Navigation Links
Discovered a new way to control genetic material altered in cancer
Date:6/5/2014

When we talk about genetic material, we are usually referring to the DNA (deoxyribonucleic acid) that we inherit from our parents. This DNA is the factory where is built a similar molecule called RNA (ribonucleic acid) which produces our proteins, such as hemoglobin or insulin , allowing the lives of our cells. But there is a special group called non-coding RNA that has a more enigmatic function.

The best known is microRNAs, tiny molecules that are responsible for turning on or off our genome like an electrical current switch. Today, an article published in the prestigious journal Molecular Cell by Manel Esteller, Director of Epigenetics and Cancer Biology Program of the Bellvitge Biomedical Research Institute (IDIBELL), ICREA researcher and Professor of Genetics at the University of Barcelona, provides a twist over this mystery.

Research shows that there is a second type of non-coding RNA, called ultra-conserved RNA that acts as switches switch, ie , controls the activity of microRNAs.

"Who watches the watchers? This was one of the issues that we set at the beginning of the research" says Esteller. "We have found that special molecules called ultra-conserved RNA were not produced in human tumors and this contributed to their growth, but we knew nothing about this mechanism. It should be an important role because these molecules are highly conserved in evolution and there is no variation from chickens to humans. We realized ultraconservated RNAs attached to the other family of non-coding RNAs , microRNAs, as a magnet and prevented its function. That is, they are the police internal affairs officers who supervise the battle soldiers in healthy cells . If a cell fails to produce the ultraconservated RNA, microRNA gets altered and hundreds of genes that should maintain cellular balance does and thus contributes to the formation of human tumors, " concludes Manel Esteller.

The results obtained by the group Esteller in Molecular Cell article are very important for understanding the function of the dark genome. Deciphering encrypted codes of cellular activity in these sequences of our DNA represents one of the most exciting challenges of modern biology. This cutting edge research is beginning to bear its first fruits in the field of medical research such as that described ultraconservated RNA is related with cancer development.


'/>"/>

Contact: Arantxa Mena
amena@idibell.cat
34-932-607-282
IDIBELL-Bellvitge Biomedical Research Institute
Source:Eurekalert  

Related medicine news :

1. New method discovered to protect against chemical weapons
2. Finnish researchers discovered a new anticancer compound
3. Extinct kitten-sized hunter discovered
4. Novel therapeutic agent for Tamiflu-resistant pH1N1 influenza virus discovered
5. First genetic link discovered to difficult-to-diagnose breast cancer sub-type
6. New pain relief targets discovered
7. Brainstem discovered as important relay site after stroke
8. Critical protein discovered for healthy cell growth in mammals
9. Molecule discovered that protects the brain from cannabis intoxication
10. CU researchers may have discovered a plan to disable Menieres disease
11. Newly discovered brown fat cells hold possibilities for treating diabetes, obesity
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Discovered a new way to control genetic material altered in cancer
(Date:6/27/2016)... ... June 27, 2016 , ... TopConsumerReviews.com recently awarded their highest five-star rating ... Millions of individuals in the United States and Canada wear eyeglasses. Once considered to ... correct vision and make a fashion statement. Even celebrities use glasses as a way ...
(Date:6/26/2016)... California (PRWEB) , ... June 26, 2016 , ... Pixel ... Cut Pro X. , "Film editors can give their videos a whole new perspective ... Christina Austin - CEO of Pixel Film Studios. , ProSlice Levels contains over ...
(Date:6/26/2016)... ... June 26, 2016 , ... Many women are ... with endometriosis. These women need a treatment plan to not only alleviate symptoms ... can help for preservation of fertility and ultimately achieving a pregnancy. The specialists ...
(Date:6/25/2016)... ... , ... The temporary closing of Bruton Memorial Library on June 21 due to a possible ... often overlooked aspect of head lice: the parasite’s ability to live away from a human ... but a necessary one in the event that lice have simply gotten out of control. ...
(Date:6/25/2016)... ... , ... As a lifelong Southern Californian, Dr. Omkar Marathe earned his Bachelors ... Geffen School of Medicine at UCLA. He trained in Internal Medicine at Scripps Green ... hematology/oncology at the UCLA-Olive View-Cedars Sinai program where he had the opportunity to train ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... , June 23, 2016 Any dentist who ... challenges of the current process. Many of them do not ... the technical difficulties and high laboratory costs involved. And those ... offer it at such a high cost that the majority ... Dr. Parsa Zadeh , founder of Dental ...
(Date:6/23/2016)... , June 23, 2016 ... CAPR ), a biotechnology company focused on ... today announced that patient enrollment in its ongoing ... Duchenne) has exceeded 50% of its 24-patient target. ... in the third quarter of 2016, and to ...
(Date:6/23/2016)... 23, 2016  Astellas today announced the establishment of Astellas Farma Colombia (AFC), a new affiliate with operations headquartered ... Latin America . ... ... ... ...
Breaking Medicine Technology: