Navigation Links
Different signaling pathways of cholangiocarcinoma
Date:3/4/2010

Cholangiocarcinoma (CCA), a bile duct cancer, is one of the major cancers in Northeast Thailand. This cancer is difficult to diagnose and has high metastatic and mortality rates. Overexpression of Met, a hepatocyte growth factor (HGF) receptor, has frequently been found in CCA and is correlated with progression of this type of cancer. HGF/Met activation induces a variety of cellular processes, including cell scattering, invasion and proliferation. Although a number of studies have been reported regarding the correlation between Met expression and CCA, the molecular mechanisms by which HGF induces CCA invasion are not completely understood.

A research article published on February 14, 2010 in the World Journal of Gastroenterology addresses this question. The research team led by Dr. Suthiphongchai T from Mahidol University used two CCA cell lines overexpressing Met, KKU-M213 and HuCCA-1, to study the role of Met in CCA invasion by activating the Met pathway with HGF. HGF strongly induced invasion and motility of the two CCA cell lines and concomitantly altered E-cadherin localization from membrane to cytosol, but did not affect the levels of secreted MMP-2, MMP-9 or uPA.

Signaling pathways responsible for HGF-induced invasion were further investigated. HGF induced ERK and PI3K/Akt pathways of both CCA cell lines but with different kinetic profiles. HGF induced sustained ERK activation in the KKU-M213 cell line, but transient ERK activation in HuCCA-1 cells. Using specific inhibitors of PI3K and ERK pathways, it was shown that HGF-induced invasion of KKU-M213 was strongly inhibited by both inhibitors, while that of HuCCA-1 was strongly inhibited by PI3K inhibitor but only weakly inhibited by ERK inhibitor. Thus, the signaling pathways responsible for HGF-induced invasiveness of the two CCA cell lines were different, in that PI3K pathway was common for both cell lines, whereas the role of ERK1/2 was likely to be dependent on the duration
'/>"/>

Contact: Jin-Lei Wang
wjg@wjgnet.com
86-105-908-0039
World Journal of Gastroenterology
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Brain cells work differently than previously thought
2. Different method of evaluating the urinary tract system reduces radiation dose
3. Different HIV rates among gay men and straight people not fully explained by sexual behavior
4. Abaxis Launches The VetScan(R) HM5 a State-of-the-Art 5-Part Differential Veterinary Hematology Analyzer
5. Sense of taste different in women with anorexia nervosa
6. Babies raised in bilingual homes learn new words differently than infants learning one language
7. Children would need different medical care in wake of dirty bomb
8. Penn researchers use brain imaging to demonstrate how men and women cope differently under stress
9. Different anticoagulant regimens yield equal results
10. UCLA study shows different areas of the brain respond to belief, disbelief and uncertainty
11. Forever young: Differentiation blocked in tumor stem cells
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/22/2014)... August 22, 2014 The New Jersey ... at Rutgers, the State University of New Jersey has ... children’s media organization, to educate young people about health ... on the strengths of both organizations. , The partnership ... health communications fellowship program, and video communications. ChopChop ...
(Date:8/22/2014)... Dennis Thompson ... News) -- The two American health-care workers infected with ... in West Africa have been released from the Atlanta ... weeks, officials said Thursday. Dr. Kent Brantly, 33, ... Nancy Writebol left the hospital Tuesday. Her family said ...
(Date:8/22/2014)... The leather seat covers provided by Lseat.comare meticulously ... customers’specific product needs. Recently, the company has unveiled its latest ... The company wants to provide worldwide clients with more high ... industry for a long time. According to the company’s sales ... rates. Among all the new products, Chevrolet Camaro leather ...
(Date:8/22/2014)... (PRWEB) August 22, 2014 Lincolnshire Marriott ... their meetings with a tap, announcing Marriott’s new iPad ... take advantage of this exclusive offer will receive a ... and set up the day’s agenda with ease. Marriott’s ... make on-the-fly changes and connect with their group with ...
(Date:8/22/2014)... 22, 2014 Minorities in Orange and Los ... comes to mental health and recovery from trauma. Casa de ... the gap between local minorities and the help they need. ... by making the connection between mental and physical health. , ... at their fitness boot camp, located at 16560 Harbor Blvd., ...
Breaking Medicine News(10 mins):Health News:New Jersey Institute for Food, Nutrition & Health to Launch Innovative Partnership with Award-Winning Children’s Anti-Obesity Organization, ChopChop Kids 2Health News:New Jersey Institute for Food, Nutrition & Health to Launch Innovative Partnership with Award-Winning Children’s Anti-Obesity Organization, ChopChop Kids 3Health News:Both U.S. Health-Care Workers Infected With Ebola Released From Hospital 2Health News:Both U.S. Health-Care Workers Infected With Ebola Released From Hospital 3Health News:Custom 1993-1996 Chevrolet Camaro Leather Seat Covers Now for Sale at Lseat.com 2Health News:Lincolnshire Marriott Resort Offers iPad Mini for Chicago Meeting Planners 2Health News:Fountain Valley Fit Body Boot Camp Announces Fitness Boot Camp Fundraising Event for Casa de Familia 2Health News:Fountain Valley Fit Body Boot Camp Announces Fitness Boot Camp Fundraising Event for Casa de Familia 3
... to get the right information about product,risks and ... MEETING, Pa., June 4 ECRI,Institute, (http://www.ecri.org ... approaches to improving patient care, has enhanced its,Alerts ... coverage of healthcare products and new alert filters., ...
... 4 Unilens Vision Inc. (OTC,Bulletin Board: ... manufactures, distributes and markets specialty contact lenses,today ... Unilens GP (Gas Permeable),products., Unilens, known ... Lens,Company", continues its tradition of providing outstanding ...
... MOUNTAINSIDE, N.J., June 4 L&M Healthcare,Communications LLC, ... of a new full-service Midwest office in Milwaukee,Wis. ... President, Client Services., These enhancements allow L&M ... meet the needs of their growing client,portfolio. Todd ...
... WASHINGTON, June 4 As talk of ... sales bring up,worries about the nation,s economic health, ... are stressed and anxious about,their financial future. An ... that,two-thirds (66 percent) of Americans identify the economy ...
... AstraZeneca (NYSE: AZN) today announced that it submitted ... Food and Drug Administration (FDA) for approval of a ... for the long-term maintenance treatment of asthma in pediatric ... currently approved for the long-term maintenance treatment of asthma ...
... in two health surveys carried out a year apart admitted ... latest Journal of Advanced Nursing. , Thirteen per cent admitted ... a further five per cent reported problems in both surveys. ... to report multiple psychological problems and health complaints. , ...
Cached Medicine News:Health News:ECRI Institute's Alert and Recall Management System Expands Effectiveness with New Content and Filters 2Health News:Unilens Vision Announces New Policies Aimed at Increasing Eye Care Professionals Profitability 2Health News:L&M Healthcare Communications LLC Expands With Hiring of New Executive Staff & Opening of Midwest Office 2Health News:Economy and Money Top Causes of Stress for Americans 2Health News:Economy and Money Top Causes of Stress for Americans 3Health News:AstraZeneca submits an sNDA for Symbicort for treatment of asthma in children as young as 6 2Health News:Nearly 1 in 5 teenagers admit eating problems, but anxiety is a bigger problem than appearance 2
(Date:8/22/2014)... 2014  - MediaLINC ... Today Lincor announced general availability of MediaLINC ... a range of education, entertainment and clinical content direct ... http://photos.prnewswire.com/prnh/20140822/702945) , " Lincor has ... patient engagement to bedside smart devices, " comments ...
(Date:8/22/2014)... , Aug. 22, 2014  Landauer, Inc. (NYSE: ... environmental radiation measurement and monitoring, outsourced medical physics services ... William E. Saxelby , its President and Chief ... Chief Executive Officer and as a member of the ... He will be replaced on an interim basis by ...
(Date:8/22/2014)... , Aug. 22, 2014  WaferGen Bio-systems, Inc. ... public offering of units of common stock and warrants ... proceeds of $20 million, prior to deducting underwriting discounts ... The shares and warrants are immediately separable and will ... expected to begin trading on The NASDAQ Stock Market ...
Breaking Medicine Technology:Lincor Unveils Next Generation TV-based Patient Engagement Solution 2Landauer, Inc. Announces Executive Management Change 2WaferGen Bio-Systems Announces Pricing of $20 Million Underwritten Offering and Uplisting to NASDAQ 2WaferGen Bio-Systems Announces Pricing of $20 Million Underwritten Offering and Uplisting to NASDAQ 3WaferGen Bio-Systems Announces Pricing of $20 Million Underwritten Offering and Uplisting to NASDAQ 4
... Dec. 29, 2010 Reportlinker.com announces that a new ... Mammography World Markets ... poised for a major new phase of growth fueled ... the computer and digital areas and the higher interest ...
... (Nasdaq: OMER ), a biopharmaceutical company ... on inflammation and disorders of the central nervous ... clinical trial of OMS201, the Company,s urological PharmacoSurgery™ ... an anti-inflammatory agent and a smooth muscle relaxant, ...
Cached Medicine Technology:Reportlinker Adds Mammography World Markets 2Omeros Announces Positive Clinical Results of OMS201 in Patients Undergoing Ureteroscopy 2Omeros Announces Positive Clinical Results of OMS201 in Patients Undergoing Ureteroscopy 3
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
Medicine Products: