Navigation Links
Discovery of essential genes for drug-resistant bacteria reveals new, high-value drug targets
Date:9/14/2012

BUFFALO, N.Y. -- Biomedical scientists collaborating on translational research at two Buffalo institutions are reporting the discovery of a novel, and heretofore unrecognized, set of genes essential for the growth of potentially lethal, drug-resistant bacteria. The study not only reveals multiple, new drug targets for this human infection, it also suggests that the typical methods of studying bacteria in rich laboratory media may not be the best way to identify much-needed antimicrobial drug targets.

The paper (http://mbio.asm.org/content/3/4/e00113-12) focuses on a Gram-negative bacteria called A. baumannii. It is published in the current issue of mBio, as an 'editor's choice' paper. The findings may be relevant to other Gram-negative bacteria as well. (A graphic related to the research is at http://www.buffalo.edu/news/13673.)

A. baumannii is responsible for a growing number of hospital-acquired infections around the world. It can be fatal to patients with serious illnesses, the elderly and those who have had surgeries. Infections also have been seen in soldiers returning from Iraq and Afghanistan with battlefield injuries.

"Generally, healthy people don't get infected," explains lead author Timothy C. Umland, PhD, research scientist at Hauptman-Woodward Medical

Research Institute (HWI) and professor of structural biology in the University at Buffalo School of Medicine and Biomedical Sciences. "But what's challenging about A. baumannii is that it can survive in the hospital environment and is very hard to eradicate with common disinfectants, leading to healthcare-associated infections."

Typically, the way that essential genes for microbial pathogens are found is by growing the bacteria under optimal conditions, says co-author Thomas A. Russo, MD, professor in the UB departm
'/>"/>

Contact: Ellen Goldbaum
goldbaum@buffalo.edu
716-645-4605
University at Buffalo
Source:Eurekalert  

Page: 1 2 3

Related medicine news :

1. Scientist awarded $1 million grant to develop tools for hepatitis C treatment discovery
2. Washingtons Life Sciences Discovery Fund awards commercialization grants
3. Discovery could help to develop drugs for organ transplant and cancer patients
4. Feelings of immaturity accompany alcohol misuse into adulthood; discovery could improve treatments
5. H1N1 discovery paves way for universal flu vaccine: UBC research
6. Scientists make breakthrough in bile duct cancer with discovery of new gene mutations
7. Researchers make promising discovery in pursuit of effective lymphoma treatments
8. Discovery suggests new combination therapy strategy for basal-like breast cancers
9. Discovery of Gene May Lead to New Male Contraceptive
10. 5 more pharmaceutical companies join NIH initiative to speed therapeutic discovery
11. Illnesses in Colorado childrens hospital prompts discovery of contaminated alcohol pads
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Discovery of essential genes for drug-resistant bacteria reveals new, high-value drug targets
(Date:6/2/2015)... 03, 2015 The JK-A0100EU secure smart ... as government, finance and healthcare. However, this keyboard can ... access control to enhance the security of their network. ... secondary authentication of a Smart Card before allowing access ... smart-chipset card reader, the keyboard supports secure PIN entry. ...
(Date:6/2/2015)... 2015 Aidan Booth And Steve ... public yesterday, and has since received rave reviews ... reviewer Tiffany Hendricks has weighed in with her ... course on her website HonestyFirstReviews.com. , "These days ... marketers looking to hone their business skills has ...
(Date:6/2/2015)... June 02, 2015 MEDIA ADVISORY, ... 571-319-9594 (cell) , Email: ewallace(at)mentalhealthamerica(dot)net , Breaking News: ... Mental Health Legislation at MHA Annual Conference Thursday ... Rep. Murphy to address the Mental Health America ... long-awaited updated version of the Helping Families in ...
(Date:6/2/2015)... On March 19th, 2015, LiveToBeSober.org held ... Hall of Legends at Detroit’s Ford Field. Hosted by ... Moore, the goal of the conference was to raise ... highlight the benefits of effective professional rehabilitation programs. It ... options that are available to them in regards to ...
(Date:6/2/2015)... June 02, 2015 Highly qualified dental care ... plan to drive prolific change in the dental tourism industry ... Team Dental Clinic offers a full range of superior ... structure for dental tourism. , Partnered with a top ... committed to advancing dentistry and has earned a reputation as ...
Breaking Medicine News(10 mins):Health News:Introducing the New CHERRY JK-A0100EU Keyboard with Integrated Smart Card Reader for Access Control Security 2Health News:100K Factory - Review of Aidan Booth and Steve Clayton's New IM System Published 2Health News:Congressman Tim Murphy to Unveil Details of New Mental Health Legislation at MHA Annual Conference Thursday 2Health News:Rehabilitation Facility Graduate Shares Her Story at "Fighting Addiction Together" Conference 2Health News:Team Dental Clinic Unveils Plan to Drive Change in the Dental Tourism Industry 2Health News:Team Dental Clinic Unveils Plan to Drive Change in the Dental Tourism Industry 3
... , CINCINNATI, July 21 ... provider of physician office-based patient-education programs, announces the launch ... delivers real-time health content to physicians all day, every ... back office, medical news and information is sourced from ...
... H5N1 Influenza Virus Two newly developed "single-shot" ... H5N1 influenza virus and may allow for mass vaccination in ... researchers from Australia report their findings in the August 2009 ... the highly infectious H5N1 influenza A virus continues to persist ...
... of patients with disorders of consciousness has shown that ... misdiagnosed as vegetative state (VS), a condition associated with ... the open access journal BMC Neurology have ... diagnoses determined by clinical consensus. Steven Laureys, from ...
... , , CHICAGO, July 21 ... graduate from northern California, Kelly Peterson, is the grand prize winner ... submitted their views on video about why careers in the clinical ... Labs Are Vital is a global program sponsored by Abbott to ...
... , BEAVERTON, Ore., July 21 ... remediation, today announced Breach Prevent for Healthcare, a customizable set ... cost-effectively comply with the new HITECH Act privacy regulations. ... Act expands HIPAA,s privacy rules with specific data breach notification ...
... , , STAMFORD, Conn., ... adoption of digital x-ray, the FCR Prima digital x-ray system from ... to meet the x-ray needs of low volume private practices, the ... reader, an electronic viewing workstation, and an archiving system, enabling facilities ...
Cached Medicine News:Health News:Healthy Advice Networks Announces the Launch of PracticeWire; Technology to Deliver Real-time Healthcare Content to Physicians 2Health News:Tips from the journals of the American Society for Microbiology 2Health News:Tips from the journals of the American Society for Microbiology 3Health News:Tips from the journals of the American Society for Microbiology 4Health News:Misdiagnosis of disorders of consciousness still commonplace 2Health News:Labs Are Vital(TM) Announces Winners of 2009 National Video Contest to Highlight Careers in Lab Sciences 2Health News:Labs Are Vital(TM) Announces Winners of 2009 National Video Contest to Highlight Careers in Lab Sciences 3Health News:ID Experts Offers Breach Prevent for Healthcare: A High-Touch, Affordable Solution for HITECH Data Breach Protection and Compliance 2Health News:ID Experts Offers Breach Prevent for Healthcare: A High-Touch, Affordable Solution for HITECH Data Breach Protection and Compliance 3Health News:ID Experts Offers Breach Prevent for Healthcare: A High-Touch, Affordable Solution for HITECH Data Breach Protection and Compliance 4Health News:Fujifilm's New Digital X-Ray System Designed to Eliminate Barriers to Digital Adoption 2Health News:Fujifilm's New Digital X-Ray System Designed to Eliminate Barriers to Digital Adoption 3
(Date:6/2/2015)... Md. , June 2, 2015 The ... of its National Practice Guideline for the Use of ... ( Practice Guideline ).  The Practice Guideline ... related to opioid use. It addresses knowledge gaps about ... recovery, while guiding evidence-based coverage standards by payers. ...
(Date:6/2/2015)... Research and Markets( http://www.researchandmarkets.com/research/ctd7zx/europe ) has announced the ... And Forecasts (2014 - 2019)" report to their offering. ... Germany . This is followed by UK ... Poland are the fastest growing segments. ... segmented on the basis of Product (Film Screen, Digital, 3D, ...
(Date:6/2/2015)... 2, 2015 The Canadian Society for Vascular Surgery ... treatments or procedures that are commonly ordered but ... of Choosing Wisely Canada.  The list identifies five ... between patients and physicians about what care is ... Vascular Surgery,s list identified the following five (5) ...
Breaking Medicine Technology:American Society of Addiction Medicine Releases National Practice Guideline for the Use of Medications in the Treatment of Addiction Involving Opioid Use 2American Society of Addiction Medicine Releases National Practice Guideline for the Use of Medications in the Treatment of Addiction Involving Opioid Use 3Europe Mammography Market Report 2014-2019 - Growth, Trends And Forecasts 2As part of the Choosing Wisely Canada campaign the Canadian Society for Vascular Surgery releases list of commonly used tests and treatments to question 2As part of the Choosing Wisely Canada campaign the Canadian Society for Vascular Surgery releases list of commonly used tests and treatments to question 3As part of the Choosing Wisely Canada campaign the Canadian Society for Vascular Surgery releases list of commonly used tests and treatments to question 4
... Therapeutics, Inc. (CTI),(Nasdaq and MTA: CTIC) today announced that the following presentations,will be made ... the 44th American Society of Clinical Oncology (ASCO) Annual Meeting,May 30 through June 3, ... Poster # Title ... (Abstract#) Sat., 8:00 AM ...
... May 26 Arpida Ltd (SWX:,ARPN) today announced ... Phase II,"intravenous-to-oral" switch trial with oral iclaprim in ... on track for,completion in 2008., The key ... clinical efficacy of an,oral capsule formulation of iclaprim ...
Cached Medicine Technology:Cell Therapeutics, Inc. (CTI) Announces Presentations at American Society of Clinical Oncology (ASCO) Annual Meeting 2Cell Therapeutics, Inc. (CTI) Announces Presentations at American Society of Clinical Oncology (ASCO) Annual Meeting 3Arpida Enrols First Patients in "Intravenous-to-Oral" Switch Trial With Oral Iclaprim 2Arpida Enrols First Patients in "Intravenous-to-Oral" Switch Trial With Oral Iclaprim 3
... Lock the heel. Control the ankle. ... our Townsend Stability Boot (TSB) technology. When ... Stablelock System, you maximize the control, stability ... in their TSB. The TSB Stablelock System ...
... the Hi-Top ankle strap allow ... back in the heel cup ... front is cut back which ... the toes. Features breathable nylon ...
The EZY Close post op shoe's flap-on-flap closure provides a secure fit and can accommodate even the bulkiest of dressing. Perfect for older patients with limited hand dexterity....
Designed for forefoot relief and healing. This shoe has a unique wedge outsole and a soft nylon upper. We also added the hi-top upper to keep the foot held back and reduce slippage. Available in five...
Medicine Products: