Navigation Links
Dipping blood sugars cause surprisingly irregular heart rhythms in diabetics
Date:4/28/2014

The findings from the research led by Professor Simon Heller of the University of Sheffield's Department of Human Metabolism and Sheffield Teaching Hospitals NHS Foundation Trust - could offer vital clues to the mechanism by which low blood sugar levels could contribute to life-threatening changes in heart rhythm, a major risk for patients with diabetes.

They also shed important new light on the 'Dead in Bed' syndrome where young people without any history of long-term complications die suddenly from the disease.

Previous studies have apparently ruled out a direct effect of hypoglycaemia (very low levels of sugar in the blood) as a cause of death in patients with Type 2 diabetes.

Few of the patients taking part in the present study reported symptoms of low blood sugar levels or irregular heartbeats and they were only detected through continuous glucose monitoring and electrocardiograms used by Sheffield researchers which tracked blood glucose levels and heart rates over a week in a group of older patients with Type 2 diabetes and a history of cardiovascular disease.

The breakthrough research was conducted by Elaine Chow, a specialist registrar at Sheffield Teaching Hospitals and the University of Sheffield under a 190K Biomedical Research Fellowship awarded by the National Institute for Health Research. The findings are being published in the May issue of Diabetes, the journal of the American Association of Diabetes.

Professor Simon Heller, Professor of Clinical Diabetes and Honorary Consultant Physician, Sheffield Teaching Hospitals NHS Foundation Trust, said: "We don't want to alarm patients, but what we've found is potentially important in explaining a possible mechanism by which low overnight blood sugars lead to prolonged, slow heart rates that could disturb blood flow to the heart, causing life-threatening heart attacks.

"While we expected to find some low overnight blood sugars we were startled to find how extensively it was occurring overnight and that it was sometimes lasting for several hours. When this occurred, we also saw evidence of prolonged periods of very slow heart rate rhythms in patients.

"While a cause for concern, these slow heart rates were not associated with any very serious heart rhythm disturbances in the study. But the findings suggest that even those on standard insulin therapy who are not aiming for intensive glucose targets should be aware of the risk of running low sugars overnight, particularly if they have known cardiovascular disease."

Previous research has focused on the effects of high blood sugars on patients with diabetes, so more research was needed to understand how low blood sugars in patients with Type 2 diabetes caused irregular heartbeats, Professor Heller emphasised.

"In an older group with a known history of cardiovascular disease this might turn out to be something to be very concerned about, but further investigation is needed to confirm the link between overnight low blood sugar levels and abnormal heart rates that disturb the flow of blood to the heart. If patients are aware they have low blood sugar levels, they can act accordingly, perhaps by checking their blood glucose in the middle of the night every now and then and talking with the doctor to change insulin type or the timing of the dose to minimise the risk of prolonged episodes of hypoglycaemia overnight.

"Clinicians responsible for the care of patients using insulin to treat Type 2 diabetes need to be more aware of the potential for prolonged nocturnal episodes of hypoglycaemia at night. They need to check for it and alter therapy to reduce the risk, especially for those who have known history of cardiovascular disease."


'/>"/>

Contact: Amy Pullan
a.l.pullan@sheffield.ac.uk
01-142-229-859
University of Sheffield
Source:Eurekalert

Related medicine news :

1. Defend Against Double-Dipping at Your Super Bowl Party
2. Routine blood glucose measurements can accurately estimate hemoglobin A1c in diabetes
3. DNA modifications measured in blood signal related changes in the brain
4. Study estimates proportion of adults affected by new blood pressure guideline
5. Adjuvant chemotherapy increases markers of molecular aging in the blood of BC survivors
6. Whether they reduce fat or not, obesity programs lower kids blood pressure
7. Simple blood test may predict if a child will become obese
8. Model predicts blood glucose levels 30 minutes later
9. Virginia Tech scientists out for blood when it comes to stopping malaria
10. Researchers identify potential new therapeutic target for controlling high blood sugar
11. Tequila plant is possible sweetener for diabetics -- helps reduce blood sugar, weight
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/25/2016)... ... June 25, 2016 , ... Experts from the American ... Annual Research Meeting June 26-28, 2016, at the Hynes Convention Center in Boston. ... including advance care planning, healthcare costs and patient and family engagement. , AIR ...
(Date:6/25/2016)... ... June 25, 2016 , ... As a lifelong Southern Californian, Dr. Omkar Marathe ... from the David Geffen School of Medicine at UCLA. He trained in Internal Medicine ... his fellowship in hematology/oncology at the UCLA-Olive View-Cedars Sinai program where he had the ...
(Date:6/24/2016)... ... ... Those who have experienced traumatic events may suffer from a complex set ... drug or alcohol abuse, as a coping mechanism. To avoid this pain and suffering, ... traumatic event. , Trauma sufferers tend to feel a range of emotions, from depression, ...
(Date:6/24/2016)... ... 24, 2016 , ... Dr. Amanda Cheng, an orthodontist ... has extensive experience with all areas of orthodontics, including robotic Suresmile technology, ... , Micro-osteoperforation is a revolutionary adjunct to orthodontic treatment. It can be used ...
(Date:6/24/2016)... NY (PRWEB) , ... June 24, 2016 , ... ... Haute Living, is proud to recognize Dr. Barry M. Weintraub as a prominent ... “the most beautiful women in the world, and the most handsome men, look ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... 2016 Dublin ... addition of the " Global Markets for Spectroscopy ... This report focuses on the ... review, including its applications in various applications. The report ... includes three main industries: pharmaceutical and biotechnology, food and ...
(Date:6/24/2016)... SAN CLEMENTE, Calif. , June 24, 2016 /PRNewswire/ ... pulmonary function testing company, is now able to perform sophisticated lung ... ndd Medical Technologies , Inc. Patients are ... labs.  Thanks to ndd,s EasyOne PRO ® , ARL patients like ... any needed testing done in the comfort of her own home. ...
(Date:6/24/2016)... Belgium , June 24, 2016 ... the appointment of Dr. Edward Futcher ... Non-Executive Director, effective June 23, 2016.Dr. Futcher was ... Nominations and Governance Committees.  As a non-executive member ... independent expertise and strategic counsel to VolitionRx in ...
Breaking Medicine Technology: