Navigation Links
Diets High in Fructose May Harm Liver in Some, Scientists Warn
Date:9/17/2012

MONDAY, Sept. 17 (HealthDay News) -- Obese people with type 2 diabetes who consume increased amounts of fructose -- a simple sugar -- may have high levels of uric acid and a reduction in liver energy stores, researchers say.

High uric acid, or hyperuricemia, is linked to lower levels of liver adenosine triphosphate (ATP), a compound involved in transferring energy between cells, scientists from Duke University Medical Center explained in a news release.

The researchers, who published their new report in the September issue of the journal Hepatology, noted that energy depletion in the liver could result in liver damage for those with the metabolic condition known as non-alcoholic fatty liver disease and in those at risk for the condition. They stressed that the public should be aware of these risks associated with a diet high in fructose.

"There is an alarming trend of increased rates of obesity, type 2 diabetes and [non-alcoholic fatty liver disease] in the U.S.," lead author Dr. Manal Abdelmalek said in the journal news release. "Given the concurrent rise in fructose consumption and metabolic diseases, we need to fully understand the impact of a high-fructose diet on liver function and liver disease."

Fructose is a simple sugar found in fruits and vegetables. It also is combined with glucose to manufacture high-fructose corn syrup, a sweetener in many packaged foods such as cereal and soda.

The researchers examined nearly 250 obese and diabetic adults participating in the Look AHEAD Study. The participants were asked to estimate the amount of fructose they consumed.

Liver ATP and uric acid levels also were measured in more than 100 patients who participated in a second study. Researchers measured the difference in liver ATP content between patients with low fructose consumption (less than 15 grams per day) and those with high fructose consumption (greater than 15 grams per day).

The study revealed that participants with high dietary fructose consumption had lower liver ATP levels when the study began and a more significant change in ATP after the fructose test. The researchers also noted that those with high uric acid levels had lower ATP stores following high fructose intake.

Based on their findings, the researchers suggested uric acid, which is produced by the breakdown of natural food substances known as purines, may serve as a marker for increased fructose consumption and low levels of liver ATP.

"High fructose consumption and elevated levels of uric acid are associated with more severe depletion of liver ATP," Abdelmalek said in the news release. "Our findings suggest that increased dietary fructose intake may impair liver 'energy balance.' Further research to define the clinical implications of these findings on metabolism and NAFLD is necessary."

Although the study found an association between a diet high in fructose and liver risks in certain people, it did not prove a cause-and-effect relationship.

More information

The American Heart Association has more about sugars and high-fructose corn syrup.

-- Mary Elizabeth Dallas

SOURCE: Hepatology, news release, Sept. 13, 2012


'/>"/>
Copyright©2012 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Long-Term Salty Diets Tied Again to High Blood Pressure
2. Certain Diets May Help Body Burn More Calories: Study
3. Atkins-Type Diets May Raise Risk of Heart Problems: Study
4. Low-Cal Diets Kept Monkeys Healthier, But Didnt Lengthen Lives
5. Increased dietary fructose linked to elevated uric acid levels and lower liver energy stores
6. Normalizing tumor blood vessels improves delivery of only the smallest nanomedicines
7. CT Scans Deliver More Radiation to Obese People: Study
8. Modest alcohol consumption lowers risk and severity of liver disease
9. Childhood Obesity May Raise Odds of Adult Liver Cancer
10. UNC study shows potential to revive abandoned cancer drug by nanoparticle drug delivery
11. Combination of 2 drugs reverses liver tumors
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Diets High in Fructose May Harm Liver in Some, Scientists Warn
(Date:10/13/2017)... ... , ... The Visiting Nurse Association (VNA) of Somerset Hills is proud to ... unique items from across the nation, this holiday-themed event will raise funds and awareness ... VNA. The boutique will be open Saturday, November 4 (10:00 a.m. – 5:00 ...
(Date:10/13/2017)... , ... October 13, 2017 , ... Yisrayl Hawkins, Pastor ... that explains one of the most popular and least understood books in the Holy ... and puzzling descriptions that have baffled scholars for centuries. Many have tossed it off ...
(Date:10/13/2017)... ... ... Journey: From the Mountains to the Mission Field”: the story of a missionary couple ... From the Mountains to the Mission Field” is the creation of published author, Carole ... and currently teaches a class of ladies at her church, which she has taught ...
(Date:10/12/2017)... San Francisco, CA (PRWEB) , ... October 12, ... ... and Dr. Cheng, are now treating sleep apnea using cutting-edge Oventus ... sleep apnea, a serious sleep disorder characterized by frequent cessation in breathing. Oral ...
(Date:10/12/2017)... ... October 12, 2017 , ... IsoComforter, Inc. ( https://isocomforter.com ... the introduction of an innovative new design of the shoulder pad. The shoulder ... maximum comfort while controlling your pain while using cold therapy. By utilizing ice and ...
Breaking Medicine News(10 mins):
(Date:10/4/2017)...  South Korean-based healthcare product Development Company I.M. Lab ... Kickstarter. The device will educate the user about ,proper, ... efficiency compared to the dated and pricey CPR training ... of the compression for a more informed CPR training. ... raise $5,000. cprCUBE ...
(Date:10/2/2017)... Mich. , Oct. 2, 2017 Diplomat ... 8th Day Software and Consulting, LLC , and ... 8th Day Software, based in Tennessee ... LLC. 8th Day expands EnvoyHealth,s service offerings for health ... development. "In an ...
(Date:10/2/2017)... , Oct. 2, 2017 Halo Labs announces the European ... system called the HORIZON at MIBio 2017 in Cambridge, ... and visible particulate matter in biopharmaceutical samples with unprecedented speed and ... the novel technique Backgrounded Membrane Imaging. ... The HORIZON subvisible particle analysis system ...
Breaking Medicine Technology: