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Digestive experts grade treatment options for inflammatory bowel disease
Date:4/7/2011

f the strength and quality of the evidence."

"While many review articles, including systematic reviews, have been published on therapy for IBD, the ACG Task Force represents the most rigorous attempt to date to synthesize all of the available evidence in an unbiased fashion. I believe it will prove an invaluable guide for clinicians and investigators," commented Nicholas J. Talley, M.D., Ph.D., FACG, who chaired the ACG IBD Task Force.

"ACG's goal was to highlight the wealth of randomized controlled trial data that can guide the clinician in the medical management of IBD," explained Delbert L. Chumley, M.D, FACG, President of the American College of Gastroenterology.

Highlights of ACG's New Recommendations on IBD Therapies

A summary of the evidence-based recommendations appears in the monograph in a series of Tables, 2 through 5.

Summary of Epidemiological Evidence Offers Fascinating Hypotheses for IBD's Causes

An estimated 1.5 million Americans suffer from UC and CD. Geography is a factor in the incidence of CD. There is a North-South gradient with a strong correlation between degrees latitude and CD incidence when the Western Hemisphere and Western Europe are evaluated. This North-South gradient also exists in the United States, with CD being less common in the South. While a similar epidemiological pattern exists for UC, the North-South gradient is not as pronounced according to the findings presented.

Those with certain immune function predispositions are more like to develop IBD, and the most likely candidate may reside within the gut microbiome, with changes in the gut flora associated with increased risk of IBD in two studies. Dietary factors are also associated with the emergence of IBD, particularly in countries where industrialization has lead to a change in eating patterns and types of foods consumed. One culprit consistently associated with CD is a diet high in refined sugar
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Contact: Jacqueline Gaulin
mediaonly@acg.gi.org
301-263-9000
American College of Gastroenterology
Source:Eurekalert

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