Navigation Links
Discovery Points to Regulation of Calcium Metabolism

Researchers may be step closer to preventing kidney stones, osteoporosis

MONDAY, June 29 (HealthDay News) -- A gene variant that contributes to both kidney stones and osteoporosis has been identified by scientists who said the variant offers a promising target for new drugs to better regulate calcium metabolism.

The single-letter variation (SNP) occurs in the gene encoding claudin 14 (CLDN14), a protein expressed in the kidney, according to a news release.

The 60 percent of humans who carry two copies of this SNP on chromosome 21 have a 65 percent greater risk of developing kidney stones than those with no copies of the SNP. It's believed the SNP may account for more than a quarter of kidney stone cases. In women, it is associated with decreased bone mineral density in the hip and spine.

The researchers examined the genomes of about 50,000 people to learn more about the association between CLDN14 and the metabolism of calcium, a key component of bone and of most kidney stones. They concluded that the SNP may contribute to increased calcium excretion in urine, a major risk factor for kidney stones and also a sign of bone loss.

The study appears online June 28 and in an upcoming print edition of the journal Nature Genetics.

This research identified "a highly plausible common biological mechanism leading to two diseases. This offers a potentially attractive new pathway for drug discovery, and the next task is to build on our understanding of how this SNP increases the risk of these diseases and how this pathway could be targeted therapeutically to address this risk," Kari Stefansson, CEO of the bio-pharmaceutical company deCODE, said in a company news release.

More information

The National Kidney Foundation has more about kidney stones.

-- Robert Preidt

SOURCE: deCODE, news release, June 28, 2009

Copyright©2009 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. IDRI Awarded $314,500 Grant From Murdock Trust to Expand TB Drug Discovery Program
2. Asthma Discovery May Lead to Better Treatments
3. Microsoft to Showcase Clinical Trial Solutions From Discovery to Approvals at Drug Information Associations 2009 Annual Meeting
4. Gaiam and Discovery Communications Announce Exclusive Licensing Deal
5. Mayo Genomic Discovery: Protecting Kidney Function During Heart Failure
6. IUPUI chemists develop Distributed Drug Discovery: Finding drugs for neglected diseases
7. Eli Lilly and Company Announces New Drug Discovery Initiative
8. VBI researchers develop new method for breast cancer biomarker discovery
9. Discovery Sheds Light on Huntingtons Disease
10. Council for American Medical Innovation and The Aspen Institute Bring Leaders Together In Washington, D.C., To Discuss The Economic Impact Of Medical Science and Discovery, and Policies Needed To Maintain U.S. Leadership at Best And Brightest Forum On Me
11. MDS Announces Strategy to Focus MDS Pharma Services on Early Stage Operations - Discovery Through Phase IIa
Post Your Comments:
Related Image:
Discovery Points to Regulation of Calcium Metabolism
(Date:11/26/2015)... Cambridge, ON (PRWEB) , ... November 26, 2015 ... ... availability of a real-time eReferral system for diagnostic imaging in the Waterloo region. ... mammography, BMD and Nuclear Medicine tests directly from their electronic medical record (EMR) ...
(Date:11/26/2015)... ... November 26, 2015 , ... PRMA Plastic Surgery is updating their record books ... their 6,000th free flap breast reconstruction surgery! , “What an accomplishment for the PRMA ... rebuild lives and it’s an honor to have served all of these women.” , ...
(Date:11/26/2015)... ... , ... Indosoft Inc., developer and distributor of the world-class Asterisk based contact ... and reliability. , The new Q-Suite 6 platform is based on the latest Java ... into a specific piece of software for many key components of the suite. Much ...
(Date:11/25/2015)... Cokato, MN (PRWEB) , ... November 25, 2015 , ... ... Thanksgiving through Christmas Eve on several models of traditional and far-infrared saunas. ... . Nordic Spruce is the most traditional Finnish sauna wood, and Finnleo uses only ...
(Date:11/25/2015)... ... November 26, 2015 , ... ... (AUC), European Union (EU), ANDI Pan African Centres of Excellence, and public R&D ... Nairobi (UNON) for the opening of the 5th African Network for Drugs and ...
Breaking Medicine News(10 mins):
(Date:11/25/2015)... Nov. 25, 2015  ARKRAY USA ... to provide evidence demonstrating the accuracy of its blood ... on Insulin Resistance, Diabetes and Cardiovascular Disease in ... the Company,s GLUCOCARD ® 01 meter and the ... requirements. The ability to accurately measure glucose levels in ...
(Date:11/25/2015)... issue of United States patent No. 9,192,509  entitled: " Methods and Apparatus ... AVACEN 100 dry heat therapy medical device and specific methods of use, referred to by the ... - ... ... ...
(Date:11/25/2015)... , November 25, 2015 ... Investors"), pursuant to which BioLight and the New Investors ... Ltd. subsidiary ("IOPtima") via a private placement. The financing ... its innovative IOPtimate™ system used in the treatment of ... pathway process for the IOPtimate™ system with the U.S. ...
Breaking Medicine Technology: