Navigation Links
Discovery of a gene associated with a leukemia mostly affecting children
Date:1/18/2011

This release is available in French.

Montreal, January 18, 2011 Cyndia Charfi, a Ph. D student in biology at Universit du Qubec Montral (UQAM), supported by her thesis supervisors, Professor ric Rassart, and Adjunct Professor Elsy Edouard, UQAM, Department of Biological Sciences and BIOMED Research Centre, made a major breakthrough in research on B-cell acute lymphocytic leukemia, a disease that occurs most commonly in children. She has successfully identified a gene that may facilitate the diagnosis of this cancer, which is characterized by an abnormal proliferation of B-cells, antibody-producing cells that defend the body against infection. Her findings were recently published in the prestigious scientific journal Blood.

The research

Cyndi Charfi first compared the transcriptome (the set of active genes in a cell) of leukemic and healthy mice. From this analysis, she was able to isolate groups of genes with abnormal activity in the leukemic mice. This led to the discovery that excessive synthesis of the Fmn2 gene and protein is associated with B-cell lymphocytic leukemia.

Although mice cells are genetically similar to human cells, they clearly are not identical. So the young researcher continued her work, this time using human cells. Her results were the same: abormal activity of Fmn2 gene was observed in human patients with B-cell lymphocytic leukemia and particularly in children.

Better diagnosis for better treatment

Leukemia refers to all cancers that attack the bone marrow cells. The bone marrow produces blood cells, hence the term "blood cancer". As there are several types of blood cells (including B-cells), there are also several types of leukemia, and the treatment differs for each type. The faster and more accurate the diagnosis of the type of leukemia, the better the treatment.

What is the significance of this discovery? According to Professor Rassart, "although it is basic research, Cyndia Charfi's findings represent a major advance and a step closer to improved diagnosis and, hopefully, treatment of this cancer, whose victims, we should recall, are mainly children."


'/>"/>

Contact: Claire Bouchard
bouchard.claire@uqam.ca
514-987-3111
Universit du Qubec Montral
Source:Eurekalert

Related medicine news :

1. Long-shot discovery may lead to advances in treating anxiety, memory disorders
2. Researchers make critical leukemia stem cell discovery
3. New discovery prevents symptoms of rare genetic disorder
4. Discovery halts breast cancer stem cells
5. New path for colon cancer drug discovery
6. Discovery blocks cancer drugs toxic side effect
7. Discovery shows promise against severe side effects
8. Life Sciences Discovery Fund to support drug discovery, foster new R&D initiative
9. Cell survival protein discovery rewrites immune system story
10. Gene discovery could yield treatments for nearsightedness
11. A discovery by Dr. Andre Veillettes team could impact the treatment of autoimmune diseases
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/26/2017)... ... June 26, 2017 , ... ... is revolutionizing the way women look and feel about themselves and their sexual ... female sexual dysfunction and urinary leakage head on with a ground breaking medical ...
(Date:6/26/2017)... ... 26, 2017 , ... If the devil is in the ... these days. According to recent estimates, 75 – 80% of the medical bills ... studies point to Electronic Health Records (EHR) with automated features designed to ease ...
(Date:6/26/2017)... ... 2017 , ... New patients with missing teeth in Fitchburg, WI, ... referral. Dr. Cotey is a trusted dentist who has placed many dental implants and ... with missing teeth in Fitchburg, WI, are encouraged to find out if they are ...
(Date:6/25/2017)... Aliso Viejo, CA (PRWEB) , ... June 24, 2017 , ... Create a feel-good lyric ... place presets above footage and sound in the timeline and write in the lyrics to ... screen before flying back out. Each line of the text can be added modularly for ...
(Date:6/25/2017)... ... June 25, 2017 , ... An increase in wetter weather in ... plants, and along with that; a humdinger of an allergy season. A relief from ... an increase in misery-causing grass and weed pollen. , “Our patients have been ...
Breaking Medicine News(10 mins):
(Date:6/13/2017)... , June 13, 2017 Zimmer Biomet Holdings, Inc. ... today announced that the U.S. Food and Drug Administration (FDA) ... 3, 2015 relating to its Zhejiang, China ... "The successful clearance of the Warning Letter ... manufacturing facility is a measure of the progress we have ...
(Date:6/9/2017)... 9, 2017 AirXpanders, Inc. (ASX: AXP) (AirXpanders ... design, manufacture, sale and distribution of the AeroForm® Tissue ... of its commercial roll-out in the United ... than one hundred (100) medical institutions and health systems, ... a needle-free alternative for women who choose reconstructive surgery ...
(Date:6/8/2017)... MCKINNEY, Texas , June 8, 2017 ... Company"), a leading developer and manufacturer of ... industry, announced today that Cressey & Company ... investment firm, has completed a growth-focused investment ... acquired a majority ownership position from selling ...
Breaking Medicine Technology: