Navigation Links
Dioxin-like chemical messenger makes brain tumors more aggressive

A research alliance of Heidelberg University Hospital and the German Cancer Research Center (Deutsches Krebsforschungszentrum, DKFZ), jointly with colleagues of the Helmholtz Center for Environmental Research in Leipzig, have discovered a new metabolic pathway which makes malignant brain tumors (gliomas) more aggressive and weakens patients' immune systems. Using drugs to inhibit this metabolic pathway is a new approach in cancer treatment. The group's results have been published in the prestigious specialist journal Nature.

Glioma is the most frequent and most malignant brain tumor in adults. In Germany, about 4,500 people are newly diagnosed with glioma every year. About 75 percent of such tumors are considered particularly aggressive with an average life expectancy of eight months to two years. The standard treatment is surgery to remove the tumor as completely as possible, followed by radiotherapy, usually in combination with chemotherapy. However, results are unsatisfactory, because these tumors are very resilient and soon start growing back. Therefore, there is an urgent need for new treatment approaches.

Tumors grow more aggressively and immune system is weakened

The Helmholtz Junior Research Group "Experimental Neuroimmunology" led by Professor Dr. Michael Platten of DKFZ and the Department of Neurooncology of Heidelberg University Hospital and the National Center for Tumor Diseases (NCT) headed by Professor Dr. Wolfgang Wick have come across the kynurenin molecule in their studies of human cancer cells and in the mouse model. Kynurenin is formed when the amino acid tryptophan a protein component taken in with food is broken down in the body. "We have been able to detect increased levels of kynurenin in cancer cells of glioma patients with particularly aggressive tumors," Professor Michael Platten explained. The current research results from Heidelberg show that this link also appears to exist in other types of cancer such as cancers of the bladder, bowel or lungs.

It was even more astonishing for the investigators to find that kynurenin activates a protein known as dioxin receptor. This, in turn, triggers a cascade of chemical reactions which ultimately promote tumor growth and weaken the immune system. So far, it had only been known that the dioxin receptor, scientifically called aryl hydrocarbon receptor (AHR), is activated by environmental toxins. "Why this receptor is even present in body cells and which is its activation partner in the body, was yet unknown," says Dr. Christiane Opitz, first author of the research article. "Kynurenin seems to have very similar effects as dioxin, but it is formed by the body itself," said Professor Platten.

Yet another new discovery was presented by the group: The amino acid tryptophan was broken down in cancer cells by a specific enzyme called tryptophan dioxygenase, or TDO for short, which scientists had previously found primarily in liver cells. "It came as a surprise to us that TDO is also active in cancer cells and strongly so in particularly aggressive tumors."

Searching for substances to specifically inhibit this metabolic pathway

The newly discovered metabolic pathway is a potential target for cancer treatment. The intention is to inhibit tumor growth and strengthen the immune system. "We will start searching for substances that specifically inhibit this metabolic pathway and may be used as potential antitumor drugs," said Professor Wolfgang Wick envisioning the next steps ahead.


Contact: Dr. Michael Platten
University Hospital Heidelberg

Related medicine news :

1. Chemical tags likely to affect metabolism, cancer development
2. NutriLuxe Offers Personal, At-Home Body Biochemical Balance Test
3. University of Michigan scientists identify chemical in bananas as potent inhibitor of HIV infection
4. Researchers discover chemical that may protect hearts of muscular dystrophy patients
5. SRI International Researchers to Present Work on Early Detection Tool for Neglected Tropical Diseases at 2010 American Chemical Society (ACS) Meeting
6. Workplace Chemicals May Boost Breast Cancer Risk
7. Exposure to 3 classes of common chemicals may affect female development
8. ACS Webinar features tips for finding and building a career in public policy and chemical industry
9. Chemicals in Beauty Products Tied to Early Puberty in Girls
10. FDA to Re-examine Anti-Bacterial Chemical in Soaps, Cleansers
11. Two New Phytochemicals with Anti-Inflammatory Activity Found in Noni Fruit
Post Your Comments:
(Date:6/27/2016)... ... June 27, 2016 , ... The OSHA ... Training Institute Education Center headquartered in Northern California, has issued an important reminder ... at their worksites. Employers with workers exposed to high temperatures should establish ...
(Date:6/27/2016)... California (PRWEB) , ... June 27, 2016 , ... "FCPX ... fully customizable inside of Final Cut Pro X," said Christina Austin - CEO of ... unique style. Final Cut Pro X users can now reveal the media ...
(Date:6/27/2016)... ... June 27, 2016 , ... ... professionals, announced today its affiliation with Tennessee Counseling Association. This new ... network of the Tennessee Counseling Association, adding exclusive benefits and promotional offers. , ...
(Date:6/27/2016)... , ... June 27, 2016 ... ... the patient payment industry today announced its strategic partnership with Connance, a ... workflows. , The two companies’ proven, proprietary technology combine to provide health ...
(Date:6/27/2016)... ... June 27, 2016 , ... A revolution is underway. ... transport experience for the millions of people who require these medical transport services ... industry through the use of technology. Now, SmartEMS has put forth an industry-changing ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... DUBLIN , June 24, 2016 ... and Markets has announced the addition of the ... their offering. ... products and provides an updated review, including its applications ... covering the total market, which includes three main industries: ...
(Date:6/24/2016)... Calif. , June 24, 2016  American Respiratory Labs (ARL), ... is now able to perform sophisticated lung assessments in patients, homes, ... , Inc. Patients are no longer limited to ... EasyOne PRO ® , ARL patients like Jeanne R. of ... in the comfort of her own home. ...
(Date:6/24/2016)... Belgium , June 24, 2016 ... today announced the appointment of Dr. Edward ... as a Non-Executive Director, effective June 23, 2016.Dr. ... Compensation and Nominations and Governance Committees.  As a ... will provide independent expertise and strategic counsel to ...
Breaking Medicine Technology: