Navigation Links
Discovery May Lead to Better Multiple Sclerosis Treatments

Lab study sheds light on why the most common drug may not work for all patients

MONDAY, March 29 (HealthDay News) -- There may be two types of multiple sclerosis and each may respond differently to treatment with the first-line drug commonly prescribed for the condition, new research suggests.

Among multiple sclerosis (MS) patients who take the popular drug, known as interferon beta, overall effectiveness is only fair, with about half of all patients experiencing an average one-third reduction in recurrences, according to researchers at Stanford University.

MS is an autoimmune disease that occurs when immune cells called T cells attack the protective myelin sheathing around the nerves of the central nervous system, resulting in symptoms such as paralysis and blindness.

In this study, which was performed in mice and human blood samples, investigators focused on two cytokines called gamma interferon and IL-17. Cytokines are chemicals used by immune cells to communicate.

The researchers found that treatment interferon beta benefited mice with MS induced by gamma-interferon-secreting T cells but worsened symptoms in mice with MS induced by IL-17-secreting T cells.

In the next phase of the study, the researchers found that human blood samples with low levels of a variety of IL-17, called IL-17F, responded well to interferon beta treatment while those with very high IL-17F levels (about one-third of patients) responded poorly to the drug.

The study results were published online March 28 in the journal Nature Medicine.

If the findings are confirmed in large human studies and by other laboratories, it could mean that MS patients might someday be able to have a blood test to determine whether they're likely to respond to treatment with interferon beta, senior study author Dr. Lawrence Steinman, a professor of neurology and neurological sciences at the Stanford University School of Medicine, stated in a university news release.

More information

The National Multiple Sclerosis Society has more about multiple sclerosis treatments.

-- Robert Preidt

SOURCE: Stanford University, news release, March 28, 2010

Copyright©2010 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. Discovery of cellular switch may provide new means of triggering cell death, treating disease
2. U discovery gives insight into brain replay process
3. Co-Creator of Six Sigma Unveils “The Great Discovery” ... the 4th Generation of Six Sigma
4. Effective prostate cancer treatment discovery
5. SeqWright Advances Genomic Discovery With Isilon IQ
6. New discovery: Plaice are spotted (on the inside)
7. UCSF enters drug discovery agreement with Genentech
8. UCSF Enters Drug Discovery Agreement with Genentech
9. Discovery Health and National Organization for Rare Disorders Partner for Second Annual Rare Disease Day With the Premiere of the Special DISEASE DETECTIVES
10. Discovery points way for new treatment for aneurysms: UBC-Providence Research
11. Discovery of mechanism in brain cell injury in Huntingtons offers new treatment approaches
Post Your Comments:
(Date:6/26/2016)... ... 26, 2016 , ... PawPaws brand pet supplements owned by Whole ... enhance the health of felines. The formula is all-natural and is made from Chinese ... PawPaws Cat Kidney Support Supplement Soft Chews are Astragalus Root Extract and ...
(Date:6/25/2016)... ... 25, 2016 , ... The temporary closing of Bruton Memorial Library on June 21 due to ... a new, often overlooked aspect of head lice: the parasite’s ability to live away from ... common occurrence, but a necessary one in the event that lice have simply gotten out ...
(Date:6/25/2016)... ... ... On Friday, June 10, Van Mitchell, Secretary of the Maryland Department of Health ... of their exemplary accomplishments in worksite health promotion. , The Wellness at Work Awards ... at the BWI Marriott in Linthicum Heights. iHire was one of 42 businesses to ...
(Date:6/24/2016)... , ... June 24, 2016 , ... Marcy was in a crisis. Her son James, ... out at his family verbally and physically. , “When something upset him, he couldn’t control ... use it. He would throw rocks at my other children and say he was going ...
(Date:6/24/2016)... ... June 24, 2016 , ... Topical BioMedics, Inc, makers of Topricin and MyPainAway Pain ... for a minimum wage raise to $12 an hour by 2020 and then adjusting it ... the lost value of the minimum wage, assure the wage floor does not erode again, ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... 24, 2016 Research and Markets has ... Companion Diagnostic Tests" report to their offering. ... Diagnostics The World Market for Companion Diagnostics ... diagnostics. Market analysis in the report includes the following: ... Vitro Diagnostic Kits) by Region (N. America, EU, ROW), 2015-2020 ...
(Date:6/23/2016)... HOUSTON , June 23, 2016  MedSource ... platform as its e-clinical software solution of choice.  ... the best possible value to their clients by ... nowEDC.  The preferred relationship establishes nowEDC as the ... pricing for MedSource,s full-service clients.  "nowEDC has long ...
(Date:6/23/2016)... -- Roche (SIX: RO, ROG; OTCQX: RHHBY) announced that ... PCT (procalcitonin) assay as a dedicated testing solution for ... clearance, Roche is the first IVD company in the ... risk assessment and management. PCT is a ... in blood can aid clinicians in assessing the risk ...
Breaking Medicine Technology: