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Diffusion Pharmaceuticals Announces Results of Phase I Human Trial of Lead Drug Candidate, Trans Sodium Crocetinate (TSC) and Completion of a $4.5 Million Private Placement
Date:9/28/2007

including impact on patient survival, when combined with radiation therapy. These clinical trials will be sponsored by Diffusion Pharmaceuticals LLC, and conducted in collaboration with The Johns Hopkins University School of Medicine and the New Approaches to Brain Tumor Therapy (NABTT) Central Nervous System (CNS) Consortium.

Dr. Stuart Grossman, Director of Clinical and Laboratory Neuro-Oncology Programs at Johns Hopkins and project leader for NABTT said, "TSC's novel mechanism of action provides a whole new approach to enhancing radiation therapy. We are excited by its prospects and intend to start clinical trials in patients with primary brain tumors as soon as possible."

In addition, the company is planning a clinical trial in peripheral vascular disease patients suffering from intermittent claudication (i.e., intense leg pain while walking) to evaluate the effect of TSC on tissue oxygenation in these patients using a standardized treadmill test. Site selection for this study is currently underway.

Diffusion Pharmaceuticals' pipeline of first-in-class small molecules uses a novel mechanism of action allowing more oxygen to reach oxygen-deprived (hypoxic) tissues in the body. The diffusion of oxygen through blood plasma and into tissue is a critical step in delivering oxygen to hypoxic tissue; Diffusion Pharmaceuticals' drugs affect this process. In preclinical studies, TSC has been shown to increases the rate of oxygen diffusion by about 30 percent. TSC has been shown in animal models to increase the diffusion of oxygen into hypoxic cancerous tumor tissue, making the cancer more susceptible to radiation therapy and increasing survival. In addition, animals suffering severe blood loss have a higher rate of survival if treated with TSC.

The ability to enhance oxygen diffusion into hypoxic tissue represents a transformative technology, with potentially far-ranging implications for human health and the practice of medicine. Diffusion Pharmac
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SOURCE Diffusion Pharmaceuticals LLC
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