Navigation Links
Different Neural Pathways at Work Going Under, Coming Out of Anesthesia
Date:1/21/2008

Mouse study on brain's orexin system could lead to new drugs with fewer side effects

MONDAY, Jan. 21 (HealthDay News) -- The neural pathway that regulates recovery of consciousness from general anesthesia is different from the one that's affected by drugs used to put patients to sleep during surgery.

That's the conclusion of a University of Pennsylvania School of Medicine study that may help in the development of improved anesthesia drugs, the researchers said.

The researchers focused on specialized neurons called orexins that regulate the body's wakeful state. They found that mice with damaged orexin systems -- similar to humans with narcolepsy -- took much longer to awake from general anesthesia than mice with normal orexin signaling systems.

However, the mice with faulty orexin systems did not fall asleep faster than normal mice when given a general anesthetic. This suggests that different processes are involved when a general anesthetic takes effect and when it wears off, the researchers said.

"The modern expectation is that anesthesiologists can simply flip a consciousness switch as easily as we might turn the room lights on or off," study author Dr. Max. B. Kelz, an assistant professor in the department of anesthesiology and critical care at the Mahoney Institute of Neurological Sciences, said in a prepared statement.

"However, what patients do not realize is that despite 160 years of widespread clinical use, the mechanisms through which the state of anesthesia arises and dissipates remain unknown," he said.

Kelz and his colleagues hope further research will lead to new ways to administer anesthesia and promote a quick, safe return to consciousness, particularly for patients who have difficulty waking up or those -- such as the elderly and people with neurodegenerative disorders -- who are more prone to anesthesia side effects.

The study findings were published this month in the journal Proceedings of the National Academy of Sciences.

More information

The American Society of Anesthesiologists has more about anesthesiology.



-- Robert Preidt



SOURCE: University of Pennsylvannia, news release, January 2008


'/>"/>
Copyright©2008 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Brain cells work differently than previously thought
2. Different method of evaluating the urinary tract system reduces radiation dose
3. Different HIV rates among gay men and straight people not fully explained by sexual behavior
4. Abaxis Launches The VetScan(R) HM5 a State-of-the-Art 5-Part Differential Veterinary Hematology Analyzer
5. Sense of taste different in women with anorexia nervosa
6. Babies raised in bilingual homes learn new words differently than infants learning one language
7. Children would need different medical care in wake of dirty bomb
8. Penn researchers use brain imaging to demonstrate how men and women cope differently under stress
9. Different anticoagulant regimens yield equal results
10. UCLA study shows different areas of the brain respond to belief, disbelief and uncertainty
11. Forever young: Differentiation blocked in tumor stem cells
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Different Neural Pathways at Work Going Under, Coming Out of Anesthesia
(Date:9/22/2017)... ... September 22, 2017 , ... SABRE ... Scholarship Sweepstakes.,  , Molli C., a graduate student from Sonora, California, who will ... Administration at St. Thomas University in Miami, Florida, was selected from a pool ...
(Date:9/22/2017)... HOUSTON, Texas (PRWEB) , ... September 22, 2017 ... ... leading network of independent freestanding emergency rooms is celebrating the one year anniversary ... anniversary of our facility opening,” said Dr. Otinwa, Facility Medical Director of First ...
(Date:9/22/2017)... ... September 22, 2017 , ... ... products at customers’ doorstep. According to Smart Mart, customers can now order vegetable, ... offer wearable, and customers can find clothing at discounted prices. Apart from this, ...
(Date:9/21/2017)... ... September 21, 2017 , ... Process Capability ... p.m. – 3:00 p.m. ET, http://www.fdanews.com/processcapabilityindices      , Quality ... run afoul of The Quality System Regulation (§820.250), and Devicemakers find themselves staring ...
(Date:9/21/2017)... (PRWEB) , ... September 21, 2017 , ... ... in their communities, nine governmental public health departments have been awarded five-year accreditation ... decisions mean that the benefits of being served by a PHAB-accredited health ...
Breaking Medicine News(10 mins):
(Date:9/13/2017)... Sept. 13, 2017   OrthoAtlanta has been named ... Football Host Committee (AFHC) for the 2018 College Football Playoff ... 2018, at Mercedes-Benz Stadium in Atlanta, Georgia ... AFHC "I,m In" campaign, participating in many activities leading up ... ...
(Date:9/12/2017)... , Sept. 12, 2017  ValGenesis Inc., ... Solutions (VLMS), is pleased to announce the appointment ... member of its Board of Directors and Chairman ... VLMS enables life science companies to manage their ... use of paper in this process. Furthermore, ValGenesis ...
(Date:9/9/2017)...  Eli Lilly and Company (NYSE: LLY ... for lasmiditan, an investigational, oral, first-in-class molecule for the ... compared to placebo in the Phase 3 SPARTAN study. ... Congress of the International Headache Society (IHC) in ... today demonstrate lasmiditan,s potential to reduce pain and provide ...
Breaking Medicine Technology: