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Discovered a mechanism that induces migration of tumor cells in liver cancer
Date:11/6/2013

issues of patients" explained Fabregat "we observed that high levels of this protein correlate always with overactivation of the TGFb pathway and, most interestingly, these patients had a tumor cell phenotype less differentiated, and potentially more aggressive . Moreover, CXCR4 was located preferentially in the areas of tumor invasion."

Future clinical application

"At clinical level," explains the researcher "we believe that patients that reveal an overactivation of TGFb coincident with high expression of CXCR4 in tumor invasion fronts, may be candidates for TGFb inhibitory potential therapies."

This study was conducted in collaboration with Emilio Ramos of liver surgery unit and Teresa Serrano pathology unit of the University Hospital of Bellvitge. "Our group performs a very basic research but through collaboration with clinicians have a more translational aspect because we can corroborate our results not only in animal models but also in human samples and study whether they can have an impact at the clinical level" said the researcher .


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Contact: Arantxa Mena
amena@idibell.cat
34-932-607-129
IDIBELL-Bellvitge Biomedical Research Institute
Source:Eurekalert  

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