Navigation Links
Discovering new uses for old drugs
Date:8/1/2012

With the cost of putting a single new drug on the pharmacy shelves topping a staggering $1 billion, scientists are reporting development of a way to determine if an already-approved drug might be used to treat a different disease. The technique for repurposing existing medicines could cut drug development costs and make new medicine available to patients faster, they report in ACS' Journal of Medicinal Chemistry.

Sivanesan Dakshanamurthy and colleagues explain that drug companies must limit efforts to market new drugs because the current approach is so expensive, time-consuming and prone to failure. Scientists long have known that drugs already approved for one disease might be effective for others. However, existing methods to identify new uses for old drugs lack accuracy and have other disadvantages. So Dakshanamurthy's team developed a comprehensive new computer method called "Train-Match-Fit-Streamline" (TMFS) that uses 11 factors to quickly pair likely drugs and diseases.

They describe using TMFS to discover evidence that Celebrex, the popular prescription medicine for pain and inflammation, has a chemical signature and architecture suggesting that it may work against a difficult-to-treat form of cancer. Likewise, they found that a medicine for hookworm might be repurposed to cut off the blood supply that enables many forms of cancer to grow and spread. "We anticipate that expanding our TMFS method to the more than 27,000 clinically active agents available worldwide across all targets will be most useful in the repositioning of existing drugs for new therapeutic targets," they said.


'/>"/>
Contact: Michael Bernstein
m_bernstein@acs.org
202-872-6042
American Chemical Society
Source:Eurekalert

Page: 1

Related medicine news :

1. Pharmacy Robots Linked to Bacterial Contamination of Drugs
2. Penn study cautions use of drugs to block niacin flush
3. Urinary Incontinence Drugs May Be More Trouble Than Theyre Worth
4. Discovery could help to develop drugs for organ transplant and cancer patients
5. Not taking gastroprotective drugs prescribed with anti-inflammatory medicines
6. Live imaging shows response to cancer drugs can be boosted by altering tumor microenvironment
7. Weight-Loss Surgery Beat Drugs for Cutting Diabetes in Very Obese
8. Seniors Stop Taking Heart Drugs In Medicare Donut Hole
9. New Psoriasis Drugs Not Much Better Than Standard Therapy, Study Finds
10. About 1 baby born each hour addicted to opiate drugs in U.S., U-M study shows
11. Blood pressure drugs linked with lower PTSD symptoms
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/20/2015)... April 21, 2015 Reality show stars, ... girlfriends at the twentieth annual Michigan International Women’s Show, ... Novi. , “There is lots to see and do ... shopping for fashion and gifts,” said Beth Anderson, executive ... entertaining and encouraging with appearances from Randy Fenoli of ...
(Date:4/20/2015)... Saint Joseph Regional Medical Center (SJRMC) has been named ... Health Analytics, a leading provider of information and solutions that ... recognized by Truven Health Analytics as a 15 Top Health ... to Truven Health Analytics' analysis of 341 health ... peers, set the standard for care in all study comparisons: ...
(Date:4/20/2015)... At the famous Avalon Hollywood on April ... EcoLuxe Lounge, with Choices Recovery as the premier sponsor. ... product placement in TV and film, gathered some of ... sound goods and services for this daylong event. ... Choices Celebrity Interview Lounge, speaking with many of the ...
(Date:4/20/2015)... Novatus, a leading provider of contract ... level to the growing European market by adding ... After a rigorous review process Novatus selected ... security and operational expertise, and extensive connectivity. , ... we expand our footprint and capabilities to grow ...
(Date:4/20/2015)... FL (PRWEB) April 20, 2015 Florida ... to receive three prestigious awards from Select Medical, during ... Tampa on Friday, April 10th. Chief Operating Officer, Debi ... stable leadership. She was one of six recipients out ... the Stu Dinney Humanitarian Award for the contributions to ...
Breaking Medicine News(10 mins):Health News:Perfect Girls Day Out at Michigan International Women’s Show Opening Thursday, April 30 in Novi Presented by Southern Shows 2Health News:Perfect Girls Day Out at Michigan International Women’s Show Opening Thursday, April 30 in Novi Presented by Southern Shows 3Health News:SJRMC Named a 15 Top Health System by Truven Health Analytics 2Health News:SJRMC Named a 15 Top Health System by Truven Health Analytics 3Health News:Choices Recovery South Bend Talks About Healthy Decisions with TV's Adrienne Janic 2Health News:Novatus Expands into European Data Centers 2Health News:Florida Hospital at Connerton Long Term Acute Care Earns Awards from Select Medical including the Stu Dinney Humanitarian Award 2Health News:Florida Hospital at Connerton Long Term Acute Care Earns Awards from Select Medical including the Stu Dinney Humanitarian Award 3
... , SEATTLE, July 17 The economic downturn ... like hypertension, stress and fatigue, but also by causing people to put off ... Physicians at The Polyclinic in Seattle are offering suggestions for how to get ... , Don, t put off necessary treatment ...
... , , WASHINGTON, July 17 ... all health care reform stakeholders to revisit cost issues considering recent reports ... , "Especially given the Congressional Budget Office,s (CBO) most recent ... understanding as to what will lead to real and quantifiable health cost ...
... , , PHILADELPHIA, July 17 , , ... Tony Ridley, members of ... by the bombings in Jakarta,s Mega Kuningan business district., WHY: ... of medical, security, aviation, logistical and communications, ...
... Companies whose disability ... says Reed Group President, Guidelines, Jon Seymour, MD. , ... Westminster, CO (Vocus) July 16, 2009 -- Companies whose disability case ... Reed Group President, Guidelines, Jon Seymour , MD. , , , , ...
... Cabinet Secretaries Kathleen Sebelius, Hilda L. Solis, ... community forum and hold m edi a ... WASHINGTON , July 17 U.S. Department of Health ... Department of Agriculture Secretary Tom Vilsack and U.S. Department of Veterans Affairs Secretary Eric K. ...
... could be prevented with better screening, study finds, , ... rare genetic disorder that inhibits a child,s learning could ... , The disorder, known as fragile X syndrome, is ... is not apparent at birth. It affects roughly one ...
Cached Medicine News:Health News:How to Afford Health Care in Hard Times 2Health News:Actuaries: Health Care Reform Must Address Costs 2Health News:Available for Interviews: Doctor, Security Specialist Assisting Victims of Jakarta Bombings 2Health News:Available for Interviews: Doctor, Security Specialist Assisting Victims of Jakarta Bombings 3Health News:Available for Interviews: Doctor, Security Specialist Assisting Victims of Jakarta Bombings 4Health News:Reed Group Will Debut New Predictive Modeling Tool at DMEC Conference 2Health News:Reed Group Will Debut New Predictive Modeling Tool at DMEC Conference 3Health News:Reed Group Will Debut New Predictive Modeling Tool at DMEC Conference 4Health News:Reed Group Will Debut New Predictive Modeling Tool at DMEC Conference 5Health News:Top Obama administration officials to hold rural health community forum 2Health News:Earlier Testing Needed for Fragile X Syndrome 2
(Date:4/20/2015)... Ga. , April 20, 2015  Halyard Health Inc., ... financial results and business highlights for the first quarter 2015 ... will issue a news release detailing first quarter results before ... call will be hosted by Robert Abernathy , Chairman ... Financial Officer. To join the live conference call, ...
(Date:4/20/2015)... , April 20, 2015 This report analyzes ... in US$ Million by the following Product Segments: Sphygmomanometers (Aneroid ... Blood Pressure Transducers. The report provides separate comprehensive analytics for ... , Europe , Asia-Pacific ... Latin America . Annual estimates and forecasts are ...
(Date:4/20/2015)... WORTH, Texas , April 20, 2015 ... market report defines and segments the concerned global with ... at $3,963.1 million 2014, and is estimated to reach ... from 2014 to 2019. Browse through the ... for an in-depth analysis of the industry trends and ...
Breaking Medicine Technology:Halyard Health Inc. To Webcast Conference Call Discussing First Quarter 2015 Financial Results 2World Blood Pressure Monitoring and Measurement Instruments Industry 2World Blood Pressure Monitoring and Measurement Instruments Industry 3World Blood Pressure Monitoring and Measurement Instruments Industry 4World Blood Pressure Monitoring and Measurement Instruments Industry 5World Blood Pressure Monitoring and Measurement Instruments Industry 6World Blood Pressure Monitoring and Measurement Instruments Industry 7World Blood Pressure Monitoring and Measurement Instruments Industry 8World Blood Pressure Monitoring and Measurement Instruments Industry 9World Blood Pressure Monitoring and Measurement Instruments Industry 10World Blood Pressure Monitoring and Measurement Instruments Industry 11World Blood Pressure Monitoring and Measurement Instruments Industry 12World Blood Pressure Monitoring and Measurement Instruments Industry 13World Blood Pressure Monitoring and Measurement Instruments Industry 14World Blood Pressure Monitoring and Measurement Instruments Industry 15World Blood Pressure Monitoring and Measurement Instruments Industry 16World Blood Pressure Monitoring and Measurement Instruments Industry 17World Blood Pressure Monitoring and Measurement Instruments Industry 18World Blood Pressure Monitoring and Measurement Instruments Industry 19World Blood Pressure Monitoring and Measurement Instruments Industry 20World Blood Pressure Monitoring and Measurement Instruments Industry 21World Blood Pressure Monitoring and Measurement Instruments Industry 22World Blood Pressure Monitoring and Measurement Instruments Industry 23World Blood Pressure Monitoring and Measurement Instruments Industry 24World Blood Pressure Monitoring and Measurement Instruments Industry 25World Blood Pressure Monitoring and Measurement Instruments Industry 26World Blood Pressure Monitoring and Measurement Instruments Industry 27World Blood Pressure Monitoring and Measurement Instruments Industry 28Global Orthopedic Braces & Support System Market is Expected to Reach $4,918.7 Million by 2019, at a CAGR of 4.4% from 2014 to 2019 2Global Orthopedic Braces & Support System Market is Expected to Reach $4,918.7 Million by 2019, at a CAGR of 4.4% from 2014 to 2019 3
... Conn., March 31, 2011 MedClean Technologies, Inc. (OTC Bulletin ... the year ended December 31, 2010. ... the year, the Company entered into new purchase agreements for ... 2010 versus purchase agreements totaling $1.2 million in 2009, an ...
... Texas, March 31, 2011 Recent information presented at ... 2 -4, 2011 indicates a rise in the failure ... System which was manufactured and marketed by DePuy Orthopaedics, ... Orthopaedic Association has released a summary of the results ...
Cached Medicine Technology:MedClean Technologies Announces 2010 Results 2MedClean Technologies Announces 2010 Results 3MedClean Technologies Announces 2010 Results 4MedClean Technologies Announces 2010 Results 5MedClean Technologies Announces 2010 Results 6MedClean Technologies Announces 2010 Results 7Failure Rate of DePuy ASR XL Hip Implant Rising 2
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
Medicine Products: