Navigation Links
Discovery of cellular 'switch' may provide new means of triggering cell death, treating disease
Date:3/11/2010

A research team led by the University of Colorado at Boulder has discovered a previously unknown cellular "switch" that may provide researchers with a new means of triggering programmed cell death, findings with implications for treating cancer.

The new results are a big step forward in understanding programmed cell death, or apoptosis, a cell suicide process that involves a series of biochemical events leading to changes like cell body shrinkage, mitochondria destruction and chromosome fragmentation, said CU-Boulder Professor Ding Xue. But unlike traumatic cell death from injury, programmed cell death is a naturally occurring aspect of animal development that may help prevent human diseases like cancer and autoimmune disorders, said Xue, lead author on the new study.

In the new study, Xue and his team found that a well-known cellular molecule called caspase known as the "executioner enzyme" for apoptosis because of its primary role of cutting up and destroying cellular proteins -- has an entirely different effect on a particular enzyme called Dicer. The team found that when caspase cleaves Dicer, it does not kill it but instead changes its function, causing Dicer to break up chromosomes -- pieces of coiled DNA containing thousands of genes -- and kill the cells that house them.

"This finding was totally unexpected," said Xue of CU-Boulder's molecular, cellular and developmental biology department. "We believe that by understanding this mechanism, we may be able to develop a new way to trigger cell death in a controlled manner as a way to treat disease."

A paper on the subject appears in the March 12 issue of Science. Co-authors on the study included CU-Boulder postdoctoral researchers Akihisa Nakagawa and Yong Shi and Tokyo Women's Medical University researchers Eriko Kage-Nakadai and Shohei Mitani.

The normal function of Dicer is to snip strands of RNA into smaller pieces that attach to messenge
'/>"/>

Contact: Ding Xue
ding.xue@colorado.edu
303-492-0271
University of Colorado at Boulder
Source:Eurekalert  

1

GOOD

Page: 1 2 3

Related medicine news :

1. U discovery gives insight into brain replay process
2. Co-Creator of Six Sigma Unveils “The Great Discovery” ... the 4th Generation of Six Sigma
3. Effective prostate cancer treatment discovery
4. SeqWright Advances Genomic Discovery With Isilon IQ
5. New discovery: Plaice are spotted (on the inside)
6. UCSF enters drug discovery agreement with Genentech
7. UCSF Enters Drug Discovery Agreement with Genentech
8. Discovery Health and National Organization for Rare Disorders Partner for Second Annual Rare Disease Day With the Premiere of the Special DISEASE DETECTIVES
9. Discovery points way for new treatment for aneurysms: UBC-Providence Research
10. Discovery of mechanism in brain cell injury in Huntingtons offers new treatment approaches
11. Discovery Links Genes to Pancreatic Cancer
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Discovery of cellular 'switch' may provide new means of triggering cell death, treating disease
(Date:5/24/2013)... HealthDay Reporter , , FRIDAY, May 24 (HealthDay ... are remarkable. But it was a physical challenge in ... of her sport. "I was an 11-year-old girl ... scoliosis was diagnosed by my orthopedic surgeon," said Lewis, ... Research Society and the American Academy of Orthopaedic Surgeons ...
(Date:5/24/2013)... 24, 2013 Western University of Health ... of “Full Accreditation” for the next seven years from ... (COE). , “This is a magnificent achievement, and one ... and student outcomes,” said College of Veterinary Medicine Dean ... appreciation to the faculty, staff, preceptors, and students that ...
(Date:5/24/2013)... KC and Monica Craichy, Founders of Living Fuel, Inc ... Kyle and Austin Craichy, will be kiteboarding with members of ... , KC Craichy said he is excited to be involved ... that virtually everyone who planned to be involved is going ... meet at Matheson Hammock Park and Beach in Miami at ...
(Date:5/24/2013)... The Mirena IUD lawyers at the ... FDA has received more than 59,229 complaints since 2004 from ... birth control device known as the Mirena IUD.* , Among ... the women “included ‘expulsion,’ where the IUD came out on ... to an ABC News article. “Abdominal pain is also common, ...
(Date:5/24/2013)... E-Dentists.com has announced the launch of their new ... a leading medical Internet marketing agency. , ... focus on providing dentists the help they need to ... keywords. The dental SEO analysis covers a full analysis ... their competitors are doing right. The goal is to ...
Breaking Medicine News(10 mins):Health News:Top-Ranked Golfer Beats Scoliosis 2Health News:Top-Ranked Golfer Beats Scoliosis 3Health News:FreeRide836 Sponsor Living Fuel, The Leader in Superfood Nutrition, Announces Kiteboard Launch For This Sunday To Raise Money For Orphans In Africa 2Health News:FreeRide836 Sponsor Living Fuel, The Leader in Superfood Nutrition, Announces Kiteboard Launch For This Sunday To Raise Money For Orphans In Africa 3Health News:Sufferers of Alleged Mirena IUD Side Effects Lodge More Than 59,000 Complaints With FDA, Rottenstein Law Group LLP Notes 2Health News:Dental SEO Analysis Launched by E-Dentists.com in Partnership with JD Media Surge 2
... poses a significant threat to human health by labeling healthy ... Ray Moynihan, Senior Research Fellow at Bond University in Australia, ... The feature comes as an international conference ... United States, hosted by The Dartmouth Institute for Health Policy ...
... , WEDNESDAY, May 30 (HealthDay News) -- Nearly one ... they can be triggered by hot summer weather. Hives are ... The condition can be acute or chronic, according to the American ... last less than a day or up to six weeks, are ...
... Children today may be busier than ever, but Case ... hasn,t suffered in fact, it appears to have ... expected the opposite outcome when they analyzed 14 play ... ( http://www.youtube.com/watch?v=sQb95itdoCM ). But as they report in ...
... shows that it is beneficial to have a loved ... study led by researchers at the Johns Hopkins Bloomberg ... true for older adults suffering from poor mental health. ... visits helps or hinders physician visit processes and found ...
... M.D., principal investigator at The Los Angeles Biomedical Research ... investigator of a project that was just awarded a ... Medicine (CIRM). The goal of the project is ... treatment of mucopolysaccharidosis I (MPS I), a fatal pediatric ...
... TUESDAY, May 29 (HealthDay News) -- Women who develop fevers ... have a child with autism spectrum disorder or another developmental ... if, fevers may increase the risk for autism is unknown, ... if they do develop a fever while pregnant because taking ...
Cached Medicine News:Health News:Overdiagnosis poses significant threat to human health 2Health News:Overdiagnosis poses significant threat to human health 3Health News:Summer's Heat May Enflame Hives 2Health News:Despite less play, children's use of imagination increases over 2 decades 2Health News:Patient mental health overlooked by physician when a family member is present 2Health News:LA BioMed's Dr. Patricia Dickson researching treatments for neurodegenerative disorders 2Health News:Fever During Pregnancy May Raise Odds for Autism in Offspring 2Health News:Fever During Pregnancy May Raise Odds for Autism in Offspring 3
(Date:5/23/2013)... 2013 Amgen (NASDAQ: AMGN ) will ... Conference on Thursday, May 30, 2013, at the Westin Boston ... a.m. Eastern Daylight Time. Arvind Sood , ... the conference. Live audio of the presentation can be accessed ... under Investors. A replay of the webcast will also be ...
(Date:5/23/2013)... recently published clinical study conducted at TOPS Comprehensive Breast ... that 3D mammography (breast tomosynthesis) significantly reduces unnecessary recalls ... study, "Implementation of Breast Tomosynthesis in a Routine Screening ... Stephen L. Rose , MD, and published in ... Roentgenology (AJR). The AJR is the scientific journal ...
(Date:5/23/2013)... Calif. , May 23, 2013 Anthem ... program that would have required them to obtain their ... by Consumer Watchdog and Whatley Kallas LLC.  ... Superior Court, alleged that Blue Cross,s mandatory mail order ... threatening their health and privacy. "This settlement ...
Breaking Medicine Technology:First Large-Scale U.S. Study Validates the Benefits of 3D Mammography (Breast Tomosynthesis) Exams 2First Large-Scale U.S. Study Validates the Benefits of 3D Mammography (Breast Tomosynthesis) Exams 3Blue Cross To Allow HIV/AIDS Patients to "Opt-Out" of Mandatory Mail-Order Rx Drug Program, Announces Consumer Watchdog 2Blue Cross To Allow HIV/AIDS Patients to "Opt-Out" of Mandatory Mail-Order Rx Drug Program, Announces Consumer Watchdog 3
... BIRMINGHAM, Ala., April 24, 2012 Today, the American Academy ... Cities for Life in Birmingham, Ala., a ... 26 million people living with diabetes in the U.S. and ... during their lifetime, Cities for Life , supported by ...
... Boston Scientific Corporation (NYSE: BSX ... of the Emerge™ PTCA[1] Dilatation Catheter.  The Emerge ... specifically to offer exceptional deliverability to address challenging ... immediately in CE Mark countries in both Monorail® ...
Cached Medicine Technology:American Academy of Family Physicians Foundation Launches Cities for Life 2American Academy of Family Physicians Foundation Launches Cities for Life 3American Academy of Family Physicians Foundation Launches Cities for Life 4Boston Scientific Announces CE Mark and European Launch of Emerge™ PTCA Dilatation Catheter 2Boston Scientific Announces CE Mark and European Launch of Emerge™ PTCA Dilatation Catheter 3Boston Scientific Announces CE Mark and European Launch of Emerge™ PTCA Dilatation Catheter 4
Slide Sorters for sorting and viewing 5 cm x 5 cm (2 inches x 2 inches) color slides....
It's a slide cabinet system, store up to 54,000 slides in only 2 square feet of space. Ideal for use in Pathology, Cytology, Hematology, Histology, Dermatology, Research, Education....
Individually, self-contained, stackable drawers....
... Our moisture resistant, plastic covered ... high, each supporting up to 500 ... weight. Each box accommodates 2000 slides ... your varied storage requirements. Come unassembled ...
Medicine Products: