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Discovery Opens Door for New Options in Prevention and Treatment of Mesothelioma
Date:7/8/2010

> “I am very hopeful about this discovery. Now that we know that the chronic inflammation caused by asbestos drives tumor growth, we can test different medicines that can suppress inflammation. Aspirin was shown to decrease the incidence of colon cancer, a tumor that like mesothelioma, is associated with chronic inflammation,” says Michele Carbone, MD.

Dr. Carbone doesn’t yet know if aspirin can help decrease the incidence of mesothelioma among exposed individuals, or if more sophisticated therapies to specifically target HMGB1 are needed, but hopes that the upcoming clinical trial in Turkey will provide those answers.

“We will start to see if targeting HMGB1 will help us detect mesothelioma in the early stages and/or to prevent it in Turkey – if the results are promising we will bring the trials back to the USA,” continues Dr. Carbone. “We are eager to start, and are very grateful to the Meso Foundation and to the many patients that support it, because it is thanks to their support that we were able to get this project off the ground.”

“Dr. Carbone’s discovery is very exciting for our organization and for the thousands of mesothelioma patients and families who struggle with this disease today. Results like these bring hope to our community and reinforce the fact that research is the key to ending mesothelioma,” says Kathy Wiedemer, Interim Executive Director of the Meso Foundation.

Mesothelioma is a malignant tumor of the lining of the lung, abdomen, or heart caused by exposure to asbestos. Medical experts consider it one of the most aggressive and deadly of all cancers. For decades, the need to develop effective treatments was mostly ignored. Thus, only one FDA-approved mesothe
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