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Digital PCR technology detects brain-tumor-associated mutation in cerebrospinal fluid
Date:7/23/2013

nnecessary procedure, could save costs. We still have a long way to go to improve survival of these malignancies, so every improvement we can make is valuable."

Breakefield is a professor of Neurology at Harvard Medical School, where Hochberg is an associate professor and Balaj a research fellow, also in Neurology. Walter Chen, MGH Neurology, is also co-lead author of the Molecular Therapy Nucleic Acid paper. Additional co-authors are Casey Maguire, Li Dan Zhu, and Sarada Sivaraman, MGH Neurology; Linda Liau, Horacio Soto, and Matthew Garrett, University of California, Los Angeles; Michael Samuels and Steven Kotsopoulos, RainDance Technologies; Lori LoGuidice and Johan Skog, Exosome Diagnostics; Clark Chen and Eric Wong, Beth Israel Deaconess Medical Center; and Bob Carter, University of California, San Diego.

The MGH has applied for a patent on the use of BEAMing PCR to analyze RNA from extracellular vesicles. The technology used to isolate tumor-associated molecules from extracellular vesicles, originally developed at the MGH, has been licensed to Exosome Diagnostics. RainDance Technologies markets the Droplet Digital PCR used in this study. Support for the study includes National Institutes of Health grants CA069246, CA141226, CA156009 and CA141150 and grants from the Brain Tumor Funders' Collaborative and the American Brain Tumor Association.


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Contact: Sue McGreevey
smcgreevey@partners.org
617-724-2764
Massachusetts General Hospital
Source:Eurekalert

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