Navigation Links
Discovery of cellular 'switch' may provide new means of triggering cell death, treating disease
Date:3/11/2010

r RNA molecules -- which carry DNA's genetic messages from the nucleus of cells to make specific proteins in cell cytoplasm -- and silence their activity, said Xue. But when caspase comes in contact with Dicer, it takes away Dicer's ability to cleave RNA and it replaces it with the ability to snip up and destroy DNA-laden chromosomes.

The experiments were undertaken on a common, eyelash-sized nematode known as Caenorhabditis elegans, a popular laboratory organism for genetic and biomedical experiments. The study of cell death in C. elegans is providing critical information to scientists trying to understand cell death mechanisms in humans and identify ways to combat human diseases caused by "inappropriate apoptosis," Xue said.

"There are many enzymes whose job it is to cut RNA, and many unrelated enzymes whose job it is to cut DNA," said CU-Boulder MCD Biology Department Chair Tom Blumenthal, who studies RNA processing in C. elegans and who was not involved in the study. "But this is the first time that anyone has shown that it is possible to cleave an RNA-cutter enzyme and thereby convert it to a DNA-cutter enzyme."

As part of the study, the team "knocked out" the C. elegans gene that encodes the Dicer enzyme. The removal of the gene compromised the apoptosis process and blocked the fragmentation of chromosomes, said Xue.

Genetic studies of C. elegans have identified many genes that are important for the five sequential steps of programmed cell death, Xue said. They include the specification of which cells should die, the activation of the cell death program, the onset of the killing process, the engulfment of cell "corpses" and the degradation of cellular debris, said Xue.

"Our findings initially seemed too good to be true," said Xue, who said the team has been working on the project for five years. "We wound up looking at the results from a number of angles, including genetics
'/>"/>

Contact: Ding Xue
ding.xue@colorado.edu
303-492-0271
University of Colorado at Boulder
Source:Eurekalert  

Page: 1 2 3

Related medicine news :

1. U discovery gives insight into brain replay process
2. Co-Creator of Six Sigma Unveils “The Great Discovery” ... the 4th Generation of Six Sigma
3. Effective prostate cancer treatment discovery
4. SeqWright Advances Genomic Discovery With Isilon IQ
5. New discovery: Plaice are spotted (on the inside)
6. UCSF enters drug discovery agreement with Genentech
7. UCSF Enters Drug Discovery Agreement with Genentech
8. Discovery Health and National Organization for Rare Disorders Partner for Second Annual Rare Disease Day With the Premiere of the Special DISEASE DETECTIVES
9. Discovery points way for new treatment for aneurysms: UBC-Providence Research
10. Discovery of mechanism in brain cell injury in Huntingtons offers new treatment approaches
11. Discovery Links Genes to Pancreatic Cancer
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Discovery of cellular 'switch' may provide new means of triggering cell death, treating disease
(Date:7/13/2014)... Recently, MillionaireCasket.com, a well-known casket manufacturer from China, ... Additionally, the company’s chief executive officer has announced a new ... are offered at discounted prices, from 15 to 26 percent ... are in huge demand in the current market. We are ... have a lot of high quality products for sale. Many ...
(Date:7/13/2014)... The North American water storage systems market is ... million by 2018, at a CAGR of 21.0%, from 2013 ... a rapid pace in North America. The U.S. is experiencing ... & wastewater storage and collection, and the increased spending on ... at a healthy rate in Canada, and is rising at ...
(Date:7/13/2014)... The report “Micronutrient Market by ... (Chelated & Non Chelated), Application Mode (Soil, Foliar, ... and Forecast to 2018” defines and segments the ... forecasting of the global value and volume for ... restraining factors for the global agriculture micronutrients market ...
(Date:7/13/2014)... 13, 2014 Fuel additives are chemicals, ... diesel, jet fuel, kerosene, and so on, in order ... for reducing the corrosion effects caused by fuels and ... to any fuel, provide economies of scale in the ... the overall cost of the fuel products. , The ...
(Date:7/13/2014)... MarketsandMarkets recently conducted a study on ... 3D rendering; Layout and Animation; Image Reconstruction]: Global ... which analyzes and studies the major market drivers, ... Eastern Europe, Middle East and Africa, Asia-Pacific and ... landscape of the 3D imaging market, providing an ...
Breaking Medicine News(10 mins):Health News:Cheap Oak Caskets Recently Unveiled By China Casket Manufacturer MillionaireCasket.com 2Health News:North American Water Storage Systems Market is Expected to Reach $5,450 million by 2018 - New Report by MicroMarket Monitor 2Health News:North American Water Storage Systems Market is Expected to Reach $5,450 million by 2018 - New Report by MicroMarket Monitor 3Health News:Micronutrient Market Worth $6,474.6 Million by 2018 - A Report by MarketsandMarkets 2Health News:Micronutrient Market Worth $6,474.6 Million by 2018 - A Report by MarketsandMarkets 3Health News:Micronutrient Market Worth $6,474.6 Million by 2018 - A Report by MarketsandMarkets 4Health News:North America Fuel Additives Market is Expected to Reach $8,100 Million by 2017 - New Report by MicroMarket Monitor 2Health News:North America Fuel Additives Market is Expected to Reach $8,100 Million by 2017 - New Report by MicroMarket Monitor 3Health News:North America Fuel Additives Market is Expected to Reach $8,100 Million by 2017 - New Report by MicroMarket Monitor 4Health News:3D Imaging Market Worth $9.82 Billion By 2018 - Report by MarketsandMarkets 2Health News:3D Imaging Market Worth $9.82 Billion By 2018 - Report by MarketsandMarkets 3Health News:3D Imaging Market Worth $9.82 Billion By 2018 - Report by MarketsandMarkets 4
... , AVENTURA, Fla., Dec. 21 Cinergy ... benefit programs for the consumer market, expressed its concern for the ... this morning. , "While the Senate and House healthcare bills are ... step towards expanding access to affordable health coverage for all Americans," ...
... that could cause hearing loss , MONDAY, Dec. 21 (HealthDay ... other music player this holiday season, consider a bonus present ... one-half or two-thirds of the actual maximum. , That,s the ... that sound over 85 decibels -- well short of the ...
... ... ... -- Medical breakthroughs and technological advances – in combination with healthy lifestyles - will ... Institute on Aging . These and other positive trends will have a profound effect ...
... , BOCA RATON, Fla., Dec. 21 ... phonics-based learn-to-read system for children and adults, has teamed up ... - equivalent to the retail value of $10,000 - to ... medical centers. In an effort to make the holidays ...
... , , ... BOSTON, Dec. 21 Researchers from Children,s Hospital Boston and Brigham ... devastating kidney disease that is the second leading cause of kidney ... study, published online December 20 by Nature Genetics , may ...
... ... funds for children’s health services in Washington area , ... Washington, DC (Vocus) December 21, 2009 -- At ... Washington, DC’s southeast neighborhood on Dec. 14, Angel Schmitz, D18 auditor, and Melanie Dickson, ...
Cached Medicine News:Health News:Cinergy Health Commentary on Senate Healthcare Vote 2Health News:Aging Institute Reveals 2010 Trends 2Health News:Aging Institute Reveals 2010 Trends 3Health News:Flipping for Phonics(TM) Helps Spread Cheer To Military Families In Fisher Houses(R) This Holiday Season 2Health News:Flipping for Phonics(TM) Helps Spread Cheer To Military Families In Fisher Houses(R) This Holiday Season 3Health News:Gene For Devastating Kidney Disease Discovered 2Health News:Gene For Devastating Kidney Disease Discovered 3Health News:Gene For Devastating Kidney Disease Discovered 4Health News:Gene For Devastating Kidney Disease Discovered 5Health News:Kohl's Department Stores Donates $432,641 To Children's National Medical Center 2
(Date:7/11/2014)... 2014 Patient engagement has become a ... are turning to an assortment of marketing activities ... of this evolving approach to patient engagement, marketers ... engage patients throughout their experiences with a disease ... mapping the patient journey and employing a consumer ...
(Date:7/11/2014)... , July 11, 2014 Research and ... Hypodermic Needles Market 2014-2018" report to their offering. ... A hypodermic needle is a hollow needle commonly used ... or or to extract fluids from it. A hypodermic ... to inject substances that cannot be ingested. Hypodermic needles ...
(Date:7/11/2014)... , July 11, 2014 Research and ... of the "Immunoprotein Diagnostic Testing Market - ... highest CAGR of 6% and is expected to ... to their offering. ... diagnostic testing has been segmented according to immunoprotein ...
Breaking Medicine Technology:New Study Uses Six-Step Patient Journey as Framework for Consumer-Focused Marketing Opportunities 2Global Hypodermic Needles Market 2014-2018: Key Vendors are Becton, Dickinson and Co, Covidien, Retractable Technologies and Terumo Corp. 2Global Hypodermic Needles Market 2014-2018: Key Vendors are Becton, Dickinson and Co, Covidien, Retractable Technologies and Terumo Corp. 3Immunoprotein Diagnostic Testing Market - Forecasts to 2019: Expected to grow at the highest CAGR of 6% and is expected to be valued at USD 4,943.0 million 2
... Nov. 17, 2010 RetireSafe, a 400,000-supporter strong ... the Medicare Evidence Development & Coverage Advisory Committee ... related to the important new Provenge treatment procedure ... urged the Committee to "consider not only the ...
... OAKS, Calif. and WASHINGTON, Nov. 17, 2010 The Amgen ... Patients | Choices | Empowerment competition and launched ... that empower patients, elevate patients, voices, and improve health outcomes. ... panel of five distinguished judges from 277 entries received from ...
Cached Medicine Technology:RetireSafe Urges Support for Provenge Prostate Cancer Treatment 2Amgen Foundation and Ashoka's Changemakers Announce Finalists in Patients | Choices | Empowerment Competition 2Amgen Foundation and Ashoka's Changemakers Announce Finalists in Patients | Choices | Empowerment Competition 3Amgen Foundation and Ashoka's Changemakers Announce Finalists in Patients | Choices | Empowerment Competition 4
... ,The S/5 Compact Critical Care Monitor ... for medium care monitoring. The monitor uses ... and accessories., ,The S/5 Compact Critical ... and features as the S/5 Critical Care ...
... safety in the operating and recovery room, ... solution for combined haemodynamic and airway gas ... post anesthesia care units. The Cardiocap II ... providing the basic haemodynamic measurements. Two of ...
... patient respiration and ventilation., ,The Capnomac Ultima ... ventilation monitors available. The Capnomac Ultima is available ... to measure the essential airway gas parameters, CO ... 2 O easily and reliability. The Capnomac Ultima ...
Adhesive discs sold on rolls of 100, 250, or 1000 each. Manufactured from non-latex medical grade adhesives & material. One size fits all chest pieces....
Medicine Products: