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Differences in bone healing in old mice may hold answers to better bone healing for seniors
Date:3/21/2013

ine levels of Notch signaling are reduced in MSCs from geriatric mice. However, MSCs from young and old mice are both able to be stimulated by Jagged1 (one of the main ligands of Notch).

"The Notch signaling pathway's importance in skeletogenesis combined with our data showing reduced baseline Notch activity in geriatric MSCs and the ability of the MSCs to respond to Jagged1 provides a rational basis for delivery of Jagged1 as a potential therapeutic option for aged fractures" says Dr Ahn.

Importantly, this model provides a validated system for further study of the age-dependent differences in fracture healingand to test alterations that will enhance that healing for years to come.


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Contact: Katie Delach
katie.delach@uphs.upenn.edu
215-776-6063
University of Pennsylvania School of Medicine
Source:Eurekalert

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