Navigation Links
Discovery could help diabetics and others with slow-to-heal wounds
Date:4/16/2010

MAYWOOD, Ill. -- A new discovery about the wound-healing process could lead to better treatments for diabetics and other patients who have wounds that are slow to heal.

Loyola University Health System researchers found that certain immune system cells slow the wound-healing process. Thus, it might be possible to improve healing by inactivating these immune system cells, said Elizabeth Kovacs, PhD, who heads the laboratory team that made the discovery.

The findings by Kovacs and colleagues are reported online, in advance of print, in the Journal of Surgical Research.

In the study, the immune system cells that impeded the healing process are called natural killer T (NKT) cells. NKT cells perform beneficial functions such as killing tumor cells and virus-infected cells. However, researchers discovered that NKT cells also migrate to wound sites and impede the healing process.

Kovacs and colleagues used an animal model to examine the effects of NKT cells on healing. Healing was significantly slower in normal mice that had NKT cells than it was in a special breed of mice that lacked NKT cells.

"We demonstrated that early wound closure was accelerated in the absence of NKT cells," Kovacs and colleagues wrote. "Importantly, we also made the novel observation that NKT cells themselves are a constituent of the early wound inflammatory infiltrate."

Certain conditions, such as diabetes and infections, can slow or prevent wounds from healing. The study found that NKT cells may be at least partially to blame. Researchers don't know how NKT cells slow healing. But they believe they may be able to inactivate NKT cells using an antibody. They are testing this prediction in a follow-up study.

Kovacs is a professor and vice chair of research in the Department of Surgery at Loyola University Chicago Stritch School of Medicine. She also is director of research of Loyola's Burn & Shock Trauma Institute.

Co-authors of the study are Jessica Palmer, Julia Tulley, Dr. John Speicher, Douglas Faunce, PhD, first author Dr. David Schneider and Dr. Richard Gamelli. Schneider is a resident at Loyola and Gamelli is dean of the Stritch School of Medicine and director of the Burn & Shock Trauma Institute.

The study was supported by the National Institutes of Health (NIH) and by the Ralph and Marion C. Falk Medical Research Trust.

Scott Somers, Ph.D., who manages wound healing research and training grants supported by the NIH's National Institute of General Medical Sciences, said, "Beyond the novel finding of a fundamental mechanism controlling wound healing, this work also highlights the contributions of physician-scientists like Dr. Schneider, a surgical resident who is training to do hypothesis-based, cutting-edge scientific investigation."


'/>"/>

Contact: Jim Ritter
jritter@lumc.edu
708-216-2445
Loyola University Health System
Source:Eurekalert

Related medicine news :

1. Discovery Health and National Organization for Rare Disorders Partner for Second Annual Rare Disease Day With the Premiere of the Special DISEASE DETECTIVES
2. Molecule Discovery Might Help ALS Patients
3. Discovery Healths New Year, New You Week Brings Transformation and Inspiration to the Resolution Season
4. Discovery points way for new treatment for aneurysms: UBC-Providence Research
5. Discovery of mechanism in brain cell injury in Huntingtons offers new treatment approaches
6. Discovery Links Genes to Pancreatic Cancer
7. Discovery of epigenetic memory during breast cancer
8. Largest academic-industry collaboration for drug discovery in depression and schizophrenia launched
9. Case Western Reserve researchers new pathway discovery published as Paper of the Week
10. Winter Issue of Discoverys Edge
11. Gene Discovery Sheds Light on Childrens Asthma
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/29/2016)... City, Missouri (PRWEB) , ... April 29, 2016 , ... ... traditional crutches which put pressure on the armpits, the M+D Crutch evenly distributes body ... strain on their wrists and hands when using the crutches than with other crutches. ...
(Date:4/29/2016)... ... April 29, 2016 , ... New York City based oral and maxillofacial surgeon Dr. ... very effective way to treat obstructive sleep apnea. Dr. Jamali is proud to offer this ... procedure that involves one or both jaw bones. This surgery is performed to correct the ...
(Date:4/29/2016)... ... ... Regenerative Medicine Solutions (RMS) scored 94.8124 out of 100 on ... place for Tampa’s Best Places to Work. They were ranked in the Big Category, ... for our team,” says RMS Human Resources Manager Irene Miller. “We work hard to ...
(Date:4/29/2016)... ... April 29, 2016 , ... International Dehydrated Foods, Inc. (IDF™) will ... and 4 at the Doubletree by Hilton Hotel in Oak Brook, Illinois. The two-day ... applications technologies for protein ingredients. , At the seminar, IDF™ will offer samples of ...
(Date:4/29/2016)... ... April 29, 2016 , ... ... for 2014. Each year, reproductive endocrinologists are required to report in vitro ... organization of professionals dedicated to the practice of assisted reproductive technologies in the ...
Breaking Medicine News(10 mins):
(Date:4/27/2016)... -- Elekta today announced that its leading-edge ... focal point of seven scientific presentations at ESTRO 35, ... & Oncology, taking place April 29 - May 3. ... and a high-field MRI scanner with sophisticated software that ... in real time. The MR-linac is designed to improve ...
(Date:4/27/2016)... April 27, 2016  Bayer Animal Health today ... from the University of Florida College of Veterinary ... Excellence in Communication Award (BECA). Brittany was selected ... awarded a total of $70,000 in scholarship funds ... years, Bayer has provided a total of $232,500 ...
(Date:4/27/2016)... 27, 2016 Global  urinalysis ... billion by 2022, according to a new report ... (Logo: http://photos.prnewswire.com/prnh/20150105/723757 ) , ... efficiency and accuracy delivered by the new generation ... novel urinalysis instruments and consumables. For instance, the ...
Breaking Medicine Technology: