Navigation Links
'Different kind of stem cell' possesses attributes favoring regenerative medicine
Date:11/19/2012

WASHINGTON -- A research team at Georgetown Lombardi Comprehensive Cancer Center say the new and powerful cells they first created in the laboratory a year ago constitute a new stem-like state of adult epithelial cells. They say these cells have attributes that may make regenerative medicine truly possible.

In the November 19 online early edition of the Proceedings of the National Academy of Sciences (PNAS), they report that these new stem-like cells do not express the same genes as embryonic stem cells and induced pluripotent stem cells (iPSCs) do. That explains why they don't produce tumors when they grow in the laboratory, as the other stem cells do, and why they are stable, producing the kind of cells researchers want them to.

"These seem to be exactly the kind of cells that we need to make regenerative medicine a reality," says the study's senior investigator, chairman of the department of pathology at Georgetown Lombardi, a part of Georgetown University Medical Center.

This study is a continuation of work that led to a breakthrough in December 2011 when Schlegel and his colleagues demonstrated that he and his team had designed a laboratory technique that keep both normal as well as cancer cells alive indefinitely which previously had not been possible.

They had discovered that adding two different substances to these cells (a Rho kinase inhibitor and fibroblast feeder cells) pushes them to morph into stem-like cells that stay alive indefinitely. When the two substances are withdrawn from the cells, they revert back to the type of cell that they once were. They dubbed these cells conditionally reprogrammed cells (CRCs).

The advance was seen as an exciting demonstration of personalized cancer medicine. In fact, a case study authored by Schlegel and his team, reported in the September 27 issue of the New England Journal of Medicine (NEJM), demonstrated how CRCs derived from normal and tumor cells
'/>"/>

Contact: Karen Mallet
km463@georgetown.edu
Georgetown University Medical Center
Source:Eurekalert

0

GOOD

Page: 1 2 3

Related medicine news :

1. Study shows different approach after progression in non-small cell lung cancer patients
2. New Diabetes Drugs Have Different Advantages, Study Says
3. Hearing impaired ears hear differently in noisy environments
4. Teens tell different tales about themselves depending on gender
5. Men, Women Do See Things Differently: Study
6. Womens Brains React Differently Than Mens to Alcoholism, Study Finds
7. More clues about why chimps and humans are genetically different
8. Hey, I’m over here: Men and women see things differently
9. Marriage has different meanings for blacks and whites
10. Cell differentiation as a novel strategy for the treatment of an aggressive type of skin cancer
11. UK cyclists take different paths
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/22/2013)... Researchers in genomic health disparities from the University of ... School of Medicine have teamed up to hold the ... Health Disparities in Genomic Medicine." The theme of ... business and government to reduce these disparities. , Despite ... States, individuals within underserved groups continue to be more ...
(Date:5/22/2013)... Hopkins researchers report that hospitals may be reaping ... complicated by preventable bloodstream infections contracted in their ... study, reported online in the American Journal ... an ICU patient who develops an avoidable central ... more to care for than a similar infection-free ...
(Date:5/22/2013)... May 22, 2013 Recent tragedies ... and the school shooting in Newtown, Connecticut all ... , Emergency medical practitioners train to ... the Emergency Medical Services for Children (EMSC) Program ... care for the youngest patients. It is estimated ...
(Date:5/22/2013)... (PRWEB) May 22, 2013 Space Girl ... as a sponsor for this weekend's I Talk to Strangers ... at 8:00 am at Cocoa Riverside Park in Cocoa, FL. ... the I Talk to Strangers social movement. , As a ... and walkers to participate in the event. Additionally, they are ...
(Date:5/22/2013)... Pamela Isom, President and CEO of ICE ... 2013 Women of Influence Award in recognition for her ... reception took place on Thursday, May 2 at The ... particularly humbling for the 5,000 people ICE Safety Solutions ... to recognize the four to nine lives saved per ...
Breaking Medicine News(10 mins):Health News:Why We Can't Wait: Conference to Eliminate Health Disparities in Genomic Medicine 2Health News:Hospitals profit when patients develop bloodstream infections 2Health News:Hospitals profit when patients develop bloodstream infections 3Health News:Hospitals profit when patients develop bloodstream infections 4Health News:When Tragedies Impact Children – Kentucky Emergency Medical Services for Children (KYEMSC) Offers Specialized Training for Pediatric Emergency Care 2Health News:Space Girl Organics to Sponsor May 25 Miracle Run/Walk 2Health News:Pamela Isom, President and CEO of ICE Safety Solutions Inc. Receives 2013 Women of Influence Recognition and Award 2
... as HIV and Hepatitis C decades back, will now get ... inquiry is soon to be launched into the contracting of ... transfusions, in what is acknowledged as the biggest treatment blunder ... , The incident took place in the late 70s ...
... study has revealed for the first time that rice bran ... research was conducted by biomedical scientists at the Department of ... has not been tested on humans, but research in the ... has been published in the British Journal of Cancer. ...
... of the “triple negative” type are destructive and lethal, and ... a novel// study Published in the May 1, 2007 issue ... tumors occur commonly among women who are African American and ... lower socioeconomic status (SES). The study also showed that triple ...
... cells to regenerate healthy human liver tissue in a ... the liver, some patients are unable to undergo surgery, ... liver to support the body. ,Researchers at ... cells to help quickly regenerate healthy liver tissue, enabling ...
... technology has found that the most potent cholesterol-lowering ... in the blood vessels that can lead to ... thickened carotid arteries compared to a placebo,” said ... of endocrinology at Wake Forest University School of ...
... southern Indian state of Karnataka is examining a proposal to ... test before marriage. ,State Health Minister R. ... government had written a letter to the federal government suggesting ... were several instances in which unsuspecting women had married HIV+ ...
Cached Medicine News:Health News:Inquiry into Past NHS Treatment Disaster 2Health News:'Triple Negative' Breast Cancers Seem to Affect the Young, Minority 2Health News:Stem Cells to Treat Liver Cancer 2Health News:Cholesterol-lowering Drug Effective at Halting Early Atherosclerosis 2
(Date:5/22/2013)... and TORONTO , May 22, ... GNBT) today announced three presentations demonstrating the superiority of ... wholly-owned subsidiary, Antigen Express, Inc. ( www.antigenexpress.com ). The ... the American Society of Clinical Oncology (ASCO) to be ... 31 through June 4, 2013. The presentation ...
(Date:5/22/2013)... 22. Mai 2013  Grifols, ein globales ... Barcelona , Spanien, präsentierte die ... höhere Dosis von PROLASTIN©-C (Alpha1-Proteinasehemmer [human]) den ... (AAT) auf ein Niveau anhebt, das innerhalb ... liegt. ATT-Mangel ist eine lebensbedrohliche, genetische Erkrankung, ...
(Date:5/22/2013)... , May 22, 2013  Medifocus, Inc. (OTCQX: MDFZF and ... , Chief Operating Officer, will present at the Second Annual ... New York City at the Grand ... to begin at 4:00 p.m. EDT and will be available ...   http://wsw.com/webcast/marcum/mfs.v/   For more information and registration, ...
Breaking Medicine Technology:Generex Announces ASCO Presentations on the Antigen Express Advanced Stage AE37 Cancer Vaccine 2Generex Announces ASCO Presentations on the Antigen Express Advanced Stage AE37 Cancer Vaccine 3Generex Announces ASCO Presentations on the Antigen Express Advanced Stage AE37 Cancer Vaccine 4Studie von Grifols zeigt, dass eine höhere Dosis von PROLASTIN-C den Alpha1-PI-Spiegel in Patienten mit AAT-Mangel in den normalen Bereich anhebt 2Studie von Grifols zeigt, dass eine höhere Dosis von PROLASTIN-C den Alpha1-PI-Spiegel in Patienten mit AAT-Mangel in den normalen Bereich anhebt 3Studie von Grifols zeigt, dass eine höhere Dosis von PROLASTIN-C den Alpha1-PI-Spiegel in Patienten mit AAT-Mangel in den normalen Bereich anhebt 4Medifocus, Inc. to Present At The Second Annual Marcum LLP MicroCap Conference 2Medifocus, Inc. to Present At The Second Annual Marcum LLP MicroCap Conference 3
... the ureter to be dilated immediately below ... base of the balloon allows fluoroscopic confirmation ... sterile in peel-open packages. Intended for one-time ... Straight Safety Wire Guide [.038 inch (0.97 ...
Used during the performance of balloon dilation procedures to inflate and deflate the balloon and measure the pressure within the balloon during the procedure. Supplied sterile in peel-open packages....
... Small 6.9 Fr Diameter with Two Large ... USA Series MICRO-6 Semi-Rigid Ureteroscope is the ... for diagnostic and therapeutic procedures. The ACMI ... time for procedures with minimal or no ...
Smooth, contoured visual obturator provides less traumatic insertion through the urethra and into the bladder....
Medicine Products: