Navigation Links
Discovery of 'executioner' protein opens door to new options for stroke ALS, spinal cord injury
Date:3/4/2013

Oxidative stress turns a protein that normally protects healthy cells into their executioner, according to a study released today in the Proceedings of the National Academy of Sciences journal.

Alvaro Estevez, an associate professor at the University of Central Florida's College of Medicine, led the multi-university team that made the discovery, which could eventually help scientists develop new therapies to combat a host of conditions from stroke to Lou Gehrig's disease

Researchers have long known that oxidative stress damages cells and results in neurodegeneration, inflammation and aging. It was commonly believed that oxidation made a "crude," demolition-like attack on cells, causing them to crumble like a building in an earthquake, Estevez said. However, the latest findings show that oxidation results in a much more targeted attack to specific parts of the cell. Oxidative stress damages a specific "chaperone" cell protein called Hsp90. It plays a role in up to 200 different cell functions. But when a form of oxidative stress called tyrosine nitration modifies that protein, it turns into the cell "executioner" shutting it down.

"The concept that a protein that is normally protective and indispensable for cell survival and growth can turn into a killing machine, and just because of one specific oxidative modification, is amazing," said Maria C. Franco, a postdoctoral associate at UCF's Burnett School of Biomedical Sciences. She co-wrote the study. "Considering that this modified protein is present in a vast number of pathologies, it gives us hopes on finding new therapeutics approaches for several different diseases."

For example, researchers could devise a drug that stroke patients could take at the onset of their symptoms to prevent more healthy cells from dying, thus limiting the damage of the stroke. Because oxidation is linked to inflammation, researchers believe tyrosine nitration could also be related to other
'/>"/>

Contact: Wendy Sarubbi
wendy.sarubbi@ucf.edu
407-266-1418
University of Central Florida
Source:Eurekalert  

Page: 1 2

Related medicine news :

1. PrimerLife Celebrates Anniversary of DNA Discovery with Launch of New Social Network
2. A new way of looking at drug discovery
3. Discovery in HIV may solve efficiency problems for gene therapy
4. Chili peppers spark discovery
5. Nottingham expertise in major European drug discovery partnership
6. DMG Productions to Feature Knee Creations Subchondroplasty® Procedure in its Health Heroes Series Airing via Discovery Channel
7. 176 Pradaxa Lawsuits Now Pending in Federal Litigation, Discovery Well Underway, Bernstein Liebhard LLP Reports
8. UGA discovery promises to improve drugs used to fight cancer, other diseases
9. Life Sciences Discovery Fund makes grants to commercialize health-related technologies
10. Discovery in Ghent could improve screening for sudden cardiac death
11. UAlberta medical researchers make key discovery in fight against Alzheimers disease
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Discovery of 'executioner' protein opens door to new options for stroke ALS, spinal cord injury
(Date:8/29/2014)... 2014 Panic attacks are extremely difficult ... of intense stress and fear, which appears with no ... causing insecurity and affecting relationships. , A panic attack ... many symptoms that patients can deal with. Anxiety, shortness ... Overcoming panic attacks is extremely important for sufferers, who ...
(Date:8/29/2014)... 29, 2014 Indosoft, Inc., a leading ... availability of monthly per-port licensing of its Q-Suite 5.7 ... center solutions, Indosoft has been successfully deploying and supporting ... large contact centers around the world for more than ... to give clients another option which complements the widespread ...
(Date:8/29/2014)... 2014 Champion boxers Laila Ali and ... appearing on the annual MDA Show of Strength Telethon ... on ABC television stations across the country. , ... of “All In, with Laila Ali," will introduce a ... the Muscular Dystrophy Association's nationally broadcast show. , Ortiz ...
(Date:8/29/2014)... UWDress.com, one of the most famous dress ... of 2014 floor length bridesmaid dresses . Additionally, ... items. According to the company’s marketing specialist, all its ... rate (up to 60 percent off) before September 10. ... special neckline: strapless, one-shoulder, bateau and more. The main ...
(Date:8/29/2014)... As reported by CNN.com in the article ... of admitting that you need help for a prescription drug ... highlights the fact that if you simply try to find ... by all of the information that is available online. Although ... it is still possible to get help. The statistics from ...
Breaking Medicine News(10 mins):Health News:60 Second Panic Solution Review Exposes Simple Panic Attacks Remedy 2Health News:Indosoft Offers Monthly Usage Licensing Terms 2Health News:Champion Boxers Fight Back Against Muscle Disease 2Health News:Champion Boxers Fight Back Against Muscle Disease 3Health News:2014 Floor Length Bridesmaid Dresses for Sale at UWDress.com 2Health News:What to Know When Seeking Drug Addiction Help 2Health News:What to Know When Seeking Drug Addiction Help 3
... small Pacific Islands, which consists of the some of ... the global conservation map//, and is said to be ... ,Martin Puta Tofinga, Minister of Environment, ... announced the establishment of the Phoenix Islands Protected Area ...
... under the Freedom of Information Act have revealed that hospitals ... use of car parks. The BBC reports that trusts had ... this service. ,The hospitals, which earned the maximum ... The Department of Health figures show that University Hospital Birmingham ...
... in the April issue of Radiology says that ultrasound is ... and also assess// the effectiveness of chemotherapy. Researchers at the ... a study where they examined the largest group of women ... cancer during pregnancy. ,"Ultrasound identified 100 percent of ...
... that promotes body growth, is produced in the brain according ... // The researchers have been able to trace the origin ... the brain in charge of memory and emotion – called ... the fact that more growth hormones are produced in females ...
... on cancer have proposed that cancer patients should be ... their care. // ,National standards in the ... standards could be enforced by the National Institute of ... the aspects of cancer services that would be standardized ...
... alcohol is not a sign that drinkers remain uninfluenced by ... like red bull after alcohol, to maintain sobriety. // ... after drinking vodka mixed with red bull felt less drunk, ... Souza-Formigoni, PhD, in a news release said “The person is ...
Cached Medicine News:Health News:Phoenix Islands To Be Protected Under Global Conservation Map 2Health News:Phoenix Islands To Be Protected Under Global Conservation Map 3Health News:Charging Car Park Fees From Cancer Patients Is Morally Wrong, Says Macmillan Cancer Relief 2Health News:Ultrasound Can Detect Breast Cancer in Pregnant Women 2Health News:Alcohol-illusion: Alcohol and Energy Drinks Combo, Maintains Sobriety? 2
(Date:8/29/2014)... 2014  Pacific Medical Data Solutions is excited to ... . The main website, along with the site,s blog, ... services and content relevant to the medical billing industry. ... viewers can now better understand how PMDS products help ... create a more visible platform about medical billing best ...
(Date:8/29/2014)... , August 29, 2014 ... participate in the inaugural Tweetchat taking place in ... Worldwide , organised by UBM Live , ... #CPhIChat is a first of its kind global ... across the supply chain, aimed to stimulate conversations ...
(Date:8/28/2014)... Aug. 28, 2014 Reportlinker.com ... report is available in its catalogue: ... Compliance Services Industry (U.S.): Analytics, Extensive ... to 2021, NAIC 541380 ... Testing Laboratories, Safety and Compliance ...
Breaking Medicine Technology:PMDS Announces New Website 2CPhI Worldwide to Host #CPhIChat Provoking Debate on the Future of Pharma 2CPhI Worldwide to Host #CPhIChat Provoking Debate on the Future of Pharma 3Testing Laboratories, Safety and Compliance Services Industry (U.S.): Analytics, Extensive Financial Benchmarks, Metrics and Revenue Forecasts to 2021, NAIC 541380 2Testing Laboratories, Safety and Compliance Services Industry (U.S.): Analytics, Extensive Financial Benchmarks, Metrics and Revenue Forecasts to 2021, NAIC 541380 3Testing Laboratories, Safety and Compliance Services Industry (U.S.): Analytics, Extensive Financial Benchmarks, Metrics and Revenue Forecasts to 2021, NAIC 541380 4Testing Laboratories, Safety and Compliance Services Industry (U.S.): Analytics, Extensive Financial Benchmarks, Metrics and Revenue Forecasts to 2021, NAIC 541380 5Testing Laboratories, Safety and Compliance Services Industry (U.S.): Analytics, Extensive Financial Benchmarks, Metrics and Revenue Forecasts to 2021, NAIC 541380 6
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
Medicine Products: