Navigation Links
Differences in bone healing in old mice may hold answers to better bone healing for seniors
Date:3/21/2013

Philadelphia By studying the underlying differences in gene expression during healing after a bone break in young versus aged mice, Jaimo Ahn, MD, PhD, assistant professor of Orthopaedic Surgery at the Perelman School of Medicine, University of Pennsylvania, and his colleagues aim to find specific pathways of fracture healing in humans. The team of researchers will present their findings in a poster presentation beginning Tuesday, March 19, 2013 at the 2013 American Academy of Orthopedic Surgeons annual meeting in Chicago.

Problems with healing after bone fractures in elderly patients can be attributed, in part, to the compromised function of certain stem cells, called MSCs, that participate in the mending of the fracture. MSCs (Mesenchymal stem cells), can differentiate into a variety of cell types: cartilage, fat and most notably in fractures bone cells.

An important pathway called Notch, for the name of the receptor that is critical in relaying the "signal" has been identified as a critical event in the healing of non-skeletal tissues in an age-dependent manner. In the new study, the Penn team suspected that Notch would play a vital role in healing aged broken bones.

The team characterized fracture healing as a function of age and time post fracture in laboratory mice. Five-month-old laboratory mice are reproductively and skeletally mature. At 25-months-old, mice of the same strain are considered "geriatric." The researchers looked for progression of tissue and healing and the expression of Notch pathway genes including the ligands (small molecules that bind Notch to spur it into action), as well as Notch receptors and their down-stream effects. They examined both the healing fracture itself as well as the MSCs from the two age groups.

The team found that young mice produce a more robust healing response (timing, quantity and quality) than geriatric mice which persisted throughout healing. Interestingly, base line levels of Notch signaling are reduced in MSCs from geriatric mice. However, MSCs from young and old mice are both able to be stimulated by Jagged1 (one of the main ligands of Notch).

"The Notch signaling pathway's importance in skeletogenesis combined with our data showing reduced baseline Notch activity in geriatric MSCs and the ability of the MSCs to respond to Jagged1 provides a rational basis for delivery of Jagged1 as a potential therapeutic option for aged fractures" says Dr Ahn.

Importantly, this model provides a validated system for further study of the age-dependent differences in fracture healingand to test alterations that will enhance that healing for years to come.


'/>"/>

Contact: Katie Delach
katie.delach@uphs.upenn.edu
215-776-6063
University of Pennsylvania School of Medicine
Source:Eurekalert

Related medicine news :

1. Study finds significant skull differences between closely linked groups
2. Mayo Clinic study links healthy muscle mass to healthy bones, finds differences by gender
3. Racial differences in diabetes diagnostic thresholds
4. Are there gender differences in anti-HIV drug efficacy?
5. BUSM/VA researchers uncover gender differences in the effects of long-term alcoholism
6. Individual gene differences can be tested in zebrafish
7. Scientists Find Gene Differences in Nonsmokers With Lung Cancer
8. Stanford/Yale study gives insight into subtle genomic differences among our own cells
9. Researchers discover gender-based differences in Alzheimers disease
10. CT depicts racial differences in coronary artery disease
11. U of T Researchers uncover major source of evolutionary differences among species
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/24/2017)... ... 24, 2017 , ... Altec Products, Inc., a leader in enterprise ... one-day technology conference in San Diego, CA. , At nVerge 2017, Altec will ... utilize and enhance their Sage ERP solutions by providing improved visibility and control to ...
(Date:5/24/2017)... DC (PRWEB) , ... May 24, 2017 , ... ... Center for Global Policy Solutions is vehemently opposed to Donald Trump’s budget, “A ... formula for despair that inspires fear, demonizes the poor, marginalizes underserved populations, undermines ...
(Date:5/24/2017)... ... May 24, 2017 , ... ... to its solutions portfolio. ExtraHop delivers an analytics-first approach, layered with machine learning, ... system, from the datacenter to the cloud to the edge. Through the new ...
(Date:5/24/2017)... ... May 24, 2017 , ... Fiberstar, Inc., http://www.FiberstarIngredients.com ... and beverage industry offers Citri-Fi®, a natural citrus fiber, to improve beverage ingredient ... As a result, labels need to deliver simple, transparent and clear messaging. Listed ...
(Date:5/23/2017)... ... May 23, 2017 , ... Allegheny Health Network ... The Alexis Joy D’Achille Center for Women’s Behavioral Health at West Penn Hospital ... western Pennsylvania for women suffering from pregnancy-related depression. Construction of the Center is ...
Breaking Medicine News(10 mins):
(Date:5/6/2017)... May 5, 2017  Hill-Rom Holdings, Inc. (NYSE: HRC), ... 100,000 square feet to its Welch Allyn campus. ... commitment to bring more than 100 new jobs to ... Allyn has maintained a significant presence for more than ... new positions, a large portion of which will be ...
(Date:5/4/2017)... SAN DIEGO , May 4, 2017  The ... Clinical and Scientific Meeting— OBP Medical , a leading ... announced the launch of a new extra-small size and ... ER-SPEC vaginal specula. Already available in small, ... sizes makes OBP Medical,s line of single-use lighted specula ...
(Date:5/3/2017)... 3, 2017 A Catheterization Laboratory is ... healthcare facility. Commonly referred to as cath lab, ... diagnostic imaging technology to give physicians visual access ... these spaces, a team of physicians perform life-saving ... coronary intervention, congenital heart defect closure, stenotic heart ...
Breaking Medicine Technology: