Navigation Links
Different genes influence smoking risk during adolescence and adulthood

Philadelphia, PA, 31 March, 2011 - There is growing evidence that the risk factors for addiction change throughout the lifespan.

The risk factors for developing addiction in adolescence are the most intensively studied because this life phase is associated with the highest addiction risk. Traits linked to addiction risk during adolescence include pleasure-seeking, behavioral disinhibition, and devaluation of the future negative consequences of behavior. In contrast, the development of substance use among adults is more commonly associated with high levels of stress, anxiety, and depression.

Thus, perhaps it is not surprising that different sets of genes are now implicated in the risk for addiction in adolescence and adulthood.

In a new study published in Biological Psychiatry, researchers found that teenagers carrying variants in two gene regions were three times more likely to become regular smokers in adolescence and twice as likely to be persistent smokers in adulthood, compared to non-carriers.

Variation in a set of dopamine-related genes was associated with a person's risk of starting smoking, and these genes had a stronger impact on smoking initiation in adolescents than in adults. Individuals carrying the risk variants had a 1.3-fold increased risk of starting smoking in their teenage years.

The other set of genes coded for subunits of the nicotinic cholinergic receptors, the brain targets for nicotine inhaled during smoking. Variation in these genes influenced the likelihood of smokers continuing the habit into adulthood, as it had a stronger influence on the smoking habits of adults than of adolescents. Those carrying these variants had a 1.3-fold increased risk of becoming a heavy and persistent smoker in adulthood.

"These findings seem to make some sense. The dopamine-related genes may be more closely associated with the risk for addiction within the context of thrill-seeking, while cholinergic receptors, which have been implicated in mood and cognition as well as addiction, might contribute to self-medication models of addiction," commented Dr. John Krystal, Editor of Biological Psychiatry.

The researchers say the findings could help develop genetic testing for those wishing to know their susceptibility to nicotine dependence and tobacco-related disease. It could also pave the way for targeted drugs that influence an individual's response to nicotine. However, further research is necessary before these goals could be implemented.


Contact: Chris J. Pfister

Related medicine news :

1. Surviving Melanoma May Take Different Toll on Women, Men
2. Women with eating disorders draw a different picture of themselves than women without
3. Some Older Drivers Vision Problems Different Than Thought
4. Experts Brains Work Differently Than Amateurs
5. A different path to fat-related heart disease
6. Ph.D. thesis shows why patients subjected to dialysis face their illness in different ways
7. Resistance Exercise May Offer Different Cardio Benefits
8. APHA 2010: Attacking the drinking culture on college campuses from different directions
9. Lung Cancer in Smokers, Nonsmokers May Be a Different Disease
10. Neuralstem stem cells survive and differentiate into neurons in rats with stroke
11. Institute for Aging Research study finds indoor and outdoor fall are different for the elderly
Post Your Comments:
(Date:6/27/2016)... ... June 27, 2016 , ... ... authorized OSHA Training Institute Education Center headquartered in Northern California, has issued an ... extreme heat at their worksites. Employers with workers exposed to high temperatures ...
(Date:6/27/2016)... ... June 27, 2016 , ... "FCPX editors can now reveal their media with ... X," said Christina Austin - CEO of Pixel Film Studios. , ProSlice Color ... users can now reveal the media of their split screens with growing colorful ...
(Date:6/27/2016)... ... June 27, 2016 , ... TherapySites, ... its affiliation with Tennessee Counseling Association. This new relationship allows TherapySites ... Tennessee Counseling Association, adding exclusive benefits and promotional offers. , "TCA is extremely ...
(Date:6/27/2016)... California (PRWEB) , ... June ... ... pioneer in the patient payment industry today announced its strategic partnership with ... health system workflows. , The two companies’ proven, proprietary technology combine to ...
(Date:6/27/2016)... ... June 27, 2016 , ... A ... revolutionize the emergency ambulance transport experience for the millions of people who require ... has disrupted the taxi industry through the use of technology. Now, SmartEMS has ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... BEVERLY HILLS, Calif. , June 23, 2016 ... faced the many challenges of the current process. Many of ... option because of the technical difficulties and high laboratory costs ... would have to offer it at such a high cost ... to afford it. Dr. Parsa Zadeh , ...
(Date:6/23/2016)... 23, 2016 Roche (SIX: RO, ROG; OTCQX: ... its Elecsys BRAHMS PCT (procalcitonin) assay as a dedicated ... shock. With this clearance, Roche is the first IVD ... solution for sepsis risk assessment and management. ... and PCT levels in blood can aid clinicians in ...
(Date:6/23/2016)... Research and Markets has announced the addition of ... their offering. The current ... environment for MedImmune to enter. The US ageing population creates ... drive considerable growth for effective anti-influenza medications. The introduction of ... but development is still in its infancy. ...
Breaking Medicine Technology: