Navigation Links
Dioxin-like chemical messenger makes brain tumors more aggressive
Date:10/6/2011

A research alliance of Heidelberg University Hospital and the German Cancer Research Center (Deutsches Krebsforschungszentrum, DKFZ), jointly with colleagues of the Helmholtz Center for Environmental Research in Leipzig, have discovered a new metabolic pathway which makes malignant brain tumors (gliomas) more aggressive and weakens patients' immune systems. Using drugs to inhibit this metabolic pathway is a new approach in cancer treatment. The group's results have been published in the prestigious specialist journal Nature.

Glioma is the most frequent and most malignant brain tumor in adults. In Germany, about 4,500 people are newly diagnosed with glioma every year. About 75 percent of such tumors are considered particularly aggressive with an average life expectancy of eight months to two years. The standard treatment is surgery to remove the tumor as completely as possible, followed by radiotherapy, usually in combination with chemotherapy. However, results are unsatisfactory, because these tumors are very resilient and soon start growing back. Therefore, there is an urgent need for new treatment approaches.

Tumors grow more aggressively and immune system is weakened

The Helmholtz Junior Research Group "Experimental Neuroimmunology" led by Professor Dr. Michael Platten of DKFZ and the Department of Neurooncology of Heidelberg University Hospital and the National Center for Tumor Diseases (NCT) headed by Professor Dr. Wolfgang Wick have come across the kynurenin molecule in their studies of human cancer cells and in the mouse model. Kynurenin is formed when the amino acid tryptophan a protein component taken in with food is broken down in the body. "We have been able to detect increased levels of kynurenin in cancer cells of glioma patients with particularly aggressive tumors," Professor Michael Platten explained. The current research results from Heidelberg show that this link also appears to exist in other types
'/>"/>

Contact: Dr. Michael Platten
michael.platten@med.uni-heidelberg.de
49-062-215-66804
University Hospital Heidelberg
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Chemical tags likely to affect metabolism, cancer development
2. NutriLuxe Offers Personal, At-Home Body Biochemical Balance Test
3. University of Michigan scientists identify chemical in bananas as potent inhibitor of HIV infection
4. Researchers discover chemical that may protect hearts of muscular dystrophy patients
5. SRI International Researchers to Present Work on Early Detection Tool for Neglected Tropical Diseases at 2010 American Chemical Society (ACS) Meeting
6. Workplace Chemicals May Boost Breast Cancer Risk
7. Exposure to 3 classes of common chemicals may affect female development
8. ACS Webinar features tips for finding and building a career in public policy and chemical industry
9. Chemicals in Beauty Products Tied to Early Puberty in Girls
10. FDA to Re-examine Anti-Bacterial Chemical in Soaps, Cleansers
11. Two New Phytochemicals with Anti-Inflammatory Activity Found in Noni Fruit
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/28/2014)... Celebration can quickly turn to tragedy if popular turkey ... Over the last decade, more than 141 serious fires ... turkey fryers, according to the U.S. Consumer Product Safety ... who tried to deep fry the turkey indoors, which ... Arthur Sanford, a burn surgeon at Loyola University Health ...
(Date:11/28/2014)... (PRWEB) November 28, 2014 Not only ... create products free of petroleum, parabens and other cancer-causing ... that fund research, education and awareness programs that help ... staff and owners have raised an incredible, record-breaking contribution ... the Cure, sales of the Sweet Red Rose Whip ...
(Date:11/28/2014)... Angeles, CA (PRWEB) November 28, 2014 ... online, reported during the hugely popular, 2014 ... the antismoking organization Truth launched ground-breaking celebrity centered ... 18-49. The MTV viewership figures were estimated by ... Truth antismoking ads placed the spotlight on celebrities ...
(Date:11/28/2014)... 28, 2014 A newly released article ... overview of the influenza virus that will soon be spreading ... , The article begins with a brief explanation of what ... It reminds families that children under the age of 5, ... chronic diseases, such as heart and lung diseases, asthma, or ...
(Date:11/28/2014)... November 28, 2014 Patten Pecans, based ... grown. With those passions driving them, they've added a ... Having tried other pecans oils, they've found this ... to be exceptionally flavorful, retaining the buttery pecan notes ... nutritional benefits found in pecans nuts is ...
Breaking Medicine News(10 mins):Health News:Turkey Fryer Mishaps Can Cause Serious Burns 2Health News:Éminence Organic Skin Care Donates Record-breaking $30,000 to Breast Cancer Research 2Health News:Éminence Organic Skin Care Donates Record-breaking $30,000 to Breast Cancer Research 3Health News:Freedom Laser Therapy Applauds American Legacy’s Creative Advertising Targeting Celebrity Smokers 2Health News:Freedom Laser Therapy Applauds American Legacy’s Creative Advertising Targeting Celebrity Smokers 3Health News:Freedom Laser Therapy Applauds American Legacy’s Creative Advertising Targeting Celebrity Smokers 4Health News:Freedom Laser Therapy Applauds American Legacy’s Creative Advertising Targeting Celebrity Smokers 5Health News:How Flu Vaccines Can Impact Families Is Discussed in New Article from Community Health Center of Snohomish County 2Health News:Patten Pecans Goes Local with Nutritious Georgia Pecan Oil 2
... procedures, survey shows , FRIDAY, July 31 (HealthDay News) -- ... visited a plastic surgeon for a "makeover" -- a ... around her lips and at the corners of her mouth. ... might lose her competitive edge in a tightening job market. ...
... , , WASHINGTON, July 31 ... Tobacco-Free Kids: , , (Logo: ... Council has taken an important step to protect the District,s kids and ... tax by 50 cents to $2.50 per pack - the seventh highest ...
... Fla., July 31 Sanofi-aventis US announced yesterday that the FDA ... in the USA. It offers results that last for years. Dr ... the product while abroad. It was approved in Europe(CE) for over ... global pharmaceutical company. The FDA approval is based on results from ...
... Md., July 31 /PRNewswire-Asia/ -- Chindex International, Inc.,("Chindex") (Nasdaq: ... products and services in the People,s Republic of China, today,announced ... results,on Monday, August 10, 2009, before the market opens. Management ... 10, 2009 to discuss financial results. , ...
... , , ... Administration (FDA) today approved the first and only antipsychotic for ... were approved for the acute treatment of schizoaffective disorder either ... INVEGA(R) was approved in 2006 for the treatment of schizophrenia. ...
... , Campaign Officially Launches ... months of college students and others wrestling with the creative challenge ... for its nationwide sign design contest. The victors are Kelsey Hazzard, ... law school this fall at the University of Virginia, and Christina ...
Cached Medicine News:Health News:Plastic Surgeons Stay Busy in Recession 2Health News:Plastic Surgeons Stay Busy in Recession 3Health News:District of Columbia Cigarette Tax Increase Delivers Victory for Kids and Taxpayers 2Health News:Chindex International, Inc. to Report First Quarter Fiscal 2010 Financial Results 2Health News:INVEGA(R) Approved as the First and Only Treatment for Schizoaffective Disorder 2Health News:INVEGA(R) Approved as the First and Only Treatment for Schizoaffective Disorder 3Health News:INVEGA(R) Approved as the First and Only Treatment for Schizoaffective Disorder 4Health News:INVEGA(R) Approved as the First and Only Treatment for Schizoaffective Disorder 5Health News:INVEGA(R) Approved as the First and Only Treatment for Schizoaffective Disorder 6Health News:INVEGA(R) Approved as the First and Only Treatment for Schizoaffective Disorder 7Health News:CandleInTheWindow.org Announces $1000 Scholarship Prize Winners 2
(Date:11/26/2014)... , November 26, 2014 Investor-Edge ... VVUS ), Horizon Pharma PLC (NASDAQ: ... and Johnson (NYSE: JNJ ), and Theravance Inc. ... companies can be accessed at: http://investor-edge.com/register . ... 4,758.25, up 0.07%, the Dow Jones Industrial Average edged 0.02% ...
(Date:11/26/2014)... SHANGHAI , Nov. 26, 2014  CARsgen, a ... (CAR-T) cell immunotherapy to treat a variety of cancers, ... led by BVCF, a China -based ... an immunotherapy company focused on the development of new ... collaboration with Shanghai Cancer Institute and Shanghai Renji Hospital, ...
(Date:11/26/2014)... N.C. , Nov. 25, 2014  At the ... Antonio this October, KaVo Kerr Group was ... Technology Expo, offering attendees the opportunity to see and ... well-respected key opinion leaders deliver lectures on the latest ... Group products include the new DEXIS CariVu Caries Detection ...
Breaking Medicine Technology:Pharma Stocks Highlight - VIVUS, Horizon Pharma, Endocyte, Johnson and Johnson, and Theravance 2Pharma Stocks Highlight - VIVUS, Horizon Pharma, Endocyte, Johnson and Johnson, and Theravance 3Pharma Stocks Highlight - VIVUS, Horizon Pharma, Endocyte, Johnson and Johnson, and Theravance 4Pharma Stocks Highlight - VIVUS, Horizon Pharma, Endocyte, Johnson and Johnson, and Theravance 5CARsgen Completes Series A Financing 2KaVo Kerr Group Showcased in Pride Institute Technology Expo at ADA Annual Meeting 2KaVo Kerr Group Showcased in Pride Institute Technology Expo at ADA Annual Meeting 3
... , Jan. 29 EP Global Communications, Inc. ... ), the parent company of Exceptional Parent ( EP ) ... has joined the EPGL Advisory Board. Dr. DeFelice is one of the ... term "nutraceutical."  , "This addition to our team of experts will ...
... , PITTSBURGH , Jan. 29 ... subsidiary Mylan Pharmaceuticals Inc. received final approval from the U.S. ... Application (ANDA) for Polyethylene Glycol 3350 and Electrolytes for Oral ... , Polyethylene Glycol 3350 and Electrolytes for Oral Solution ...
Cached Medicine Technology:EP Global Communications, Inc. Welcomes Stephen DeFelice, MD, to Advisory Board 2EP Global Communications, Inc. Welcomes Stephen DeFelice, MD, to Advisory Board 3Mylan Receives Approval for Generic Version of GoLytely(R) 2
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
Medicine Products: