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Discarded immune cells induce the relocation of stem cells
Date:5/23/2013

n hematopoietic stem cells in the bone marrow. "As a consequence, the stem cells are released into the blood", explains Mara Casanova, first author of the study.

According to Dr. Hidalgo, "Key questions that arise from our study relate to the role of the hematopoietic stems cells expelled from the bone marrow, and how the elimination of neutrophils might affect other important stem cell populations, for example those that produce tumors".

The research also reveals that the aging of neutrophils follows a day/night, or circadian, cycle, suggesting possible implications for disease processesfor instance heart attackthat occur more frequently at certain times of day.

"Our study shows that stem cells are affected by day/night cycles thanks to this cell recycling. It is possible that the malign stem cells that cause cancer use this mechanism to relocate, for example during metastasis", Hidalgo emphasizes.

But this finding could have more direct implications for cardiovascular health. According to the authors, the daily changes in the function of neutrophils could be responsible for the tendency of acute cardiovascular and inflammatory events, such as heart attack, sepsis or stroke, to occur at certain times of day.

Dr. Hidalgo concludes, "Given that this new discovery describes fundamental processes in the body that were unknown before, it will now be possible to interpret the alterations to certain physiological patterns that occur in many diseases."


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Contact: Ainhoa Iriberri
airiberri@cnic.es
34-610-295-556
Centro Nacional de Investigaciones Cardiovasculares
Source:Eurekalert

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