Navigation Links
Discovery of a gene associated with a leukemia mostly affecting children
Date:1/18/2011

This release is available in French.

Montreal, January 18, 2011 Cyndia Charfi, a Ph. D student in biology at Universit du Qubec Montral (UQAM), supported by her thesis supervisors, Professor ric Rassart, and Adjunct Professor Elsy Edouard, UQAM, Department of Biological Sciences and BIOMED Research Centre, made a major breakthrough in research on B-cell acute lymphocytic leukemia, a disease that occurs most commonly in children. She has successfully identified a gene that may facilitate the diagnosis of this cancer, which is characterized by an abnormal proliferation of B-cells, antibody-producing cells that defend the body against infection. Her findings were recently published in the prestigious scientific journal Blood.

The research

Cyndi Charfi first compared the transcriptome (the set of active genes in a cell) of leukemic and healthy mice. From this analysis, she was able to isolate groups of genes with abnormal activity in the leukemic mice. This led to the discovery that excessive synthesis of the Fmn2 gene and protein is associated with B-cell lymphocytic leukemia.

Although mice cells are genetically similar to human cells, they clearly are not identical. So the young researcher continued her work, this time using human cells. Her results were the same: abormal activity of Fmn2 gene was observed in human patients with B-cell lymphocytic leukemia and particularly in children.

Better diagnosis for better treatment

Leukemia refers to all cancers that attack the bone marrow cells. The bone marrow produces blood cells, hence the term "blood cancer". As there are several types of blood cells (including B-cells), there are also several types of leukemia, and the treatment differs for each type. The faster and more accurate the diagnosis of the type of leukemia, the better the treatment.

What is the significance of this discovery? According to Professor Rassart, "although it is basic research, Cyndia Charfi's findings represent a major advance and a step closer to improved diagnosis and, hopefully, treatment of this cancer, whose victims, we should recall, are mainly children."


'/>"/>

Contact: Claire Bouchard
bouchard.claire@uqam.ca
514-987-3111
Universit du Qubec Montral
Source:Eurekalert

Related medicine news :

1. Long-shot discovery may lead to advances in treating anxiety, memory disorders
2. Researchers make critical leukemia stem cell discovery
3. New discovery prevents symptoms of rare genetic disorder
4. Discovery halts breast cancer stem cells
5. New path for colon cancer drug discovery
6. Discovery blocks cancer drugs toxic side effect
7. Discovery shows promise against severe side effects
8. Life Sciences Discovery Fund to support drug discovery, foster new R&D initiative
9. Cell survival protein discovery rewrites immune system story
10. Gene discovery could yield treatments for nearsightedness
11. A discovery by Dr. Andre Veillettes team could impact the treatment of autoimmune diseases
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/24/2017)... ... March 24, 2017 , ... The iaedp Foundation, the premier provider ... caring for those suffering from the full spectrum of disordered eating, announced today that ... professionals from nearly all 50 states and several countries converged on the Green Valley ...
(Date:3/24/2017)... ... March 24, 2017 , ... As the ... create a communications platform that positions them as the go-to thought leader in ... their online publication as an always-on, always-fresh news, views and advocacy engine, called ...
(Date:3/24/2017)... ... March 24, 2017 , ... Viewers who like to educate themselves ... facts, cultural practices, goods, services, and societal issues tend to appreciate and love the ... popular practice of utilizing running events for causes around the world. , ...
(Date:3/24/2017)... ... March 24, 2017 , ... ... with God #TruthwithGrace”: a devotional journal chronicling the writer’s path toward true communion ... to Walk with God #TruthwithGrace” is the creation of published author Lea Michelle ...
(Date:3/24/2017)... ... , ... “The Adventures of Joey, The Dog Who Barks at Puddles”: a ... to the fullest, as God intended. “The Adventures of Joey, The Dog Who Barks ... pursuing her passion for writing, especially about truth and human behavior. , Published by ...
Breaking Medicine News(10 mins):
(Date:3/24/2017)... FinancialBuzz.com News Commentary   ... Medical cannabis products around the world are projected to ... global medical cannabis market will reach a value of USD 55.8 billion ... for the new growing industry. By the end of 2016, 28 states ... medical cannabis. More conservative states like Arkansas and ...
(Date:3/24/2017)... Today Stock-Callers.com have issued research reports ... Inc. (NASDAQ: NVCN), Hologic Inc. (NASDAQ: HOLX), Edwards Lifesciences Corp. ... ). These companies are part of the Healthcare sector, which ... 23 rd , 2017, with the NYSE Health Care Index ... companies in the S&P 500 were down about 0.4% as ...
(Date:3/24/2017)... 23, 2017  Mirabilis Medical, a ... for non-invasive surgery, announced today CE Mark authorization ... of uterine fibroids throughout the European Union.  The ... from the US Food and Drug Administration to ... in the United States.  The Mirabilis System combines ...
Breaking Medicine Technology: