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Dietary supplements for patients after lung injury do not appear to improve outcomes; may be harmful
Date:10/5/2011

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"This study suggests that twice-daily enteral supplementation of n-3 fatty acids, GLA, and antioxidants change plasma levels of n-3 fatty acids but do not improve clinical outcomes or biomarkers of systemic inflammation in patients with ALI and in fact may be harmful," the authors conclude.

(JAMA. 2011;306[14]:1574-1581. Available pre-embargo to the media at www.jamamedia.org)

Editor's Note: Please see the article for additional information, including other authors, author contributions and affiliations, financial disclosures, funding and support, etc.

Please Note: The presentation of this study will be available online at http://webtv.esicm.org beginning at 8:45 a.m. CT Wednesday, October 5.

Editorial: Pharmaconutrition in Acute Lung Injury

Deborah J. Cook, M.D., M.Sc., of McMaster University Health Sciences Center, Hamilton, Ontario, and Daren K. Heyland, M.D., M.Sc., of Queens University, Kingston, Ontario, Canada write in an accompanying editorial that more research is needed regarding the use of pharmaconutrition.

"Translational research as was used in the OMEGA trial will elucidate effects, or lack thereof, on inflammatory, immunologic, metabolic, and other processes. Clinical research will test whether modulating pathophysiology improves morbidity and mortality. Larger trials will help to inform practitioners regarding which interventions do more good than harm, which do more harm than good, and which truly have no effect. Interdisciplinary collaboration incorporating basic principles of nutrition will be needed to accelerate the generation of new knowledge. Currently, international audits of nutrition practice suggest that use of these and other pharmaconutrients is low. If and when the time is ripe, the fruits of these labors will be harvested in knowledge translation activities that drive quality improvement to he
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Contact: Craig Boerner
craig.boerner@vanderbilt.edu
615-322-4747
JAMA and Archives Journals
Source:Eurekalert

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