Navigation Links
Discovery in liver cancer cells provides new target for drugs
Date:3/22/2011

Richmond, Va. (March 23, 2011) Researchers at Virginia Commonwealth University Massey Cancer Center and VCU Institute of Molecular Medicine (VIMM) have discovered a novel mechanism in gene regulation that contributes to the development of a form of liver cancer called hepatocellular carcinoma (HCC). Currently, there is virtually no effective treatment for HCC, and this breakthrough identifies a promising new target for therapeutic intervention.

In the journal Hepatology, Devanand Sarkar, M.B.B.S., Ph.D., Harrison Endowed Scholar in Cancer Research at VCU Massey Cancer Center, a Blick scholar and assistant professor in the Department of Human and Molecular Genetics and a member of the VIMM at VCU School of Medicine, describes for the first time how RNA-induced silencing complex (RISC) contributes to the development of liver cancer.

RISC is an important factor in post-transcriptional gene regulation, which occurs between transcription (where DNA is converted to RNA) and translation (where RNA is converted to protein). These processes regulate functions such as cellular growth, division and death. Sarkar and his team identified the proteins AEG-1 and SND1 as factors that increase RISC activity and lead to the development of liver cancer.

For years, Sarkar has been studying the role of AEG-1 in cancer with his collaborator on this research, Paul B. Fisher, M.Ph., Ph.D., Thelma Newmeyer Corman Endowed Chair in Cancer Research at VCU Massey, professor and chair of the Department of Human and Molecular Genetics and director of the VIMM.

"AEG-1 works as a scaffold protein," says Sarkar. "If you think about scaffolding outside of a biological setting, its function is to help facilitate things like construction. In this case, AEG-1 was found to work with another protein, SND1, to provide the scaffold for the formation of RISC. Since both AEG-1 and SND1 are increased in HCC, the net effect is increased RISC activity."


'/>"/>
Contact: John Wallace
wallacej@vcu.edu
804-628-1550
Virginia Commonwealth University
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Finding of long-sought drug target structure may expedite drug discovery
2. New laser technique opens doors for drug discovery
3. LRI awards wide-ranging research grants to drive next generation of scientific discovery in lupus
4. Clinical observation leads to lung cancer discovery
5. New weight loss discovery by Harvard scientists moves us closer to the Pill for obesity
6. Leicester leads on heart attack genetic link discovery
7. Discovery of new gene mutation in schizophrenia offers a new target for drug therapies
8. UT MD Anderson discovery wins 2010 Cozzarelli Prize
9. Biomarker discovery may lead to reliable blood test for ectopic pregnancy
10. Washington Life Sciences Discovery Fund announces grants to commercialize promising technologies
11. Discovery May Explain Why Brain Cancer Is So Hard to Treat
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/1/2014)... October 01, 2014 Anti Aging Clinic ... skin rejuvenating destination of choice, is announcing a discounted ... through to December. , “We’re doing this because we ... to our top skin clinic in Toronto,” says Dr. ... so much at Anti Aging Clinic, including laser facials, ...
(Date:10/1/2014)... Dar, Ethiopia, at the occasion of the Leishmaniasis ... 150 African and international leishmaniasis experts, results of ... efficacy monitoring plan, carried out by MSF, ... and Ethiopia, were presented to key decision makers ... of kala-azar with the combination of Sodium Stibogluconate ...
(Date:10/1/2014)... WOODLAND HILLS, CA (PRWEB) October 01, 2014 ... Mamaly Reshad will speak to a group of dental ... week in the northern Spain city of Oviedo. Dr. ... known prosthodontist and lecturer with clients on two continents, ... mouth complex and aesthetic full mouth reconstruction. , “These ...
(Date:10/1/2014)... 2014 Two bicyclists began a journey ... the country in an effort to raise funds and ... The cyclists, a father-daughter team, plan to bike more ... Washington and finishing in Key West Florida. Funds ... Warriors®, a national nonprofit organization that assists post-9/11 service ...
(Date:10/1/2014)... UP4 Probiotics will be donating a portion of ... Network to End Domestic Violence ( http://www.nnedv.org ) during ... nationwide polling that took place during August and September ... “We are proud to have been chosen by your ... UP4 Women’s Probiotics during the month of October,” said ...
Breaking Medicine News(10 mins):Health News:Anti Aging Clinic, the GTA’s Premier Provider of Anti Aging Treatments, Announces Deal on Units of Botox 2Health News:Results of large-scale roll out of combination treatment for kala-azar in Eastern Africa 2Health News:Woodland Hills Dental Implants Expert Training Dental Specialists in Spain Later This Week 2Health News:Woodland Hills Dental Implants Expert Training Dental Specialists in Spain Later This Week 3Health News:Woodland Hills Dental Implants Expert Training Dental Specialists in Spain Later This Week 4Health News:Father-Daughter Cycling Duo to Ride Cross-Country to Benefit Hope For The Warriors 2Health News:UP4 Probiotics Partners with The National Network to End Domestic Violence 2
... bones, teeth, and other parts of the body for early ... like something out of science fiction. But those devices are ... current issue of Chemical & Engineering News (C&EN), ACS, weekly ... that these new diagnostic tools will have the ability to ...
... In an international study of patients with a devastating ... have found intriguing evidence that career choice may influence where ... The study was led by Baycrest,s Rotman Research Institute in ... of California, San Francisco and several U.S. and European clinical ...
... (HealthDay News) -- Young people with the kind of irregular ... surgery to fix the problem instead of taking medication first, ... person,s pulse rate to change from minute to minute, can ... condition is rare in younger people and can occur for ...
... researchers have confirmed there is a genetic risk factor ... still needed, these findings will make it possible to ... Barcelona (UB) have discovered that the genetic variant 677C>T ... known in genetic studies) is linked to osteoporotic vertebral ...
... Reporter , TUESDAY, Sept. 21 (HealthDay News) -- Living ... The rigors of having to lose weight, strictly limit ... medications lead many people to disregard their doctor,s orders. ... counseling and reading materials on how to manage heart ...
... clinical trials and 11 systematic reviews of trials published every ... we ever cope?, ask Hilda Bastian, Paul Glasziou, and Sir ... also decry the continued poor quality of many of these ... evidence, the authors recommend that we must now reduce unnecessary ...
Cached Medicine News:Health News:For sufferers of an early-onset dementia, career choice may determine location of disease in brain 2Health News:For sufferers of an early-onset dementia, career choice may determine location of disease in brain 3Health News:Surgery May Be Best for Irregular Heartbeat in Young 2Health News:Genetic factor in osteoporosis discovered 2Health News:Counseling May Not Help Heart Failure Patients Comply With Rx 2Health News:Counseling May Not Help Heart Failure Patients Comply With Rx 3
(Date:10/1/2014)... 1, 2014   Cypher Genomics, Inc., the ... J. Patrick Ravenel as chief technology officer. Ravenel ... systems experience and a proven track record of designing ... "Patrick has been recognized as a top designer ... is known industry-wide for delivering innovative products that operate ...
(Date:10/1/2014)... Calif. , Oct. 1, 2014 /PRNewswire/ ... ), a clinical-stage biopharmaceutical company focused on ... positive results from its 371 patient Phase ... with constipation-predominant irritable bowel syndrome (IBS-C).  Results ... clinically meaningful improvement in IBS-C symptoms for ...
(Date:9/30/2014)... LONDON , Sept. 30, 2014 This report ... Million by the following Product Categories: Enteral Feeding Pumps, Nasogastric ... analytics for the US Canada, Japan , ... Latin America , and Rest of World. ... through 2018. Also, a six-year historic analysis is provided for ...
Breaking Medicine Technology:Cypher Genomics Appoints J. Patrick Ravenel Chief Technology Officer 2Ardelyx Reports Positive Results from Its Phase 2b Clinical Trial Evaluating Tenapanor in IBS-C Patients 2Ardelyx Reports Positive Results from Its Phase 2b Clinical Trial Evaluating Tenapanor in IBS-C Patients 3Ardelyx Reports Positive Results from Its Phase 2b Clinical Trial Evaluating Tenapanor in IBS-C Patients 4Ardelyx Reports Positive Results from Its Phase 2b Clinical Trial Evaluating Tenapanor in IBS-C Patients 5Ardelyx Reports Positive Results from Its Phase 2b Clinical Trial Evaluating Tenapanor in IBS-C Patients 6Global Enteral Feeding Devices Industry 2Global Enteral Feeding Devices Industry 3Global Enteral Feeding Devices Industry 4Global Enteral Feeding Devices Industry 5Global Enteral Feeding Devices Industry 6Global Enteral Feeding Devices Industry 7Global Enteral Feeding Devices Industry 8Global Enteral Feeding Devices Industry 9Global Enteral Feeding Devices Industry 10Global Enteral Feeding Devices Industry 11Global Enteral Feeding Devices Industry 12Global Enteral Feeding Devices Industry 13Global Enteral Feeding Devices Industry 14Global Enteral Feeding Devices Industry 15Global Enteral Feeding Devices Industry 16Global Enteral Feeding Devices Industry 17Global Enteral Feeding Devices Industry 18Global Enteral Feeding Devices Industry 19
... Microfluidic Systems, a privately-held company, announced today ... area of automated biological sample processing and detection. ... Automatically Lyse A Sample".  This patent covers a ... controls critical conditions such as temperature, power, and ...
... FOUNTAIN HILLS, Ariz., Sept. 23 Sunridge International ... today that it has shipped its first order ... for several Middle Eastern countries.  AME plans to ... throughout the region, while simultaneously conducting a short ...
Cached Medicine Technology:Microfluidic Systems (MFSI) is Awarded Four New Patents in the Field of Automated Biological Sample Processing and Detection. 2Sunridge Ships First Order to the Middle East 2
Inquire...
Inquire...
Inquire...
... X-22 Series is up to 10 inches/ 25 cm ... 11 rotors, the Allegra X-22 Series is the space-saving ... Only 18 inches / 46 cm wide • 11 ... 3 different ways to Spin 1.5 mL & ...
Medicine Products: