Navigation Links
Discovery Boosts Boys' Prospects for Post-Cancer Fertility

Testicular cells could be preserved for later use, study suggests

FRIDAY, Nov. 20 (HealthDay News) -- New research suggests it may become possible for pre-pubescent boys stricken by cancer to prepare for the future when they may be infertile but still want to become natural fathers.

Scientists in the Netherlands found that testicular stem cells can be cultured and multiplied, potentially creating sperm. This raises the prospect that men made infertile by childhood cancer treatments could impregnate women by having the cells implanted in their testicles.

It may take some time to figure out how to make this process work. But a delay may not be a problem, said study co-author Ans van Pelt, since "it may easily take more than 10 years before a boy diagnosed with cancer today has a wish to have his own child."

Currently, there's no way for a boy who hasn't reached puberty to produce sperm and save it for a future time when he wants to become a natural father. Chemotherapy, in particular, can cause infertility in boys.

Van Pelt, a fertility researcher at the University of Amsterdam, and colleagues took stem cells from the testicles of six patients during prostate cancer surgery. They then tried to coax the cells to multiply.

The findings are published in the Nov. 18 issue of the Journal of the American Medical Association.

The researchers succeeded, and the stem cells, which form sperm, multiplied.

There are caveats. The cells came from adult men, not boys who haven't reached puberty. Researchers don't know if the cells can create sperm in humans. And it's possible that the cells could transmit cancer to the recipients, so researchers will have to figure out how to prevent that possibility.

Also, the costs are unclear. It may not be expensive to remove testicular tissue and store it, but work in the laboratory and transplantation into a patient could cost more, van Pelt said.

Still, van Pelt said, "this is a big step forward."

But would parents and boys undergoing chemotherapy even be thinking a decade or more ahead, especially while dealing with the strain of cancer itself?

"Yes, since the parents of these boys are very much concerned about the future fertility of their son," van Pelt said. "We have investigated this already, and found that over 60 percent of parents would want to store testicular tissue of their son."

Dr. Jill P. Ginsberg, director of the Cancer Survivorship Program at Children's Hospital of Philadelphia, said that parents of these children do indeed look forward. "Fertility is an important part of any survivor's quality of life, and families are able to understand this even at the time of diagnosis, which is incredibly stressful," she said.

More information

Learn more about childhood cancer from the Nemours Foundation.

SOURCES: Ans van Pelt, Ph.D., fertility researcher, University of Amsterdam, the Netherlands; Jill P. Ginsberg, M.D., director, Cancer Survivorship Program, Children's Hospital of Philadelphia; Nov. 18, 2009, Journal of the American Medical Association

Copyright©2009 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. SENSA(R) WEIGHT-LOSS PROGRAM: The Accidental Discovery Thats Transforming The Way People Lose Weight Breaks the Top 500 at in Less Than Two Weeks of Publication
2. Gene Discovery Gives Clues to Crohns Disease, Colitis
3. VIA Pharmaceuticals Featured at Cambridge Healthtech Institute Discovery on Target 2009 Conference
4. NIAID announces vaccine adjuvant discovery contracts
5. Jan Dr. G Garavaglia Examines Shocking Cases That Shook the Forensic World in an All-New Discovery Health Special
6. Gene Discovery May Advance Head and Neck Cancer Therapy
7. Boston Biotech R&D Conference to Showcase Next-Generation Newsmakers and Massachusetts as Leader in Biotech Discovery
8. Discovery could improve hepatitis C treatment
9. Discoverys Edge Fall Issue --
10. 3rd Annual Collaborative Drug Discovery - UCSF Community Meeting for Catalyzing Humanitarian and Commercial Research to be Held October 1st
11. Discovery May Pave Way to Better Diabetes Care
Post Your Comments:
(Date:6/26/2016)... ... June 26, 2016 , ... Pixel Film Studios Released ProSlice Levels, ... editors can give their videos a whole new perspective by using the title ... Pixel Film Studios. , ProSlice Levels contains over 30 Different presets to choose ...
(Date:6/25/2016)... TX (PRWEB) , ... June 25, 2016 , ... Austin ... of the American College of Mohs Surgery and to Dr. Russell Peckham for medical ... and highly effective treatment for skin cancer. The selective fellowship in Mohs Micrographic Surgery ...
(Date:6/25/2016)... ... June 25, 2016 , ... Dr. Calvin Johnson has dedicated ... has implemented orthobiologic procedures as a method for treating his patients. The procedure ... doctors to perform the treatment. Orthobiologics are substances that orthopaedic surgeons use to ...
(Date:6/24/2016)... ... June 24, 2016 , ... June 19, 2016 is ... associated with chronic pain and the benefits of holistic treatments, Serenity Recovery Center ... suffering with Sickle Cell Disease. , Sickle Cell Disease (SCD) is a disorder of ...
(Date:6/24/2016)... Diego, CA (PRWEB) , ... June 24, 2016 , ... ... with the American Cancer Society and the Road To Recovery® program to drive cancer ... to seniors and other adults to ensure the highest quality of life and ongoing ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... June 23, 2016  MedSource announced today that ... e-clinical software solution of choice.  This latest decision ... value to their clients by offering a state-of-the-art ... relationship establishes nowEDC as the EDC platform of ... full-service clients.  "nowEDC has long been a preferred ...
(Date:6/23/2016)... 23, 2016 Research and Markets ... Market by Type (Organic Chemical (Sugar, Petrochemical, Glycerin), Inorganic ... Coating, Parenteral) - Global Forecast to 2021" report ... The global pharmaceutical excipients market is projected to ... of 6.1% in the forecast period 2016 to 2021. ...
(Date:6/23/2016)... Research and Markets has announced the addition of ... Forecast to 2022" report to their offering. ... date financial data derived from varied research sources to present ... impact on the market during the next five years, including ... sub markets, regional and country level analysis. The report provides ...
Breaking Medicine Technology: