Navigation Links
Discovery could help diabetics and others with slow-to-heal wounds
Date:4/16/2010

MAYWOOD, Ill. -- A new discovery about the wound-healing process could lead to better treatments for diabetics and other patients who have wounds that are slow to heal.

Loyola University Health System researchers found that certain immune system cells slow the wound-healing process. Thus, it might be possible to improve healing by inactivating these immune system cells, said Elizabeth Kovacs, PhD, who heads the laboratory team that made the discovery.

The findings by Kovacs and colleagues are reported online, in advance of print, in the Journal of Surgical Research.

In the study, the immune system cells that impeded the healing process are called natural killer T (NKT) cells. NKT cells perform beneficial functions such as killing tumor cells and virus-infected cells. However, researchers discovered that NKT cells also migrate to wound sites and impede the healing process.

Kovacs and colleagues used an animal model to examine the effects of NKT cells on healing. Healing was significantly slower in normal mice that had NKT cells than it was in a special breed of mice that lacked NKT cells.

"We demonstrated that early wound closure was accelerated in the absence of NKT cells," Kovacs and colleagues wrote. "Importantly, we also made the novel observation that NKT cells themselves are a constituent of the early wound inflammatory infiltrate."

Certain conditions, such as diabetes and infections, can slow or prevent wounds from healing. The study found that NKT cells may be at least partially to blame. Researchers don't know how NKT cells slow healing. But they believe they may be able to inactivate NKT cells using an antibody. They are testing this prediction in a follow-up study.

Kovacs is a professor and vice chair of research in the Department of Surgery at Loyola University Chicago Stritch School of Medicine. She also is director of research of Loyola's Burn & Shock Trauma Institute.

Co-authors of the study are Jessica Palmer, Julia Tulley, Dr. John Speicher, Douglas Faunce, PhD, first author Dr. David Schneider and Dr. Richard Gamelli. Schneider is a resident at Loyola and Gamelli is dean of the Stritch School of Medicine and director of the Burn & Shock Trauma Institute.

The study was supported by the National Institutes of Health (NIH) and by the Ralph and Marion C. Falk Medical Research Trust.

Scott Somers, Ph.D., who manages wound healing research and training grants supported by the NIH's National Institute of General Medical Sciences, said, "Beyond the novel finding of a fundamental mechanism controlling wound healing, this work also highlights the contributions of physician-scientists like Dr. Schneider, a surgical resident who is training to do hypothesis-based, cutting-edge scientific investigation."


'/>"/>

Contact: Jim Ritter
jritter@lumc.edu
708-216-2445
Loyola University Health System
Source:Eurekalert

Related medicine news :

1. Discovery Health and National Organization for Rare Disorders Partner for Second Annual Rare Disease Day With the Premiere of the Special DISEASE DETECTIVES
2. Molecule Discovery Might Help ALS Patients
3. Discovery Healths New Year, New You Week Brings Transformation and Inspiration to the Resolution Season
4. Discovery points way for new treatment for aneurysms: UBC-Providence Research
5. Discovery of mechanism in brain cell injury in Huntingtons offers new treatment approaches
6. Discovery Links Genes to Pancreatic Cancer
7. Discovery of epigenetic memory during breast cancer
8. Largest academic-industry collaboration for drug discovery in depression and schizophrenia launched
9. Case Western Reserve researchers new pathway discovery published as Paper of the Week
10. Winter Issue of Discoverys Edge
11. Gene Discovery Sheds Light on Childrens Asthma
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/18/2017)... ... 2017 , ... “Kingdom Mandate for Kingdom Builders”: a call to walk as ... Builders” is the creation of published author, John F. McGeorge, Jr. Dr. John ... in 1983. He spent three decades training pastors and Christian leaders. He ...
(Date:8/18/2017)... ... 2017 , ... “Steve the Snake”: an entertaining and moral-based short story about ... published author, Harold Flash Haskins Jr., a husband, father and grandfather who served as ... “I write moral-based short stories for children and teens. My goal is to teach ...
(Date:8/17/2017)... (PRWEB) , ... August 17, 2017 , ... ... practice, is adding a new location in Goldsboro, NC to its family of ... that is Riccobene Associates’ trademark starting August 15, 2017. , Riccobene Associates ...
(Date:8/17/2017)... ... August 17, 2017 , ... The award-winning producers ... feature the National Council for Therapeutic Recreation Certification (NCTRC), slated to air nationwide, ... 1981, NCTRC is a non-profit, international organization dedicated to professional excellence for the ...
(Date:8/17/2017)... Boston, MA (PRWEB) , ... August 17, 2017 ... ... investors will come together on September 19, 2017 for Anti-Infectives Rx. This off-the-record ... Joseph B. Martin Conference Center at Harvard Medical School. , Industry leaders and ...
Breaking Medicine News(10 mins):
(Date:8/7/2017)... Inc. (NYSE: DPLO), the nation,s largest independent specialty pharmacy, announced ... comparisons, unless otherwise noted, are to the quarter ended June ... Quarter 2017 Highlights include: Revenue of ... Total prescriptions dispensed of 220,000, compared to ... Gross profit per prescription dispensed of ...
(Date:8/3/2017)...  Opioid addiction and other drugs of abuse, blood ... threatening outcomes, were problems taken on directly as laboratory ... support them, met this week. This according to Kalorama ... of abuse, procalcitonin and acute kidney injury were key ... meeting in San Diego, CA. ...
(Date:8/2/2017)... Aug. 2, 2017 CaryRx, a next-generation full-service pharmacy, ... service for patients in the Washington D.C. ... pharmacy by providing delivery of medications through the convenience of ... delivery or delivered within one hour to any location in ... to bring this invaluable service to Washington D.C. ...
Breaking Medicine Technology: