Navigation Links
Discovery Sheds Light on Huntington's Disease
Date:6/4/2009

stitute of Neurological Disorders and Stroke.

Because the damage from the faulty gene is limited to the corpus striatum, researchers went searching for proteins that interacted specifically and exclusively with the huntingtin protein in that part of the brain.

Rhes is found almost exclusively in the corpus striatum, according to the study.

Using human and mouse cells, researchers found that rhes interacted with both healthy and mutant versions of huntingtin protein, but that it bound much more strongly to mutant huntingtin, also known as mHtt.

"Touching or binding is one matter, but death is altogether another," Snyder said.

Further tests using human embryonic cells and brain cells taken from mice showed that when both mHtt and rhes were present in the same cells, half the cells died within 48 hours. Rhes or mHtt alone did not cause cell death.

"Here's the rhes protein, we've known about it for years, nobody ever really knew what it did in the brain or anywhere else," Snyder said. "And it turns out it looks like the key to Huntington's disease."

Researchers also did a set of tests to learn more about the role of rhes. Previous research has shown that the abnormal huntingtin proteins form clumps in cells throughout the body and brain, but that there are fewer of the clumps in the corpus striatum.

"This has led to much controversy: Are the clumps toxic, or is it the lack of clumps that's toxic to these brain cells?" said Srinivasa Subramaniam, a postdoctoral fellow at Johns Hopkins.

Experiments showed that adding rhes to cells with abnormal huntingtin led to fewer clumps, but the cells died.

Researchers said that the unclumping of mutant huntingtin proteins by rhes might cause the cell death.

"Since rhes is highly found in the corpus striatum, clumping somehow protects cells in other tissues of the body from dying," Subramaniam said.

The team is curr
'/>"/>

Copyright©2009 ScoutNews,LLC.
All rights reserved  

Page: 1 2 3

Related medicine news :

1. Discovery of sugar sensor in intestine could benefit diabetes
2. Discovery suggests location of genes for breast density, a strong risk factor for breast cancer
3. Stem cell research produces a key discovery for Fragile X Syndrome
4. Welch Foundation gives $1.6 million for drug discovery research
5. New discovery leaves blood-doping athletes scratching their heads
6. Chemical Diversity Initiates International Prostrate Cancer Discovery Partnership
7. New discovery leaves blood-doping athletes scratching their heads
8. Discovery of widespread tumor growth gene holds promise for effective anti-cancer treatment
9. Discovery supports theory of Alzheimers disease as form of diabetes
10. Discovery Health CME Explores the Benefits and Risks of Aspirin in Aspirin Therapy: Maximizing the Benefits
11. New discovery may improve treatment of one of the worlds leading causes of blindness
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Discovery Sheds Light on Huntington's Disease 
(Date:12/26/2014)... DW-InductionHeating.com (DaWei Induction Heating Co.) is a ... producing and marketing of a series of induction heating ... new series of induction brazing equipments . , ... induction brazing refers to the joining of two ... heat. The manager says that there are fundamental differences ...
(Date:12/25/2014)... This is a professional and in-depth study ... with a focus on the Chinese market. The report ... Sterilizers manufacturers and is a valuable source of guidance ... industry. This report provides a basic overview of the ... this part, the report presents the company profile, product ...
(Date:12/25/2014)... The report “TS-1 (Colorectal Cancer) – Forecast and ... landscape, unmet needs, current pipeline and commercial opportunities in ... which is typically used for treating colorectal cancer. It ... gastric cancer and pancreatic cancer. TS-1 is composed of ... approved in 1999 in Japan for the treatment of ...
(Date:12/25/2014)... December 26, 2014 Recently, iFitDress.com, the popular ... women, has announced its new selection of black one-shoulder ... on sale now; they are available at discounted prices, up ... “The promotion will last for three weeks only. You know, ... Those who are interested in our new items can visit ...
(Date:12/25/2014)... (PRWEB) December 25, 2014 Recently, ... discounts on all its wedding dresses. BellasDress has chosen ... more for gift choices for the holiday season. ... can pick suitable wedding gowns here at discount prices. ... shopping experience at its website. , “All ...
Breaking Medicine News(10 mins):Health News:Induction Brazing Equipment Series From DaWei Induction Heating Co., A Reliable Supplier Of Induction Heating Equipment 2Health News:Sterilizers Industry Global and Chinese Analysis for 2009-2019 Now Available at ReportsnReports.com 2Health News:Sterilizers Industry Global and Chinese Analysis for 2009-2019 Now Available at ReportsnReports.com 3Health News:TS-1 Colorectal Cancer Market Analysis and Forecast to 2023 Report at RnRMarketReserach.com 2Health News:TS-1 Colorectal Cancer Market Analysis and Forecast to 2023 Report at RnRMarketReserach.com 3Health News:iFitDress.com: Black One-Shoulder Cocktail Dresses for 2015 2Health News:BellasDress.com’s Christmas Sale: Trendy Wedding Dresses With Big Discounts 2
... on the human genome project , which is ... the genes will enable one to have the information to ... even skin. It will also help say whether a cell ... in the womb for diseases, and device specific advancements against ...
... published in the December issue of the Journal ... in peripheral blood mononuclear cells (PBMCs) from individuals ... infected patients treated with antifilarial agents. According ... the National Institute of Allergy and Infectious Diseases ...
... the heart attack patients should get an immediate procedures to ... , ,Cleveland Clinic cardiologist, Dr. Deepak Bhatt analyzed medical ... that patients whose white blood cell count is in what ... risk of death after a heart attack than patients with ...
... Lewy body disease, and Multiple System Arophy - ... symptomatic due to a deficiency of a specific ... is dopamine. When the neurons that produce these ... oxidation, the eventual results are tremors and sometimes ...
... to diagnose and many a times the diagnosis is ... emerging as a promising technique for early diagnosis of ... facilitating rapid amplification of small amounts of a genome ... Urology Congress in India. Presence of even one ...
... ingredient found in many non-prescription cough and cold medications. ... risk of stroke by 23 percent. Dr.Ralph I. Horwitz, ... have linked exposure to PPA to the occurrence of ... results when an artery wall ruptures and prevents blood ...
Cached Medicine News:
(Date:12/24/2014)... Mexico , Dec. 24, 2014  Novastem, ... of its first patient in its study for ... the American Stroke Association, ischemic strokes account for ... to enroll qualified patients in the study, entitled ... Administration of Allogeneic Mesenchymal Stem Cells and Intrathecal ...
(Date:12/24/2014)... , Dec. 24, 2014 Kinex Pharmaceuticals announced ... KX2-361 at Roswell Park Cancer Institute. KX2-361 ... drug that has shown potent inhibitory activity against a ... that are resistant to Temozolomide (T98G), the most widely ... a well-established brain tumor mouse model, KX2-361 consistently clears ...
(Date:12/24/2014)... Dec. 24, 2014  Diplomat Pharmacy, Inc. (NYSE: ... is proud to announce Jennifer Hagerman , Pharm.D., ... will take office as the president of the Michigan ... ceremony will take place Feb. 28, 2015, at the ... at the Renaissance Center in Detroit, Michigan ...
Breaking Medicine Technology:Novastem Treats First Patient Using Stemedica's Mesenchymal and Neural Stem Cell Combination Therapy for Ischemic Stroke 2Novastem Treats First Patient Using Stemedica's Mesenchymal and Neural Stem Cell Combination Therapy for Ischemic Stroke 3Novastem Treats First Patient Using Stemedica's Mesenchymal and Neural Stem Cell Combination Therapy for Ischemic Stroke 4Kinex Pharmaceuticals Announces First Patient Dosed with KX2-361 in a Phase 1 Clinical Study 2Kinex Pharmaceuticals Announces First Patient Dosed with KX2-361 in a Phase 1 Clinical Study 3Diplomat's senior director of education and quality to be inducted as 2015 president of the Michigan Pharmacists Association 2Diplomat's senior director of education and quality to be inducted as 2015 president of the Michigan Pharmacists Association 3
... Show Superior Decrease in Pain Scores Compared to Saline ... the results of a six-month safety and efficacy study ... decreasing the pain of knee osteoarthritis (OA) at 26 ... superior to saline in decreasing pain at 26 weeks ...
... Phase 3 Avanafil Study REVIVE (TA-301) is Complete MOUNTAIN ... VVUS ), a biopharmaceutical company developing innovative, next-generation ... sexual health, today announced that it has initiated an ... avanafil, in males with erectile dysfunction (ED). VIVUS ...
Cached Medicine Technology:Ferring Pharmaceuticals Unveils Six-Month Efficacy Data for EUFLEXXA(R) for the Treatment of Osteoarthritis Knee Pain 2Ferring Pharmaceuticals Unveils Six-Month Efficacy Data for EUFLEXXA(R) for the Treatment of Osteoarthritis Knee Pain 3VIVUS Initiates Open Label Safety Study of Avanafil for Erectile Dysfunction 2VIVUS Initiates Open Label Safety Study of Avanafil for Erectile Dysfunction 3
Designed to give maximum drying area while taking up minimal bench space....
The Durafuge 100 spins swing-out rotors at 4000 rpm and fixed-angle rotors at up to 6300 rpm....
Thermostatically controlled, large capacity surface to quickly evaporate water and solvents from slides and mounting media....
Compact instrument that quickly dries racks of slides using warm air....
Medicine Products: