Navigation Links
Discovery of essential genes for drug-resistant bacteria reveals new, high-value drug targets
Date:9/14/2012

BUFFALO, N.Y. -- Biomedical scientists collaborating on translational research at two Buffalo institutions are reporting the discovery of a novel, and heretofore unrecognized, set of genes essential for the growth of potentially lethal, drug-resistant bacteria. The study not only reveals multiple, new drug targets for this human infection, it also suggests that the typical methods of studying bacteria in rich laboratory media may not be the best way to identify much-needed antimicrobial drug targets.

The paper (http://mbio.asm.org/content/3/4/e00113-12) focuses on a Gram-negative bacteria called A. baumannii. It is published in the current issue of mBio, as an 'editor's choice' paper. The findings may be relevant to other Gram-negative bacteria as well. (A graphic related to the research is at http://www.buffalo.edu/news/13673.)

A. baumannii is responsible for a growing number of hospital-acquired infections around the world. It can be fatal to patients with serious illnesses, the elderly and those who have had surgeries. Infections also have been seen in soldiers returning from Iraq and Afghanistan with battlefield injuries.

"Generally, healthy people don't get infected," explains lead author Timothy C. Umland, PhD, research scientist at Hauptman-Woodward Medical

Research Institute (HWI) and professor of structural biology in the University at Buffalo School of Medicine and Biomedical Sciences. "But what's challenging about A. baumannii is that it can survive in the hospital environment and is very hard to eradicate with common disinfectants, leading to healthcare-associated infections."

Typically, the way that essential genes for microbial pathogens are found is by growing the bacteria under optimal conditions, says co-author Thomas A. Russo, MD, professor in the UB departm
'/>"/>

Contact: Ellen Goldbaum
goldbaum@buffalo.edu
716-645-4605
University at Buffalo
Source:Eurekalert  

Page: 1 2 3

Related medicine news :

1. Scientist awarded $1 million grant to develop tools for hepatitis C treatment discovery
2. Washingtons Life Sciences Discovery Fund awards commercialization grants
3. Discovery could help to develop drugs for organ transplant and cancer patients
4. Feelings of immaturity accompany alcohol misuse into adulthood; discovery could improve treatments
5. H1N1 discovery paves way for universal flu vaccine: UBC research
6. Scientists make breakthrough in bile duct cancer with discovery of new gene mutations
7. Researchers make promising discovery in pursuit of effective lymphoma treatments
8. Discovery suggests new combination therapy strategy for basal-like breast cancers
9. Discovery of Gene May Lead to New Male Contraceptive
10. 5 more pharmaceutical companies join NIH initiative to speed therapeutic discovery
11. Illnesses in Colorado childrens hospital prompts discovery of contaminated alcohol pads
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Discovery of essential genes for drug-resistant bacteria reveals new, high-value drug targets
(Date:11/26/2014)... Loffler Companies has been selected as a ... online information and news publication for resellers of imaging ... year Loffler has earned this prestigious award and the ... Awards honor the best and the brightest in the ... were chosen for their innovative marketing and sales programs, ...
(Date:11/26/2014)... (PRWEB) November 26, 2014 Senior Planning ... Florida-based SeniorNet, a nonprofit organization providing the adult ... up to help seniors navigate the rough seas of ... on educating seniors on the topic of Medicaid eligibility ... somewhat complicated process of applying for this coverage. ...
(Date:11/26/2014)... NY (PRWEB) November 26, 2014 Call ... research requirements or email the details on sales(at)researchmoz(dot)us ... diabetes and drug discovery market 2014" with deep study ... is the result of high blood sugar. The global ... directly linked to the growing number of diabetics in ...
(Date:11/26/2014)... Baton Rouge, Louisiana (PRWEB) November 26, 2014 ... and neck pain relief and specialists in minimally ... Dr. K. Samer Shamieh into the rapidly growing ... management specialists. The addition coincides with the ... cutting-edge, reliable medical treatment for Louisiana residents who ...
(Date:11/26/2014)... Nov. 25, 2014 (HealthDay News) -- Youngsters who enter ... new study suggests. Early puberty was linked with ... poor self-image and high anxiety levels, according to the ... such as conflict with family and peers, and having ... study found. Although the study found an association ...
Breaking Medicine News(10 mins):Health News:Loffler Companies Recognized as an Elite Dealer for Sixth Consecutive Year 2Health News:Senior Planning Services Teams Up with SeniorNet To Educate Seniors On Medicaid Planning 2Health News:Latest Report on Diabetes Market 2014 - Global Market Size, Share, Trends and Forecast by Researchmoz.us 2Health News:Latest Report on Diabetes Market 2014 - Global Market Size, Share, Trends and Forecast by Researchmoz.us 3Health News:Louisiana Back Institute Welcomes Dr. K. Samer Shamieh into Medical Provider Network 2Health News:Early Puberty Linked to Increased Risk of Depression in Teens 2
... with material that was learned well, study suggests , , , ... can help boost your memory and remember facts, but only ... new study suggests. , This type of memory is called ... in contrast to "procedural memory," which applies to skills. Sleep ...
... Perrigo Company,(Nasdaq: PRGO ; TASE) today announced ... of $150 million of the Company,s common stock,through ... program. Any,remaining balance of the previously authorized program ... programs since November 2000,Perrigo has repurchased 11.4 million ...
... An anti-virus drug attacks influenza A by changing the motion ... to infect healthy cells, according to a recently published research ... Iowa States John D. Corbett Professor in Chemistry, and Sarah ... of the antiviral drug amantadine on influenza A. Thats the ...
... CDC Director Dr. Ann Albright, WASHINGTON, Feb. 1 , WHAT: ... briefing, "Your Eyes: the Windows to Your Health -- A Briefing ... Eyecare in Prevention," to be presented ... only one-third know they are living ...
... View of LTC Sector Required for Accurate Evaluation of,Seniors, ... on the January,31 New York Times news article reporting ... funding update to help care for the growing,number of ... Alliance for,Quality Nursing Home Care said it will work ...
... is imminent if Propofol coverage isn,t reinstated, NEW ... to,immediately retract its refusal to cover Propofol under all ... Gastroenterologists,and Anesthesiologist Alliance, a call to file a consumer ... once solely a New York State issue has now ...
Cached Medicine News:Health News:A Daytime Nap Can Boost Memory 2Health News:Iowa State chemists track how drug changes, blocks flu virus 2Health News:In Unfolding Budget Debate, Alliance to Spotlight Flawed MedPAC Policy Guidance, Failure to Evaluate Medicaid Margins in Recommending Medicare Funding Levels 2Health News:National Health Care Alliance Gains New Members Against Aetna's New Anesthesia Policy 2Health News:National Health Care Alliance Gains New Members Against Aetna's New Anesthesia Policy 3
(Date:11/26/2014)... Nov. 25, 2014  Unilife Corporation (NASDAQ: UNIS, ASX: ... delivery systems, today announced that its Chairman and CEO, ... the Piper Jaffray 26th Annual Healthcare Conference at the ... Tuesday, December 2, 2014. The conference ... "live" listen only Webcast. To listen, please go to: ...
(Date:11/26/2014)... , Nov. 25, 2014 Jazz Pharmaceuticals plc (Nasdaq: ... its corporate presentations at two upcoming investor conferences.  ... UK on Tuesday, December 2, 2014 at 6:45 a.m. ... president and head of EUSA International, will provide an overview of ... th Annual Piper Jaffray Healthcare Conference in New ...
(Date:11/26/2014)... China, Nov. 26, 2014 China Nepstar Chain ... "Company"), a leading retail drugstore chain in China based ... its unaudited financial results for the third quarter ended September ... 30, 2014: , Same store sales increased by ... , Revenue increased by 8.1% to RMB738.3 million (US$120.3 million) ...
Breaking Medicine Technology:Unilife to Present at the Piper Jaffray 26th Annual Healthcare Conference on December 2nd 2Jazz Pharmaceuticals Announces Participation in Two Investor Conferences 2China Nepstar Chain Drugstore Ltd. Reports Third Quarter 2014 Financial Results 2China Nepstar Chain Drugstore Ltd. Reports Third Quarter 2014 Financial Results 3China Nepstar Chain Drugstore Ltd. Reports Third Quarter 2014 Financial Results 4China Nepstar Chain Drugstore Ltd. Reports Third Quarter 2014 Financial Results 5China Nepstar Chain Drugstore Ltd. Reports Third Quarter 2014 Financial Results 6China Nepstar Chain Drugstore Ltd. Reports Third Quarter 2014 Financial Results 7China Nepstar Chain Drugstore Ltd. Reports Third Quarter 2014 Financial Results 8China Nepstar Chain Drugstore Ltd. Reports Third Quarter 2014 Financial Results 9China Nepstar Chain Drugstore Ltd. Reports Third Quarter 2014 Financial Results 10China Nepstar Chain Drugstore Ltd. Reports Third Quarter 2014 Financial Results 11
... , SOUTH SAN FRANCISCO, Calif. , ... biopharmaceutical company focused on innovative oncology therapies, today announced that Ronald ... 12th Annual BIO CEO and Investor Conference on Tuesday, February 9, ... Astoria in New York City . , A live audio ...
... DIEGO , Feb. 5 Volcano Corporation (Nasdaq: ... by Lightlab Imaging, Inc. on January 7, 2009 in ... reached a verdict against Volcano and its wholly owned subsidiary, Axsun ... an agreement to supply tunable lasers to Lightlab for use in ...
Cached Medicine Technology:Poniard Pharmaceuticals to Present at 12th Annual BIO CEO and Investor Conference 2Volcano Corporation Announces Litigation Status 2Volcano Corporation Announces Litigation Status 3
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
Medicine Products: