Navigation Links
Different drug combinations work best for prevention versus treatment of colorectal tumors
Date:4/7/2013

unnatural waythrough exposure to carcinogenic chemicalswhereas in humans, cancer often has genetic origins.

To evaluate the effectiveness of sulindac and atorvastatin in an animal model more relevant to humans, Chang, Clapper and their colleagues used a unique mouse that had genetic alterations that cause them to develop multiple colorectal adenomas, without exposure to carcinogens. "No one had previously tested the effectiveness of this drug combination against colorectal cancer originating from alterations in the genome," Clapper says. "In some ways, using this type of preclinical tumor model represents a new paradigm for doing prevention studies and therapeutic studies."

In the new study, the researchers treated the mice with either drug alone or in combination for 100 days and used colonoscopic examinations to evaluate the presence and size of tumors before and after treatment. In mice that had tumors prior to treatment, only combination therapy reduced the number of adenomas in the colon by the end of the treatment period.

The results were strikingly different in mice that were tumor-free when treatment began. In these mice, exposure to atorvastatin alone or in combination with sulindac resulted in about a three-fold increase in the percentage of mice that were tumor-free by the end of the treatment period. Among these mice, 44 percent of those treated with atorvastatin alone and 30 percent of those treated with both drugs did not develop tumors, compared with 13 percent of mice that received no treatment and nine percent that received sulindac alone. Moreover, atorvastatin treatment completely inhibited the formation of microscopic adenomas in these mice.

The findings demonstrate that the effectiveness of the two drugs at preventing and treating colorectal adenomas depends on whether tumors are present prior to the onset of treatment. "Based on this study, we're able to say that if you don't have a tumor to begin with, ma
'/>"/>

Contact: Diana Quattrone
diana.quattrone@fccc.edu
215-728-7784
Fox Chase Cancer Center
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Despite Olympic fever, British women remain indifferent about sport
2. More Danish women are physically active than their European neighbors, but remain indifferent to sport
3. German women are more physically active than their European counterparts yet remain indifferent to sport
4. Moffitt researchers say silencing of retinoblastoma gene regulates differentiation of myeloid cells
5. Sleep Specialist Dr. Gerald Suh Differentiates Behavioral from Physiological Sleep Disorders
6. Protein paves the way for correct stem cell differentiation
7. Obese Women With Diabetes May Need Different Workouts Than Men
8. People with low risk for cocaine dependence have differently shaped brain to those with addiction
9. Dr. Kent Stobaugh Retiring from Oral & Maxillofacial Surgeons to Pursue Different Opportunities: SA4i Emphasizes Significant Contributions to People’s Lives
10. Psychological common ground could ease tensions among those with different religious beliefs
11. Pain Intensity May Help Differentiate 2 Skin Cancers
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/20/2014)... York, New York (PRWEB) September 20, 2014 ... power morcellators ( http://www.injurybeacon.com/power-morcellator/ ) in gynecological ... that yet another insurer has announced plans to ... statement posted on its website last month, Harrisburg, ... procedures effective November 1, 2014. The insurer said ...
(Date:9/20/2014)... Traditionally dentists have advised their patients against drinking coffee ... is re-visiting that advice and changing his stance after considering ... have on oral health. “There’s good news and great news,” ... beneficial in protecting against gum disease, and red wine can ... was from the September 2014 issue of Boston University ...
(Date:9/20/2014)... September 20, 2014 Earlier this week, Home ... may have had their credit card information pilfered by hackers, ... a slew of headline articles like this one ... only eye opening numbers. , “Most people tend to ... like it’s a way to score a game,” says Joe ...
(Date:9/20/2014)... The Arizona Advanced Manufacturing ... National Manufacturing Day by opening its doors to the ... additive manufacturing labs will be offered between 10 a.m. ... Southern and Dobson campus (1833 W. Southern Ave, Mesa, ... , The AzAMI at MCC was established in the ...
(Date:9/20/2014)... 2014 The children of Branches now ... active play they need. An empty lot at the ... Campus was transformed into a kid-designed playspace in less ... from Branches (@BranchesFL), ESPN (@TeamESPN), Disney (@CitizenDisney), area residents ... a playground is more than a playground. It’s a ...
Breaking Medicine News(10 mins):Health News:As Power Morcellator Concerns Grow, Bernstein Liebhard LLP Notes Another Insurer’s Decision to Drop Coverage for Uterine Morcellation 2Health News:As Power Morcellator Concerns Grow, Bernstein Liebhard LLP Notes Another Insurer’s Decision to Drop Coverage for Uterine Morcellation 3Health News:South Charlotte Dentist, Dr. James Wells, is Changing His Advice on Coffee and Wine Drinking 2Health News:South Charlotte Dentist, Dr. James Wells, is Changing His Advice on Coffee and Wine Drinking 3Health News:Don’t Let Data Breach Fatigue Cause Dangerous Cyber Security Complacency 2Health News:Don’t Let Data Breach Fatigue Cause Dangerous Cyber Security Complacency 3Health News:Don’t Let Data Breach Fatigue Cause Dangerous Cyber Security Complacency 4Health News:Don’t Let Data Breach Fatigue Cause Dangerous Cyber Security Complacency 5Health News:National Manufacturing Day Open House at Mesa Community College Oct. 3 2Health News:Volunteers Improve Miami Kids’ Lives and Futures with Play 2Health News:Volunteers Improve Miami Kids’ Lives and Futures with Play 3Health News:Volunteers Improve Miami Kids’ Lives and Futures with Play 4
... MiLife Coaching Limited,announces the publication of their third ... weight management coaching system to boost employee,health and ... , MiLife is an ... physical activity management system. It incorporates biofeedback and,the ...
... season prompts tips on how to avoid most common cause ... -- If you didn,t know better, you could confuse carbon ... U.S. Environmental Protection Agency has a new fact sheet out ... deaths and 15,000 visits to the emergency room caused each ...
... Eklin Medical Systems, a leading,provider of digital ... and practice management software (VIA) for veterinary,care, introduced ... North American,Veterinary Conference being held in Orlando, January ... economical solution for digital imaging based on Eklin,s ...
... INSM ), a developer of follow-on ... dedicated to the development of, diagnosis and prevention of ... that the European Medicines Agency (EMEA) has granted Premacure ... mecasermin rinfabate, for the prevention of retinopathy of prematurity ...
... Varian, Inc.,(NasdaqGS: VARI) plans to release its financial ... Pacific Time (PT) on Wednesday February 4,2009. A live ... to,review those quarterly results is scheduled to follow at ... That live webcast can be accessed from Varian, ...
... 21 Horphag Research, exclusive worldwide,suppliers of Pycnogenol(R) ... earned the 2008 Frost & Sullivan North American ... This award, presented,last week at Frost & Sullivan,s ... Research,s efforts in conducting numerous research projects,over the ...
Cached Medicine News:Health News:MiLife Proven to Boost Vitality of Unilever Employees Using Smart Affordable Technology 2Health News:Eklin Launches New RapidStudy(TM) CDx Digital Radiography System at NAVC 2Health News:Eklin Launches New RapidStudy(TM) CDx Digital Radiography System at NAVC 3Health News:Insmed and Premacure Announce European Orphan Designation for IPLEX(TM) in Retinopathy of Prematurity in Infants 2Health News:Insmed and Premacure Announce European Orphan Designation for IPLEX(TM) in Retinopathy of Prematurity in Infants 3Health News:Horphag Research Receives 2008 Frost & Sullivan North American Health Ingredients Excellence In Research Award 2Health News:Horphag Research Receives 2008 Frost & Sullivan North American Health Ingredients Excellence In Research Award 3
(Date:9/19/2014)... Technologies Corp. (NASDAQ: BSTC ), a biopharmaceutical company ... in the U.S. and XIAPEX ® in the ... will present a corporate overview at the 21 st ... The presentation will take place on Friday, September 26, ... in New York, NY . A live ...
(Date:9/19/2014)... September 19, 2014 Aufgrund ... den äußerst erfolgreichen Serialisierungs-Countdown-Kalender aktualisiert, der jetzt auch ... PDF, verfügbar unter pharmaserialisation.com , zeigt die ... jeweils in Kraft treten. Für international ... länger um das "ob", sondern darum, "wann" sie ...
(Date:9/19/2014)... , Sept. 19, 2014 Intarcia ... interim clinical data for its lead candidate ITCA 650 ... patients with high baseline HbA1c levels at the 50 ... the Study of Diabetes (EASD). Data from the open-label, ... levels of blood sugar in patients with poorly controlled ...
Breaking Medicine Technology:BioSpecifics Technologies Corp. to Present at the 21st Annual BioCentury NewsMakers in the Biotech Industry Conference 2Pharma IQ stellt weltweite Serialisierungsfristen in seinen Countdown-Kalender 2014 - 2018 2Intarcia Announces Presentation of Phase 3 Data at EASD Showing ITCA 650 Markedly Reduces Blood Sugar In Patients With Poorly Controlled Type 2 Diabetes 2Intarcia Announces Presentation of Phase 3 Data at EASD Showing ITCA 650 Markedly Reduces Blood Sugar In Patients With Poorly Controlled Type 2 Diabetes 3Intarcia Announces Presentation of Phase 3 Data at EASD Showing ITCA 650 Markedly Reduces Blood Sugar In Patients With Poorly Controlled Type 2 Diabetes 4
... at American Society of Clinical ... Oncology Annual Meeting, PRINCETON, ... updated long-term follow-up and overall,survival (OS) results from a Phase 2 ... (DTIC) where 11.4%, or 4 of,35 patients, were still alive at ...
... Noted in Management of Transplant Recipients with Cancer, ... of,immunosuppression in post-transplant patients with cancer is challenging.,Clinicians ... effectively while,simultaneously monitoring the impact of chemotherapeutic agents ... improving management of such patients will be,presented today ...
Cached Medicine Technology:Ipilimumab Plus Chemotherapy is Associated with Prolonged Survival and Increased Disease Control Rates in Patients with Advanced Melanoma 2Ipilimumab Plus Chemotherapy is Associated with Prolonged Survival and Increased Disease Control Rates in Patients with Advanced Melanoma 3Ipilimumab Plus Chemotherapy is Associated with Prolonged Survival and Increased Disease Control Rates in Patients with Advanced Melanoma 4Penn State Hershey Transplant Program Uses Assay to Monitor Cell-Mediated Immunity 2
... Our breadth of infectious disease ELISA products ... With standard assay protocols for faster integration ... ELISA products provide increased reliability and run-to-run ... antibody detection assays for a wide range ...
... Our breadth of infectious disease ELISA products ... With standard assay protocols for faster integration ... ELISA products provide increased reliability and run-to-run ... antibody detection assays for a wide range ...
... ELISA products make us a leader in ... faster integration into the busy laboratory, our ... and run-to-run consistency. Our Infectious Disease ELISA ... wide range of serological assays including ToRCH, ...
... disease ELISA products make us a leader ... for faster integration into the busy laboratory, ... reliability and run-to-run consistency. Our Infectious Disease ... a wide range of serological assays including ...
Medicine Products: