Navigation Links
Discovery first step to new therapies
Date:7/14/2008

In an Australian first, scientists at Sydney's Centenary Institute have mapped the anatomy of a membrane protein. This exciting discovery has the potential to turn the way we discover new drugs on its head and reduce the development time for new treatments.

"These membrane proteins are the target for 70% of all therapeutic drugs so an increased understanding of them is vital for future drug discoveries," said Centenary Institute Executive Director, Professor Mathew Vadas.

Publishing this month in the prestigious international journal, Nature Structural & Molecular Biology, Dr Mika Jormakka and his colleagues at UNSW, say understanding membrane protein structures will help develop better treatments for some of Australia's biggest killers such as cancer.

Dr Jormakka explains: "The best way to imagine the way we currently discover new drugs is to think of a lock and key. The lock is the membrane protein that causes the body to respond to treatment and the key is the drug."

"Up until recently we have never known what the lock looked like so we have to build thousands of keys (drugs) until we stumble upon one that fits. By mapping membrane proteins we are creating a map of the locks this should make it much easier to design a key that fits."

Work on membrane proteins is still in its infancy, particularly in Australia. Having joined the Centenary Institute last year to head up the new Structural Biology laboratory, Dr Jormakka is widely recognised as a leader in the field.

"It is an exciting time to be working in structural biology as we are still very much at the start of the story," he explains. "There are only around 70 membrane proteins out of a potential 10,000 that have ever been mapped."

"At Centenary, we are now trying to map membrane proteins that are involved in 'pumping' drugs out of cells thereby reducing the effectiveness of cancer chemotherapy agents and antibiotics among other drugs."

"By understanding how these membrane proteins work, we have the potential to eliminate the trial and error nature of patient treatment and to create targeted therapies." Professor Vadas explains Dr Jormakka is working in a complicated scientific field but that his work is critical to improved drug therapies.

"For Dr Jormakka the higher the degree of difficulty the more interested he becomes. He is prepared to investigate very difficult subjects and his success to date is extremely encouraging," says Professor Vadas. "We are proud to have recruited such a talented young scientist to Centenary to lead our new Structural Biology program. We look forward to further scientific advances from him and his team which will have the potential to improve outcomes for patients."


'/>"/>

Contact: Erin Sharp
e.sharp@centenary.org.au
61-295-656-118
Research Australia
Source:Eurekalert

Related medicine news :

1. Discovery of key malaria proteins could mean sticky end for parasite
2. 9/11 Workers Refute Citys Allegation of Discovery Abuse and Malingering
3. Discovery of gene mechanism could bring about new ways to treat metastatic cancer
4. MYSTERY ER Season 2 Takes Viewers Behind the Curtain for Real-Life Medical Mysteries on Discovery Health
5. NIAID creates HIV vaccine discovery branch
6. Could new discovery about a shape-shifting protein lead to a mighty morpheein bacteria fighter?
7. Core Informatics Deploys Core LIMS to Support Antibody Discovery at Fabrus
8. Dynamin drug discovery team win prestigious international epilepsy grant
9. Singapore Is One of the Fastest Growing Bioclusters in Asia; Wave of Investments in Drug Discovery and Translational Research
10. New Molecule Discovery Shows Promise Against Tamoxifen-Resistant Breast Cancers
11. Stem cell discovery sheds light on placenta development
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/27/2017)... (PRWEB) , ... April 27, 2017 , ... ... containerization, today announced an exhibitor sponsorship at MobileIron Live! 2017 in ... new technologies for an immersive, educational approach to helping organizations maximize the benefits ...
(Date:4/26/2017)... ... April 26, 2017 , ... Jump Technologies, ... today announced it has completed a round of funding to accelerate its growth ... partners. Black Granite Capital is a growth equity firm focused on investments in ...
(Date:4/26/2017)... ... April 26, 2017 , ... Datos Health , ... partnership with Med-e-Mass , the largest Electronic Medical Records (EMR) provider in South ... care plan incentives to a patient’s remote health progress, empowering the patient to take ...
(Date:4/26/2017)... ... , ... RawTrition now brings you BioEnergy which is a powder capsule whole ... , RawTrition is taking nutrients to the next level! The superfoods in RawTrition's ... form (unlike the synthetically made options that are on the market). , Founder of ...
(Date:4/25/2017)... ... April 25, 2017 , ... Bellus Medical, a leader ... in a new class of photodynamic cosmetics (PDC). , Allumera® is the first ... outward signs of aging, and minimize the appearance of pores – all with ...
Breaking Medicine News(10 mins):
(Date:4/20/2017)... , April 20, 2017 Eyevensys, ... the first non-viral gene expression technology that enables the ... eye to address a wide range of ophthalmic diseases, ... and Healthcare products Regulatory Agency (MHRA) to advance its ... ...
(Date:4/19/2017)... The Mobile X-Ray product segment is the most ... the forecast period Mobile X-Ray segment is the ... X-Ray devices market, which is estimated to be valued at ... CAGR of 7% over the forecast period. Mobile X-Ray segment ... US$ 100 Mn in 2017 over 2016. The segment,s revenue ...
(Date:4/19/2017)... PUNE, India , April 19, 2017 ... Type and Application, Forecast to 2022 report has covered and ... provides statistics and information on market size, shares and growth ... with major drivers, challenges and opportunities in the global market. ... Browse 152 Tables and ...
Breaking Medicine Technology: