Navigation Links
Discovery of a novel mechanism for the development of colon cancer
Date:5/5/2008

Recent work from the Finnish Academy Center of Excellence on Cancer Biology at the University of Helsinki, Finland, has shed light on the mechanisms of colon tumor development and may help to design better treatment for this disease.

Colon cancer is one of the most common malignancies in Western countries: both men and women face a lifetime risk of nearly 6% for the development of invasive colorectal cancer. Epidemiologic studies have shown that several factors contribute to the development of this disease, such as high fat, red-meat diet, obesity and lack of vegetables and fibre in the diet.

In the great majority of cases, colorectal cancer arises from an initially benign overgrowth of colonic lining, a so-called adenomatous polyp (Fig. 1), which acquires with time harmful mutations and transforms into a dangerous colonic carcinoma. Observational studies suggest that the adenoma-to-carcinoma sequence takes up to 10 years. Although nearly half of Western population may harbor adenomatous polyps by the age of 50, it is estimated that only a few percent of adenomas will progress to cancer.

The study published as an advance online publication of Cancer Cell, describe a mechanism by which harmless colon polyps acquire the ability to form malignant tumors. Researchers from the University of Helsinki discovered that PROX1, a protein that in embryos controls formation of normal organs, such as liver or eye, becomes abnormally overproduced at early stages of carcinoma development. PROX1 allows tumor cells to grow even in the absence of stimulating signals from surrounding normal tissues, which leads to dangerous overgrowth and development of advanced tumors.

Removal of PROX1 from cancer cells reverses their malignant behaviour, suggesting that PROX1 is a promising target for the development of future therapies for colon cancer.


'/>"/>

Contact: Kari Alitalo
kari.alitalo@helsinki.fi
358-505-003-572
University of Helsinki
Source:Eurekalert

Page: 1

Related medicine news :

1. Investigators unveil new drug discovery tool for Alzheimers disease
2. Discovery to hasten new malaria treatments, vaccines for children
3. Life Sciences Discovery Fund Awards $2.2 Million to Support New Solid-Tumor Research Program
4. World-first discovery could help treat life-threatening tumors
5. St. Jude Discovery Offers New Avenues to Understanding an Aggressive Form of Leukemia
6. St. Jude discovery offers new avenues to understanding an aggressive form of leukemia
7. Jefferson scientists discovery may help explain smoking-pancreatic cancer link
8. Pollin Pediatric Research Prize awarded for discovery of lifesaving treatment of RDS
9. Mitosis gets harder thanks to new gene discovery
10. ARCA Discovery Changes Name to ARCA biopharma to Reflect Focus on Drug Commercialization
11. GeneGo Rolls out MetaMiner Cystic Fibrosis - the First Disease-Specific Software Platform to Advance Drug Discovery
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/28/2017)... ... June 28, 2017 , ... Eating disorders have the ... 62 minutes, at least one person dies as a direct result from an eating ... exists for qualified treatment providers. The iaedp Foundation meets this challenge by offering what ...
(Date:6/28/2017)... ... June 28, 2017 , ... Canadian ... announce that a two year study conducted by the University of Saskatchewan in ... successful in remediating potash brine-impacted groundwater. As a part of the study, batch ...
(Date:6/27/2017)... ... June 27, 2017 , ... Excel Medical, the leader in ... position of Executive Vice President, Sales and Marketing. Finnegan is a widely known ... device sales leadership. He has received industry recognition for innovations and new approaches ...
(Date:6/27/2017)... ... June 27, 2017 , ... The Congressional Budget Office (CBO) ... and replace the 2010 Patient Protection and Affordable Care Act (ACA), would result in ... be expected under current law. , More than 20 million Americans have gained health ...
(Date:6/27/2017)... ... June 27, 2017 , ... The Kelahan Agency, ... services to residents of southern New Hampshire, is teaming up with the New ... hunger and homelessness in the region. , New Horizons for New Hampshire provides ...
Breaking Medicine News(10 mins):
(Date:5/30/2017)... -- Hill-Rom Holdings, Inc. (NYSE: HRC), will present at the ... Tuesday, June 13, 2017, in Rancho Palos Verdes, ... chief executive officer, is scheduled to present at 3:20 p.m. ... accessed at http://ir.hill-rom.com/events.cfm . A recorded replay will be ... September 13, 2017. ...
(Date:5/26/2017)... DUBLIN , May 26, 2017  Endo International plc ... Campanelli , President and CEO, will represent the Company in ... Global Healthcare Conference on Tuesday, June 13, 2017 at 10:40 ... held at Terranea Resort in Rancho Palos Verdes, ... archive for the event will be available on the Company,s ...
(Date:5/23/2017)... Calif. , May 23, 2017  Leaf ... most innovative medical devices for pressure ulcer prevention, ... the American Association of Critical Care Nurses, National ... May 22-25. The Leaf Patient Monitoring ... specifically for the hospital environment.  The system seamlessly ...
Breaking Medicine Technology: