Navigation Links
Discovery first step to new therapies
Date:7/14/2008

In an Australian first, scientists at Sydney's Centenary Institute have mapped the anatomy of a membrane protein. This exciting discovery has the potential to turn the way we discover new drugs on its head and reduce the development time for new treatments.

"These membrane proteins are the target for 70% of all therapeutic drugs so an increased understanding of them is vital for future drug discoveries," said Centenary Institute Executive Director, Professor Mathew Vadas.

Publishing this month in the prestigious international journal, Nature Structural & Molecular Biology, Dr Mika Jormakka and his colleagues at UNSW, say understanding membrane protein structures will help develop better treatments for some of Australia's biggest killers such as cancer.

Dr Jormakka explains: "The best way to imagine the way we currently discover new drugs is to think of a lock and key. The lock is the membrane protein that causes the body to respond to treatment and the key is the drug."

"Up until recently we have never known what the lock looked like so we have to build thousands of keys (drugs) until we stumble upon one that fits. By mapping membrane proteins we are creating a map of the locks this should make it much easier to design a key that fits."

Work on membrane proteins is still in its infancy, particularly in Australia. Having joined the Centenary Institute last year to head up the new Structural Biology laboratory, Dr Jormakka is widely recognised as a leader in the field.

"It is an exciting time to be working in structural biology as we are still very much at the start of the story," he explains. "There are only around 70 membrane proteins out of a potential 10,000 that have ever been mapped."

"At Centenary, we are now trying to map membrane proteins that are involved in 'pumping' drugs out of cells thereby reducing the effectiveness of cancer chemotherapy agents and antibiotics among other drugs."

"By understanding how these membrane proteins work, we have the potential to eliminate the trial and error nature of patient treatment and to create targeted therapies." Professor Vadas explains Dr Jormakka is working in a complicated scientific field but that his work is critical to improved drug therapies.

"For Dr Jormakka the higher the degree of difficulty the more interested he becomes. He is prepared to investigate very difficult subjects and his success to date is extremely encouraging," says Professor Vadas. "We are proud to have recruited such a talented young scientist to Centenary to lead our new Structural Biology program. We look forward to further scientific advances from him and his team which will have the potential to improve outcomes for patients."


'/>"/>

Contact: Erin Sharp
e.sharp@centenary.org.au
61-295-656-118
Research Australia
Source:Eurekalert

Related medicine news :

1. Discovery of key malaria proteins could mean sticky end for parasite
2. 9/11 Workers Refute Citys Allegation of Discovery Abuse and Malingering
3. Discovery of gene mechanism could bring about new ways to treat metastatic cancer
4. MYSTERY ER Season 2 Takes Viewers Behind the Curtain for Real-Life Medical Mysteries on Discovery Health
5. NIAID creates HIV vaccine discovery branch
6. Could new discovery about a shape-shifting protein lead to a mighty morpheein bacteria fighter?
7. Core Informatics Deploys Core LIMS to Support Antibody Discovery at Fabrus
8. Dynamin drug discovery team win prestigious international epilepsy grant
9. Singapore Is One of the Fastest Growing Bioclusters in Asia; Wave of Investments in Drug Discovery and Translational Research
10. New Molecule Discovery Shows Promise Against Tamoxifen-Resistant Breast Cancers
11. Stem cell discovery sheds light on placenta development
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/27/2016)... ... June 27, 2016 , ... ... payment industry today announced its strategic partnership with Connance, a healthcare industry ... The two companies’ proven, proprietary technology combine to provide health systems, hospitals ...
(Date:6/26/2016)... ... 2016 , ... Pixel Film Studios Released ProSlice Levels, a Media Slicing Effect ... videos a whole new perspective by using the title layers in ProSlice Levels ... , ProSlice Levels contains over 30 Different presets to choose from. FCPX ...
(Date:6/25/2016)... (PRWEB) , ... June 25, 2016 , ... Austin residents ... the American College of Mohs Surgery and to Dr. Russell Peckham for medical and ... highly effective treatment for skin cancer. The selective fellowship in Mohs Micrographic Surgery completed ...
(Date:6/25/2016)... ... June 25, 2016 , ... Dr. ... from injury. Recently, he has implemented orthobiologic procedures as a method for treating ... one of the first doctors to perform the treatment. Orthobiologics are substances that ...
(Date:6/24/2016)... (PRWEB) , ... June 24, 2016 , ... June 19, ... the dangers associated with chronic pain and the benefits of holistic treatments, Serenity ... who are suffering with Sickle Cell Disease. , Sickle Cell Disease (SCD) is a ...
Breaking Medicine News(10 mins):
(Date:6/26/2016)... 27, 2016  VMS Rehab Systems, Inc. ( www.vmsrehabsystemsinc.com ... whatever measures required to build a strong and stable ... currently listed on the OTC Markets-pink current trading platform. ... CEO, "We are seeing an anomaly in market trading ... only by the Company, but shareholders and market players ...
(Date:6/24/2016)... , June 24, 2016  Collagen Matrix, ... design, development and manufacturing of collagen and mineral ... announced today that Bill Messer has ... Marketing to further leverage the growing portfolio of ... devices. Bill joins the Collagen Matrix ...
(Date:6/24/2016)... 24, 2016 ... the addition of the " Global Markets for ... This report focuses on ... updated review, including its applications in various applications. The ... which includes three main industries: pharmaceutical and biotechnology, food ...
Breaking Medicine Technology: