Navigation Links
Discovery Points to Regulation of Calcium Metabolism
Date:6/29/2009

Researchers may be step closer to preventing kidney stones, osteoporosis

MONDAY, June 29 (HealthDay News) -- A gene variant that contributes to both kidney stones and osteoporosis has been identified by scientists who said the variant offers a promising target for new drugs to better regulate calcium metabolism.

The single-letter variation (SNP) occurs in the gene encoding claudin 14 (CLDN14), a protein expressed in the kidney, according to a news release.

The 60 percent of humans who carry two copies of this SNP on chromosome 21 have a 65 percent greater risk of developing kidney stones than those with no copies of the SNP. It's believed the SNP may account for more than a quarter of kidney stone cases. In women, it is associated with decreased bone mineral density in the hip and spine.

The researchers examined the genomes of about 50,000 people to learn more about the association between CLDN14 and the metabolism of calcium, a key component of bone and of most kidney stones. They concluded that the SNP may contribute to increased calcium excretion in urine, a major risk factor for kidney stones and also a sign of bone loss.

The study appears online June 28 and in an upcoming print edition of the journal Nature Genetics.

This research identified "a highly plausible common biological mechanism leading to two diseases. This offers a potentially attractive new pathway for drug discovery, and the next task is to build on our understanding of how this SNP increases the risk of these diseases and how this pathway could be targeted therapeutically to address this risk," Kari Stefansson, CEO of the bio-pharmaceutical company deCODE, said in a company news release.

More information

The National Kidney Foundation has more about kidney stones.



-- Robert Preidt



SOURCE: deCODE, news release, June 28, 2009


'/>"/>
Copyright©2009 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. IDRI Awarded $314,500 Grant From Murdock Trust to Expand TB Drug Discovery Program
2. Asthma Discovery May Lead to Better Treatments
3. Microsoft to Showcase Clinical Trial Solutions From Discovery to Approvals at Drug Information Associations 2009 Annual Meeting
4. Gaiam and Discovery Communications Announce Exclusive Licensing Deal
5. Mayo Genomic Discovery: Protecting Kidney Function During Heart Failure
6. IUPUI chemists develop Distributed Drug Discovery: Finding drugs for neglected diseases
7. Eli Lilly and Company Announces New Drug Discovery Initiative
8. VBI researchers develop new method for breast cancer biomarker discovery
9. Discovery Sheds Light on Huntingtons Disease
10. Council for American Medical Innovation and The Aspen Institute Bring Leaders Together In Washington, D.C., To Discuss The Economic Impact Of Medical Science and Discovery, and Policies Needed To Maintain U.S. Leadership at Best And Brightest Forum On Me
11. MDS Announces Strategy to Focus MDS Pharma Services on Early Stage Operations - Discovery Through Phase IIa
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Discovery Points to Regulation of Calcium Metabolism
(Date:5/27/2016)... ... ... Aimed at nurses and employees in the health care world, this installment ... nursing and health care industry. It also provides insight to the developing trends and ... As the nursing industry is coming out of one of the biggest recessions in ...
(Date:5/26/2016)... ... 2016 , ... There are many ways to cook a hot dog, but ... Americans prefer their dogs straight off the grill. Of the 90 percent of Americans ... to cook a hot dog, far outpacing other cooking methods such as steaming (12 ...
(Date:5/26/2016)... ... 26, 2016 , ... Georgia State University College of Law ... , Answering to the increasing demand for curricular specializations, the Certificate in Intellectual ... and land use law. ,  , “The demand for lawyers with specific knowledge ...
(Date:5/26/2016)... Pittsburgh, PA (PRWEB) , ... May 26, 2016 ... ... transplantation, and one that has a significant negative impact on long-term patient survival, ... to date. The results, published online this week in the Journal of Thoracic ...
(Date:5/26/2016)... NY (PRWEB) , ... May 26, 2016 , ... ... Hereditary Retinal Degeneration” for the Foundation Fighting Blindness, Long Island Chapter on June ... to the public. , Dr. Maisel, founder of Retina Group of New ...
Breaking Medicine News(10 mins):
(Date:5/26/2016)... -- According to a new market report published ... Industry Analysis, Size, Share, Growth, Trends, and Forecast 2015 - ... valued at US$ 5.89 Bn in 2014 and is anticipated ... 2023 to reach US$ 7.99 Bn in 2023. ... free drug delivery devices and the market is estimated based ...
(Date:5/26/2016)... 2016   Change Healthcare , a ... solutions and technology-enabled services designed to enable ... a strategic channel partnership with SourceMed, the ... and revenue cycle management services that empower ... clinics to optimize revenue, operational efficiency and ...
(Date:5/25/2016)... PUNE, India , May 25, 2016 ... "Medical Animation Market by Type (3D, 2D, 4D), by ... Patient Education), by End User (Medical Device Manufacturers, Hospitals/ ... report studies the global Medical Animation Market for the ... expected to reach USD 301.3 Million by 2021 from ...
Breaking Medicine Technology: