Navigation Links
Discovery Boosts Boys' Prospects for Post-Cancer Fertility
Date:11/20/2009

Testicular cells could be preserved for later use, study suggests

FRIDAY, Nov. 20 (HealthDay News) -- New research suggests it may become possible for pre-pubescent boys stricken by cancer to prepare for the future when they may be infertile but still want to become natural fathers.

Scientists in the Netherlands found that testicular stem cells can be cultured and multiplied, potentially creating sperm. This raises the prospect that men made infertile by childhood cancer treatments could impregnate women by having the cells implanted in their testicles.

It may take some time to figure out how to make this process work. But a delay may not be a problem, said study co-author Ans van Pelt, since "it may easily take more than 10 years before a boy diagnosed with cancer today has a wish to have his own child."

Currently, there's no way for a boy who hasn't reached puberty to produce sperm and save it for a future time when he wants to become a natural father. Chemotherapy, in particular, can cause infertility in boys.

Van Pelt, a fertility researcher at the University of Amsterdam, and colleagues took stem cells from the testicles of six patients during prostate cancer surgery. They then tried to coax the cells to multiply.

The findings are published in the Nov. 18 issue of the Journal of the American Medical Association.

The researchers succeeded, and the stem cells, which form sperm, multiplied.

There are caveats. The cells came from adult men, not boys who haven't reached puberty. Researchers don't know if the cells can create sperm in humans. And it's possible that the cells could transmit cancer to the recipients, so researchers will have to figure out how to prevent that possibility.

Also, the costs are unclear. It may not be expensive to remove testicular tissue and store it, but work in the laboratory and transplantation into a patient could cost more, van Pelt said.

Still, van Pelt said, "this is a big step forward."

But would parents and boys undergoing chemotherapy even be thinking a decade or more ahead, especially while dealing with the strain of cancer itself?

"Yes, since the parents of these boys are very much concerned about the future fertility of their son," van Pelt said. "We have investigated this already, and found that over 60 percent of parents would want to store testicular tissue of their son."

Dr. Jill P. Ginsberg, director of the Cancer Survivorship Program at Children's Hospital of Philadelphia, said that parents of these children do indeed look forward. "Fertility is an important part of any survivor's quality of life, and families are able to understand this even at the time of diagnosis, which is incredibly stressful," she said.

More information

Learn more about childhood cancer from the Nemours Foundation.



SOURCES: Ans van Pelt, Ph.D., fertility researcher, University of Amsterdam, the Netherlands; Jill P. Ginsberg, M.D., director, Cancer Survivorship Program, Children's Hospital of Philadelphia; Nov. 18, 2009, Journal of the American Medical Association


'/>"/>
Copyright©2009 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. SENSA(R) WEIGHT-LOSS PROGRAM: The Accidental Discovery Thats Transforming The Way People Lose Weight Breaks the Top 500 at Amazon.com in Less Than Two Weeks of Publication
2. Gene Discovery Gives Clues to Crohns Disease, Colitis
3. VIA Pharmaceuticals Featured at Cambridge Healthtech Institute Discovery on Target 2009 Conference
4. NIAID announces vaccine adjuvant discovery contracts
5. Jan Dr. G Garavaglia Examines Shocking Cases That Shook the Forensic World in an All-New Discovery Health Special
6. Gene Discovery May Advance Head and Neck Cancer Therapy
7. Boston Biotech R&D Conference to Showcase Next-Generation Newsmakers and Massachusetts as Leader in Biotech Discovery
8. Discovery could improve hepatitis C treatment
9. Discoverys Edge Fall Issue -- http://discoverysedge.mayo.edu/
10. 3rd Annual Collaborative Drug Discovery - UCSF Community Meeting for Catalyzing Humanitarian and Commercial Research to be Held October 1st
11. Discovery May Pave Way to Better Diabetes Care
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/5/2016)... ... , ... The event is being held on April 7, 2016 from 5:30 ... Over Parkinson’s will fund nearly $100,000 for research for the care and cure of ... and is the architect of this informative event to raise awareness and funds for ...
(Date:2/5/2016)... ... February 05, 2016 , ... Freed-Hardeman University President Joe ... signed a joint enrollment and degree completion agreement. The agreement, which begins ... degrees at FHU|Dickson. , The agreement allows students to be jointly admitted ...
(Date:2/5/2016)... ... February 05, 2016 , ... ... franchises from across the country gathered at the La Valencia Hotel in San ... PROSHRED Chicago was named the year’s most outstanding franchise, walking away with ...
(Date:2/5/2016)... ... February 05, 2016 , ... Boar’s Head Brand®, one ... time for this weekend’s Big Game. Take the stress out of your party preparation ... your guests happy at every stage of the game. , “The key to hosting ...
(Date:2/5/2016)... ... February 05, 2016 , ... Stuart Bentkover, MD, FACS is ... to provide the most effective tattoo removal today, Dr. Bentkover is the only doctor ... by Cynosure, the PicoSure has been approved by the Food and Drug Administration (FDA) ...
Breaking Medicine News(10 mins):
(Date:2/4/2016)... 4, 2016  Omnicell, Inc. (NASDAQ: OMCL ), a ... healthcare systems, today announced results for its fiscal year ... --> --> GAAP results: Revenue for ... $5.1 million or 4.1% from the third quarter of ... fourth quarter of 2014. Revenue for the year ended ...
(Date:2/4/2016)... Feb. 4, 2016 In response to the opioid ... Deputy Commissioner for Medical Products and Tobacco, along with other ... the agency,s approach to opioid medications. The plan will focus ... patients in pain access to effective relief. ... , Re-examine the risk-benefit paradigm for opioids and ensure ...
(Date:2/4/2016)... -- --> --> ... Automated External Defibrillator (AED) Market by Product (Semi-Automated External ... Hospitals, Homecare & Nursing Homes) - Forecast to 2019", ... and segments the concerned market with an analysis and ... grow to about $367.0 million by 2019, at a ...
Breaking Medicine Technology: