Treatment of Cerebral Aneurysms 3Final Published Trial Data in The Lancet Supports Safety and Effectiveness of MicroVention-Terumo's HydroCoil® Embolic System for Treatment of Cerebral Aneurysms 4
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
Medicine Products: