Navigation Links
Discovery of a gene associated with a leukemia mostly affecting children
Date:1/18/2011

This release is available in French.

Montreal, January 18, 2011 Cyndia Charfi, a Ph. D student in biology at Universit du Qubec Montral (UQAM), supported by her thesis supervisors, Professor ric Rassart, and Adjunct Professor Elsy Edouard, UQAM, Department of Biological Sciences and BIOMED Research Centre, made a major breakthrough in research on B-cell acute lymphocytic leukemia, a disease that occurs most commonly in children. She has successfully identified a gene that may facilitate the diagnosis of this cancer, which is characterized by an abnormal proliferation of B-cells, antibody-producing cells that defend the body against infection. Her findings were recently published in the prestigious scientific journal Blood.

The research

Cyndi Charfi first compared the transcriptome (the set of active genes in a cell) of leukemic and healthy mice. From this analysis, she was able to isolate groups of genes with abnormal activity in the leukemic mice. This led to the discovery that excessive synthesis of the Fmn2 gene and protein is associated with B-cell lymphocytic leukemia.

Although mice cells are genetically similar to human cells, they clearly are not identical. So the young researcher continued her work, this time using human cells. Her results were the same: abormal activity of Fmn2 gene was observed in human patients with B-cell lymphocytic leukemia and particularly in children.

Better diagnosis for better treatment

Leukemia refers to all cancers that attack the bone marrow cells. The bone marrow produces blood cells, hence the term "blood cancer". As there are several types of blood cells (including B-cells), there are also several types of leukemia, and the treatment differs for each type. The faster and more accurate the diagnosis of the type of leukemia, the better the treatment.

What is the significance of this discovery? According to Professor Rassart, "although it is basic research, Cyndia Charfi's findings represent a major advance and a step closer to improved diagnosis and, hopefully, treatment of this cancer, whose victims, we should recall, are mainly children."


'/>"/>

Contact: Claire Bouchard
bouchard.claire@uqam.ca
514-987-3111
Universit du Qubec Montral
Source:Eurekalert

Related medicine news :

1. Long-shot discovery may lead to advances in treating anxiety, memory disorders
2. Researchers make critical leukemia stem cell discovery
3. New discovery prevents symptoms of rare genetic disorder
4. Discovery halts breast cancer stem cells
5. New path for colon cancer drug discovery
6. Discovery blocks cancer drugs toxic side effect
7. Discovery shows promise against severe side effects
8. Life Sciences Discovery Fund to support drug discovery, foster new R&D initiative
9. Cell survival protein discovery rewrites immune system story
10. Gene discovery could yield treatments for nearsightedness
11. A discovery by Dr. Andre Veillettes team could impact the treatment of autoimmune diseases
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/24/2017)... ... 23, 2017 , ... The Pharmacy and Medically Underserved Areas ... original co-sponsorship of nearly one-quarter of the U.S. House of Representatives. The Senate ... Drug Stores (NACDS) strongly backs the legislation. , “NACDS thanks for their leadership ...
(Date:1/24/2017)... Ariz. (PRWEB) , ... January 23, 2017 , ... ... recently analyzed statistics from 140 Buzzies users who entered metrics into the product’s ... earlier clinical data. The new data showed that within just 30 seconds of ...
(Date:1/23/2017)... ... , ... PKF O’Connor Davies , LLP, the nation’s 26th largest accounting ... Firm, will participate in the 40th Annual "Empire State Building Run Up" on Feb. ... steps, a vertical distance equal to about a fifth of a mile, to reach ...
(Date:1/23/2017)... (PRWEB) , ... January 23, 2017 , ... Wooden and plastic balance boards have been ... and improve balance. Kumo Board is the first and only balance board to ... to be soft and rigid at the same time as well as skill-level adjustable for ...
(Date:1/23/2017)... ... 23, 2017 , ... METTLER TOLEDO has announced the availability ... Simple PAT Tools . , Crystallization is a common step used ... Chemists now spend more time developing better intermediate and final crystallization steps. ...
Breaking Medicine News(10 mins):
(Date:1/24/2017)... -- The global peripheral I.V. catheter market accounted for ... to grow at a CAGR of 6.0% during 2016-2022. ... share in the global market between the two types ... hospital segment accounted for the highest share in the ... I.V. catheter market is witnessing high growth rate, due ...
(Date:1/23/2017)... , Jan. 23, 2017  HOPE BIOSCIENCES ... rights to develop and commercialize nuc -gemcitabine™ ... a Korean pharmaceutical company. nuc ... aptamer against surface nucleolin found on many cancer ... Unlike ADCs (antibody drug conjugates) or SMDCs (small ...
(Date:1/23/2017)... 23, 2017  Based on its recent analysis ... recognizes Ansell, a global leader in protection solutions, ... of the Year Award. Ansell,s comprehensive product portfolio, ... global footprint have placed it in a position ... The Company,s established product line and robust innovation ...
Breaking Medicine Technology: