Navigation Links
Differences in bone healing in old mice may hold answers to better bone healing for seniors
Date:3/21/2013

Philadelphia By studying the underlying differences in gene expression during healing after a bone break in young versus aged mice, Jaimo Ahn, MD, PhD, assistant professor of Orthopaedic Surgery at the Perelman School of Medicine, University of Pennsylvania, and his colleagues aim to find specific pathways of fracture healing in humans. The team of researchers will present their findings in a poster presentation beginning Tuesday, March 19, 2013 at the 2013 American Academy of Orthopedic Surgeons annual meeting in Chicago.

Problems with healing after bone fractures in elderly patients can be attributed, in part, to the compromised function of certain stem cells, called MSCs, that participate in the mending of the fracture. MSCs (Mesenchymal stem cells), can differentiate into a variety of cell types: cartilage, fat and most notably in fractures bone cells.

An important pathway called Notch, for the name of the receptor that is critical in relaying the "signal" has been identified as a critical event in the healing of non-skeletal tissues in an age-dependent manner. In the new study, the Penn team suspected that Notch would play a vital role in healing aged broken bones.

The team characterized fracture healing as a function of age and time post fracture in laboratory mice. Five-month-old laboratory mice are reproductively and skeletally mature. At 25-months-old, mice of the same strain are considered "geriatric." The researchers looked for progression of tissue and healing and the expression of Notch pathway genes including the ligands (small molecules that bind Notch to spur it into action), as well as Notch receptors and their down-stream effects. They examined both the healing fracture itself as well as the MSCs from the two age groups.

The team found that young mice produce a more robust healing response (timing, quantity and quality) than geriatric mice which persisted throughout healing. Interestingly, base l
'/>"/>

Contact: Katie Delach
katie.delach@uphs.upenn.edu
215-776-6063
University of Pennsylvania School of Medicine
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Study finds significant skull differences between closely linked groups
2. Mayo Clinic study links healthy muscle mass to healthy bones, finds differences by gender
3. Racial differences in diabetes diagnostic thresholds
4. Are there gender differences in anti-HIV drug efficacy?
5. BUSM/VA researchers uncover gender differences in the effects of long-term alcoholism
6. Individual gene differences can be tested in zebrafish
7. Scientists Find Gene Differences in Nonsmokers With Lung Cancer
8. Stanford/Yale study gives insight into subtle genomic differences among our own cells
9. Researchers discover gender-based differences in Alzheimers disease
10. CT depicts racial differences in coronary artery disease
11. U of T Researchers uncover major source of evolutionary differences among species
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/17/2014)... of the most popular vaccine brands for children may ... be overlooking some cost factors when choosing vaccines, driving ... option, according to a new study by University of ... can be driven by numerous factors," says Sheldon H. ... of computer science and of mathematics at the U. ...
(Date:4/17/2014)... (April 17, 2014) Two recent papers by ... and colleagues may help scientists develop treatments or ... fever, Japanese encephalitis and other disease-causing flaviviruses. , ... and molecular genetics at the School of Medicine ... Hughes Medical Institute, and colleagues recently published articles ...
(Date:4/17/2014)... April 17, 2014U.S. military personnel who served in ... concussive traumatic brain injury (TBI) were compared to ... other medical reasons. Differences in measures of overall ... months after injury are reported in an article ... journal from Mary Ann Liebert, Inc., publishers. The ...
(Date:4/17/2014)... IL, April 17, 2014-- Colic affects about one in ... for numerous pediatric visits during the first several months ... colic symptoms was showing promise; however, the April 1, ... (BMJ2014;348:g2107; Sung, Valerie) reported on a study, "Probiotics and ... L reuteri for infant colic did ...
(Date:4/17/2014)... An international team led by researchers at UC Davis ... plays a key role in cell division, also boosts ... the first time the complex has been shown to ... B1/Cdk1 an excellent target to control cellular energy production, ... was published online today in the journal Developmental ...
Breaking Medicine News(10 mins):Health News:Study recalculates costs of combination vaccines 2Health News:CU researchers discover target for treating dengue fever 2Health News:Long-term effects of battle-related 'blast plus impact' concussive TBI in US military 2Health News:New study says probiotic use for infant colic is not effective in reducing symptoms 2Health News:Dual role: Key cell division proteins also power up mitochondria 2
... undergo abdominal/pelvic computed tomography (CT) receive unindicated and unnecessary ... according to a study presented today at the annual ... "It is the responsibility of all physicians who ... is as low as reasonably achievable without compromising the ...
... ATLANTA, Nov. 29 The following is an investment ... Intellivest Securities Research, Inc., ("ISR") a Georgia registered investment ... BIOC) which serves companies in the pharmaceutical, biotechnology and ... their clients manage, process and submit medical imaging portions ...
... blamed for something leads to more self-defensive finger pointing, study ... game is a contagious one, a new study reports, even ... people see someone blame someone else for a problem, even ... engage in blaming others, too. , "When we see ...
... , , CHICAGO, Nov. 28 Welcome ... PACS solution for the clinical routine from Siemens Healthcare. ... from Siemens where 2D, 3D, and 4D reading come together in one place, ... multimodality images are read today. Siemens is unveiling this innovation at ...
... Mass., Nov. 27 GSI Group Inc. (Pink Sheets: GSIGQ)(the ... today announced that an annual meeting of the Company,s shareholders ... time and location of the meeting will be announced in ... requisition notice from Stephen Bershad, a holder of greater than ...
... , , ROCHESTER, N.Y., Nov. 27 ... and fortunately every year, new vaccines are being added to ... for the same period of time? And, if not, when ... , In this month,s issue of Pediatrics, the Journal ...
Cached Medicine News:Health News:Unindicated CT series result in unnecessary radiation exposure for patients 2Health News:Unindicated CT series result in unnecessary radiation exposure for patients 3Health News:Research Report on BioClinica, Inc. as Speculative Buy 2Health News:When Accusations Start to Fly, They Multiply 2Health News:Siemens Healthcare Unveils syngo.plaza at RSNA 2009 2Health News:Siemens Healthcare Unveils syngo.plaza at RSNA 2009 3Health News:GSI Group Calls Shareholders Meeting 2Health News:Why Some Vaccines May Require A Booster 2Health News:Why Some Vaccines May Require A Booster 3
(Date:1/14/2014)... Jan. 14, 2014  Luminex Corporation (Nasdaq: LMNX ) ... fourth quarter of 2013 on Monday, February 3, 2014. A ... the close of trading. (Logo: http://photos.prnewswire.com/prnh/20100104/LUMINEXLOGO ... discuss the operating highlights and financial results for the fourth ...
(Date:1/14/2014)... The Brandeis Medical Center, led by Dr. Emmanuel Brandeis , ... laser tattoo removal experience with the advanced Astanza Duality laser and ... quality cosmetic services with cutting edge medical technology and offering expert ... has seen a dramatic increase in the presence of ...
(Date:1/14/2014)... -- Acumed,s new SLIC Screw System - a jointed ... place and insert the screw accurately - offers surgeons ... repair or reconstruction as it holds the bones reduced ... http://photos.prnewswire.com/prnh/20140114/MN45636 ) The SLIC Screw is ...
Breaking Medicine Technology:Luminex Corporation Fourth Quarter Earnings Release Scheduled for February 3, 2014 2Luminex Corporation Fourth Quarter Earnings Release Scheduled for February 3, 2014 3Beverly Hills Physician Features Tattoo Removal with the Astanza Duality Laser, Offers $99 Special 2Acumed introduces the Scapho-Lunate Inter Carpal (SLIC) Screw System 2Acumed introduces the Scapho-Lunate Inter Carpal (SLIC) Screw System 3
... Sanofi Pasteur, the vaccines division of Sanofi (EURONEXT: ... congratulations to the four winners of the International BioGENEius ... an exemplary understanding of biotechnology through science research projects. ... Challenge since its inception in the early 1990s. Sanofi ...
... Shield LLC today announced the new SILVER STORM™ waterproof, ... with other infection prevention products, at the APIC infection ... been designed to help prevent cross contamination infections which ... According to a bacteria study of common touch ...
Cached Medicine Technology:Sanofi Pasteur Commends Winners of International BioGENEius Challenge 2Sanofi Pasteur Commends Winners of International BioGENEius Challenge 3
With this more compact transducer face, this is the transducer of choice for obstetric imaging in areas with a small acoustic window....
Compact, bench-top analyser with minimal water volume requirements and easy waste management....
... The OPTI LION is a compact ... single-use cassettes instead of reagents or ... patient sample is analyzed., ,In addition ... the OPTI LION measures ionized calcium ...
... is precision, ergonomics, and value!, ... with soft non-slip, contoured handle , ... light plunger spring action , Completely ... without the need for recalibration , ...
Medicine Products: