Navigation Links
Discovery explains how cellular pathways converge to regulate food intake and body weight
Date:7/3/2012

BOSTON -- In the complex chain of molecular events that underlie eating behaviors and body weight, the AMP-activated protein kinase (AMPK) enzyme has proven to be a critical link.

Now, researchers at Beth Israel Deaconess Medical Center (BIDMC) have identified the mechanism responsible for inhibition of AMPK activity in the hypothalamus, a discovery that not only provides a deeper understanding of energy balance but also reveals a critical integration point where multiple signaling pathways, including PI3K-AKT and mTOR converge.

Described in the July 3 issue of Cell Metabolism, the findings could yield new opportunities for the development of treatments for both metabolic diseases and cancer.

"AMPK is an evolutionarily conserved 'fuel gauge,'" says senior author Barbara Kahn, MD, a scientist in the Division of Endocrinology, Diabetes and Metabolism at BIDMC and the George Richards Minot Professor of Medicine at Harvard Medical School. Activated when cellular energy supplies are low, AMPK also functions at the whole body level to regulate metabolism and energy balance.

The Kahn laboratory was the first to describe AMPK's critical role in mediating the actions of leptin, the hormone produced by fat cells that serves as a master regulator of neuroendocrine, metabolic, vascular, sympathetic and immune function. In 2002, Kahn demonstrated that AMPK is activated by leptin in skeletal muscle, thereby enabling the hormone to metabolize fatty acids. Subsequently, in 2004, her laboratory discovered that an opposing scenario takes place in the brain's hypothalamus, where AMPK is inhibited by leptin.

"Having determined that leptin's effects on food intake and body weight depend on the inhibition of AMPK in the hypothalamus, we wanted to determine the signaling events that were responsible for this effect," she explains.

The PI3K-AKT, mTOR-p70S6 kinase and AMPK pathways play distinct and critical roles in
'/>"/>

Contact: Bonnie Prescott
bprescot@bidmc.harvard.edu
617-667-7306
Beth Israel Deaconess Medical Center
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Scientist awarded $1 million grant to develop tools for hepatitis C treatment discovery
2. Washingtons Life Sciences Discovery Fund awards commercialization grants
3. Discovery could help to develop drugs for organ transplant and cancer patients
4. Feelings of immaturity accompany alcohol misuse into adulthood; discovery could improve treatments
5. H1N1 discovery paves way for universal flu vaccine: UBC research
6. Scientists make breakthrough in bile duct cancer with discovery of new gene mutations
7. Researchers make promising discovery in pursuit of effective lymphoma treatments
8. Discovery suggests new combination therapy strategy for basal-like breast cancers
9. Discovery of Gene May Lead to New Male Contraceptive
10. 5 more pharmaceutical companies join NIH initiative to speed therapeutic discovery
11. Illnesses in Colorado childrens hospital prompts discovery of contaminated alcohol pads
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/1/2015)... (PRWEB) March 01, 2015 Theme and ... new transition pack for Final Cut Pro ... accordion style transitions to any FCPX editors project.” Said ... our users the tools needed to easily drag and ... The user gets many different controls over the parameters ...
(Date:2/28/2015)... March 01, 2015 Heart diseases are ... 10 percent of urban adult population and 5 percent ... heart diseases and 20-30 percent of them require specialized ... ailments and coronary vascular diseases (CVD). , A division ... new market research report titled “Indian Coronary Stent Market ...
(Date:2/28/2015)... The Heart Fit Clinic started doing External Counterpulsation ... The Heart Fit Clinic is also selling the machines ... The goal is to scale the business to help ... buy External Counterpulsation machines can be difficult process. ... process and achieve the desired results. , The ...
(Date:2/28/2015)... February 28, 2015 Vancouver personal injury lawyers ... claims are affected by time limits. They stated that in ... person’s claim or even nullify it. Many a time, delays ... a client’s rights under BC law. As a result, experts ... by accidents should consult a personal injury lawyer in order ...
(Date:2/28/2015)... The Mesothelioma Applied Research Foundation (Meso ... Symposium on Malignant Mesothelioma on Monday, March 2. The ... Bethesda in Bethesda, Maryland. The following award recipients will ... the mission to cure mesothelioma. , The Klaus Brauch ... Miriam Ratner. Miriam runs the Meso Foundation’s monthly spousal ...
Breaking Medicine News(10 mins):Health News:Announcing a New Transition Pack from Pixel Film Studios, Transccordion for Final Cut Pro X 2Health News:India Coronary Stent Market 2019 Forecasts Analysis in New Research Report Available at MarketReportsOnline.com 2Health News:India Coronary Stent Market 2019 Forecasts Analysis in New Research Report Available at MarketReportsOnline.com 3Health News:Clinicians Can Now Purchase External Counterpulsation with Heart Fit Clinic 2Health News:Jiwa Law Corporation Recently Announced That Time Delays May Weaken Personal Injury Claims 2Health News:Cancer Research Foundation Honors Award Recipients 2Health News:Cancer Research Foundation Honors Award Recipients 3Health News:Cancer Research Foundation Honors Award Recipients 4
... came to St. Louis Children,s Hospital in the summer of ... pressure in his lungs. Washington University physicians and surgeons ... fast to save his life. They collaborated to make several ... use of an artificial lung in a toddler. Their ...
... THURSDAY, June 16 (HealthDay News) -- No long-term decrease in ... officers from the New York Police Department,s Emergency Services Unit ... Trade Center, according to a new study. Researchers analyzed ... who responded to the attack and found that most had ...
... HealthDay Reporter , THURSDAY, June 16 (HealthDay News) -- The ... popular diabetes drug Actos (pioglitazone) may increase the risk of ... The agency,s warning comes five days after Germany and France ... in a class of drugs called thiazolidinediones, the only other ...
... University of Texas Health Science Center at Houston (UTHealth) could ... produce the type of fat ringing the waists of millions. ... Cell Stem Cell . The scientists have developed ... day could aid in the delivery of drugs that slow ...
... 16 (HealthDay News) -- Researchers have pinpointed the brain regions ... one of the most fundamental aspects of self-awareness. The ... of the brain that create a unified view of the ... body, according to the study published online June 16 in ...
... Kathleen Doheny HealthDay Reporter , THURSDAY, June 16 ... grades in high school and the beginning years of college, ... as they adopt more traditional sleeping schedules, a change occurs. ... Peszka, an associate professor of psychology at Hendrix College in ...
Cached Medicine News:Health News:Washington University surgeons successfully use artificial lung in toddler 2Health News:Washington University surgeons successfully use artificial lung in toddler 3Health News:Washington University surgeons successfully use artificial lung in toddler 4Health News:Lung Health of Police Responders From 9/11 Called 'Encouraging' 2Health News:Diabetes Drug Actos May Raise Risk for Bladder Cancer: FDA 2Health News:Diabetes Drug Actos May Raise Risk for Bladder Cancer: FDA 3Health News:New stem cell research could aid in battle against bulging waistlines 2Health News:Scientists Pinpoint Parts of Brain That Help People Recognize Themselves 2Health News:Night Owls' Poor Sleep Habits Can Hurt Grades 2Health News:Night Owls' Poor Sleep Habits Can Hurt Grades 3
(Date:2/27/2015)... 27, 2015  Bionik Laboratories Corp. (OTC:DWTPD), a ... that it acquired Bionik Laboratories, Inc., a ... sale to qualified accredited investors of units consisting of ... of approximately $6.2 million. Shares of the Company,s common ... Markets under the symbol "DWTPD" until FINRA,s approval of ...
(Date:2/27/2015)... , Feb. 27, 2015  Two mass ... in applications as their effectiveness is established, ... Information.  Kalorama Information says that while mass ... most powerful tool in proteomic biomarker discovery ... through its traditional techniques has struggled to ...
(Date:2/26/2015)... February 27, 2015 RnRMarketResearch.com ... market research report to its store. This report ... therapeutic pipeline. The report "Corneal Ulcers - Pipeline ... therapeutic development for Corneal Ulcers. Corneal Ulcers are ... bacterial infections, viral infections & fungal infections. The ...
Breaking Medicine Technology:Bionik Laboratories Raises $6.2 Million 2Bionik Laboratories Raises $6.2 Million 3Report: "Softer" Mass Spec Techniques Gaining Popularity in Biomarker Discovery 2Report: "Softer" Mass Spec Techniques Gaining Popularity in Biomarker Discovery 3Corneal Ulcers Therapeutics Companies and Drugs Pipeline H2 2014 Review Research Report 2Corneal Ulcers Therapeutics Companies and Drugs Pipeline H2 2014 Review Research Report 3Corneal Ulcers Therapeutics Companies and Drugs Pipeline H2 2014 Review Research Report 4Corneal Ulcers Therapeutics Companies and Drugs Pipeline H2 2014 Review Research Report 5
... Ill., Feb. 8, 2011 Sysmex America, Inc. ... Service Agreement with PeaceHealth, a not-for-profit integrated healthcare ... group clinics and laboratories located in Alaska, Washington ... the agreement ensures either the installation of a ...
... MedShape Solutions, Inc., the industry ... announced the introduction and first human clinical use ... fixation device that simplifies and improves soft tissue ... surgery. After receiving 510(k) clearance from the U.S. ...
Cached Medicine Technology:PeaceHealth Standardizes Hematology Operations With Sysmex 2PeaceHealth Standardizes Hematology Operations With Sysmex 3MedShape Solutions, Inc. Announces Breakthrough in ACL Reconstruction 2MedShape Solutions, Inc. Announces Breakthrough in ACL Reconstruction 3
... Tri-Active is the result of DEKA ... combination of three different methods capable ... your skin. This treatment is designed ... cellulite through the combined action of ...
... Smartepil II Plus is the latest evolution ... fast, safe and reliable system for epilation ... preset protocols in its modern software, Smartepil ... vascular treatments in full respect of the ...
This instrument measures intraocular pressure without,contacting. Alignment is performed semi-automatically....
The convenience of safe and precise Patient Controlled Analgesia in a flexible system designed with advanced technology. This is progressive, innovative, and effective pain management in a sophistica...
Medicine Products: