Navigation Links
Different mutations in single gene suggest Parkinson's is primarily an inherited genetic disorder
Date:4/16/2008

JACKSONVILLE, Fla. Two new international studies by researchers at the Mayo Clinic site in Florida are rounding out the notion that Parkinsons disease is largely caused by inherited genetic mutations that pass through scores of related generations over hundreds, if not thousands of years. These genetic influences, which can be small but additive, or large and causative, overturn common beliefs that the neurodegenerative disease mostly occurs in a random fashion or is due to undetermined environmental factors.

These latest studies bring the total of number of disease-related mutations in an as yet poorly understood gene, leucine-rich repeat kinase 2 (LRRK2), to seven, all of which are linked, either weakly or strongly, to typical, late onset development of Parkinsons disease in people around the world. One mutation (R1628P) doubles the risk of Parkinsons disease in ethnic Chinese, according to a study published on Wednesday, April 16, 2008 in the online edition of the Annals of Neurology. The second study, published April 15 in Neurology, demonstrates that another very rare mutation (R1441C), found in people on three continents, increases risk by more than 10-fold.

The R1628P was identified by the strong collaborative effort of researchers from Taiwan, Singapore, Japan, and the U.S. The research institutions included the National Taiwan University Hospital, led by Dr. Ruey-Meei Wu, Chang Gung Memorial Hospital led by Dr. Yih-Ru Wu, National Neuroscience Institute of Singapore led by Dr. Eng-King Tan and Juntendo University, led by Dr. Nobutaka Hattori. This group believes the R1628P mutation arose from a single individual in the Han Chinese population about 2,500 years ago and has since spread through generations of descendants, wherever they live. This is the second common LRRK2 mutation discovered in Asians a mutation labeled G2385R believed to have originated 4,500 years ago was first reported in the journal Neurogenetics in 2006 and subseq
'/>"/>

Contact: Cynthia Nelson
nelson.cynthia1@mayo.edu
904-953-2299
Mayo Clinic
Source:Eurekalert

Page: 1 2 3 4 5

Related medicine news :

1. Clinical trial volunteers mostly indifferent -- but not blind to -- researchers financial conflicts
2. Are teenage brains really different?
3. Emergency on-field treatment for neck injuries in young sports athletes no different than adults
4. Study Reveals Emergency On-Field Treatment for Neck Injuries in Young Collision Sports Athletes No Different Than Adults
5. When it comes to emotions, Eastern and Western cultures see things very differently: Study
6. Lumping different countries together -- why the 2008 EPI is of limited use
7. Treating acne: 2 different acid peels are both effective, study finds
8. Bug guts map brings scientists closer to understanding different bugs role in the body
9. Do Jerusalems Arabs and Jews receive a different quality of medical care?
10. Melanomas may appear noticeably different than other moles
11. Different Neural Pathways at Work Going Under, Coming Out of Anesthesia
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/1/2015)... NTOCC today launches the Knowledge & ... that seek to improve care transitions and positively impact ... to bring light to tools or resources that align ... the healthcare industry through the promotion of public policy, ... Following that vision, the Knowledge & Resource Center serves ...
(Date:4/1/2015)... After a particularly harsh winter, many roads ... lead to costly damage, so Amica Insurance has ... the following suggestions from AAA: , , ... inflated to the manufacturer’s recommended levels. , ... and uneven tire wear can be signs of bad shocks ...
(Date:4/1/2015)... April 01, 2015 The Pennsylvania Court ... lawsuits ( http://www.risperdallawsuit2014.com/ ) has scheduled a meeting ... the Philadelphia Court of Common Pleas, the meeting will ... Hall. Court records indicate that the proceeding will address ... of Risperdal users who experienced gynecomastia (male breast growth) ...
(Date:4/1/2015)... (PRWEB) April 01, 2015 EAGAN, Minn. ... Minnesota and its family of companies (Blue Cross) today ... out the year with net income of $61.5 million, ... losses. The organization reported a net operating loss of ... a negative operating margin of one-tenth of one percent ...
(Date:4/1/2015)... Parents of teenaged and adolescent children ... the latest post discusses Teen Violence Related to Substance ... Dating Violence Awareness Month, the substance abuse treatment center ... help parents identify if there may be problems with ... drugs or alcohol. , “People learn how to establish ...
Breaking Medicine News(10 mins):Health News:National Transitions of Care Coalition Launches Knowledge & Resource Center 2Health News:National Transitions of Care Coalition Launches Knowledge & Resource Center 3Health News:Prepare for potholes with 7 tips from Amica Insurance 2Health News:Pennsylvania Court Overseeing Hundreds of Risperdal Lawsuits Schedules April Meeting 2Health News:Pennsylvania Court Overseeing Hundreds of Risperdal Lawsuits Schedules April Meeting 3Health News:Blue Cross and Blue Shield of Minnesota Reports 2014 Results 2Health News:Blue Cross and Blue Shield of Minnesota Reports 2014 Results 3Health News:Best Drug Rehabilitation Issues Toolkit for Teen Violence Related to Substance Abuse 2
... ... Saunders for Chairman of the President,s Council on Physical Fitness & Sports ... will be held February 10 at 2:35 PM on the Senate Floor ... appointment to chairman of the President,s Council on Physical Fitness & Sports ...
... ... On WaveMaker Cloud Development Platform and Amazon EC2 , ... San Francisco, CA (PRWEB) -- WaveMaker Software™, the ... using WaveMaker and Amazon EC2. This application makes malaria research data available through a ...
... researchers say , , MONDAY, Feb. 8 (HealthDay News) ... and the antidepressant Paxil may increase their risk of ... , "Paxil can deprive women of the benefit of ... tamoxifen for a long time," said lead researcher Dr. ...
... , Feb. 8 Since 2003, Amway has mobilized ... better lives for children in need. , Now in its ... Children has improved the lives of an estimated 7 million children ... global impact. , Employees and distributors alike have volunteered more ...
... Ewing sarcoma: potential new drug target? Ewing ... that affects children and young adults. The protein CD99 is ... in the disease is unknown. Now, Katia Scotlandi and colleagues, ... have identified a crucial role for CD99 in the development ...
... occurs in the corneas of mountain climbers, but does ... to 6,300 meters (about 20,670 feet), according to a ... Ophthalmology, one of the JAMA/Archives journals. "High-altitude ... the authors write as background information in the article. ...
Cached Medicine News:Health News:Senator Janis Lee Sponsors Senate Resolution Supporting Kevin Saunders for Chairman of the President's Council on Physical Fitness & Sports 2Health News:Senator Janis Lee Sponsors Senate Resolution Supporting Kevin Saunders for Chairman of the President's Council on Physical Fitness & Sports 3Health News:Senator Janis Lee Sponsors Senate Resolution Supporting Kevin Saunders for Chairman of the President's Council on Physical Fitness & Sports 4Health News:MARA Fights Malaria With WaveMaker and Amazon Web Services 2Health News:MARA Fights Malaria With WaveMaker and Amazon Web Services 3Health News:MARA Fights Malaria With WaveMaker and Amazon Web Services 4Health News:Paxil Blocks Tamoxifen, Lowers Survival Odds Against Breast Cancer 2Health News:Paxil Blocks Tamoxifen, Lowers Survival Odds Against Breast Cancer 3Health News:Amway One by One Campaign for Children Reaches 7 Million Kids 2Health News:Amway One by One Campaign for Children Reaches 7 Million Kids 3Health News:JCI online early table of contents: Feb. 8, 2010 2Health News:JCI online early table of contents: Feb. 8, 2010 3Health News:JCI online early table of contents: Feb. 8, 2010 4Health News:JCI online early table of contents: Feb. 8, 2010 5Health News:JCI online early table of contents: Feb. 8, 2010 6Health News:High-altitude climbs may cause corneal swelling, but do not appear to affect vision 2
(Date:4/1/2015)... 1, 2015 Trinity Biotech plc (Nasdaq: ... of diagnostic products for the point-of-care and clinical ... Limited, its wholly-owned subsidiary (the "Issuer"), intends to ... million aggregate principal amount of Exchangeable Senior Notes ... institutional buyers pursuant to Rule 144A under the ...
(Date:4/1/2015)... 1, 2015  Pittman Motors has significantly expanded ... PLG42K, PLG42S, PLG52, and PLG63 planetary gearboxes. These ... brushless DC motors and complement Pittman,s existing spur ... 35 standard motor-gearbox family combinations to the Pittman ... high torque loads with excellent efficiency and are ...
(Date:4/1/2015)... MOUNTAIN VIEW, Calif. , April 1, ... ) announces that it has signed a definitive ... device company that develops, manufactures and sells minimally ... drainage of targeted areas within the gastrointestinal tract. ... The Xlumena portfolio includes the ...
Breaking Medicine Technology:Trinity Biotech plc Announces Proposed Offering of $100 Million of Exchangeable Senior Notes due 2045 2Trinity Biotech plc Announces Proposed Offering of $100 Million of Exchangeable Senior Notes due 2045 3Trinity Biotech plc Announces Proposed Offering of $100 Million of Exchangeable Senior Notes due 2045 4Pittman Motors Expands PLG Planetary Gearbox Offering 2Boston Scientific Agrees to Acquire Xlumena 2Boston Scientific Agrees to Acquire Xlumena 3Boston Scientific Agrees to Acquire Xlumena 4Boston Scientific Agrees to Acquire Xlumena 5
... Simcere Pharmaceutical Group ("Simcere" or the "Company") (NYSE: ... specializing in the development, manufacturing, and marketing of ... that Shanghai Celgen Bio-Pharmaceutical Co., Ltd. ("Shanghai Celgen") ... interest, has received new drug registration approval for ...
... Cempra Pharmaceuticals, a developer of differentiated antibiotics, ... (IV) solithromycin demonstrates excellent tolerability and ... up to 800 mg.  Oral administration of solithromycin ... 1 studies.  The presentation will be at the ...
Cached Medicine Technology:Simcere Announces Recent Progress of Qiangke's Registration 2Intravenous (IV) Administration of Cempra Pharmaceutical's Solithromycin (CEM-101) Demonstrates Excellent Systemic Tolerability in a Phase 1 Clinical Trial 2Intravenous (IV) Administration of Cempra Pharmaceutical's Solithromycin (CEM-101) Demonstrates Excellent Systemic Tolerability in a Phase 1 Clinical Trial 3Intravenous (IV) Administration of Cempra Pharmaceutical's Solithromycin (CEM-101) Demonstrates Excellent Systemic Tolerability in a Phase 1 Clinical Trial 4Intravenous (IV) Administration of Cempra Pharmaceutical's Solithromycin (CEM-101) Demonstrates Excellent Systemic Tolerability in a Phase 1 Clinical Trial 5Intravenous (IV) Administration of Cempra Pharmaceutical's Solithromycin (CEM-101) Demonstrates Excellent Systemic Tolerability in a Phase 1 Clinical Trial 6Intravenous (IV) Administration of Cempra Pharmaceutical's Solithromycin (CEM-101) Demonstrates Excellent Systemic Tolerability in a Phase 1 Clinical Trial 7
... monitors and controls patient temperature primarily in ... surgery, trauma, or other medical conditions. The ... provided from a patient temperature probe. Circulating ... and 42C (107.6F) to achieve a preset ...
... The Littmann Electronic Stethoscope Model 4100WS ... (ANR) technology allowing you to reduce ambient ... without eliminating critical body sounds. Three frequency ... lung, and other body sounds: Bell (20-200 ...
... The OmniMD orthopedics EMR addresses the vast ... specific EMR includes clinically-defined templates for common ... review of systems. The system also includes ... are used to capture accurate charges and ...
Intrinsic Dual Chamber ICD With MVP Mode (Managed Ventricular Pacing). MVP promotes intrinsic conduction and is clinically proven to reduce unnecessary right ventricular (RV) pacing to approximately...
Medicine Products: