Navigation Links
Different subtypes of triple-negative breast cancer respond to different therapies
Date:6/27/2011

Vanderbilt-Ingram Cancer Center researchers have identified six subtypes of an aggressive and difficult-to-treat form of breast cancer, called "triple-negative breast cancer (TNBC)."

In the July issue of the Journal of Clinical Investigation, Cancer Center Director Jennifer Pietenpol, Ph.D., and colleagues describe the molecular features of these six distinct subtypes and identify chemotherapies to which the different subtypes respond in cultured cells and animal tumor models. Knowing the specific subtype could help physicians determine which therapies would work best in patients with TNBC and also inform the discovery and development of new drugs to treat this aggressive form of breast cancer, the authors suggest.

Triple negative breast cancers (TNBC) account for 10 percent to 20 percent of all breast cancers and tend to be more aggressive than other types of breast cancer.

"It's a pretty significant health problem from the standpoint that 11 percent of Caucasians, 17 percent of Hispanics, and 25 percent of African-Americans have this type of breast cancer," Pietenpol said.

While some patients with TNBC initially respond well to standard chemotherapy, these tumors are more likely to recur after treatment and have a poorer prognosis (less than 30 percent of women with metastatic TNBC which has spread outside the breast survive 5 years).

The difficulty in treating these tumors stems from what they lack.

The term "triple-negative breast cancer," explained Pietenpol, "is just a definition of what (the cancer) isn't."

TNBC tumors lack the estrogen receptors (ER) and progesterone receptors (PR) that drive the majority (about 60 percent) of breast cancers. They also show no amplification of another receptor, called HER2, which drives about 20 percent to 30 percent of breast cancers.

The absence of these receptors means that the tumors are unlikely to respond to hormone therapies like tamoxifen and to therapies ta
'/>"/>

Contact: Dagny Stuart
dagny.stuart@Vanderbilt.Edu
615-322-4747
Vanderbilt University Medical Center
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Reading Arabic or English May Tax Brain Differently
2. Study finds much different work histories for disability rejects, beneficiaries
3. Breast Cancer Recurrence Rates Appear Different When Radiation Used
4. Vitamin D deficiency is associated with different types of obesity in black and white children
5. Signaling pathway reveals mechanism for B cell differentiation in immune response
6. Men and Women May Truly See Things Differently
7. Two Different Heart Drugs May Work Equally Well for High-Risk Patients
8. Many Moms Have Kids With Different Dads, U.S. Study Finds
9. Different genes influence smoking risk during adolescence and adulthood
10. Surviving Melanoma May Take Different Toll on Women, Men
11. Women with eating disorders draw a different picture of themselves than women without
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/22/2015)... 2015 Joan Lunden, award-winning American journalist, ... the upcoming 32nd Annual Miami Breast Cancer Conference ... Resource®, LLC (PER®) , shares that “a fast-growing, virulent” ... if she had not followed up her clean mammogram ...
(Date:1/22/2015)... Calif. (PRWEB) January 22, 2015 ... Susan Bonilla (D-Concord) and Kristin Olsen (R-Modesto) were ... their leadership in advancing biotechnology, biomedical science, medical ... and Olsen each received the “2014 Life Sciences ...
(Date:1/22/2015)... IsoComforter, Inc. has introduced the most innovative and easy ... treat specific body parts and muscle groups. , IsoComforter, ... use patented cold therapy machine with the innovative IsoTube design ... injuries. IsoComforter has become the industry leader in cold ...
(Date:1/22/2015)... January 22, 2015 Payday lending practices ... communities and cause financial distress to the states that ... at Howard University’s Center on Race and Wealth. , ... economic activity, payday loans at the same time substantially ...
(Date:1/22/2015)... 22, 2015 As interest in the value ... gains momentum worldwide, Rev. Eric J. Hall , president ... (HCCN), will be the keynote speaker on January 27 ... public health system. , The conference, “Hope and Resilience: Innovative ...
Breaking Medicine News(10 mins):Health News:Joan Lunden Reveals Diagnostic Approach That Led To Early Detection;To Keynote 32nd Annual Miami Breast Cancer Conference® 2Health News:Joan Lunden Reveals Diagnostic Approach That Led To Early Detection;To Keynote 32nd Annual Miami Breast Cancer Conference® 3Health News:Joan Lunden Reveals Diagnostic Approach That Led To Early Detection;To Keynote 32nd Annual Miami Breast Cancer Conference® 4Health News:Joan Lunden Reveals Diagnostic Approach That Led To Early Detection;To Keynote 32nd Annual Miami Breast Cancer Conference® 5Health News:Joan Lunden Reveals Diagnostic Approach That Led To Early Detection;To Keynote 32nd Annual Miami Breast Cancer Conference® 6Health News:California Biomedical Community Honors Senator Holly Mitchell, Assemblymembers Susan Bonilla & Kristin Olsen 2Health News:California Biomedical Community Honors Senator Holly Mitchell, Assemblymembers Susan Bonilla & Kristin Olsen 3Health News:IsoComforter Introduces Best of Class Cold Therapy Product to the Worldwide Market 2Health News:Howard University Spotlights the Economic Impact of Payday Lending in Southern States 2Health News:HealthCare Chaplaincy CEO to Keynote Spiritual Care Summit in Israel 2Health News:HealthCare Chaplaincy CEO to Keynote Spiritual Care Summit in Israel 3
... Implemented to Make Health Care More Accessible ... Members Displaced by Hurricane Gustav, DALLAS, Sept. 2 ... Cross and Blue Shield of,Texas (BCBSTX) announced several actions to ... the impact of Hurricane Gustav was less than,originally anticipated and ...
... suggests , , TUESDAY, Sept. 2 (HealthDay News) -- Suicides among ... 15-year decline, and the trend may owe, in part, to ... Researchers thought a spike in youth suicides in 2004 may ... increase in suicides continued during 2005. , Looking at suicide ...
... of obese adults will develop painful osteoarthritis of the knee ... North Carolina at Chapel Hill suggests. , The study also ... mass index or BMI increased, with the greatest risk found ... were overweight or obese at 45 or older. , "These ...
... A new study shows that the innate immune system ... to airway inflammation, chronic rhinosinusitis and bronchial asthma. Researchers ... have revealed that eosinophils, a particular type of white ... environmental fungus Alternaria alternata . The groundbreaking findings, ...
... on Medicare to Expedite Mandatory Accreditation,Adopt Clearer ... The Power Mobility,Coalition (PMC), an association of ... concerns today about recent findings that,questioned whether ... (CMS),accurately reviewed durable medical equipment (DME) claims ...
... Celebrity Allergy Sufferer Finola Hughes Offers Tips to ... autumn approaches and days cool,down, folks begin preparing ... (Photo: http://www.newscom.com/cgi-bin/prnh/20080902/NETU094 ), For the ... and,asthma, the warmth of home may be anything ...
Cached Medicine News:Health News:Blue Cross and Blue Shield of Texas Prepared to Assist Members Affected by Hurricane Gustav 2Health News:Blue Cross and Blue Shield of Texas Prepared to Assist Members Affected by Hurricane Gustav 3Health News:Youth Suicides Continue to Rise in U.S. 2Health News:Youth Suicides Continue to Rise in U.S. 3Health News:Nearly half of US adults will develop painful knee osteoarthritis by age 85: study 2Health News:Innate immune system targets asthma-linked fungus for destruction 2Health News:Innate immune system targets asthma-linked fungus for destruction 3Health News:Power Mobility Coalition Voices Concern Over Government Reports Outlining Lack of Oversight in the Medicare Durable Medical Equipment Benefit 2Health News:Power Mobility Coalition Voices Concern Over Government Reports Outlining Lack of Oversight in the Medicare Durable Medical Equipment Benefit 3Health News:How To Allergy-Proof Your Home For Fall 2Health News:How To Allergy-Proof Your Home For Fall 3
(Date:1/23/2015)... 23, 2015  Northwest Biotherapeutics, Inc. (NASDAQ: NWBO )("NW ... for operable and inoperable solid tumor cancers, announced today that ... th Annual Phacilitate Immunotherapy Forum in Washington ... will take place on January 26 at 10:30 a.m. EST ...
(Date:1/23/2015)... Jan. 23, 2015 /PRNewswire/-- Harwood Feffer LLP ( www.hfesq.com ) ... of Advaxis, Inc. ("Advaxis" or the "Company") (NASDAQ: ... its fiduciary duties to shareholders. On January ... website reporting that Advaxis had misrepresented the clinical data ...
(Date:1/23/2015)... 23, 2015  iMD Companies, Inc. (ICBU) has repositioned itself as ... and grab a foothold in the hydroponic, hemp and medical ... a presence in the sector, and recently partnering with the ... hemp and medical marijuana, iMD is committing to bring its ...
Breaking Medicine Technology:NW Bio To Present At The 7th Annual Phacilitate Immunotherapy Forum 2NW Bio To Present At The 7th Annual Phacilitate Immunotherapy Forum 3Harwood Feffer LLP Announces Investigation of Advaxis, Inc. 2iMD Companies Poised to Make Impact in Multi-Billion Dollar Medical Marijuana Sector With Recent Investments and Strategic Partnerships 2
... have identified mutations in a gene that predict a high ... Although the researchers caution that further research is needed to ... or IKAROS, lead to leukemia relapse, the findings ... to assess the risk of treatment failure. By using a ...
... Tiantan Puhua Hospital Stem Cells Center ( http://www.stemcellspuhua.com ... to effectively treat neurological disorders, announced today six ... research staff that significantly expand the hospital,s treatment ... The six senior doctors include the distinguished Dr. ...
Cached Medicine Technology:Gene Abnormality Found to Predict Childhood Leukemia Relapse 2Gene Abnormality Found to Predict Childhood Leukemia Relapse 3Gene Abnormality Found to Predict Childhood Leukemia Relapse 4Gene Abnormality Found to Predict Childhood Leukemia Relapse 5Gene Abnormality Found to Predict Childhood Leukemia Relapse 6Stem Cell Treatment Leader Tiantan Puhua Adds Experienced International Medical Staff for Expanding Numbers of Patients 2Stem Cell Treatment Leader Tiantan Puhua Adds Experienced International Medical Staff for Expanding Numbers of Patients 3
... Only Heartlab delivers the performance ... cardiovascular information management systems. As ... and services set the benchmark. ... functionality, high-speed performance and technological ...
The only catheter designed specially for visualization of peripheral vessels: carotids, renals, and illiacs...
... Harmonic Echo technology constructs images ... far less artifacts and noise than ... a technology to transmit distortion-free, fundamental-frequency ... ultrasound beam is a pure sinusoidal ...
AngioSpeed V series, it is an Angiography system designed for vascular treatment in various radiological regions, cardiology, and neurology. SHIMADZU brings you a single system with all units fused t...
Medicine Products: