Navigation Links
Digoxin may be a possible treatment for prostate cancer
Date:4/2/2011

ORLANDO, Fla. Scientists have identified digoxin as a possible therapy for prostate cancer, using a combination of laboratory science and epidemiology that is unprecedented in its cooperative nature.

"Epidemiologists and basic scientists often do not understand each other, as we often are only clear on our own strengths and the other's weaknesses," said Elizabeth Platz, Sc.D., M.P.H, professor of epidemiology and the Martin D. Abeloff, M.D., scholar in cancer prevention at Johns Hopkins University.

For the current paper, published in Cancer Discovery, the newest journal of the American Association for Cancer Research, which will debut at the AACR 102nd Annual Meeting 2011, Platz shares authorship with Srinivasan Yegnasubramanian, M.D., Ph.D., assistant professor of oncology at Johns Hopkins. Platz said the multidisciplinary team of scientists had come together to identify existing drugs that could be used to treat prostate cancer in a process called drug repositioning.

"If you use drugs that are already available then you have a long history of safety research that does not necessarily need to be redone, and we can move more quickly to testing whether the drug will actually work in a new setting," said Platz.

The idea of drug repositioning has been offered before, but each branch of scientific inquiry had enough flaws that it had not previously gained substantial traction. "When we combined the basic science and the epidemiology approaches, the flaws were not the same and were covered by their respective strengths," she said.

Platz, Yegnasubramanian and colleagues from Johns Hopkins and Harvard combined a high-throughput laboratory-based screen and a large, prospective cohort study.

In the first stage, the laboratory scientists conducted an in vitro prostate cancer cell toxicity screen of 3,187 compounds, and digoxin, a known heart failure drug emerged as a leading candidate due to its potency in inhibiting cell proliferation in vitro.

In the second stage, the epidemiology team observed the drug's use in a cohort of 47,884 men who were followed from 1986 to 2006. Regular digoxin users had a 24 percent lower risk of prostate cancer, while those who had used the drug for more than 10 years had a 46 percent reduced risk.

Platz said this multidisciplinary team is now working toward identifying the pathways digoxin targets in prostate cancer. Knowing the targets will help inform the design of a trial that will confirm whether digoxin or molecules acting on the same targets has utility as a prostate cancer treatment.


'/>"/>

Contact: Jeremy Moore
Jeremy.Moore@aacr.org
267-646-0557
American Association for Cancer Research
Source:Eurekalert

Related medicine news :

1. Freezing Wrinkles a Possible Alternative to Botox
2. Remove childrens catheters as soon as possible to prevent bloodstream infections
3. FDA Panel Examines Possible Links Between Food Dyes, ADHD
4. Researchers find possible clues to tamoxifen resistance in breast cancer patients
5. A possible new target for treatment of multiple sclerosis
6. A safer, more effective morphine may be possible with Indiana University discovery
7. Scientists ID possible biomarker to gauge Alzheimers prognosis, effect of therapies
8. Researchers discover possible biomarker and therapeutic target for melanoma
9. Accurate measurement of radioactive thoron possible at last
10. Nature Reviews Cancer article traces possible role of damaged DNA in tumor development
11. Potassium levels possible key to racial disparity in Type 2 diabetes
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/9/2016)... ... ... Cellairis is a worldwide mobile device and computer repair franchise that is ... and Samsung Galaxy devices with premium parts and accessories. Cellairis has recently set-up for ... for customers. While customers do their shopping, Cellairis can accomplish a number of mobile ...
(Date:12/9/2016)... ... ... An inventor from Cana, Va., wanted to fulfill the need for a ... , The patent-pending SAFETY STRAP FOR AMPUTEES improves accessibility. It eliminates discrimination. It is ... in a matter of minutes, or even seconds. The SAFETY STRAP FOR AMPUTEES is ...
(Date:12/9/2016)... ... December 09, 2016 , ... The ... Cable Network (PCN) during the summer of 2016. The program was made possible ... the United States Department of Health and Human Services Administration. The broadcast, ...
(Date:12/8/2016)... ... December 08, 2016 , ... ... announce that “Natural Language Processing–Enabled and Conventional Data Capture Methods for Input to ... Medical Informatics . , Results of the comparative usability study demonstrate that a ...
(Date:12/8/2016)... ... ... David J. Dykeman , Ginger Pigott , and J. Rick Taché ... Dec. 12, 2016, at the Fairmont Newport Beach in California. Greenberg Traurig is a ... & Medical Technology Group have been featured speakers at every DeviceTalks conference since 2011. ...
Breaking Medicine News(10 mins):
(Date:12/8/2016)... 2016 KEY FINDINGS ... Patient warming and cooling ... during surgeries, lowering the risks of neurological disorders post cardiac ... The patient warming systems can be segmented into convective warming ... turn reduce the stay at hospitals thus, lowering the healthcare ...
(Date:12/8/2016)... KEY FINDINGS The global medical ... Various reasons for growth of the medical lifting sling ... chronic diseases, high recovery cost of injuries and government ... lifting sling refers to an assistive device that helps ... connect to the lift and hold the patient. It ...
(Date:12/8/2016)... Allergy Diagnostics Market: Scope and Methodology ... are used to determine the presence of allergens ... etc. in the samples by determining the presence ... report on global allergy diagnostics market, analyzes the ... report consists of an executive summary that provides ...
Breaking Medicine Technology: