Navigation Links
Direct-acting antivirals now ready for prime time
Date:4/24/2013

longer treatment durations will be evaluated in the near future. In the meantime, we feel it's not time to bury pegylated interferon just yet."

"Many patients can tolerate 12 weeks of an interferon based regime particularly when it produces SVR rates of more than 90%; so clearly the results of the NEUTRINO study will be welcomed by clinicians and patients" added Prof. Thursz.

STARTVerso1

  • Faldaprevir, an oral once-daily protease inhibitor, in combination with peginterferon alfa-2a and ribavirin (PegIFN/RBV) significantly increased SVR12 rates in treatment-nave HCV GT-1 patients in Europe and Japan compared with PegIFN/RBV alone and was well tolerated. In total 652 patients were treated and 88% of patients treated with faldaprevir were eligible to stop all treatment at week 24.

QUEST-1 and -2

  • QUEST-1: Simeprevir, an oral once-daily protease inhibitor, in combination with peginterferon alfa-2a and ribavirin (PegIFN/RBV) achieved SVR12 rates of 80% compared to placebo, 50% (p<0.001). Of the 394 patients, 85% in the simeprevir treatment group were eligible to complete treatments at week 24. On-treatment failure rate was also much lower with simeprevir treatment, compared to placebo.
  • QUEST-2: Simeprevir versus placebo as part of regimen including PegIFN or PegIFN/RBV was well tolerated. SVR12 rates significantly increased in the simeprevir group compared to placebo (81 vs. 50% respectively (p<0.001) and of the 391 patients treated, 91% were eligible to stop all treatment at week 24.

Prof. Mark Thursz commented on the exciting protease inhibitor data showcased at the congress: "With genotype-1 the most common and most challenging type of HCV to cure, both studies have demonstrated extremely encouraging results with cleaner profiles than existing protease inhibitors. It is unlikely telaprevir and boceprevir will remain in the hepatic armoury for much longer."

"We tr
'/>"/>

Contact: Dimple Natali
easlpressoffice@cohnwolfe.com
44-790-013-8904
European Association for the Study of the Liver
Source:Eurekalert

Page: 1 2 3 4

Related medicine news :

1. CONRAD to host HIV symposium at 2nd Annual Antivirals Congress
2. Sylvia Nasser Creates New Online Gym to Get Women Summer Body Ready
3. Get the Grill Ready: Fresh Spanish Calçots Available for Pre-Order at LaTienda.com
4. Hobe Sound, Fla. Residents Get Ready for Relay for Life
5. Ready for debut: Fruit-juice-infused chocolate with 50 percent less fat
6. Colorado Springs Gets Ready for Actors, Models and Talent for Christ (AMTC) Auditions on April 13th
7. New HIPAA Omnibus Rule Ready Compliance Products and Subscription Plan
8. Ready-to-Eat Foods for Toddlers Often Too Salty: Study
9. Gourmet Gift Baskets for Easter, 2013 have just hit the #1 Gift Basket web site, premiergiftbaskets.biz. They were just introduced Friday and sales are already mounting.
10. Ready for Distribution: Nouvelle Compression Wear Helps Speed Recovery Following Breast Augmentation, Facelift, Liposuction and Breast Reduction for Men and Women
11. Health Benefits of Marriage Mostly Apply to Those Already Healthy
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/30/2014)... 2014 Integrated Medicine Alliance , ... another new medical specialty practice through a unique partnership ... will be located within the company’s Shrewsbury location and ... Isaac Tawfik of American Heart Center, P.C., a highly ... will offer Integrated Medicine Alliance patients top notch cardiovascular ...
(Date:9/30/2014)... been awarded a three-year $1.7 million grant from ... new imaging technologies and data analysis techniques that ... of neurons in the brain interact to process ... the precise interactions between millions of nerve cells ... alterations in these interactions that may be responsible ...
(Date:9/30/2014)... September 30, 2014 Elevate , the ... perform better in and out of the gym by providing ... caught the attention of Shane Michaels, prompting an investigative review. ... is the reason most people simply just don’t have the ... staying focused at work, getting the motivation to finish a ...
(Date:9/30/2014)... (PRWEB) September 30, 2014 Hospice ... its annual “In Celebration” gala, honoring three outstanding ... mission of striving to provide extraordinary and dignified ... facing a serious or life-limiting illness. , The ... in Rye, NY and recognized William (Bill) J. ...
(Date:9/30/2014)... Dr. Karl R.O.S. Johnson, DC, has developed ... care that is dramatically improving the health and lives ... & Nutrition—applies a proprietary, multi-dimensional approach that goes beyond ... of inflammation, neurology of the joint and neurology of ... brain to the spine, to the legs, knees and ...
Breaking Medicine News(10 mins):Health News:Integrated Medicine Alliance Announces New Cardiology Practice 2Health News:UMD receives inaugural BRAIN Initiative Award 2Health News:Elevate: Review Exposes Blue Star Nutraceutical’s Latest Supplement for Ultimate Brain Function, Focus, and Energy 2Health News:Hospice & Palliative Care of Westchester Honors Outstanding Individuals at Annual ‘In Celebration’ Gala 2Health News:Newly Developed Program Eases Chronic Knee Pain without Surgery and in as Little as Two Days 2Health News:Newly Developed Program Eases Chronic Knee Pain without Surgery and in as Little as Two Days 3
... suggests weight loss may be an early sign of ... before the onset of // definite dementia symptoms and ... in the elderly is common and may be associated ... in people who already have dementia. For the study ...
... researchers have linked breathing cancer-causing compounds during pregnancy // ... They also believe that nearly all childhood cancers can ... noxious substances. ,The study compared a chemical emissions ... died from leukemia and other cancers between 1968 and ...
... the New Year has brought with it a new lease ... For these //patients the uphill struggle doesn’t stop with finding ... , Research has shown that despite all high tech ... a common phenomenon. Transplant surgeon Ignazio Marino, M.D., of Thomas ...
... hormones could be responsible for some of the problems ... measuring levels of five different sex hormones in men ... those found in healthy people. All the MS patients ... brain damage characteristic of the disease. ,Results showed ...
... the use of estrogen replacement therapy with a lower risk ... is known as a good indicator of exposure to estrogen. ... BMD related to the risk of cognitive problems. All of ... of the study. Researchers then measured their BMD at several ...
... a recent study researchers say estrogen may provide protection ... different diets to female mice and followed their progress for ... of specific ingredients.// ,Diet one contained milk protein, and ... of estrogen. The other three diets contained soy protein with ...
Cached Medicine News:
(Date:9/30/2014)... , Sept. 30, 2014 STUDY OBJECTIVES ... study is to provide an overview of the ... for protein drugs/therapeutics. The key objective is to ... protein drugs as an important tool in the ... present and future strategies within the protein therapeutics ...
(Date:9/30/2014)... DENVER , Sept. 30, 2014  According ... "the world of cancer clinical trials is going ... clinical trials and the work of the current ... these types of ,next generation, clinical trials, which ... tomorrow."  The company has been ...
(Date:9/30/2014)... -- The Chinese wound care market is in the ... incidence of lifestyle diseases, coupled with the increase in ... quality of wound care products provide the impetus for ... health insurance schemes and increased reimbursement rate for wound ... findings of primary and secondary researches, this research service ...
Breaking Medicine Technology:Global Markets and Manufacturing Technologies for Protein Drugs -- Focus on Cytokines and Monoclonal Antibodies 2Global Markets and Manufacturing Technologies for Protein Drugs -- Focus on Cytokines and Monoclonal Antibodies 3Global Markets and Manufacturing Technologies for Protein Drugs -- Focus on Cytokines and Monoclonal Antibodies 4Small Denver Company Pharmatech driving a large revolution in how cancer clinical trials are managed 2China Wound Care Market 2China Wound Care Market 3
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
Medicine Products: