Navigation Links
Differences in effects on atherosclerosis of regular moderate drinking and binge drinking
Date:9/20/2011

An excellent study among experimental mice has reported very dramatic differences between the effects of alcohol administered in moderation on a daily basis and the same total weekly amount of alcohol administered on only two days of the week: (replicating binge drinking). The mice used in the study that were given regular moderate amounts of alcohol showed no weight gain, improved lipid values, and much less development of atherosclerosis than did control animals. However, those given alcohol in a binge-drinking pattern showed worse outcomes than control animals, and much worse outcomes than those given regular moderate doses of alcohol.

The authors examined the effect of daily-moderate (2 drinks/day, 7 days/week) and weekend-binge (7 drinks/day, 2 days/week) patterns of alcohol consumption on plasma lipid levels and physiological parameters of atherosclerotic plaque development This experimental study provides strong support for the frequent finding among humans in epidemiologic studies, that is: benefits from regular moderate drinking and adverse effects from binge drinking. It is especially important since, being an experimental study, the potential confounding effects of other lifestyle habits, such as smoking or poor diet, are not an issue, as is always the case for observational studies among humans.

One Forum reviewer stated: "This is a very nice study, confirming in an animal model the biphasic nature of the effect of alcohol on progression of atherosclerosis. We are still far from tempting to suggest realistic mechanisms. On the other hand, the evidence perfectly fits the usual hormetic mechanism, where low doses regularly supplied are protective while high doses in a single shot are worsening the progression of disease." Another reviewer stated: "By controlled experiment it gives crisp and clear-cut results that are useful and intuitive when considering what we thought we knew, and what we may indeed do know. Cheers to the brave mice!" Still another Forum reviewer thought that it is good to have confirmation in a controlled experiment of what has been shown in epidemiologic studies. "It is nice to not have to agonize over smoking and other lifestyle factors that may confound results in human observational studies none of the mice were smokers."


'/>"/>

Contact: R. Curtis Ellison
ellison@bu.edu
508-333-1256
Boston University Medical Center
Source:Eurekalert

Related medicine news :

1. Genetic differences may cause higher rates of prostate cancer in African-American men
2. Genetics, lifestyle provide clues to racial differences in head and neck cancer
3. Regional differences in the care of acute stroke patients
4. Stomach Cancer Tumors Have Genetic Differences: Researchers
5. Pro Golfers Reveal Biomechanical Differences in Swing
6. Study of golf swings pinpoints biomechanical differences between pros and amateurs
7. Couples report gender differences in relationship, sexual satisfaction over time
8. Gender differences in risk pathways for adolescent substance abuse and early adult alcoholism
9. Brain Scan Spots Differences in Tots With ADHD Symptoms
10. Brain imaging study of preschoolers with ADHD detects brain differences linked to symptoms
11. Study: Stark differences in media use between minority and white youth
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/20/2017)... ... ... Are you an adult with gluten intolerance or Celiac disease living with ... participating in a research study that focuses on family interactions when dealing with dietary ... aspects of adults who have gluten sensitivities who cohabitate with other adults who may ...
(Date:8/19/2017)... ... August 19, 2017 , ... ... is the first organization with pending recognition status from the Centers for Disease ... via group telehealth classes and live video conferencing. , The DPP resulted ...
(Date:8/19/2017)... ... August 19, 2017 , ... Physician Partners of ... location as an interventional pain management physician. He brings a wealth of pain ... migraine headaches, and significant experience in spinal cord stimulation for chronic pain. , ...
(Date:8/18/2017)... ... August 18, 2017 , ... ... specialized asset-light logistics provider of complex transport solutions for mission-critical and non-discretionary ... Unitrans International Corporation, a division of Roadrunner Transportation Systems, Inc. (NYSE: RRTS). ...
(Date:8/18/2017)... ... ... The Dawn Johnson Insurance Group, a Missouri-based insurance and financial planning firm ... for efforts to educate the local population on cancer realities while attracting donations to ... , Each day in America, roughly 4,600 new cases of cancer are diagnosed and ...
Breaking Medicine News(10 mins):
(Date:8/10/2017)... 2017  Physical Rehabilitation Network (PRN), acquired the long-standing outpatient ... Colorado . The reputable clinic will continue to be ... with his staff of four clinicians. Lipkin received his doctorate ... over 10 years of experience with a strong background in ... marks the 10th PRN clinic in and around the ...
(Date:8/7/2017)... Zimmer Biomet Holdings, Inc. (NYSE and SIX: ZBH), ... Board of Directors has approved the payment of a quarterly ... The cash dividend of ... 27, 2017 to stockholders of record as of the close ... are subject to approval of the Board of Directors and ...
(Date:8/4/2017)... The search for test results that can ... has long been the goal of healthcare providers and ... the largest meeting of lab professionals and IVD firms ... firm Kalorama Information.  The firm said scores of companies ... supplies and software were at the American Association for ...
Breaking Medicine Technology: