Navigation Links
Discovered a new way to control genetic material altered in cancer
Date:6/5/2014

When we talk about genetic material, we are usually referring to the DNA (deoxyribonucleic acid) that we inherit from our parents. This DNA is the factory where is built a similar molecule called RNA (ribonucleic acid) which produces our proteins, such as hemoglobin or insulin , allowing the lives of our cells. But there is a special group called non-coding RNA that has a more enigmatic function.

The best known is microRNAs, tiny molecules that are responsible for turning on or off our genome like an electrical current switch. Today, an article published in the prestigious journal Molecular Cell by Manel Esteller, Director of Epigenetics and Cancer Biology Program of the Bellvitge Biomedical Research Institute (IDIBELL), ICREA researcher and Professor of Genetics at the University of Barcelona, provides a twist over this mystery.

Research shows that there is a second type of non-coding RNA, called ultra-conserved RNA that acts as switches switch, ie , controls the activity of microRNAs.

"Who watches the watchers? This was one of the issues that we set at the beginning of the research" says Esteller. "We have found that special molecules called ultra-conserved RNA were not produced in human tumors and this contributed to their growth, but we knew nothing about this mechanism. It should be an important role because these molecules are highly conserved in evolution and there is no variation from chickens to humans. We realized ultraconservated RNAs attached to the other family of non-coding RNAs , microRNAs, as a magnet and prevented its function. That is, they are the police internal affairs officers who supervise the battle soldiers in healthy cells . If a cell fails to produce the ultraconservated RNA, microRNA gets altered and hundreds of genes that should maintain cellular balance does and thus contributes to the formation of human tumors, " concludes Manel Esteller.

The results obtained by the group Esteller in Molecular Cell article are very important for understanding the function of the dark genome. Deciphering encrypted codes of cellular activity in these sequences of our DNA represents one of the most exciting challenges of modern biology. This cutting edge research is beginning to bear its first fruits in the field of medical research such as that described ultraconservated RNA is related with cancer development.


'/>"/>

Contact: Arantxa Mena
amena@idibell.cat
34-932-607-282
IDIBELL-Bellvitge Biomedical Research Institute
Source:Eurekalert  

Related medicine news :

1. New method discovered to protect against chemical weapons
2. Finnish researchers discovered a new anticancer compound
3. Extinct kitten-sized hunter discovered
4. Novel therapeutic agent for Tamiflu-resistant pH1N1 influenza virus discovered
5. First genetic link discovered to difficult-to-diagnose breast cancer sub-type
6. New pain relief targets discovered
7. Brainstem discovered as important relay site after stroke
8. Critical protein discovered for healthy cell growth in mammals
9. Molecule discovered that protects the brain from cannabis intoxication
10. CU researchers may have discovered a plan to disable Menieres disease
11. Newly discovered brown fat cells hold possibilities for treating diabetes, obesity
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Discovered a new way to control genetic material altered in cancer
(Date:6/20/2017)... ... ... As a leading dental practice, Wall Centre Dental supports Stroke Awareness Month ... bleeding gums in Vancouver, BC, may be developing gingivitis, the first stage of ... and diabetes. Drs. Parviz Roshan, Siamak Tehrani and Milton Reskovich offer laser gum therapy ...
(Date:6/20/2017)... ... June 20, 2017 , ... This year, participants in the ... finding product improvements that could reduce the occurrence of unplanned extubations (UEs). ... breathing or to provide medication. Sometimes, patient movement can cause unplanned extubations which ...
(Date:6/20/2017)... ... June 20, 2017 , ... Uniform Advantage ... featuring seven new products designed to create tailored looks and athleisure-inspired outfits. UA Flex ... cotton easy care stretch twill. , With trendy looks hitting the medical community, UA ...
(Date:6/20/2017)... ... , ... John D'Eri, CEO of Rising Tide Car Wash , will ... during the Autism Society of America 's 49th annual conference to be held ... (DJFF) was founded in 2002 as the nation's first autism organization focused exclusively ...
(Date:6/20/2017)... ... June 20, 2017 , ... International water ... The Sharon Kleyne Hour Power of Water, Global Climate Change and Your Health ... world’s water crisis and how it affects the human eyes. , According ...
Breaking Medicine News(10 mins):
(Date:6/9/2017)... , June 9, 2017 AirXpanders, Inc. ... focused on the design, manufacture, sale and distribution of ... on the progress of its commercial roll-out in ... available in more than one hundred (100) medical institutions ... AeroForm offers a needle-free alternative for women who ...
(Date:6/7/2017)... -- Endo International plc (NASDAQ: ENDP ) ... Joseph R. Goodwin , U.S. District Court Judge for ... , entered a case management order in MDL 2325, ... Litigation (the "MDL") that includes a provision requiring plaintiffs ... on specific causation within one hundred twenty (120) days ...
(Date:6/3/2017)... June 3, 2017  Eli Lilly and Company ... results from the Phase 3 MONARCH 2 study ... 6 inhibitor, in combination with fulvestrant, significantly improved ... alone in women with hormone-receptor-positive (HR+), human epidermal ... who have relapsed or progressed after endocrine therapy ...
Breaking Medicine Technology: