Navigation Links
Discovery of Gene May Lead to New Male Contraceptive
Date:5/24/2012

THURSDAY, May 24 (HealthDay News) -- The discovery of a key gene involved in sperm development could eventually lead to the creation of a new type of non-hormonal birth control for men, a study involving mice suggests.

Researchers found that a gene called Katnal1 is critical to enable sperm to mature in the testes. Finding a way to regulate this gene could prevent sperm from maturing, making them incapable of fertilizing eggs.

This finding also could lead to new treatments for cases of male infertility in which the Katnal1 gene malfunctions and hampers sperm development, according to the study, from researchers at the University of Edinburgh in Scotland.

The researchers found that male mice modified to lack the Katnal1 gene were infertile. Further investigation revealed that the gene was essential for sperm development and maturation.

Successful trials in mice do not necessarily mean the success will translate to humans, however.

The study was published in the journal PLoS Genetics.

"If we can find a way to target this gene in the testes, we could potentially develop a non-hormonal contraceptive," study author Lee Smith, of the University of Edinburgh's Center for Reproductive Health, said in a journal news release.

"The important thing is that the effects of such a drug would be reversible because Katnal1 only affects sperm cells in the later stages of development, so it would not hinder the early stages of sperm production and the overall ability to produce sperm," Smith said.

"Although other research is being carried out into non-hormonal male contraceptives, identification of a gene that controls sperm production in the way Katnal1 does is a unique and significant step forward in our understanding of testis biology," Smith concluded.

More information

The U.S. Department of Health and Human Services Office on Women's Health has more about birth control methods.

-- Robert Preidt

SOURCE: PLoS Genetics, news release, May 24, 2012


'/>"/>
Copyright©2010 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Discovery suggests new combination therapy strategy for basal-like breast cancers
2. Researchers make promising discovery in pursuit of effective lymphoma treatments
3. Scientists make breakthrough in bile duct cancer with discovery of new gene mutations
4. H1N1 discovery paves way for universal flu vaccine: UBC research
5. Feelings of immaturity accompany alcohol misuse into adulthood; discovery could improve treatments
6. Discovery could help to develop drugs for organ transplant and cancer patients
7. Washingtons Life Sciences Discovery Fund awards commercialization grants
8. Scientist awarded $1 million grant to develop tools for hepatitis C treatment discovery
9. New discovery of proteins involved in positioning muscular nuclei
10. Cell signaling discovery provides new hope for blood disorders
11. Gene mutation discovery sparks hope for effective endometriosis screening
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Discovery of Gene May Lead to New Male Contraceptive
(Date:2/10/2016)... ... February 10, 2016 , ... Intalere’s ... together more than 200 of the country’s top healthcare executives to share insights ... true benefit of the Forum is the provider-centric perspective, experience, expertise and strategy ...
(Date:2/10/2016)... ... February 10, 2016 , ... Armune BioScience signed a ... network of laboratory service centers across the country. Launched in April of 2015, Apifiny ... detection of prostate cancer. Apifiny order volume exceeded 3,000 tests in 2015. Primary care ...
(Date:2/10/2016)... ... February 10, 2016 , ... A ... Ohio Safety Congress and Expo event March 9-11, 2016. Hosted by Ohio's Bureau ... Center. , As the longest running and largest worker's compensation event in ...
(Date:2/10/2016)... ... February 10, 2016 , ... ... 1 UNF Drive, Jacksonville, FL 32224, February 26th: Amateur & Professional Divisions ... Division - Time: 7:00pm – 10:00pm | Ticket Prices $30, Social Media: ...
(Date:2/10/2016)... ... February 10, 2016 , ... Anxiety of older Americans ... start of Medicare Part D a decade ago, according to The Senior Citizens ... adults on how they are coping with rapidly rising costs. “The implications are ...
Breaking Medicine News(10 mins):
(Date:2/10/2016)... , Feb. 10, 2016  Resolve Therapeutics, ... transformative new approaches to the treatment of lupus ... of a multiple ascending dose study in patients ... compound RSLV-132. --> ... placebo-controlled multiple ascending dose study of RSLV-132 in ...
(Date:2/10/2016)...  Rich Pharmaceuticals, Inc. (OTC Markets: RCHA) ("Rich Pharmaceuticals" ... of its issued and outstanding shares of common stock ... 11, 2016. The Company,s common stock will trade on ... temporary ticker symbol "RCHAD". After 20 trading days, the ... (RCHA).  --> --> ...
(Date:2/10/2016)... , Feb. 10, 2016  The Baylor ... received an in-kind gift from ... VeinViewer® Vision vein finder for the nursing ... students as they learn how to start ... with traditional technique. ...
Breaking Medicine Technology: