Navigation Links
Differences in effects on atherosclerosis of regular moderate drinking and binge drinking

An excellent study among experimental mice has reported very dramatic differences between the effects of alcohol administered in moderation on a daily basis and the same total weekly amount of alcohol administered on only two days of the week: (replicating binge drinking). The mice used in the study that were given regular moderate amounts of alcohol showed no weight gain, improved lipid values, and much less development of atherosclerosis than did control animals. However, those given alcohol in a binge-drinking pattern showed worse outcomes than control animals, and much worse outcomes than those given regular moderate doses of alcohol.

The authors examined the effect of daily-moderate (2 drinks/day, 7 days/week) and weekend-binge (7 drinks/day, 2 days/week) patterns of alcohol consumption on plasma lipid levels and physiological parameters of atherosclerotic plaque development This experimental study provides strong support for the frequent finding among humans in epidemiologic studies, that is: benefits from regular moderate drinking and adverse effects from binge drinking. It is especially important since, being an experimental study, the potential confounding effects of other lifestyle habits, such as smoking or poor diet, are not an issue, as is always the case for observational studies among humans.

One Forum reviewer stated: "This is a very nice study, confirming in an animal model the biphasic nature of the effect of alcohol on progression of atherosclerosis. We are still far from tempting to suggest realistic mechanisms. On the other hand, the evidence perfectly fits the usual hormetic mechanism, where low doses regularly supplied are protective while high doses in a single shot are worsening the progression of disease." Another reviewer stated: "By controlled experiment it gives crisp and clear-cut results that are useful and intuitive when considering what we thought we knew, and what we may indeed do know. Cheers to the brave mice!" Still another Forum reviewer thought that it is good to have confirmation in a controlled experiment of what has been shown in epidemiologic studies. "It is nice to not have to agonize over smoking and other lifestyle factors that may confound results in human observational studies none of the mice were smokers."


Contact: R. Curtis Ellison
Boston University Medical Center

Related medicine news :

1. Genetic differences may cause higher rates of prostate cancer in African-American men
2. Genetics, lifestyle provide clues to racial differences in head and neck cancer
3. Regional differences in the care of acute stroke patients
4. Stomach Cancer Tumors Have Genetic Differences: Researchers
5. Pro Golfers Reveal Biomechanical Differences in Swing
6. Study of golf swings pinpoints biomechanical differences between pros and amateurs
7. Couples report gender differences in relationship, sexual satisfaction over time
8. Gender differences in risk pathways for adolescent substance abuse and early adult alcoholism
9. Brain Scan Spots Differences in Tots With ADHD Symptoms
10. Brain imaging study of preschoolers with ADHD detects brain differences linked to symptoms
11. Study: Stark differences in media use between minority and white youth
Post Your Comments:
(Date:11/24/2015)... ... November 24, 2015 , ... Dehydration, defined as a loss ... to perspiration in the hot sun, and heat stroke and death will quickly follow. ... radio host Sharon Kleyne. Every cell, system and structure requires water to function properly. ...
(Date:11/24/2015)... ... 2015 , ... “I am so thrilled, as a newbie here, to leave a mark for ... $7,500 School Lounge Makeover® from California Casualty . Stephanie is in her fifth year ... much longer tenure. , “This is such an amazing school and we deserve a space ...
(Date:11/24/2015)... ... November 24, 2015 , ... ... and safety labels , has been featured in the American Feed ... exclusively to representing the business, legislative and regulatory interests of the U.S. animal ...
(Date:11/24/2015)... ... ... Add a fresh touch to this year’s holiday festivities with indoor plants ... style and cheer to any space. , Holiday plants are more than just festive ... all year long. , “Holiday plants make a room come alive,” says Justin Hancock, ...
(Date:11/24/2015)... ... , ... On the pleasant autumn morning of November 15, 2015, nearly 130 ... for Autism held at Steep Rock Preserve in Washington, Connecticut. The run, which offers ... triumph. , Created and hosted by The Glenholme School, a special needs boarding and ...
Breaking Medicine News(10 mins):
(Date:11/24/2015)... 24, 2015 Teledyne DALSA , a Teledyne ... technology, will introduce its CMOS X-Ray detector for mammography ... 29 to December 3, at McCormick Place in ... diagnostic and interventional imaging will be on display in the ... of advanced CMOS X-Ray detectors is the industry benchmark for ...
(Date:11/24/2015)... , Nov. 24, 2015  Enova Illumination is ... of Helsinki, Finland to combine ... are at the cutting edge of medical visualization: Enova ... the United States and Novocam ... Together, they provide the world,s most powerful battery-operated LED ...
(Date:11/24/2015)... Nov. 24, 2015  Freudenberg Medical has developed specialty tubing ... outside of medical facilities. Africa ... care is sparse. Nevertheless, prompt diagnosis is important to treat ... the virus. With the help of a portable mini-lab or ... to village in affected areas and perform rapid testing for ...
Breaking Medicine Technology: