Navigation Links
Discovery of a new means to erase pain
Date:7/9/2014

Qubec City, July 9, 2014 A study published in the scientific journal Nature Neuroscience by Yves De Koninck and Robert Bonin, two researchers at Universit Laval, reveals that it is possible to relieve pain hypersensitivity using a new method that involves rekindling pain so that it can subsequently be erased. This discovery could lead to novel means to alleviate chronic pain.

The researchers from the Faculty of Medicine at Universit Laval and Institut universitaire en sant mentale de Qubec (IUSMQ) were inspired by previous work on memory conducted some fifteen years ago. These studies had revealed that when a memory is reactivated during recall, its neurochemical encoding is temporarily unlocked. Simultaneous administration of a drug that blocks neurochemical reconsolidation of the memory results in its erasure.

The investigators wanted to see whether a similar mechanism was at play during neurochemical encoding of pain sensitization. To this end, they injected capsaicin in the foot of mice. Capsaicin, the pungent chemical in chili pepper, triggers a burning sensation. The procedure, which causes no physical damage, triggers pain hypersensitivity through a process of protein synthesis in the spinal cord. After capsaicin injections, the mechanical pressure at which mice would flinch was about a third of that in the normal situation.

Three hours later, the researchers administered a second dose of capsaicin and, at the same time, a drug that blocks protein synthesis. The hypersensitivity then vanished rapidly. Within less than 2 hours, the pressure tolerated by the mice was back to 70% of normal.

Yves De Koninck explains that "when the protein synthesis inhibitor is administered alone, the hypersensitivity remains. The second injection of capsaicin is necessary to render the sensitivity to pain unstable and be able to interfere with its neurochemical reconsolidation. The challenge now will be to find protein synthesis inhibitors that are nontoxic and cause minimal side effects in humans".

Yves De Koninck is a professor of psychiatry and neuroscience at Universit Laval and scientific director of the Institut universitaire en sant mentale de Qubec. Robert Bonin is a postdoctoral fellow in Professor De Koninck's laboratory, where he works on the mechanisms underlying the etiology of chronic pain. He is the recipient of a Catherine Bushnell Fellowship from the Louise and Alan Edwards Foundation. The work was supported financially by the Canadian Institutes of Health Research and the Fonds de la recherche en sant du Qubec.


'/>"/>

Contact: Andrée-Anne Stewart
andree-anne.stewart@dc.ulaval.ca
418-656-3952
Universit Laval
Source:Eurekalert

Related medicine news :

1. Causes of serious pain syndrome closer to discovery
2. Cell division discovery could optimise timing of chemotherapy and explain some cancers
3. Major discovery on the mechanism of drug resistance in leukemia and other cancers
4. Discovery links rare, childhood neurodegenerative diseases to common problem in DNA repair
5. Discovery of anti-appetite molecule released by fiber could help tackle obesity
6. Brain cell discovery could open doors to targeted cancer therapies
7. LSTM-Eisai-UoL awarded GHIT Fund to deliver anti-Wolbachia drug discovery
8. Discovery sheds new light on marijuanas anxiety relief effects
9. Zebrafish discovery may shed light on human kidney function
10. NUS researchers make new discovery of protein as a promising target for treatment of ATC
11. Drug discovery potential of natural microbial genomes
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/25/2016)... ... ... of Bruton Memorial Library on June 21 due to a possible lice infestation, as reported ... head lice: the parasite’s ability to live away from a human host, and to infest ... in the event that lice have simply gotten out of control. , As lice are ...
(Date:6/25/2016)... ... June 25, 2016 , ... On Friday, June 10, ... Bronze Wellness at Work award to iHire in recognition of their exemplary accomplishments in ... the 7th annual Maryland Workplace Health & Wellness Symposium at the BWI Marriott in ...
(Date:6/24/2016)... CA (PRWEB) , ... June 24, 2016 , ... Marcy was in a crisis. Her ... would lash out at his family verbally and physically. , “When something upset him, he ... he would use it. He would throw rocks at my other children and say he ...
(Date:6/24/2016)... (PRWEB) , ... June 24, 2016 , ... Topical BioMedics, Inc, makers of Topricin and ... that call for a minimum wage raise to $12 an hour by 2020 and then ... will restore the lost value of the minimum wage, assure the wage floor does not ...
(Date:6/24/2016)... ... June 24, 2016 , ... ... feeding the Frederick area economy by obtaining investment capital for emerging technology companies. ... 2½ years that have already resulted in more than a million dollars of ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... 2016   Pulmatrix, Inc ., (NASDAQ: ... drugs, announced today that it was added to the ... its comprehensive set of U.S. and global equity indexes ... important milestone for Pulmatrix," said Chief Executive Officer ... our progress in developing drugs for crucial unmet medical ...
(Date:6/24/2016)... , June 24, 2016  Arkis BioSciences, ... less invasive and more durable cerebrospinal fluid treatments, ... funding.  The Series-A funding is led by Innova ... Fund, and other private investors.  Arkis, new financing ... instrumentation and the market release of its in-licensed ...
(Date:6/23/2016)... 23, 2016 Research and Markets has ... - Forecast to 2022" report to their offering. ... for the patients with kidney failure, it replaces the function ... the patient,s blood and thus the treatment helps to keep ... in balance. Increasing number of ESRD patients ...
Breaking Medicine Technology: