Navigation Links
Differences in effects on atherosclerosis of regular moderate drinking and binge drinking
Date:9/20/2011

An excellent study among experimental mice has reported very dramatic differences between the effects of alcohol administered in moderation on a daily basis and the same total weekly amount of alcohol administered on only two days of the week: (replicating binge drinking). The mice used in the study that were given regular moderate amounts of alcohol showed no weight gain, improved lipid values, and much less development of atherosclerosis than did control animals. However, those given alcohol in a binge-drinking pattern showed worse outcomes than control animals, and much worse outcomes than those given regular moderate doses of alcohol.

The authors examined the effect of daily-moderate (2 drinks/day, 7 days/week) and weekend-binge (7 drinks/day, 2 days/week) patterns of alcohol consumption on plasma lipid levels and physiological parameters of atherosclerotic plaque development This experimental study provides strong support for the frequent finding among humans in epidemiologic studies, that is: benefits from regular moderate drinking and adverse effects from binge drinking. It is especially important since, being an experimental study, the potential confounding effects of other lifestyle habits, such as smoking or poor diet, are not an issue, as is always the case for observational studies among humans.

One Forum reviewer stated: "This is a very nice study, confirming in an animal model the biphasic nature of the effect of alcohol on progression of atherosclerosis. We are still far from tempting to suggest realistic mechanisms. On the other hand, the evidence perfectly fits the usual hormetic mechanism, where low doses regularly supplied are protective while high doses in a single shot are worsening the progression of disease." Another reviewer stated: "By controlled experiment it gives crisp and clear-cut results that are useful and intuitive when considering what we thought we knew, and what we may indeed do know. Cheers to the brave mice!" Still another Forum reviewer thought that it is good to have confirmation in a controlled experiment of what has been shown in epidemiologic studies. "It is nice to not have to agonize over smoking and other lifestyle factors that may confound results in human observational studies none of the mice were smokers."


'/>"/>

Contact: R. Curtis Ellison
ellison@bu.edu
508-333-1256
Boston University Medical Center
Source:Eurekalert

Related medicine news :

1. Genetic differences may cause higher rates of prostate cancer in African-American men
2. Genetics, lifestyle provide clues to racial differences in head and neck cancer
3. Regional differences in the care of acute stroke patients
4. Stomach Cancer Tumors Have Genetic Differences: Researchers
5. Pro Golfers Reveal Biomechanical Differences in Swing
6. Study of golf swings pinpoints biomechanical differences between pros and amateurs
7. Couples report gender differences in relationship, sexual satisfaction over time
8. Gender differences in risk pathways for adolescent substance abuse and early adult alcoholism
9. Brain Scan Spots Differences in Tots With ADHD Symptoms
10. Brain imaging study of preschoolers with ADHD detects brain differences linked to symptoms
11. Study: Stark differences in media use between minority and white youth
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/2/2016)... ... December 02, 2016 , ... The annual time frame to change Medicare health ... is ending December 7th. Currently-enrolled Medicare beneficiaries who are looking to switch from their ... D) need to make changes during this period order for their new policy to ...
(Date:12/2/2016)... (PRWEB) , ... December 02, 2016 , ... More than ... and while 84 percent of parents report speaking with their child about sex related ... sexually transmitted diseases. , Mediaplanet is proud to announce the launch of its second ...
(Date:12/2/2016)... ... December 02, 2016 , ... Sourced from the Isbre Springs beneath the 5,000 ... unmatched natural purity of just 6 ppm TDS (Total Dissolved Solids) in addition to ... been available in several ShopRite and FoodTown stores in NJ and received rave comments ...
(Date:12/2/2016)... Miami, FL (PRWEB) , ... December 02, 2016 ... ... over 5,100 hot meals to needy individuals and families from eight different sites ... Florida on Thanksgiving Day. Over 1,000 volunteers worked very hard on Thanksgiving morning ...
(Date:11/30/2016)... , ... November 30, 2016 , ... ... they now offer a comprehensive in-house dental plan for all patients. Understanding that ... a plan that gives patients a number of perks, including discounts on many ...
Breaking Medicine News(10 mins):
(Date:12/2/2016)... YORK , December 2, 2016 ... Braces & Support) is Expected to Gain a Significant Market ... to Orthopedic Ailments  ... , According to ... Study on Medical Implants Sterile Packaging: Clamshell Product Type Segment ...
(Date:12/2/2016)... On Thursday, the NASDAQ Composite and ... the Dow Jones Industrial Average managed to stay in green. ... which prompted Stock-callers this morning to look at the performances ... NUVA ), Smith & Nephew PLC (NYSE: SNN ... Cesca Therapeutics Inc. (NASDAQ: KOOL ). You can ...
(Date:12/2/2016)... -- The concept of rare diseases and the idea that ... has been taking shape in Europe ... initiatives related to orphan medicinal products have been emerging at ... states individually. Many member states in the EU have led ... medicinal products, the result of which took the shape of ...
Breaking Medicine Technology: