Navigation Links
Discovery of Gene May Lead to New Male Contraceptive
Date:5/24/2012

THURSDAY, May 24 (HealthDay News) -- The discovery of a key gene involved in sperm development could eventually lead to the creation of a new type of non-hormonal birth control for men, a study involving mice suggests.

Researchers found that a gene called Katnal1 is critical to enable sperm to mature in the testes. Finding a way to regulate this gene could prevent sperm from maturing, making them incapable of fertilizing eggs.

This finding also could lead to new treatments for cases of male infertility in which the Katnal1 gene malfunctions and hampers sperm development, according to the study, from researchers at the University of Edinburgh in Scotland.

The researchers found that male mice modified to lack the Katnal1 gene were infertile. Further investigation revealed that the gene was essential for sperm development and maturation.

Successful trials in mice do not necessarily mean the success will translate to humans, however.

The study was published in the journal PLoS Genetics.

"If we can find a way to target this gene in the testes, we could potentially develop a non-hormonal contraceptive," study author Lee Smith, of the University of Edinburgh's Center for Reproductive Health, said in a journal news release.

"The important thing is that the effects of such a drug would be reversible because Katnal1 only affects sperm cells in the later stages of development, so it would not hinder the early stages of sperm production and the overall ability to produce sperm," Smith said.

"Although other research is being carried out into non-hormonal male contraceptives, identification of a gene that controls sperm production in the way Katnal1 does is a unique and significant step forward in our understanding of testis biology," Smith concluded.

More information

The U.S. Department of Health and Human Services Office on Women's Health has more about birth control methods.

-- Robert Preidt

SOURCE: PLoS Genetics, news release, May 24, 2012


'/>"/>
Copyright©2010 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Discovery suggests new combination therapy strategy for basal-like breast cancers
2. Researchers make promising discovery in pursuit of effective lymphoma treatments
3. Scientists make breakthrough in bile duct cancer with discovery of new gene mutations
4. H1N1 discovery paves way for universal flu vaccine: UBC research
5. Feelings of immaturity accompany alcohol misuse into adulthood; discovery could improve treatments
6. Discovery could help to develop drugs for organ transplant and cancer patients
7. Washingtons Life Sciences Discovery Fund awards commercialization grants
8. Scientist awarded $1 million grant to develop tools for hepatitis C treatment discovery
9. New discovery of proteins involved in positioning muscular nuclei
10. Cell signaling discovery provides new hope for blood disorders
11. Gene mutation discovery sparks hope for effective endometriosis screening
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Discovery of Gene May Lead to New Male Contraceptive
(Date:6/25/2016)... ... June 25, 2016 , ... "With 30 hand-drawn hand gesture ... said Christina Austin - CEO of Pixel Film Studios. , ProHand Cartoon’s package ... Final Cut Pro X . Simply select a ProHand generator and drag it ...
(Date:6/25/2016)... ... 25, 2016 , ... Conventional wisdom preaches the benefits of moderation, whether it’s ... setting the bar too high can result in disappointment, perhaps even self-loathing. However, those ... goal. , Research from PsychTests.com reveals that behind the tendency to ...
(Date:6/24/2016)... ... 24, 2016 , ... The Pulmonary Hypertension Association (PHA) learned ... receive two significant new grants to support its work to advance research and ... by recognizing patients, medical professionals and scientists for their work in fighting pulmonary ...
(Date:6/24/2016)... ... ... People across the U.S. are sharpening their pencils and honing their writing ... which patients and their families pay tribute to a genetic counselor by nominating him ... Genetic Counselors (NSGC) Annual Education Conference (AEC) this September. , In April, Genome ...
(Date:6/24/2016)... ... ... recruitment firm Slone Partners is pleased to announce the placement of Suzanne ... of North American Capital Sales at HTG Molecular . , In ... commercialization of the HTG EdgeSeq system and associated reagents in North America. , Headquartered ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... SAN CLEMENTE, Calif. , June 24, 2016 /PRNewswire/ ... pulmonary function testing company, is now able to perform sophisticated lung ... ndd Medical Technologies , Inc. Patients are ... labs.  Thanks to ndd,s EasyOne PRO ® , ARL patients like ... any needed testing done in the comfort of her own home. ...
(Date:6/24/2016)...  Arkis BioSciences, a leading innovator in the ... cerebrospinal fluid treatments, today announced it has secured ... led by Innova Memphis, followed by Angel Capital ... Arkis, new financing will accelerate the commercialization of ... of its in-licensed Endexo® technology. ...
(Date:6/23/2016)... startling report released today, National Safety Council research shows ... plan to eliminate prescription opioid overdoses. Prescription Nation ... the worst drug crisis in recorded U.S. history, assigned a "Making ... , New Mexico , Tennessee ... states, three – Michigan , Missouri ...
Breaking Medicine Technology: