Navigation Links
Discovery of 'executioner' protein opens door to new options for stroke ALS, spinal cord injury
Date:3/4/2013

Oxidative stress turns a protein that normally protects healthy cells into their executioner, according to a study released today in the Proceedings of the National Academy of Sciences journal.

Alvaro Estevez, an associate professor at the University of Central Florida's College of Medicine, led the multi-university team that made the discovery, which could eventually help scientists develop new therapies to combat a host of conditions from stroke to Lou Gehrig's disease

Researchers have long known that oxidative stress damages cells and results in neurodegeneration, inflammation and aging. It was commonly believed that oxidation made a "crude," demolition-like attack on cells, causing them to crumble like a building in an earthquake, Estevez said. However, the latest findings show that oxidation results in a much more targeted attack to specific parts of the cell. Oxidative stress damages a specific "chaperone" cell protein called Hsp90. It plays a role in up to 200 different cell functions. But when a form of oxidative stress called tyrosine nitration modifies that protein, it turns into the cell "executioner" shutting it down.

"The concept that a protein that is normally protective and indispensable for cell survival and growth can turn into a killing machine, and just because of one specific oxidative modification, is amazing," said Maria C. Franco, a postdoctoral associate at UCF's Burnett School of Biomedical Sciences. She co-wrote the study. "Considering that this modified protein is present in a vast number of pathologies, it gives us hopes on finding new therapeutics approaches for several different diseases."

For example, researchers could devise a drug that stroke patients could take at the onset of their symptoms to prevent more healthy cells from dying, thus limiting the damage of the stroke. Because oxidation is linked to inflammation, researchers believe tyrosine nitration could also be related to other health problems including heart disease, cancer, aging and chronic pain.

"These are very exciting results and could begin a major shift in medicine," said Joseph Beckman, from Oregon State University Environmental Health Sciences Center, a collaborator on the study. "Preventing this process of tyrosine nitration may protect against a wide range of degenerative diseases."

"Most people think of things like heart disease, cancer, aging, liver disease, even the damage from spinal injury as completely different medical issues," Beckman said. "To the extent they can often be traced back to inflammatory processes that are caused by oxidative attack and cellular damage, they can be more similar than different. It could be possible to develop therapies with value against many seemingly different health problems."


'/>"/>

Contact: Wendy Sarubbi
wendy.sarubbi@ucf.edu
407-266-1418
University of Central Florida
Source:Eurekalert  

Related medicine news :

1. PrimerLife Celebrates Anniversary of DNA Discovery with Launch of New Social Network
2. A new way of looking at drug discovery
3. Discovery in HIV may solve efficiency problems for gene therapy
4. Chili peppers spark discovery
5. Nottingham expertise in major European drug discovery partnership
6. DMG Productions to Feature Knee Creations Subchondroplasty® Procedure in its Health Heroes Series Airing via Discovery Channel
7. 176 Pradaxa Lawsuits Now Pending in Federal Litigation, Discovery Well Underway, Bernstein Liebhard LLP Reports
8. UGA discovery promises to improve drugs used to fight cancer, other diseases
9. Life Sciences Discovery Fund makes grants to commercialize health-related technologies
10. Discovery in Ghent could improve screening for sudden cardiac death
11. UAlberta medical researchers make key discovery in fight against Alzheimers disease
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Discovery of 'executioner' protein opens door to new options for stroke ALS, spinal cord injury
(Date:5/23/2017)... ... May 23, 2017 , ... The Gallery ... Kevin Sadati, is pleased to announce a new treatment option called Vivace Microneedling. ... their face, neck, and body through a virtually pain-free, non-surgical treatment. Vivace Microneedling ...
(Date:5/23/2017)... ... May 23, 2017 , ... New patients from Charleston, SC, are ... dentist practicing in Mt. Pleasant, SC, with or without a referral. A full mouth ... with missing teeth in Charleston, SC. Those who suffer from gum disease, ...
(Date:5/23/2017)... WI (PRWEB) , ... May 23, 2017 , ... Patients ... to call Dr. Angela Cotey’s practice to schedule an appointment, with or without a ... and frequently offers pulpotomy treatments to pediatric patients as a healthy alternative to a ...
(Date:5/22/2017)... PA (PRWEB) , ... May 22, 2017 , ... An ... to write with a pen. "My wife’s hand was damaged in a firework accident, ... something that helps people with manual problems." , He then designed and created a ...
(Date:5/22/2017)... ... May 22, 2017 , ... ... larger group investing in InsightRX, an early stage company in San Francisco that ... pharmacological characteristics. Greatpoint Ventures Innovation Fund acted as the lead investor ...
Breaking Medicine News(10 mins):
(Date:5/18/2017)...  Two Bayer U.S. Pharmaceutical leaders received top awards ... 28 th Woman of the Year ... longstanding mission of furthering the advancement and impact of ... Cindy Powell-Steffen , senior director of brand activation and ... Libby Howe , a regional business manager for New ...
(Date:5/15/2017)... Inc., a privately-held CNS pharmaceutical company based in ... disease (PD), has enrolled the first patient in the RASMET ... study involving patients with PD and taking place at 12 ... period. The first stage is open label and involves single ... Denver , Boca Raton ...
(Date:5/10/2017)... -- Hologic, Inc. (Nasdaq: HOLX ) announced ... quarter ended April 1, 2017 .   GAAP diluted ... to the prior year period as the sale of ... while non-GAAP diluted EPS of $0.50 increased 6.4%.  Revenue ... currency terms.  Excluding the effects of blood screening and ...
Breaking Medicine Technology: